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  1. Book: Physiological pharmaceutics

    Washington, Neena / Washington, Clive / Wilson, Clive G.

    barriers to drug absorption

    2002  

    Author's details Neena Washington, Clive Washington and Clive G. Wilson
    Keywords Biological Availability ; Pharmaceutical Preparations / administration & dosage ; Pharmaceutical Preparations / metabolism ; Arzneimittel ; Resorption
    Subject Absorption ; Fertigarzneimittel ; Therapeutikum ; Medikament ; Medukamente ; Pharmakon ; Pharmaka ; Arzneistoff ; Arzneimittelwirkstoff ; Arznei ; Pharmazeutikum ; Pharmazeutika ; Pharmazeutischer Wirkstoff ; Arzneidroge
    Language English
    Size 312 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Taylor & Francis
    Publishing place London
    Publishing country Great Britain
    Document type Book
    Old title 1. Aufl. u.d.T. Washington, Neena: Physiological pharmaceutics
    HBZ-ID HT013410099
    ISBN 0-7484-0610-7 ; 0-748-40610-7 ; 0-748-40562-3 ; 978-0-7484-0610-4 ; 978-0-748-40610-4 ; 978-0-748-40562-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 3268 order for loan Magazin

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  2. Book: Physiological pharmaceutics

    Wilson, Clive G. / Washington, Neena

    biological barriers to drug absorption

    (Ellis Horwood series in pharmaceutical technology)

    1989  

    Author's details Clive G. Wilson ; Neena Washington
    Series title Ellis Horwood series in pharmaceutical technology
    Keywords Absorption ; Pharmacokinetics ; Arzneimittel ; Resorption
    Subject Fertigarzneimittel ; Therapeutikum ; Medikament ; Medukamente ; Pharmakon ; Pharmaka ; Arzneistoff ; Arzneimittelwirkstoff ; Arznei ; Pharmazeutikum ; Pharmazeutika ; Pharmazeutischer Wirkstoff ; Arzneidroge ; Absorption
    Language English
    Size 186 S. : Ill., graph. Darst.
    Publisher Horwood u.a
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    New title 2. Aufl. u.d.T. Washington, Neena: Physiological pharmaceutics
    HBZ-ID HT003486698
    ISBN 0-7458-0543-4 ; 0-470-21545-3 ; 978-0-7458-0543-6 ; 978-0-470-21545-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 2281 order for loan Magazin

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  3. Article ; Online: In vitro dissolution testing models of ocular implants for posterior segment drug delivery.

    Adrianto, Muhammad Faris / Annuryanti, Febri / Wilson, Clive G / Sheshala, Ravi / Thakur, Raghu Raj Singh

    Drug delivery and translational research

    2021  Volume 12, Issue 6, Page(s) 1355–1375

    Abstract: The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal therapy requires injections that are administered frequently due to the rapid clearance of the drug ... ...

    Abstract The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal therapy requires injections that are administered frequently due to the rapid clearance of the drug molecules. As an alternative, intraocular implants can offer drug release for long-term therapy. However, one of the several challenges in developing intraocular implants is selecting an appropriate in vitro dissolution testing model. In order to determine the efficacy of ocular implants in drug release, multiple in vitro test models were emerging. While these in vitro models may be used to analyse drug release profiles, the findings may not predict in vivo retinal drug exposure as this is influenced by metabolic and physiological factors. This review considers various types of in vitro test methods used to test drug release of ocular implants. Importantly, it discusses the challenges and factors that must be considered in the development and testing of the implants in an in vitro setup.
    MeSH term(s) Drug Delivery Systems ; In Vitro Techniques ; Intravitreal Injections ; Pharmaceutical Preparations ; Solubility
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-021-01043-z
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  4. Article ; Online: The transit of dosage forms through the colon.

    Wilson, Clive G

    International journal of pharmaceutics

    2010  Volume 395, Issue 1-2, Page(s) 17–25

    Abstract: Colonic transit is a subject of great relevance when considering in vivo/in vitro relationships for oral controlled release dosage forms. Our knowledge of colonic motility has first come from the clinic, where measurement of the whole gut transit of ... ...

