Result 1 - 10 of total 486
Western journal of medicine and surgery
2024 Volume 2, Issue 7, Page(s) 77–78
| Language | English |
|---|---|
| Publishing date | 2024-01-11 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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The North-Western medical and surgical journal
2023 Volume 3, Issue 10, Page(s) 456–457
| Language | English |
|---|---|
| Publishing date | 2023-06-15 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2020 Volume 9, Issue 1, Page(s) 285
Abstract: Background: FMS-like tyrosine kinase 3 (FLT3) is the most frequent mutation in AML. With two FLT3 inhibitors recently approved by the FDA (midostaurin and gilteritinib), there is a need to evaluate these targeted agents.: Purpose: To assess the ... ...
| Abstract | Background: FMS-like tyrosine kinase 3 (FLT3) is the most frequent mutation in AML. With two FLT3 inhibitors recently approved by the FDA (midostaurin and gilteritinib), there is a need to evaluate these targeted agents. Purpose: To assess the clinical effectiveness of FLT3 inhibitors in AML patients. Methods: Standard systematic review methods were utilised. Searches were conducted to July 2020 for completed and in-progress randomised controlled trials of FLT3 inhibitors in AML. A fixed-effect meta-analysis was undertaken. Results: Eight completed trials involving 2656 patients and assessing five different FLT3 inhibitors (sorafenib, lestaurtinib, midostaurin, gilteritinib and quizartinib) were included. The pooled results were as follows (FLT3 inhibitor/control): overall survival hazard ratio (HR) = 0.83 (95% confidence interval [CI] 0.75 to 0.92, p = 0.0005), event-free survival HR = 0.85 (95% CI 0.77 to 0.94, p = 0.002), relapse-free survival HR = 0.76 (95% CI 0.64 to 0.90, p = 0.001), complete remission relative risk (RR) = 1.11 (95% CI 1.00 to 1.22. p = 0.05) and 60-day mortality RR = 1.04 (95% CI 0.77 to 1.40, p = 0.79). Relative risk of grade 3 and above vascular, dermatological, respiratory and hepatobiliary adverse events were found to be statistically significantly higher in the FLT3 inhibitor group compared to control, but the actual numbers of events were relatively small. Nineteen ongoing trials are still in progress, only one of which specifically targets older patients with AML. Conclusions: There is evidence to support the use of FLT3 inhibitors in patients with AML, but more data is needed to verify the optimum use of the drugs regarding type of inhibitor, disease stage and patient characteristics, not only in relation to disease control, but adverse events and quality of life. There are a large number of ongoing trials; therefore, the results of this review are not a fait accompli; thus, is it recommended that the review be updated in a couple of years' time. Given the challenges in extracting the complete data set required to assess clinical effectiveness, it is highly recommended that ongoing and future trials improve transparency and consistency of reporting of all trial outcomes, particularly disease control and adverse events, to enable a global clinical effectiveness assessment. Systematic review registration: PROSPERO CRD42017055581. |
|---|---|
| MeSH term(s) | Humans ; Leukemia, Myeloid, Acute/drug therapy ; Neoplasm Recurrence, Local ; Quality of Life ; Treatment Outcome ; fms-Like Tyrosine Kinase 3/genetics |
| Chemical Substances | FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) |
| Language | English |
| Publishing date | 2020-12-07 |
| Publishing country | England |
| Document type | Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review |
| ZDB-ID | 2662257-9 |
| ISSN | 2046-4053 ; 2046-4053 |
| ISSN (online) | 2046-4053 |
| ISSN | 2046-4053 |
| DOI | 10.1186/s13643-020-01540-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2013
Abstract: This book traces the developments of the post-war monetary story, with an emphasis both on theory and practice. A survey of monetary policy and a discussion of the effects of a credit squeeze are set against a survey of the very different American scene. ...
