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Article: Amyloid-beta precursor protein processing in neurodegeneration.

Wilquet, Valérie / De Strooper, Bart

2004 Volume 14, Issue 5, Page(s) 582–588

Abstract: The amyloid-beta precursor protein is proteolytically cleaved by secretases, resulting in a series of fragments, including the amyloid-beta peptide of Alzheimer's disease. The amyloid precursor protein, when membrane anchored, could operate as a receptor. ...

Abstract	The amyloid-beta precursor protein is proteolytically cleaved by secretases, resulting in a series of fragments, including the amyloid-beta peptide of Alzheimer's disease. The amyloid precursor protein, when membrane anchored, could operate as a receptor. After cleavage, the soluble ectodomain exerts a trophic function in the subventricular zone. The amyloid-beta peptide itself has a depressant role in synaptic transmission, with both physiological and pathological implications. During the past two years, much time has been invested in determining the molecular pathways that regulate the processing and the signal transduction of the amyloid precursor protein. However, the absence of consistent and informative phenotypes in different loss of function animal models make elucidating the molecular actions of the amyloid-beta precursor protein an ongoing challenge.
MeSH term(s)	Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid Precursor Protein Secretases ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Aspartic Acid Endopeptidases ; Brain/metabolism ; Brain/physiopathology ; Cell Membrane/metabolism ; Endopeptidases/metabolism ; Humans ; Mutation/genetics ; Nerve Degeneration/metabolism ; Neurons/metabolism ; Protein Structure, Tertiary/physiology
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Endopeptidases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; BACE1 protein, human (EC 3.4.23.46)
Language	English
Publishing date	2004-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2004.08.001
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Article ; Online: Improved algorithm for the transmittance estimation of spectra obtained with SOIR/Venus Express.

Trompet, Loic / Mahieux, Arnaud / Ristic, Bojan / Robert, Séverine / Wilquet, Valérie / Thomas, Ian R / Vandaele, Ann Carine / Bertaux, Jean-Loup

Applied optics

2016 Volume 55, Issue 32, Page(s) 9275–9281

Abstract: The Solar Occultation in the InfraRed (SOIR) instrument onboard the ESA Venus Express spacecraft, an infrared spectrometer sensitive from 2.2 to 4.3 μm, probed the atmosphere of Venus from June 2006 until December 2014. During this time, it performed ... ...

Abstract	The Solar Occultation in the InfraRed (SOIR) instrument onboard the ESA Venus Express spacecraft, an infrared spectrometer sensitive from 2.2 to 4.3 μm, probed the atmosphere of Venus from June 2006 until December 2014. During this time, it performed more than 750 solar occultations of the Venus mesosphere and lower thermosphere. A new procedure has been developed for the estimation of the transmittance in order to decrease the number of rejected spectra, to check that the treated spectra are well calibrated, and to improve the quality of the calibrated spectra by reducing the noise and accurately normalizing it to the solar spectrum.
Language	English
Publishing date	2016-11-10
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.55.009275
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Article ; Online: Improved calibration of SOIR/Venus Express spectra.

Vandaele, Ann Carine / Mahieux, Arnaud / Robert, Séverine / Berkenbosch, Sophie / Clairquin, Roland / Drummond, Rachel / Letocart, Vincent / Neefs, Eddy / Ristic, Bojan / Wilquet, Valérie / Colomer, Frédéric / Belyaev, Denis / Bertaux, Jean-Loup

Optics express

2013 Volume 21, Issue 18, Page(s) 21148–21161

Abstract: The SOIR instrument on board the ESA Venus Express mission has been operational since the insertion of the satellite around Venus in April 2006. Since then, it has delivered high quality IR solar occultation spectra of the atmosphere of Venus. The ... ...

