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  1. Book: Radiation cytogenetics

    Kato, Takamitsu A. / Wilson, Paul F.

    methods and protocols

    (Methods in molecular biology ; 1984 ; Springer protocols)

    2019  

    Author's details edited by Takamitsu A. Kato, Paul F. Wilson
    Series title Methods in molecular biology ; 1984
    Springer protocols
    Collection
    Language English
    Size x, 138 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020133205
    ISBN 978-1-4939-9430-4 ; 9781493994328 ; 1-4939-9430-1 ; 1493994328
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1984- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Learning how and why complex improvement interventions work: insights from implementation science.

    Wilson, Paul / Kislov, Roman

    BMJ quality & safety

    2023  Volume 32, Issue 8, Page(s) 438–440

    MeSH term(s) Humans ; Implementation Science ; Medication Errors ; Medication Reconciliation ; Learning ; Quality Improvement
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2592909-4
    ISSN 2044-5423 ; 2044-5415
    ISSN (online) 2044-5423
    ISSN 2044-5415
    DOI 10.1136/bmjqs-2023-016008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Making implementation science more efficient: capitalizing on opportunities beyond the field.

    Wensing, Michel / Wilson, Paul

    Implementation science : IS

    2023  Volume 18, Issue 1, Page(s) 40

    Abstract: Implementation researchers often find themselves as research partners in practice improvement projects, clinical trials or other applied health studies. The implementation science component in these projects can be described as supportive, descriptive or ...

    Abstract Implementation researchers often find themselves as research partners in practice improvement projects, clinical trials or other applied health studies. The implementation science component in these projects can be described as supportive, descriptive or explanatory. This commentary reflects on the potential contributions of such projects to implementation science. They may provide evidence on implementation strategies, so it is essential to identify and evaluate these separately from the clinical and preventive interventions of interest. The use of theory on implementation processes and associated factors can contribute to knowledge accumulation, particularly if the focus is on what actually gets implemented when, why and how. The development and validation of relevant measures is a third potential contribution to implementation science. Although not all issues in implementation science can be addressed in this way, capitalization on the opportunities beyond the field can contribute to implementation science.
    MeSH term(s) Humans ; Implementation Science ; Knowledge ; Research Personnel
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2225822-X
    ISSN 1748-5908 ; 1748-5908
    ISSN (online) 1748-5908
    ISSN 1748-5908
    DOI 10.1186/s13012-023-01298-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Geographic inequalities in need and provision of social prescribing link workers.

    Wilding, Anna / Sutton, Matthew / Agboraw, Efundem / Munford, Luke / Wilson, Paul

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2024  

    Abstract: Background: Long-term health conditions are major challenges for care systems. Social prescribing link workers have been introduced via Primary Care Networks (PCNs) across England since 2019 to address the wider determinants of health by connecting ... ...

    Abstract Background: Long-term health conditions are major challenges for care systems. Social prescribing link workers have been introduced via Primary Care Networks (PCNs) across England since 2019 to address the wider determinants of health by connecting individuals to activities, groups, or services within their local community.
    Aim: To assess whether the rollout of social prescribing link workers was in areas with the highest need.
    Design and setting: A retrospective study of social prescribing link workers in England from 2019 to 2023.
    Method: We combined workforce, population, survey, and area-level data at the PCN-level from April 2020 to October 2023. We measured population need prior to the rollout of link workers using reported lack of support from local services in the 2019 GP Patient Survey. To assess if rollout reflected need, we used linear regression to relate provision of link workers (measured by full-time equivalent (FTE) per 10,000 patients) in each quarter to population need for support.
    Results: Populations in urban, more deprived areas and with higher proportions of minority ethnicities had the highest reported lack of support. Geographically these were in the North West and London. Initially, there was no association between need and provision; then from July 2022, this became negative and significant. By October 2023, a 10-percentage point higher need for support was associated with a 0.035 (95%CI(-0.634 to -0.066)) lower FTE per 10,000 patients.
    Conclusion: Rollout of link workers has not been sufficiently targeted at areas with the highest need. Future deployments should be targeted at those areas.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/BJGP.2023.0602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 576: Show issues Location:
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    Zs.MO 100: Show issues

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  5. Article ; Online: Seq2Sat and SatAnalyzer toolkit: Towards comprehensive microsatellite genotyping from sequencing data.

    Liu, Peng / Wilson, Paul / Redquest, Bridget / Keobouasone, Sonesinh / Manseau, Micheline

    Molecular ecology resources

    2024  Volume 24, Issue 3, Page(s) e13929

    Abstract: Accurate and efficient microsatellite loci genotyping is an essential process in population genetics that is also used in various demographic analyses. Protocols for next-generation sequencing of microsatellite loci enable high-throughput and cross- ... ...