    Abstract Colonic transit is a subject of great relevance when considering in vivo/in vitro relationships for oral controlled release dosage forms. Our knowledge of colonic motility has first come from the clinic, where measurement of the whole gut transit of different excreted markers was used as a method of discriminating pathologies. X-ray contrast, although widely available, was used sparing due to the accumulating dosimetry associated with each exposure. Although such methods were used for swallowing studies, gamma scintigraphy allowed physicians to measure colon function with a more moderate radiation burden. The ability to label meal and dosage form separately and to measure dispersion with more certainty, prompted the use in pharmaceutical sciences; finally, the relationship between blood concentrations and transit of different sized dosage began to be understood. This mini-review considers the development of colon transit measurements and how different designs of clinical assessment assist in elucidating size and shape influence on colon transit in man.
    MeSH term(s) Administration, Oral ; Chemistry, Pharmaceutical ; Colon/anatomy & histology ; Colon/diagnostic imaging ; Colon/physiology ; Delayed-Action Preparations ; Dosage Forms ; Drinking ; Drug Administration Schedule ; Eating ; Feeding Behavior ; Gastrointestinal Transit ; Humans ; Particle Size ; Radionuclide Imaging ; Time Factors
    Chemical Substances Delayed-Action Preparations ; Dosage Forms
    Language English
    Publishing date 2010-08-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2010.04.044
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A Review of the Emerging Role of Silk for the Treatment of the Eye.

    Tran, Simon H / Wilson, Clive G / Seib, F Philipp

    Pharmaceutical research

    2018  Volume 35, Issue 12, Page(s) 248

    Abstract: Silk is a remarkable biopolymer with a long history of medical use. Silk fabrications have a robust track record for load-bearing applications, including surgical threads and meshes, which are clinically approved for use in humans. The progression of top- ...

    Abstract Silk is a remarkable biopolymer with a long history of medical use. Silk fabrications have a robust track record for load-bearing applications, including surgical threads and meshes, which are clinically approved for use in humans. The progression of top-down and bottom-up engineering approaches using silk as the basis of a drug delivery or cell-loaded matrix helped to re-ignite interest in this ancient material. This review comprehensively summarises the current applications of silk for tissue engineering and drug delivery, with specific reference to the eye. Additionally, the review also covers emerging trends for the use of silk as a biologically active biopolymer for the treatment of eye disorders. The review concludes with future capabilities of silk to contribute to advanced, electronically-enhanced ocular drug delivery concepts.
    MeSH term(s) Animals ; Biocompatible Materials/chemistry ; Drug Delivery Systems/methods ; Eye Diseases/therapy ; Humans ; Silk/chemistry ; Tissue Engineering/methods ; Wound Healing
    Chemical Substances Biocompatible Materials ; Silk
    Language English
    Publishing date 2018-11-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-018-2534-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1937: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Book: Pharmacokinetic modelling using STELLA on the Apple Macintosh

    Washington, Clive / Washington, Neena / Wilson, Clive G.

    (Ellis Horwood series in pharmaceutical technology)

    1990  

    Author's details Clive Washington, Neena Washington and Clive Wilson
    Series title Ellis Horwood series in pharmaceutical technology
    Keywords Pharmacokinetics ; Computer Simulation ; Software
    Size 118 S. : Ill., graph. Darst.
    Publisher Ellis Horwood
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003802131
    ISBN 0-13-662768-4 ; 978-0-13-662768-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 2490 order for loan Magazin
    1991 A 2490a order for loan Magazin

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  7. Book: RADIONUCLIDE IMAGING IN DRUG RESEARCH

    Wilson, Clive G. / Hardy, John G.

    1982  

    Author's details EDITED BY CLIVE GEORGE WILSON AND JOHN G. HARDY
    Keywords CHEMISTRY, PHARMACEUTICAL ; DRUG EVALUATION ; RADIOISOTOPES ; Radionuklid ; Szintographie ; Arzneimittelforschung
    Subject Pharmaforschung ; Arzneimittel ; Wirkstoffforschung ; Arzneistoffforschung ; Drug discovery ; Radioisotop ; Radioaktives Isotop ; Radioaktives Element ; Radioaktiver Kern ; Radionuklide ; Radioisotope
    Size 330 S. : ILL.
    Publisher CROOM HELM
    Publishing place LONDON (U.A.)
    Document type Book
    HBZ-ID HT002554763
    ISBN 0-7099-2716-9 ; 978-0-7099-2716-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1982 B 1078 order for loan Magazin

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  8. Article ; Online: Mucoadhesive bilayered buccal platform for antifungal drug delivery into the oral cavity.

    Uzunoğlu, Burcum / Wilson, Clive G / Sağıroğlu, Meral / Yüksel, Selin / Şenel, Sevda

    Drug delivery and translational research

    2020  Volume 11, Issue 1, Page(s) 318–327

    Abstract: A drug delivery technology comprising a mucoadhesive bilayered buccally anchored tablet containing natamycin was developed. The concept was to anchor the tablet to the buccal tissue and allow controlled release of the drug through the matrix into the ... ...