Abstract	The SOIR instrument on board the ESA Venus Express mission has been operational since the insertion of the satellite around Venus in April 2006. Since then, it has delivered high quality IR solar occultation spectra of the atmosphere of Venus. The different steps from raw spectra to archived data are described and explained in detail here. These consist of corrections for the dark current and for the non-linearity of the detector; removing bad pixels, as well as deriving noise. The spectral calibration procedure is described, along with all ancillary data necessary for the understanding and interpretation of the SOIR data. These include the full characterization of the AOTF filter, one of the major elements of the instrument. All these data can be found in the ESA PSA archive.
Language	English
Publishing date	2013-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.21.021148
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Article: Dihydropteridine reductase as an alternative to dihydrofolate reductase for synthesis of tetrahydrofolate in Thermus thermophilus.

Wilquet, Valérie / Van de Casteele, Mark / Gigot, Daniel / Legrain, Christianne / Glansdorff, Nicolas

Journal of bacteriology

2003 Volume 186, Issue 2, Page(s) 351–355

Abstract: A strategy devised to isolate a gene coding for a dihydrofolate reductase from Thermus thermophilus DNA delivered only clones harboring instead a gene (the T. thermophilus dehydrogenase [DH(Tt)] gene) coding for a dihydropteridine reductase which ... ...

Abstract	A strategy devised to isolate a gene coding for a dihydrofolate reductase from Thermus thermophilus DNA delivered only clones harboring instead a gene (the T. thermophilus dehydrogenase [DH(Tt)] gene) coding for a dihydropteridine reductase which displays considerable dihydrofolate reductase activity (about 20% of the activity detected with 6,7-dimethyl-7,8-dihydropterine in the quinonoid form as a substrate). DH(Tt) appears to account for the synthesis of tetrahydrofolate in this bacterium, since a classical dihydrofolate reductase gene could not be found in the recently determined genome nucleotide sequence (A. Henne, personal communication). The derived amino acid sequence displays most of the highly conserved cofactor and active-site residues present in enzymes of the short-chain dehydrogenase/reductase family. The enzyme has no pteridine-independent oxidoreductase activity, in contrast to Escherichia coli dihydropteridine reductase, and thus appears more similar to mammalian dihydropteridine reductases, which do not contain a flavin prosthetic group. We suggest that bifunctional dihydropteridine reductases may be responsible for the synthesis of tetrahydrofolate in other bacteria, as well as archaea, that have been reported to lack a classical dihydrofolate reductase but for which possible substitutes have not yet been identified.
MeSH term(s)	Amino Acid Sequence ; Dihydropteridine Reductase/physiology ; Molecular Sequence Data ; Staining and Labeling ; Tetrahydrofolate Dehydrogenase/analysis ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/physiology ; Tetrahydrofolates/biosynthesis ; Thermus thermophilus/genetics ; Thermus thermophilus/metabolism
Chemical Substances	Tetrahydrofolates ; 5,6,7,8-tetrahydrofolic acid (43ZWB253H4) ; Tetrahydrofolate Dehydrogenase (EC 1.5.1.3) ; Dihydropteridine Reductase (EC 1.5.1.34)
Language	English
Publishing date	2003-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2968-3
ISSN	1098-5530 ; 0021-9193
ISSN (online)	1098-5530
ISSN	0021-9193
DOI	10.1128/JB.186.2.351-355.2004
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Article: Chromosomal anomalies in individuals with autism: a strategy towards the identification of genes involved in autism.

Castermans, Dries / Wilquet, Valérie / Steyaert, Jean / Van de Ven, Wim / Fryns, Jean-Pierre / Devriendt, Koen

Autism : the international journal of research and practice

2004 Volume 8, Issue 2, Page(s) 141–161

Abstract: We review the different strategies currently used to try to identify susceptibility genes for idiopathic autism. Although identification of genes is usually straightforward in Mendelian disorders, it has proved to be much more difficult to establish in ... ...