| Abstract | This book traces the developments of the post-war monetary story, with an emphasis both on theory and practice. A survey of monetary policy and a discussion of the effects of a credit squeeze are set against a survey of the very different American scene. Comparative analysis of the 'new money markets' is also included as is discussion of the significant developments in the world's major capital markets |
|---|---|
| Language | English |
| Size | Online-Ressource (355 p) |
| Publisher | Taylor and Francis |
| Publishing place | Hoboken |
| Document type | Book ; Online |
| Note | Description based upon print version of record |
| ISBN | 9780415313957 ; 0415313953 |
| Database | Library catalogue of the German National Library of Science and Technology (TIB), Hannover |
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A Comparative Analysis
(Routledge Library Editions: Banking & Finance)
2012
Abstract: This book provides a comparative analysis of the several types of banking structure and the ways in which banks undertake their business. It surveys central banking arrangements in a number of countries. Against an historical background, it describes ... ...
| Series title | Routledge Library Editions: Banking & Finance |
|---|---|
| Abstract | This book provides a comparative analysis of the several types of banking structure and the ways in which banks undertake their business. It surveys central banking arrangements in a number of countries. Against an historical background, it describes banking systems ranging from the so-called 'unit banking' of the USA to the branch banking arrangements that derive from British experience, as well as many systems in between. The business of banking is analysed comparatively within the framework of a simplified bank balance sheet, special attention being given to industrial banking and to assets |
| Language | English |
| Size | Online-Ressource (481 p) |
| Document type | Book ; Online |
| Note | Description based upon print version of record |
| ISBN | 9780415538527 ; 0415538521 |
| Database | ECONomics Information System |
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The Medical journal of Australia
2003 Volume 462, Page(s) 684
| MeSH term(s) | Hexachlorocyclohexane ; Insecticides/toxicity |
|---|---|
| Chemical Substances | Insecticides ; Hexachlorocyclohexane (59NEE7PCAB) |
| Language | English |
| Publishing date | 2003-09-03 |
| Publishing country | Australia |
| Document type | Journal Article |
| ZDB-ID | 186082-3 |
| ISSN | 1326-5377 ; 0025-729X |
| ISSN (online) | 1326-5377 |
| ISSN | 0025-729X |
| DOI | 10.5694/j.1326-5377.1959.tb129428.x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ua VI Zs.398: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Journal of the Royal Society, Interface
2014 Volume 11, Issue 100, Page(s) 20140680
Abstract: Static and dynamic mechanical instabilities were previously suggested, and then rejected, as mediators of aneurysmal development, which leaves open the question of the underlying mechanism. In this paper, we suggest as a new paradigm the interpretation ... ...
| Abstract | Static and dynamic mechanical instabilities were previously suggested, and then rejected, as mediators of aneurysmal development, which leaves open the question of the underlying mechanism. In this paper, we suggest as a new paradigm the interpretation of aneurysms as mechanobiological instabilities. For illustrative purposes, we compare analytical calculations with computational simulations of the growth and remodelling of idealized fusiform abdominal aortic aneurysms and experimental and clinical findings. We show that the concept of mechanobiological stability is consistent with the impact of risk factors such as age, smoking or diabetes on the initiation and enlargement of these lesions as well as adaptive processes in the healthy abdominal aorta such as dilatation during ageing or in hypertension. In general, high stiffness, an increased capacity for stress-mediated matrix production, and slow matrix turnover all improve the mechanobiological stability of blood vessels. This theoretical understanding may help guide prognosis and the development of future therapies for aneurysms as it enables systematic ways to attenuate enlargement. |
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| MeSH term(s) | Aging/metabolism ; Aging/pathology ; Aorta, Abdominal/metabolism ; Aorta, Abdominal/pathology ; Aorta, Abdominal/physiopathology ; Aortic Aneurysm, Abdominal/metabolism ; Aortic Aneurysm, Abdominal/pathology ; Aortic Aneurysm, Abdominal/physiopathology ; Diabetes Mellitus/pathology ; Diabetes Mellitus/physiopathology ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Humans ; Hypertension/metabolism ; Hypertension/pathology ; Hypertension/physiopathology ; Models, Cardiovascular ; Smoking/adverse effects ; Smoking/metabolism ; Smoking/physiopathology |
| Language | English |
| Publishing date | 2014-09-11 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2156283-0 |
| ISSN | 1742-5662 ; 1742-5689 |
| ISSN (online) | 1742-5662 |
| ISSN | 1742-5689 |
| DOI | 10.1098/rsif.2014.0680 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Proceedings. Mathematical, physical, and engineering sciences
2013 Volume 469, Issue 2150, Page(s) 20120556
Abstract: Abdominal aortic aneurysms (AAAs) are characterized by significant changes in the architecture of the aortic wall, notably, loss of functional elastin and smooth muscle. Because collagen is the principal remaining load-bearing constituent of the ... ...
