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  1. Article ; Online: Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

    Steinthorsdottir, Valgerdur / McGinnis, Ralph / Williams, Nicholas O / Stefansdottir, Lilja / Thorleifsson, Gudmar / Shooter, Scott / Fadista, João / Sigurdsson, Jon K / Auro, Kirsi M / Berezina, Galina / Borges, Maria-Carolina / Bumpstead, Suzannah / Bybjerg-Grauholm, Jonas / Colgiu, Irina / Dolby, Vivien A / Dudbridge, Frank / Engel, Stephanie M / Franklin, Christopher S / Frigge, Michael L /
    Frisbaek, Yr / Geirsson, Reynir T / Geller, Frank / Gretarsdottir, Solveig / Gudbjartsson, Daniel F / Harmon, Quaker / Hougaard, David Michael / Hegay, Tatyana / Helgadottir, Anna / Hjartardottir, Sigrun / Jääskeläinen, Tiina / Johannsdottir, Hrefna / Jonsdottir, Ingileif / Juliusdottir, Thorhildur / Kalsheker, Noor / Kasimov, Abdumadjit / Kemp, John P / Kivinen, Katja / Klungsøyr, Kari / Lee, Wai K / Melbye, Mads / Miedzybrodska, Zosia / Moffett, Ashley / Najmutdinova, Dilbar / Nishanova, Firuza / Olafsdottir, Thorunn / Perola, Markus / Pipkin, Fiona Broughton / Poston, Lucilla / Prescott, Gordon / Saevarsdottir, Saedis / Salimbayeva, Damilya / Scaife, Paula Juliet / Skotte, Line / Staines-Urias, Eleonora / Stefansson, Olafur A / Sørensen, Karina Meden / Thomsen, Liv Cecilie Vestrheim / Tragante, Vinicius / Trogstad, Lill / Simpson, Nigel A B / Aripova, Tamara / Casas, Juan P / Dominiczak, Anna F / Walker, James J / Thorsteinsdottir, Unnur / Iversen, Ann-Charlotte / Feenstra, Bjarke / Lawlor, Deborah A / Boyd, Heather Allison / Magnus, Per / Laivuori, Hannele / Zakhidova, Nodira / Svyatova, Gulnara / Stefansson, Kari / Morgan, Linda

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 5976

    Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal ... ...

    Abstract Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adult ; Aged ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Asia, Central/epidemiology ; Blood Pressure/genetics ; Case-Control Studies ; Datasets as Topic ; Europe/epidemiology ; Female ; Fibroblast Growth Factor 5/genetics ; Genetic Loci/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Hypertension, Pregnancy-Induced/genetics ; MDS1 and EVI1 Complex Locus Protein/genetics ; Middle Aged ; Multifactorial Inheritance ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/genetics ; Pregnancy ; Prospective Studies
    Chemical Substances Adaptor Proteins, Signal Transducing ; FGF5 protein, human ; MDS1 and EVI1 Complex Locus Protein ; MECOM protein, human ; SH2B3 protein, human ; Fibroblast Growth Factor 5 (129653-64-1) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-19733-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

    McGinnis, Ralph / Steinthorsdottir, Valgerdur / Williams, Nicholas O / Thorleifsson, Gudmar / Shooter, Scott / Hjartardottir, Sigrun / Bumpstead, Suzannah / Stefansdottir, Lilja / Hildyard, Lucy / Sigurdsson, Jon K / Kemp, John P / Silva, Gabriela B / Thomsen, Liv Cecilie V / Jääskeläinen, Tiina / Kajantie, Eero / Chappell, Sally / Kalsheker, Noor / Moffett, Ashley / Hiby, Susan /
    Lee, Wai Kwong / Padmanabhan, Sandosh / Simpson, Nigel A B / Dolby, Vivien A / Staines-Urias, Eleonora / Engel, Stephanie M / Haugan, Anita / Trogstad, Lill / Svyatova, Gulnara / Zakhidova, Nodira / Najmutdinova, Dilbar / Dominiczak, Anna F / Gjessing, Håkon K / Casas, Juan P / Dudbridge, Frank / Walker, James J / Pipkin, Fiona Broughton / Thorsteinsdottir, Unnur / Geirsson, Reynir T / Lawlor, Debbie A / Iversen, Ann-Charlotte / Magnus, Per / Laivuori, Hannele / Stefansson, Kari / Morgan, Linda

    Nature genetics

    2017  Volume 49, Issue 8, Page(s) 1255–1260

    Abstract: Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have ... ...

    Abstract Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10
    MeSH term(s) Cohort Studies ; Female ; Fetus ; Follow-Up Studies ; Genetic Predisposition to Disease ; Genome, Human ; Genome-Wide Association Study ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Pre-Eclampsia/genetics ; Pregnancy ; Pregnancy Proteins/genetics ; Vascular Endothelial Growth Factor Receptor-1/blood ; Vascular Endothelial Growth Factor Receptor-1/genetics
    Chemical Substances Pregnancy Proteins ; FLT1 protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2017-06-19
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng.3895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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