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  1. Article ; Online: Effects of Plant-Based Protein Interventions, with and without an Exercise Component, on Body Composition, Strength and Physical Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Stoodley, Isobel L / Williams, Lily M / Wood, Lisa G

    Nutrients

    2023  Volume 15, Issue 18

    Abstract: Maintaining muscle mass, strength, and function is crucial for our aging population. Exercise and dietary protein intake are recommended strategies; however, animal proteins have been the most studied. Plant-based protein sources have lower digestibility ...

    Abstract Maintaining muscle mass, strength, and function is crucial for our aging population. Exercise and dietary protein intake are recommended strategies; however, animal proteins have been the most studied. Plant-based protein sources have lower digestibility and incomplete amino acid profiles. However new innovative plant-based proteins and products may have overcome these issues. Therefore, this systematic review aimed to synthesize the current research and evaluate the effects of plant-based protein interventions compared to placebo on body composition, strength, and physical function in older adults (≥60 years old). The secondary aim was whether exercise improved the effectiveness of plant-based protein on these outcomes. Randomized controlled trials up to January 2023 were identified through Medline, EMBASE, CINAHL, and Cochrane Library databases. Studies contained a plant-protein intervention, and assessed body composition, strength, and/or physical function. Thirteen articles were included, all using soy protein (0.6-60 g daily), from 12 weeks to 1 year. Narrative summary reported positive effects on muscle mass over time, with no significant differences compared to controls (no intervention, exercise only, animal protein, or exercise + animal protein interventions). There was limited impact on strength and function. Meta-analysis showed that plant-protein interventions were comparable to controls, in all outcomes. In conclusion, plant-protein interventions improved muscle mass over time, and were comparable to other interventions, warranting further investigation as an anabolic stimulus in this vulnerable population.
    Language English
    Publishing date 2023-09-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15184060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis.

    Berthon, Bronwyn S / Williams, Lily M / Williams, Evan J / Wood, Lisa G

    Advances in nutrition (Bethesda, Md.)

    2022  Volume 13, Issue 5, Page(s) 1799–1819

    Abstract: Lactoferrin (Lf) is a glycoprotein present in human and bovine milk with antimicrobial and immune-modulating properties. This review aimed to examine the evidence for the effect of Lf supplementation on inflammation, immune function, and respiratory ... ...

    Abstract Lactoferrin (Lf) is a glycoprotein present in human and bovine milk with antimicrobial and immune-modulating properties. This review aimed to examine the evidence for the effect of Lf supplementation on inflammation, immune function, and respiratory tract infections (RTIs) in humans. Online databases were searched up to December 2020 to identify relevant, English-language articles that examined the effect of Lf supplementation in human subjects of all ages, on either inflammation, immune cell populations or activity, or the incidence, duration, or severity of respiratory illness or RTIs. Twenty-five studies (n = 20 studies in adults) were included, of which 8 of 13 studies (61%) in adults reported a decrease in at least 1 systemic inflammatory biomarker. Immune function improved in 6 of 8 studies (75%) in adults, with changes in immune cell populations in 2 of 6 studies (33%), and changes in immune cell activity in 2 of 5 studies (40%). RTI outcomes were reduced in 6 of 10 studies (60%) (n = 5 in adults, n = 5 in children), with decreased incidence in 3 of 9 studies (33%), and either decreased frequency (2/4, 50%) or duration (3/6, 50%) in 50% of studies. In adults, Lf reduced IL-6 [mean difference (MD): -24.9 pg/mL; 95% CI: -41.64, -8.08 pg/mL], but not C-reactive protein (CRP) [standardized mean difference: -0.09; 95% CI: -0.82, 0.65], or NK cell cytotoxicity [MD: 4.84%; 95% CI: -3.93, 13.60%]. RTI incidence was reduced in infants and children (OR: 0.78; 95% CI: 0.61, 0.98) but not in adults (OR: 1.00; 95% CI: 0.76, 1.32). Clinical studies on Lf supplementation are limited, although findings show 200 mg Lf/d reduces systemic inflammation, while formulas containing 35-833 mg Lf/d may reduce RTI incidence in infants and children, suggesting improved immune function. Future research is required to determine optimal supplementation strategies and populations most likely to benefit from Lf supplementation. This trial was registered at PROSPERO (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232186) as CRD42021232186.
    MeSH term(s) Adult ; Biomarkers ; Child ; Dietary Supplements ; Glycoproteins ; Humans ; Immunity ; Infant ; Inflammation/drug therapy ; Inflammation/prevention & control ; Interleukin-6 ; Lactoferrin/analysis ; Lactoferrin/pharmacology ; Lactoferrin/therapeutic use ; Respiratory Tract Infections/prevention & control
    Chemical Substances Biomarkers ; Glycoproteins ; Interleukin-6 ; Lactoferrin (EC 3.4.21.-)
    Language English
    Publishing date 2022-05-01
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1093/advances/nmac047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Medicinal Mushroom Extracts from