Abstract	We review the different strategies currently used to try to identify susceptibility genes for idiopathic autism. Although identification of genes is usually straightforward in Mendelian disorders, it has proved to be much more difficult to establish in polygenic disorders like autism. Neither genome screens of affected siblings nor the large number of association studies using candidate genes have resulted in finding autism susceptibility genes. We focus on the alternative approach of 'positional cloning' through chromosomal aberrations in individuals with autism. In particular, balanced aberrations such as reciprocal translocations or inversions offer a unique opportunity, since only the genes in the breakpoint regions are candidate genes. This approach, in combination with others, is likely to produce results in the coming years.
MeSH term(s)	Autistic Disorder/etiology ; Autistic Disorder/genetics ; Child ; Chromosome Aberrations ; Genetic Predisposition to Disease ; Genetic Testing ; Humans ; Wills
Language	English
Publishing date	2004-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1338513-6
ISSN	1362-3613
ISSN	1362-3613
DOI	10.1177/1362361304042719
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Article ; Online: Publisher Correction: Martian dust storm impact on atmospheric H

Vandaele, Ann Carine / Korablev, Oleg / Daerden, Frank / Aoki, Shohei / Thomas, Ian R / Altieri, Francesca / López-Valverde, Miguel / Villanueva, Geronimo / Liuzzi, Giuliano / Smith, Michael D / Erwin, Justin T / Trompet, Loïc / Fedorova, Anna A / Montmessin, Franck / Trokhimovskiy, Alexander / Belyaev, Denis A / Ignatiev, Nikolay I / Luginin, Mikhail / Olsen, Kevin S /

Baggio, Lucio / Alday, Juan / Bertaux, Jean-Loup / Betsis, Daria / Bolsée, David / Clancy, R Todd / Cloutis, Edward / Depiesse, Cédric / Funke, Bernd / Garcia-Comas, Maia / Gérard, Jean-Claude / Giuranna, Marco / Gonzalez-Galindo, Francisco / Grigoriev, Alexey V / Ivanov, Yuriy S / Kaminski, Jacek / Karatekin, Ozgur / Lefèvre, Franck / Lewis, Stephen / López-Puertas, Manuel / Mahieux, Arnaud / Maslov, Igor / Mason, Jon / Mumma, Michael J / Neary, Lori / Neefs, Eddy / Patrakeev, Andrey / Patsaev, Dmitry / Ristic, Bojan / Robert, Séverine / Schmidt, Frédéric / Shakun, Alexey / Teanby, Nicholas A / Viscardy, Sébastien / Willame, Yannick / Whiteway, James / Wilquet, Valérie / Wolff, Michael J / Bellucci, Giancarlo / Patel, Manish R / López-Moreno, Jose-Juan / Forget, François / Wilson, Colin F / Young, Roland / Svedhem, Håkan / Vago, Jorge L / Rodionov, Daniel

Nature

2019 Volume 569, Issue 7754, Page(s) E1

Abstract: The surname of author Cathy Quantin-Nataf was misspelled 'Quantin-Nata' , authors Ehouarn Millour and Roland Young were missing from the ACS Science Team list, and minor changes have been made to the author and affiliation lists; see accompanying ... ...

Abstract	The surname of author Cathy Quantin-Nataf was misspelled 'Quantin-Nata' , authors Ehouarn Millour and Roland Young were missing from the ACS Science Team list, and minor changes have been made to the author and affiliation lists; see accompanying Amendment. These errors have been corrected online.
Language	English
Publishing date	2019-04-17
Publishing country	England
Document type	Published Erratum
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-1163-x
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Article ; Online: Martian dust storm impact on atmospheric H

Nature

2019 Volume 568, Issue 7753, Page(s) 521–525

Abstract: Global dust storms on Mars are ... ...

Abstract	Global dust storms on Mars are rare
Language	English
Publishing date	2019-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-1097-3
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Article: NADP+‐dependent glutamate dehydrogenase in the Antarctic psychrotolerant bacterium Psychrobacter sp. TAD1: Characterization, protein and DNA sequence, and relationship to other glutamate dehydrogenases

Di Fraia, Raffaela / Wilquet, Valerie / Ciardiello, M. Antonietta / Carratore, Vito / Antignani, Antonella / Camardella, Laura / Glansdorff, Nicolas / di Prisco, Guido

European journal of biochemistry. 2000 Jan., v. 267, no. 1

2000

Abstract: The Antarctic psychrotolerant bacterium Psychrobacter sp. TAD1 contains two distinct glutamate dehydrogenases (GDH), each specific for either NADP+ or NAD+. This feature is quite unusual in bacteria, which generally have a single GDH. NADP+‐dependent GDH ...