    Abstract Accurate and efficient microsatellite loci genotyping is an essential process in population genetics that is also used in various demographic analyses. Protocols for next-generation sequencing of microsatellite loci enable high-throughput and cross-compatible allele scoring, common issues that are not addressed by conventional capillary-based approaches. To improve this process, we have developed an all-in-one software, called Seq2Sat (sequence to microsatellite), in C++ to support automated microsatellite genotyping. It directly takes raw reads of microsatellite amplicons and conducts read quality control before inferring genotypes based on depth-of-read, read ratio, sequence composition and length. We have also developed a module for sex identification based on sex chromosome-specific locus amplicons. To allow for greater user access and complement autoscoring, we developed SatAnalyzer (microsatellite analyzer), a user-friendly web-based platform that conducts reads-to-report analyses by calling Seq2Sat for genotype autoscoring and produces interactive genotype graphs for manual editing. SatAnalyzer also allows users to troubleshoot multiplex optimization by analysing read quality and distribution across loci and samples in support of high-quality library preparation. To evaluate its performance, we benchmarked our toolkit Seq2Sat/SatAnalyzer against a conventional capillary gel method and existing microsatellite genotyping software, MEGASAT, using two datasets. Results showed that SatAnalyzer can achieve >99.70% genotyping accuracy and Seq2Sat is ~5 times faster than MEGASAT despite many more informative tables and figures being generated. Seq2Sat and SatAnalyzer are freely available on github (https://github.com/ecogenomicscanada/Seq2Sat) and dockerhub (https://hub.docker.com/r/rocpengliu/satanalyzer).
    MeSH term(s) Genotype ; Software ; Genetics, Population ; Alleles ; High-Throughput Nucleotide Sequencing/methods ; Microsatellite Repeats ; Genotyping Techniques/methods ; Sequence Analysis, DNA/methods
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2406833-0
    ISSN 1755-0998 ; 1755-098X
    ISSN (online) 1755-0998
    ISSN 1755-098X
    DOI 10.1111/1755-0998.13929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Grandiose narcissism associates with higher cognitive performance under stress through more efficient attention distribution: An eye-tracking study.

    Stefanova, Vasilena / Scheepers, Christoph / Wilson, Paul / Papageorgiou, Kostas A

    PloS one

    2024  Volume 19, Issue 5, Page(s) e0302644

    Abstract: Narcissism is a part of the Dark Triad that consists also of the traits of Machiavellianism and psychopathy. Two main types of narcissism exist: grandiose and vulnerable narcissism. Being a Dark Triad trait, narcissism is typically associated with ... ...

    Abstract Narcissism is a part of the Dark Triad that consists also of the traits of Machiavellianism and psychopathy. Two main types of narcissism exist: grandiose and vulnerable narcissism. Being a Dark Triad trait, narcissism is typically associated with negative outcomes. However, recent research suggests that at least the grandiose type may be linked (directly or indirectly) to positive outcomes including lower levels of psychopathology, higher school grades in adolescents, deeper and more strategic learning in university students and higher cognitive performance in experimental settings. The current pre-registered, quasi-experimental study implemented eye-tracking to assess whether grandiose narcissism indirectly predicts cognitive performance through wider distribution of attention on the Raven's Progressive Matrices task. Fifty-four adults completed measures of the Dark Triad, self-esteem and psychopathology. Eight months to one year later, participants completed the Raven's, while their eye-movements were monitored during high stress conditions. When controlling for previous levels of psychopathology, grandiose narcissism predicted higher Raven's scores indirectly, through increased variability in the number of fixations across trials. These findings suggest that grandiose narcissism predicts higher cognitive performance, at least in experimental settings, and call for further research to understand the implications of this seemingly dark trait for performance across various settings.
    MeSH term(s) Humans ; Male ; Female ; Narcissism ; Cognition/physiology ; Adult ; Attention/physiology ; Young Adult ; Eye-Tracking Technology ; Stress, Psychological ; Adolescent ; Self Concept
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0302644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Niches and guilds of bryophytes along a 3000-meter elevational gradient

    Wilson, Paul / Coleman, Lena Ayala

    Bryologist. 2022 Feb. 3, v. 125, no. 1

    2022  

    Abstract: A long and steep elevational gradient presents the opportunity to study the niches of a large number of species within a small geographic area. Along such a gradient in the Sierra Nevada of California, all bryophytes were recorded in 253 plots. Along ... ...