    Williams, Lily M / Berthon, Bronwyn S / Stoodley, Isobel L / Williams, Evan J / Wood, Lisa G

    Nutrients

    2023  Volume 15, Issue 9

    Abstract: Medicinal mushroom extracts (MMEs) exert immunomodulatory effects on innate immunity. The present study aimed to examine the effect of medicinal mushroom components ... ...

    Abstract Medicinal mushroom extracts (MMEs) exert immunomodulatory effects on innate immunity. The present study aimed to examine the effect of medicinal mushroom components on
    MeSH term(s) Animals ; Agaricales ; Trametes ; Influenza A Virus, H1N1 Subtype ; Leukocytes, Mononuclear ; Lipopolysaccharides/pharmacology ; Pyroglyphidae ; Immunity, Innate ; Cytokines
    Chemical Substances Lipopolysaccharides ; Cytokines
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15092227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Effects of Prebiotics, Synbiotics, and Short-Chain Fatty Acids on Respiratory Tract Infections and Immune Function: A Systematic Review and Meta-Analysis.

    Williams, Lily M / Stoodley, Isobel L / Berthon, Bronwyn S / Wood, Lisa G

    Advances in nutrition (Bethesda, Md.)

    2021  Volume 13, Issue 1, Page(s) 167–192

    Abstract: Prebiotics, synbiotics, and SCFAs have been shown to decrease systemic inflammation and play a protective role in chronic respiratory conditions. However, their effects on infection and immune function are unclear. The objective of this systematic review ...

    Abstract Prebiotics, synbiotics, and SCFAs have been shown to decrease systemic inflammation and play a protective role in chronic respiratory conditions. However, their effects on infection and immune function are unclear. The objective of this systematic review was to summarize the current evidence for prebiotic, synbiotic, and SCFA supplementation on respiratory tract infections (RTIs) and immune function. The protocol for this systematic review was registered with PROSPERO (National Institute for Health Research, University of York, UK), accessed online at https://www.crd.york.ac.uk/prospero (CRD42019118786). Relevant English-language articles up to May 2021 were identified via online databases: MEDLINE, EMBASE, CINAHL, and Cochrane Library. Included studies (n = 58) examined the effect of prebiotics, synbiotics, or SCFA, delivered orally, on the incidence, severity, or duration of RTIs and/or markers of immune function (e.g., peripheral blood immunophenotyping, NK cell activity). The majority of studies were randomized controlled trials reporting on RTIs in infants and children. The meta-analysis indicated that the numbers of subjects with ≥1 RTI were reduced with prebiotic (OR, 0.73; 95% CI: 0.62-0.86; P = 0.0002; n = 17) and synbiotic (OR, 0.75; 95% CI: 0.65-0.87; P = 0.0001; n = 9) supplementation compared to placebo. Further, NK cell activity was increased with synbiotic (standardized mean difference, 0.74; 95% CI: 0.42-1.06; P < 0.0001, n = 3) supplementation. This review provides evidence that prebiotic, specifically oligosaccharide, supplementation may play a protective role in RTIs in infants and children. There is less evidence for this effect in adults. Supplementation with prebiotic and synbiotic treatment may alter immune function by increasing NK cell activity, though effects on immunophenotype were less clear.
    MeSH term(s) Adult ; Child ; Fatty Acids, Volatile ; Humans ; Immunity ; Infant ; Prebiotics ; Probiotics/therapeutic use ; Randomized Controlled Trials as Topic ; Respiratory Tract Infections/prevention & control ; Synbiotics
    Chemical Substances Fatty Acids, Volatile ; Prebiotics
    Language English
    Publishing date 2021-09-19
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1093/advances/nmab114
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article ; Online: Nutrition in Asthma.

