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  1. AU="Willis, Zachary I"
  2. AU="Kruger, Eric S"
  3. AU="Ge, Shiyu"
  4. AU="Srivastava, Rajat"
  5. AU="Nemanja Vuksanovic"

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  1. Artikel ; Online: Sinusitis treatment guidelines associated with increased amoxicillin-based and decreased broad-spectrum antibiotics dispensed.

    Willis, Zachary I

    The Journal of pediatrics

    2023  Band 261, Seite(n) 113544

    Mesh-Begriff(e) Humans ; Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Sinusitis/drug therapy
    Chemische Substanzen Amoxicillin (804826J2HU) ; Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2023-05-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2023.113544
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Monoclonal Antibodies for COVID-19 in Children: Case Series Should be Just the Start.

    Teoh, Zheyi / Willis, Zachary I

    Journal of the Pediatric Infectious Diseases Society

    2023  Band 12, Heft 3, Seite(n) 156–158

    Abstract: Two new articles describe the use and implementation of monoclonal antibodies to treat COVID-19 in children. While these studies provide valuable guidance for pediatric clinicians, more studies of monoclonal antibodies and other COVID-19 therapies in ... ...

    Abstract Two new articles describe the use and implementation of monoclonal antibodies to treat COVID-19 in children. While these studies provide valuable guidance for pediatric clinicians, more studies of monoclonal antibodies and other COVID-19 therapies in children are needed.
    Mesh-Begriff(e) Humans ; Child ; Retrospective Studies ; COVID-19 ; Antibodies, Monoclonal/therapeutic use
    Chemische Substanzen Antibodies, Monoclonal
    Sprache Englisch
    Erscheinungsdatum 2023-03-16
    Erscheinungsland England
    Dokumenttyp Editorial ; Comment
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piad006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: ED respiratory viral testing and antibiotic prescribing behavior.

    Ciccone, Emily J / Willis, Zachary I

    The Journal of pediatrics

    2022  Band 251, Seite(n) 220–224

    Mesh-Begriff(e) Humans ; Anti-Bacterial Agents/therapeutic use
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2022-11-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.08.057
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Revised Daptomycin Interpretation Criteria for Enterococcus faecium: What Are the Implications for Children?

    Willis, Zachary I / Wilson, William S

    Journal of the Pediatric Infectious Diseases Society

    2019  Band 9, Heft 2, Seite(n) 265–267

    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Child ; Daptomycin/therapeutic use ; Enterococcus faecium ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/drug therapy ; Humans ; Microbial Sensitivity Tests
    Chemische Substanzen Anti-Bacterial Agents ; Daptomycin (NWQ5N31VKK)
    Sprache Englisch
    Erscheinungsdatum 2019-10-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piz066
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: A Piece of the Puzzle: The Role of Molecular Testing in Antimicrobial Stewardship.

    Willis, Zachary I / de St Maurice, Annabelle

    Journal of the Pediatric Infectious Diseases Society

    2021  Band 10, Heft 9, Seite(n) 930–935

    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Humans ; Microbial Sensitivity Tests ; Molecular Diagnostic Techniques
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2021-06-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piab037
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The Cost of Vancomycin and Piperacillin/Tazobactam Treatment.

    Willis, Zachary I / Jhaveri, Ravi

    JAMA pediatrics

    2018  Band 172, Heft 5, Seite(n) 494

    Mesh-Begriff(e) Acute Kidney Injury ; Child ; Child, Hospitalized ; Humans ; Piperacillin ; Tazobactam ; Vancomycin
    Chemische Substanzen Vancomycin (6Q205EH1VU) ; Tazobactam (SE10G96M8W) ; Piperacillin (X00B0D5O0E)
    Sprache Englisch
    Erscheinungsdatum 2018-03-06
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2018.0052
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Um IV Zs.74: Hefte anzeigen Standort:
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  7. Artikel: Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.