    Abstract A long and steep elevational gradient presents the opportunity to study the niches of a large number of species within a small geographic area. Along such a gradient in the Sierra Nevada of California, all bryophytes were recorded in 253 plots. Along with species occurrence, the wetness, incline, shadiness and substrate type of the spot where each bryophyte was living were recorded. The average of these ecological traits (i.e., the central tendency of the species niche) was tabulated along with a determination of whether the species was a specialist or generalist for that niche dimension. Moving to guilds, co-occurrence in plots was used to aggregate species into ecological coalitions using the program RCLUS. These coalitions occupy different parts of an ordination of species, but they reveal more subtlety than the ordination itself. An ecotone was evident between the foothill bryophyte vegetation zone and a higher elevation zone. Other ecotones were not obvious; for example, we did not detect a sharp boundary between a conifer zone and a subalpine zone, rather the turnover of species was incremental and individualistic. For naturalists who know the species, being able to characterize them ecologically contributes to thoughts of the assembly of communities and the conservatism of clades.
    Keywords Bryophyta ; conifers ; ecotones ; hills ; mountains ; vegetation ; California
    Language English
    Dates of publication 2022-0203
    Size p. 115-134.
    Publishing place American Bryological and Lichenological Society
    Document type Article
    ZDB-ID 2173787-3
    ISSN 1938-4378 ; 0007-2745
    ISSN (online) 1938-4378
    ISSN 0007-2745
    DOI 10.1639/0007-2745-125.1.115
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Alginate/xanthan gum hydrogels as forensic blood substitutes for bloodstain formation and analysis.

    Orr, Amanda / Wilson, Paul / Stotesbury, Theresa

    Soft matter

    2023  Volume 19, Issue 20, Page(s) 3711–3722

    Abstract: Understanding the behaviour of human blood outside of the body has important implications in forensic research, especially related to bloodstain pattern analysis (BPA). The design of forensic blood substitutes (FBSs) can provide many advantages, ... ...

    Abstract Understanding the behaviour of human blood outside of the body has important implications in forensic research, especially related to bloodstain pattern analysis (BPA). The design of forensic blood substitutes (FBSs) can provide many advantages, including the incorporation of multiple physiological components for use as safe and reliable materials for forensic applications. In this work, we present the design of synthetic alginate and xanthan gum-based hydrogels that contain electrosprayed microparticles (MPs) with and without crosslinked DNA. In addition to the MPs, the alginate/xanthan gum FBS materials include fillers to alter the physical appearance and fluid properties of the material. The optimized FBS consisted of alginate (1% w/v) and xanthan gum (5.0 × 10
    MeSH term(s) Animals ; Cattle ; Humans ; Hydrogels ; Blood Substitutes ; Alginates ; Blood Stains ; Polysaccharides, Bacterial
    Chemical Substances Hydrogels ; xanthan gum (TTV12P4NEE) ; Blood Substitutes ; Alginates ; Polysaccharides, Bacterial
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d3sm00341h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Public health emergency archetypes: a framework to guide efforts to ensure equitable access to medical countermeasures.

    Wilson, Paul A / Thornton, Ian / Gandhi, Gian

    BMJ global health

    2023  Volume 8, Issue 5

    MeSH term(s) Humans ; Public Health ; Medical Countermeasures ; COVID-19
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2023-012436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A qualitative evaluation of the national rollout of a diabetes prevention programme in England.

    Brunton, Lisa / Soiland-Reyes, Claudia / Wilson, Paul

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 1043

    Abstract: Background: The National Health Service Diabetes Prevention Programme (NHS DPP) was commissioned by NHS England in 2016 and rolled out in three 'waves' across the whole of England. It aims to help people with raised blood glucose levels reduce their ... ...

    Abstract Background: The National Health Service Diabetes Prevention Programme (NHS DPP) was commissioned by NHS England in 2016 and rolled out in three 'waves' across the whole of England. It aims to help people with raised blood glucose levels reduce their risk of developing type 2 diabetes through behaviour change techniques (e.g., weight loss, dietary changes and exercise). An independent, longitudinal, mixed methods evaluation of the NHS DPP was undertaken. We report the findings from the implementation work package: a qualitative interview study with designated local leads, responsible for the local commissioning and implementation of the programme. The aim of the study was to explore how local implementation processes were enacted and adapted over time.
    Methods: We conducted a telephone interview study across two time-points. Twenty-four semi-structured interviews with local leads across 19 sampled case sites were undertaken between October 2019 and January 2020 and 13 interviews with local leads across 13 sampled case sites were conducted between July 2020 and August 2020. Interviews aimed to reflect on the experience of implementation and explore how things changed over time.
    Results: We identified four overarching themes to show how implementation was locally enacted and adapted across the sampled case sites: 1. Adapting to provider change; 2. Identification and referral; 3. Enhancing uptake in underserved populations; and 4. Digital and remote service options.
    Conclusion: This paper reports how designated local leads, responsible for local implementation of the NHS DPP, adapted implementation efforts over the course of a changing national diabetes prevention programme, including how local leads adapted implementation during the COVID-19 pandemic. This paper highlights three main factors that influence implementation: the importance of facilitation, the ability (or not) to tailor interventions to local needs and the role of context in implementation.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/prevention & control ; State Medicine ; Pandemics ; COVID-19/epidemiology ; COVID-19/prevention & control ; Qualitative Research
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-10002-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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