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  1. Article ; Online: Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.

    Wilson, Robert B / Lathigara, Dhruvi / Kaushal, Devesh

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: The study aimed to perform a systematic review and meta-analysis of the evidence for the prevention of future cancers following bariatric surgery. A systematic literature search of the Cochrane Library, Embase, Scopus, Web of Science and PubMed databases ...

    Abstract The study aimed to perform a systematic review and meta-analysis of the evidence for the prevention of future cancers following bariatric surgery. A systematic literature search of the Cochrane Library, Embase, Scopus, Web of Science and PubMed databases (2007-2023), Google Scholar and grey literature was conducted. A meta-analysis was performed using the inverse variance method and random effects model. Thirty-two studies involving patients with obesity who received bariatric surgery and control patients who were managed with conventional treatment were included. The meta-analysis suggested bariatric surgery was associated with a reduced overall incidence of cancer (RR 0.62, 95% CI 0.46-0.84,
    MeSH term(s) Male ; Humans ; Female ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Metabolic Syndrome/complications ; Bariatric Surgery ; Risk ; Incidence ; Neoplasms/etiology ; Neoplasms/complications
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076192
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  2. Article: Current management of gastro-oesophageal reflux disease-treatment costs, safety profile, and effectiveness: a narrative review.

    Lata, Tahmina / Trautman, Jodie / Townend, Philip / Wilson, Robert B

    Gastroenterology report

    2023  Volume 11, Page(s) goad008

    Abstract: Background: The purpose of this study was to review the current management of gastro-oesophageal reflux disease (GORD), including treatment costs, safety profile and effectiveness.: Methods: A literature review was performed of randomized-controlled ... ...

    Abstract Background: The purpose of this study was to review the current management of gastro-oesophageal reflux disease (GORD), including treatment costs, safety profile and effectiveness.
    Methods: A literature review was performed of randomized-controlled trials, systematic reviews, Cochrane reports and National/Societal guidelines of the medical, endoscopic and surgical management of GORD. Proton pump inhibitor (PPI) prescribing patterns and expenditure were reviewed in different countries, including Australia, Canada, New Zealand, UK and USA.
    Results: Proton pump inhibitors (PPIs) are primarily indicated for control of GORD, Helicobacter pylori eradication (combined with antibiotics), preventing NSAID-induced gastrointestinal bleeding and treating peptic ulcer disease. There is widespread overprescribing of PPIs in Western and Eastern nations in terms of indication and duration, with substantial expense for national health providers. Despite a favourable short-term safety profile, there are observational associations of adverse effects with long-term PPIs. These include nutrient malabsorption, enteric infections and cardiovascular events. The prevalence of PPI use makes their long-term safety profile clinically relevant. Cost-benefit, symptom control and quality-of-life outcomes favour laparoscopic fundoplication rather than chronic PPI treatment. Laparoscopic fundoplication in long-term management of PPI-responsive GORD is supported by SAGES, NICE and ACG, and PPI-refractory GORD by AGA and SAGES guidelines. The importance of establishing a definitive diagnosis prior to invasive management is emphasized, especially in PPI-refractory heartburn.
    Conclusions: We examined evidence-based guidelines for PPI prescribing and deprescribing in primary care and hospital settings and the need for PPI stewardship and education of health professionals. This narrative review presents the advantages and disadvantages of surgical, endoscopic and medical management of GORD, which may assist in shared decision making and treatment choice in individual patients.This paper was presented (GS020) at the 88th RACS Annual Scientific Conference, 6-10 May, 2019.
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/goad008
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  3. Article ; Online: Changes in the coelomic microclimate during carbon dioxide laparoscopy: morphological and functional implications.

    Wilson, Robert B

    Pleura and peritoneum

    2017  Volume 2, Issue 1, Page(s) 17–31

    Abstract: In this article the adverse effects of laparoscopic ... ...

    Abstract In this article the adverse effects of laparoscopic CO
    Language English
    Publishing date 2017-03-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2861909-2
    ISSN 2364-768X ; 2364-7671
    ISSN (online) 2364-768X
    ISSN 2364-7671
    DOI 10.1515/pp-pp-2017-0001
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  4. Article ; Online: A Novel Metric for Predicting Severity of Disease Features in Friedreich's Ataxia.

    Rodden, Layne N / Rummey, Christian / Kessler, Sudha / Wilson, Robert B / Lynch, David R

    Movement disorders : official journal of the Movement Disorder Society

    2023  Volume 38, Issue 6, Page(s) 970–977

    Abstract: Background: Friedreich's ataxia (FRDA), most commonly caused by a GAA triplet repeat (GAA-TR) expansion in intron 1 of the FXN gene, is characterized by deficiency of frataxin protein and clinical features such as progressive ataxia, dysarthria, ... ...