    Abstract A drug delivery technology comprising a mucoadhesive bilayered buccally anchored tablet containing natamycin was developed. The concept was to anchor the tablet to the buccal tissue and allow controlled release of the drug through the matrix into the mouth. Carbomer (Carbopol ® 974 P NF) was used to formulate the mucoadhesive layer. Hydroxypropyl methylcellulose (HPMC) (Methocel® K4M) at 10, 15, 20, and 40% w/w was used for the drug-containing layer. Natamycin, an amphoteric macrolide antifungal agent, was incorporated into the formulations. In addition, tablets containing erythrosine as a marker were prepared in order to examine the distribution and retention of the dye in the oral cavity. As expected, the in vitro analysis showed that the concentration of natamycin released decreased with the increasing proportion of HPMC in the formulation. A small volunteer study was conducted using the tablets containing 10% and 20% HPMC to quantitate the patterns of distribution of the drug released into the oral cavity (upper right buccal vestibule, lower right and left buccal vestibules, and sublingual region). The mucoadhesive bilayered buccal tablet formulation provided a unidirectional release of the drug from the tablet into the oral cavity in a prolonged release fashion, maintaining drug concentration above the MIC value (2 μg/mL) for Candida albicans. The amount of the drug in the sublingual region was found to be lowest when compared with other regions, which is due to the higher flow of saliva in this region. Graphical abstract.
    MeSH term(s) Adhesiveness ; Antifungal Agents ; Humans ; Mouth ; Mouth Mucosa ; Tablets
    Chemical Substances Antifungal Agents ; Tablets
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-020-00798-1
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  9. Article ; Online: The vitreous humor as a barrier to nanoparticle distribution.

    Mains, Jenifer / Wilson, Clive G

    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

    2013  Volume 29, Issue 2, Page(s) 143–150

    Abstract: The vitreous humor represents a significant barrier to the penetration of nanoparticulate-based ocular drug delivery systems. The gel structure and biochemical components of the vitreous will impact the rate of nanoparticle movement through the tissue to ...

    Abstract The vitreous humor represents a significant barrier to the penetration of nanoparticulate-based ocular drug delivery systems. The gel structure and biochemical components of the vitreous will impact the rate of nanoparticle movement through the tissue to reach the retinal tissue. Also the structure of the vitreous, flow systems operating within it, age-related structural changes, and the presence of inflammation will also have a potential effect on movement. To effectively target the posterior retina, the physical properties of the nanoparticle formulation are a key element in the design of a system that will penetrate through the vitreous barrier.
    MeSH term(s) Aging/drug effects ; Aging/pathology ; Aging/physiology ; Animals ; Drug Delivery Systems/methods ; Humans ; Nanoparticles/administration & dosage ; Particle Size ; Vitreous Body/blood supply ; Vitreous Body/drug effects ; Vitreous Body/metabolism ; Vitreous Body/physiopathology
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1237021-6
    ISSN 1557-7732 ; 1080-7683
    ISSN (online) 1557-7732
    ISSN 1080-7683
    DOI 10.1089/jop.2012.0138
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2099: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: The gut in the beaker: Missing the surfactants?

    Wilson, Clive G / Halbert, Gavin W / Mains, Jenifer

    International journal of pharmaceutics

    2016  Volume 514, Issue 1, Page(s) 73–80

    Abstract: Gastrointestinal drug administration is the preferred route for the majority of drugs however, the natural physiology and physicochemistry of the gastrointestinal tract is critical to absorption but complex and influenced by factors such as diet or ... ...

    Abstract Gastrointestinal drug administration is the preferred route for the majority of drugs however, the natural physiology and physicochemistry of the gastrointestinal tract is critical to absorption but complex and influenced by factors such as diet or disease. The pharmaceutical sciences drive for product consistency has led to the development of in vitro product performance tests whose utility and interpretation is hindered by the complexity, variability and a lack of understanding. This article explores some of these issues with respect to the drug, formulation and the presence of surfactant excipients and how these interact with the natural bile salt surfactants. Interactions start in the mouth and during swallowing but the stomach and small intestine present the major challenges related to drug dissolution, solubility, the impact of surfactants and supersaturation along with precipitation. The behaviour of lipid based formulations and the influence of surfactant excipients is explored along with the difficulties of translating in vitro results to in vivo performance. Possible future research areas are highlighted with the conclusion that, "a great deal of work using modern methods is still required to clarify the situation".
    MeSH term(s) Administration, Oral ; Animals ; Chemistry, Pharmaceutical/methods ; Excipients/chemistry ; Gastrointestinal Tract/metabolism ; Humans ; Intestinal Absorption/drug effects ; Lipids/chemistry ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Solubility ; Surface-Active Agents/chemistry
    Chemical Substances Excipients ; Lipids ; Pharmaceutical Preparations ; Surface-Active Agents
    Language English
    Publishing date 2016-11-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2016.09.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
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