| Abstract | Abdominal aortic aneurysms (AAAs) are characterized by significant changes in the architecture of the aortic wall, notably, loss of functional elastin and smooth muscle. Because collagen is the principal remaining load-bearing constituent of the aneurysmal wall, its turnover must play a fundamental role in the natural history of the lesion. Nevertheless, detailed investigations of the effects of different aspects of collagen turnover on AAA development are lacking. A finite-element membrane model of the growth and remodelling of idealized AAAs was thus used to investigate parametrically four of the primary aspects of collagen turnover: rates of production, half-life, deposition stretch (prestretch) and material stiffness. The predicted rates of aneurysmal expansion and spatio-temporal changes in wall thickness, biaxial stresses and maximum collagen fibre stretch at the apex of the lesion depended strongly on all four factors, as did the predicted clinical endpoints (i.e. arrest, progressive expansion or rupture). Collagen turnover also affected the axial expansion, largely due to mechanical changes within the shoulder region of the lesion. We submit, therefore, that assessment of rupture risk could be improved by future experiments that delineate and quantify different aspects of patient-specific collagen turnover and that such understanding could lead to new targeted therapeutics. |
|---|---|
| Language | English |
| Publishing date | 2013-05-01 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 209241-4 |
| ISSN | 1471-2946 ; 1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207 |
| ISSN (online) | 1471-2946 |
| ISSN | 1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207 |
| DOI | 10.1098/rspa.2012.0556 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Z 46/95: Show issues |
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Journal of the Royal Society, Interface
2012 Volume 9, Issue 74, Page(s) 2047–2058
Abstract: Complementary advances in medical imaging, vascular biology and biomechanics promise to enable computational modelling of abdominal aortic aneurysms to play increasingly important roles in clinical decision processes. Using a finite-element-based growth ... ...
| Abstract | Complementary advances in medical imaging, vascular biology and biomechanics promise to enable computational modelling of abdominal aortic aneurysms to play increasingly important roles in clinical decision processes. Using a finite-element-based growth and remodelling model of evolving aneurysm geometry and material properties, we show that regional variations in material anisotropy, stiffness and wall thickness should be expected to arise naturally and thus should be included in analyses of aneurysmal enlargement or wall stress. In addition, by initiating the model from best-fit material parameters estimated for non-aneurysmal aortas from different subjects, we show that the initial state of the aorta may influence strongly the subsequent rate of enlargement, wall thickness, mechanical behaviour and thus stress in the lesion. We submit, therefore, that clinically reliable modelling of the enlargement and overall rupture-potential of aneurysms may require both a better understanding of the mechanobiological processes that govern the evolution of these lesions and new methods of determining the patient-specific state of the pre-aneurysmal aorta (or correlation to currently unaffected portions thereof) through knowledge of demographics, comorbidities, lifestyle, genetics and future non-invasive or minimally invasive tests. |
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| MeSH term(s) | Anisotropy ; Aorta, Abdominal/pathology ; Aorta, Abdominal/physiopathology ; Aortic Aneurysm, Abdominal/pathology ; Aortic Aneurysm, Abdominal/physiopathology ; Finite Element Analysis ; Humans ; Models, Cardiovascular ; Vascular Stiffness |
| Language | English |
| Publishing date | 2012-04-04 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 2156283-0 |
| ISSN | 1742-5662 ; 1742-5689 |
| ISSN (online) | 1742-5662 |
| ISSN | 1742-5689 |
| DOI | 10.1098/rsif.2012.0097 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of forestry. 2005 July-Aug, v. 103, no. 5
2005
| Keywords | forest surveys ; forest products industry ; sawmills ; logs ; history ; Maine |
|---|---|
| Language | English |
| Dates of publication | 2005-07 |
| Size | p. 218-223. |
| Document type | Article |
| ZDB-ID | 300414-4 |
| ISSN | 0022-1201 |
| ISSN | 0022-1201 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 653: Show issues |
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