    Abstract Background: Friedreich's ataxia (FRDA), most commonly caused by a GAA triplet repeat (GAA-TR) expansion in intron 1 of the FXN gene, is characterized by deficiency of frataxin protein and clinical features such as progressive ataxia, dysarthria, impaired proprioception and vibration, abolished deep tendon reflexes, Babinski sign, and vision loss in association with non-neurological features such as skeletal anomalies, hearing loss, cardiomyopathy, and diabetes. Pathogenic GAA-TRs range in size from 60 to 1500 triplets and negatively correlate with age of onset. Clinical severity is predicted by a combination of GAA-TR length and disease duration (DD) via multivariable regressions, which cannot typically be used for the small sample sizes in most studies on this rare disease.
    Objective: We aimed to develop a single metric, which we call "disease burden" (DB), that encompasses both GAA-TR length and DD for predicting disease features of FRDA in small sample sizes.
    Methods: Linear regression and multivariable regression analysis was used to determine correlation coefficients between different disease features of FRDA.
    Results: Using large datasets for validation, we found that DB predicts measures of neurological dysfunction in FRDA better than GAA-TR length or DD. Analogous results were found using small datasets.
    Conclusions: FRDA DB is a novel metric of disease severity that has utility in small datasets to demonstrate correlations that would not otherwise be evident with either GAA-TR or DD alone. This is important for discovering new biomarkers, as well as improving the prediction of severity of disease features in FRDA. © 2023 International Parkinson and Movement Disorder Society.
    MeSH term(s) Humans ; Friedreich Ataxia/genetics ; Trinucleotide Repeats ; Trinucleotide Repeat Expansion/genetics ; Introns ; Severity of Illness Index ; Iron-Binding Proteins/genetics ; Iron-Binding Proteins/metabolism
    Chemical Substances Iron-Binding Proteins
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

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  5. Article ; Online: Reprogramming of Mesothelial-Mesenchymal Transition in Chronic Peritoneal Diseases by Estrogen Receptor Modulation and TGF-β1 Inhibition.

    Wilson, Robert B / Archid, Rami / Reymond, Marc A

    International journal of molecular sciences

    2020  Volume 21, Issue 11

    Abstract: In chronic peritoneal diseases, mesothelial-mesenchymal transition is determined by cues from the extracellular environment rather than just the cellular genome. The transformation of peritoneal mesothelial cells and other host cells into myofibroblasts ... ...

    Abstract In chronic peritoneal diseases, mesothelial-mesenchymal transition is determined by cues from the extracellular environment rather than just the cellular genome. The transformation of peritoneal mesothelial cells and other host cells into myofibroblasts is mediated by cell membrane receptors, Transforming Growth Factor β1 (TGF-β1), Src and Hypoxia-inducible factor (HIF). This article provides a narrative review of the reprogramming of mesothelial mesenchymal transition in chronic peritoneal diseases, drawing on the similarities in pathophysiology between encapsulating peritoneal sclerosis and peritoneal metastasis, with a particular focus on TGF-β1 signaling and estrogen receptor modulators. Estrogen receptors act at the cell membrane/cytosol as tyrosine kinases that can phosphorylate Src, in a similar way to other receptor tyrosine kinases; or can activate the estrogen response element via nuclear translocation. Tamoxifen can modulate estrogen membrane receptors, and has been shown to be a potent inhibitor of mesothelial-mesenchymal transition (MMT), peritoneal mesothelial cell migration, stromal fibrosis, and neoangiogenesis in the treatment of encapsulating peritoneal sclerosis, with a known side effect and safety profile. The ability of tamoxifen to inhibit the transduction pathways of TGF-β1 and HIF and achieve a quiescent peritoneal stroma makes it a potential candidate for use in cancer treatments. This is relevant to tumors that spread to the peritoneum, particularly those with mesenchymal phenotypes, such as colorectal CMS4 and MSS/EMT gastric cancers, and pancreatic cancer with its desmoplastic stroma. Morphological changes observed during mesothelial mesenchymal transition can be treated with estrogen receptor modulation and TGF-β1 inhibition, which may enable the regression of encapsulating peritoneal sclerosis and peritoneal metastasis.
    MeSH term(s) Animals ; Cancer-Associated Fibroblasts/drug effects ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Chronic Disease ; Epithelial Cells/drug effects ; Epithelial-Mesenchymal Transition ; Estrogen Receptor Modulators/pharmacology ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Flavonoids/pharmacology ; Glycolysis/drug effects ; Glycolysis/physiology ; Humans ; NF-kappa B/metabolism ; Peritoneal Diseases/drug therapy ; Peritoneal Diseases/metabolism ; Peritoneal Diseases/pathology ; Peritoneal Fibrosis/drug therapy ; Peritoneal Fibrosis/metabolism ; Peritoneal Fibrosis/pathology ; Peritoneum/cytology ; Receptors, Estrogen/metabolism ; Tamoxifen/therapeutic use ; Transforming Growth Factor beta1/antagonists & inhibitors ; Transforming Growth Factor beta1/metabolism ; Tumor Microenvironment/drug effects
    Chemical Substances 4-(para-hydroxyphenyl)-7,4'-dihydroxy-3',5'-dimethoxy-8-methylisoflavan ; Estrogen Receptor Modulators ; Flavonoids ; NF-kappa B ; Receptors, Estrogen ; Transforming Growth Factor beta1 ; Tamoxifen (094ZI81Y45)
    Language English
    Publishing date 2020-06-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21114158
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  6. Article ; Online: Pathways of Gastric Carcinogenesis,

    Toh, James W T / Wilson, Robert B

    International journal of molecular sciences

    2020  Volume 21, Issue 17

    Abstract: Helicobacter ... ...