Abstract	The Antarctic psychrotolerant bacterium Psychrobacter sp. TAD1 contains two distinct glutamate dehydrogenases (GDH), each specific for either NADP+ or NAD+. This feature is quite unusual in bacteria, which generally have a single GDH. NADP+‐dependent GDH has been purified to homogeneity and the gene encoding GDH has been cloned and expressed. The enzyme has a hexameric structure. The amino acid sequence determined by peptide and gene analyses comprises 447 residues, yielding a protein with a molecular mass of 49 285 Da. The sequence shows homology with hexameric GDHs, with identity levels of 52% and 49% with Escherichia coli and Clostridium symbiosum GDH, respectively. The coenzyme‐binding fingerprint motif GXGXXG/A (common to all GDHs) has Ser at the last position in this enzyme. The overall hydrophilic character is increased and a five‐residue insertion in a loop between two α‐helices may contribute to the increase in protein flexibility. Psychrobacter sp. TAD1 GDH apparent temperature optimum is shifted towards low temperatures, whereas irreversible heat inactivation occurs at temperatures similar to those of E. coli GDH. The catalytic efficiency in the temperature range 10–30 °C is similar or lower than that of E. coli GDH. Unlike E. coli GDH the enzyme exhibits marked positive cooperativity towards 2‐oxoglutarate and NADPH. This feature is generally absent in prokaryotic GDHs. These observations suggest a regulatory role for this GDH, the most crucial feature being the structural/functional properties required for fine regulation of activity, rather than the high catalytic efficiency and thermolability encountered in several cold‐active enzymes.
Keywords	Clostridium symbiosum ; DNA ; Escherichia coli ; NADP (coenzyme) ; Psychrobacter ; amino acid sequences ; bacteria ; catalytic activity ; functional properties ; genes ; glutamate dehydrogenase ; glutamic acid ; heat inactivation ; hydrophilicity ; molecular weight ; nucleotide sequences ; temperature ; Antarctic region
Language	English
Dates of publication	2000-01
Size	p. 121-131.
Publishing place	Blackwell Science Ltd
Document type	Article
ZDB-ID	3032-6
ISSN	1432-1033 ; 0014-2956
ISSN (online)	1432-1033
ISSN	0014-2956
DOI	10.1046/j.1432-1327.2000.00972.x
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Article: In-flight performance and calibration of SPICAV SOIR onboard Venus Express.

Mahieux, Arnaud / Berkenbosch, Sophie / Clairquin, Roland / Fussen, Didier / Mateshvili, Nina / Neefs, Eddy / Nevejans, Dennis / Ristic, Bojan / Vandaele, Ann Carine / Wilquet, Valérie / Belyaev, Denis / Fedorova, Anna / Korablev, Oleg / Villard, Eric / Montmessin, Franck / Bertaux, Jean-Loup

Applied optics

2008 Volume 47, Issue 13, Page(s) 2252–2265

Abstract: Solar occultation in the infrared, part of the Spectoscopy for Investigation of Characteristics of the Atmosphere of Venus (SPICAV) instrument onboard Venus Express, combines an echelle grating spectrometer with an acousto-optic tunable filter (AOTF). It ...

Abstract	Solar occultation in the infrared, part of the Spectoscopy for Investigation of Characteristics of the Atmosphere of Venus (SPICAV) instrument onboard Venus Express, combines an echelle grating spectrometer with an acousto-optic tunable filter (AOTF). It performs solar occultation measurements in the IR region at high spectral resolution. The wavelength range probed allows a detailed chemical inventory of Venus's atmosphere above the cloud layer, highlighting the vertical distribution of gases. A general description of the instrument and its in-flight performance is given. Different calibrations and data corrections are investigated, in particular the dark current and thermal background, the nonlinearity and pixel-to-pixel variability of the detector, the sensitivity of the instrument, the AOTF properties, and the spectral calibration and resolution.
Language	English
Publishing date	2008-04-12
Publishing country	United States
Document type	Journal Article
ISSN	1559-128X
ISSN	1559-128X
DOI	10.1364/ao.47.002252
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