    Aparicio, Camila / Willis, Zachary I / Nakamura, Mari M / Wolf, Joshua / Little, Cordell / Maron, Gabriela M / Sue, Paul K / Anosike, Brenda I / Miller, Christine / Bio, Laura L / Singh, Prachi / James, Scott H / Oliveira, Carlos R

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background: Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical ... ...

    Abstract Background: Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical COVID-19 in children and adolescents.
    Methods: Two independent reviewers screened the literature (Medline and EMBASE) for studies published through August 2023 that reported outcome data on patients aged ≤21 years with COVID-19. Critical disease was defined as an invasive mechanical ventilation requirement, intensive care unit admission, or death. Random effects models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (CI), and heterogeneity was explored through subgroup analyses.
    Results: Among 10,178 articles, 136 studies met the inclusion criteria for review. Data from 70 studies, which collectively examined 172,165 children and adolescents with COVID-19, were pooled for meta-analysis. In previously healthy children, the absolute risk of critical disease from COVID-19 was 4% (95% CI, 1%-10%). Compared with no comorbidities, the pooled OR for critical disease was 3.95 (95% CI, 2.78-5.63) for presence of one comorbidity and 9.51 (95% CI, 5.62-16.06) for ≥2 comorbidities. Key risk factors included cardiovascular and neurological disorders, chronic pulmonary conditions (excluding asthma), diabetes, obesity, and immunocompromise, all with statistically significant ORs >2.00.
    Conclusions: While the absolute risk for critical COVID-19 in children and adolescents without underlying health conditions is relatively low, the presence of one or more comorbidities was associated with markedly increased risk. These findings support the importance of risk stratification in tailoring pediatric COVID-19 management.
    Sprache Englisch
    Erscheinungsdatum 2024-01-18
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.01.17.24301452
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Outpatient Fluoroquinolone Use in Children, 2000-2018.

    Ross, Rachael K / Gerber, Jeffrey S / Willis, Zachary I / Hersh, Adam L / Kinlaw, Alan C

    Journal of the Pediatric Infectious Diseases Society

    2020  Band 10, Heft 5, Seite(n) 576–585

    Abstract: Background: While fluoroquinolones are commonly used in adults, the use in children has been low. Since 2000, there were 3 US Food and Drug Administration (FDA) Boxed warnings regarding fluoroquinolones (2008, 2013, and 2016). Our objective was to ... ...

    Abstract Background: While fluoroquinolones are commonly used in adults, the use in children has been low. Since 2000, there were 3 US Food and Drug Administration (FDA) Boxed warnings regarding fluoroquinolones (2008, 2013, and 2016). Our objective was to describe the use of fluoroquinolones in children and assess the impact of 3 recent FDA warnings on fluoroquinolone use.
    Methods: From 2000 to 2018, we assessed claims for all outpatient prescription fills to measure the use of systemic fluoroquinolones and other broad-spectrum antibiotics in children  less than 18 years old in the MarketScan Commercial Claims and Encounters database. We describe demographics, indication for antibiotic, and clinical characteristics. To assess the impact of FDA warnings on fill rates, we conducted an interrupted time-series analysis.
    Results: The cohort included 34.6 million unique beneficiaries less than 18 years old with 441 062 fluoroquinolone fills (5.5 fills per 1000 person-years). The fluoroquinolone fill rate was highest among children > 11 years old. Urinary tract infection was the most common associated diagnosis (21.8%). Since 2008, the fluoroquinolone fill rate has declined. By the end of the study period in December 2018, in the (counterfactual) absence of the FDA warnings, fluoroquinolone fill rate would have been 7.5 (95% confidence interval [CI]: 5.2-9.7); however, the corresponding rate in observed data was 2.8 (95% CI: 1.7-3.9).
    Conclusions: Fluoroquinolone use was low compared with other common broad-spectrum antibiotics and declining trends over time were associated with FDA warnings, even though these warnings were not pediatric specific. Future work should assess the adverse events at issue in these warnings in children.
    Mesh-Begriff(e) Adolescent ; Anti-Bacterial Agents/adverse effects ; Child ; Drug Labeling ; Fluoroquinolones/adverse effects ; Humans ; Outpatients ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/epidemiology
    Chemische Substanzen Anti-Bacterial Agents ; Fluoroquinolones
    Sprache Englisch
    Erscheinungsdatum 2020-12-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piaa156
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis

    Aparicio, Camila / Willis, Zachary I. / Nakamura, Mari M. / Wolf, Joshua / Little, Cordell / Maron, Gabriela M. / Sue, Paul K. / Anosike, Brenda I. / Miller, Christine / Bio, Laura L. / Singh, Prachi / James, Scott H. / Oliveira, Carlos R.

    medRxiv

    Abstract: Background: Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical ... ...

    Abstract Background: Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical COVID-19 in children and adolescents. Methods: Two independent reviewers screened the literature (Medline and EMBASE) for studies published through August 2023 that reported outcome data on patients aged 21 years or younger with COVID-19. Critical disease was defined as an invasive mechanical ventilation requirement, intensive care unit admission, or death. Random effects models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (CI), and heterogeneity was explored through subgroup analyses. Results: Among 10,178 articles, 136 studies met the inclusion criteria for review. Data from 70 studies, which collectively examined 172,165 children and adolescents with COVID-19, were pooled for meta-analysis. In previously healthy children, the absolute risk of critical disease from COVID-19 was 4% (95% CI, 1%-10%). Compared with no comorbidities, the pooled OR for critical disease was 3.95 (95% CI, 2.78-5.63) for presence of one comorbidity and 9.51 (95% CI, 5.62-16.06) for ≥2 comorbidities. Key risk factors included cardiovascular and neurological disorders, chronic pulmonary conditions (excluding asthma), diabetes, obesity, and immunocompromise, all with statistically significant ORs >2.00. Conclusions: While the absolute risk for critical COVID-19 in children and adolescents without underlying health conditions is relatively low, the presence of one or more comorbidities was associated with markedly increased risk. These findings support the importance of risk stratification in tailoring pediatric COVID-19 management.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2024-01-18
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2024.01.17.24301452
    Datenquelle COVID19

    Volltext online

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  10. Artikel ; Online: Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis

    Aparicio, Camila / Willis, Zachary I / Nakamura, Mari M / Wolf, Joshua / Little, Cordell / Maron, Gabriela M / Sue, Paul K / Anosike, Brenda I / Miller, Christine / Bio, Laura L / Singh, Prachi / James, Scott H / Oliveira, Carlos R / PIDS Pediatric COVID-19 Therapies Task Force

    medRxiv

    Abstract: Background: Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical ... ...

    Abstract Background: Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical COVID-19 in children and adolescents. Methods: Two independent reviewers screened the literature (Medline and EMBASE) for studies published through August 2023 that reported outcome data on patients aged 21 years or younger with COVID-19. Critical disease was defined as an invasive mechanical ventilation requirement, intensive care unit admission, or death. Random effects models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (CI), and heterogeneity was explored through subgroup analyses. Results: Among 10,178 articles, 136 studies met the inclusion criteria for review. Data from 70 studies, which collectively examined 172,165 children and adolescents with COVID-19, were pooled for meta-analysis. In previously healthy children, the absolute risk of critical disease from COVID-19 was 4% (95% CI, 1%-10%). Compared with no comorbidities, the pooled OR for critical disease was 3.95 (95% CI, 2.78-5.63) for presence of one comorbidity and 9.51 (95% CI, 5.62-16.06) for ≥2 comorbidities. Key risk factors included cardiovascular and neurological disorders, chronic pulmonary conditions (excluding asthma), diabetes, obesity, and immunocompromise, all with statistically significant ORs >2.00. Conclusions: While the absolute risk for critical COVID-19 in children and adolescents without underlying health conditions is relatively low, the presence of one or more comorbidities was associated with markedly increased risk. These findings support the importance of risk stratification in tailoring pediatric COVID-19 management.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2024-01-18
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2024.01.17.24301452
    Datenquelle COVID19

    Volltext online

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