    Williams, Evan J / Berthon, Bronwyn S / Stoodley, Isobel / Williams, Lily M / Wood, Lisa G

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 5, Page(s) 646–661

    Abstract: An emerging body of evidence suggests that diet plays an important role in both the development and management of asthma. The relationship between dietary intake and asthma risk has been explored in epidemiological studies, though intervention trials ... ...

    Abstract An emerging body of evidence suggests that diet plays an important role in both the development and management of asthma. The relationship between dietary intake and asthma risk has been explored in epidemiological studies, though intervention trials examining the effects of nutrient intake and dietary patterns on asthma management are scarce. Evidence for diets high in fruits and vegetables, antioxidants, omega-3 fatty acids and soluble fiber such as the Mediterranean diet is conflicting. However, some studies suggest that these diets may reduce the risk of asthma, particularly in young children, and could have positive effects on disease management. In contrast, a Westernized dietary pattern, high in saturated fatty acids, refined grains, and sugars may promote an inflammatory environment resulting in the onset of disease and worsening of asthma outcomes. This review will summarize the state of the evidence for the impact of whole dietary patterns, as well as individual nutrients, on the prevalence and management of asthma.
    MeSH term(s) Antioxidants/therapeutic use ; Asthma/epidemiology ; Asthma/etiology ; Asthma/therapy ; Child ; Child, Preschool ; Fatty Acids ; Fatty Acids, Omega-3/therapeutic use ; Humans ; Nutritional Status ; Sugars
    Chemical Substances Antioxidants ; Fatty Acids ; Fatty Acids, Omega-3 ; Sugars
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1742385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Nutrition in Asthma

    Williams, Evan J. / Berthon, Bronwyn S. / Stoodley, Isobel / Williams, Lily M. / Wood, Lisa G.

    Seminars in Respiratory and Critical Care Medicine

    (Advances in Asthma)

    2022  Volume 43, Issue 05, Page(s) 646–661

    Abstract: An emerging body of evidence suggests that diet plays an important role in both the development and management of asthma. The relationship between dietary intake and asthma risk has been explored in epidemiological studies, though intervention trials ... ...

    Series title Advances in Asthma
    Abstract An emerging body of evidence suggests that diet plays an important role in both the development and management of asthma. The relationship between dietary intake and asthma risk has been explored in epidemiological studies, though intervention trials examining the effects of nutrient intake and dietary patterns on asthma management are scarce. Evidence for diets high in fruits and vegetables, antioxidants, omega-3 fatty acids and soluble fiber such as the Mediterranean diet is conflicting. However, some studies suggest that these diets may reduce the risk of asthma, particularly in young children, and could have positive effects on disease management. In contrast, a Westernized dietary pattern, high in saturated fatty acids, refined grains, and sugars may promote an inflammatory environment resulting in the onset of disease and worsening of asthma outcomes. This review will summarize the state of the evidence for the impact of whole dietary patterns, as well as individual nutrients, on the prevalence and management of asthma.
    Keywords asthma ; nutrition ; bronchoconstriction
    Language English
    Publishing date 2022-03-10
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1742385
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Soluble fibre as a treatment for inflammation in asthma

    Williams, Lily M / Scott, Hayley A / Wood, Lisa G

    Journal of nutrition & intermediary metabolism. 2019 Dec., v. 18

    2019  

    Abstract: Asthma is a highly prevalent inflammatory disease of the airways. Bacterial metabolites of soluble fibre fermentation, such as short chain fatty acids (SCFAs), have been shown to exert anti-inflammatory effects via free fatty acid receptor activation and ...

    Abstract Asthma is a highly prevalent inflammatory disease of the airways. Bacterial metabolites of soluble fibre fermentation, such as short chain fatty acids (SCFAs), have been shown to exert anti-inflammatory effects via free fatty acid receptor activation and epigenetic regulation through inhibition of histone deacetylases (HDACs). The aim of the present review was to summarise the available evidence for soluble fibre in the treatment and prevention asthma. There is substantial preclinical evidence suggesting soluble fibre may be beneficial in the airways. The clinical evidence in this area is limited, however available studies to date have reported promising evidence for the future of soluble fibre interventions as an adjunct treatment in asthma management.
    Keywords asthma ; epigenetics ; fermentation ; free fatty acids ; histone deacetylase ; inflammation ; nutrition ; soluble fiber
    Language English
    Dates of publication 2019-12
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2834238-0
    ISSN 2352-3859
    ISSN 2352-3859
    DOI 10.1016/j.jnim.2019.100108
    Database NAL-Catalogue (AGRICOLA)

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