    Abstract Helicobacter pylori
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Carcinogenesis/drug effects ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Gastric Juice/metabolism ; Helicobacter Infections/complications ; Helicobacter Infections/microbiology ; Helicobacter pylori/isolation & purification ; Humans ; Phytochemicals/pharmacology ; Stomach Neoplasms/etiology ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Stomach Neoplasms/prevention & control
    Chemical Substances Antioxidants ; Phytochemicals ; Ascorbic Acid (PQ6CK8PD0R)
    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21176451
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  7. Article: The Role of Serum Levels of Neurofilament Light (NfL) Chain as a Biomarker in Friedreich Ataxia.

    Frempong, Bernice / Wilson, Robert B / Schadt, Kimberly / Lynch, David R

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 653241

    Language English
    Publishing date 2021-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.653241
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  8. Article: Treatment of recurrent

    Hopkins, Roy J / Wilson, Robert B

    Gastroenterology report

    2017  Volume 6, Issue 1, Page(s) 21–28

    Abstract: Clostridium ... ...

    Abstract Clostridium difficile
    Language English
    Publishing date 2017-12-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/gox041
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  9. Article ; Online: Therapeutic developments in Friedreich ataxia.

    Wilson, Robert B

    Journal of child neurology

    2012  Volume 27, Issue 9, Page(s) 1212–1216

    Abstract: Friedreich ataxia is an inherited, severe, progressive neuro- and cardiodegenerative disorder for which there currently is no approved therapy. Friedreich ataxia is caused by the decreased expression and/or function of frataxin, a mitochondrial matrix ... ...

    Abstract Friedreich ataxia is an inherited, severe, progressive neuro- and cardiodegenerative disorder for which there currently is no approved therapy. Friedreich ataxia is caused by the decreased expression and/or function of frataxin, a mitochondrial matrix protein that binds iron and is involved in the formation of iron-sulfur clusters. Decreased frataxin function leads to decreased iron-sulfur cluster formation, mitochondrial iron accumulation, cytosolic iron depletion, oxidative stress, and mitochondrial dysfunction. Cloning of the disease gene for Friedreich ataxia and elucidation of many aspects of the biochemical defects underlying the disorder have led to several major therapeutic initiatives aimed at increasing frataxin expression, reversing mitochondrial iron accumulation, and alleviating oxidative stress. These initiatives are in preclinical and clinical development and are reviewed herein.
    MeSH term(s) Animals ; Friedreich Ataxia/genetics ; Friedreich Ataxia/metabolism ; Friedreich Ataxia/physiopathology ; Friedreich Ataxia/therapy ; Gene Expression Regulation/physiology ; Humans ; Iron/metabolism ; Iron-Binding Proteins/genetics ; Iron-Binding Proteins/metabolism ; Mitochondria/metabolism ; Oxidative Stress/physiology ; Frataxin
    Chemical Substances Iron-Binding Proteins ; Iron (E1UOL152H7)
    Language English
    Publishing date 2012-07-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639288-x
    ISSN 1708-8283 ; 0883-0738
    ISSN (online) 1708-8283
    ISSN 0883-0738
    DOI 10.1177/0883073812449691
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2301: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Time is of the essence: evaluation of emergency department triage and time performance in the preoperative management of acute abdomen.

    Teo, Adrian / Wang, Cindy / Wilson, Robert B

    ANZ journal of surgery

    2019  Volume 89, Issue 9, Page(s) 1102–1107

    Abstract: Background: Acute abdomen is a time-critical condition, which requires prompt diagnosis, initiation of first-line preoperative therapy and expedient surgical intervention. The earliest opportunity to intervene occurs at presentation to the emergency ... ...

    Abstract Background: Acute abdomen is a time-critical condition, which requires prompt diagnosis, initiation of first-line preoperative therapy and expedient surgical intervention. The earliest opportunity to intervene occurs at presentation to the emergency department triage. The aim of this audit was to evaluate the relationship between emergency triage and time performance measures in the preoperative management of abdominal emergencies.
    Methods: Retrospective audit of time performance measures of key clinical events from emergency triage. Patient characteristics, elapsed time from triage to commencement of fluid resuscitation, intravenous antibiotics and emergency surgery and post-operative outcomes were obtained from review of operative medical records data over a 1-year duration.
    Results: There was variability in triage allocation of patients with acute abdomen requiring urgent surgery. Category 3 was the most commonly assigned triage category (65.6%). The majority of patients (94.8%) had initial clinical assessment within the National Emergency Access Target '4-hour' rule, and 41.7% seen within 1-h from triage. Despite this, in cases of intra-abdominal sepsis, there was nearly a fourfold elapsed time for first dose intravenous antibiotics, beyond the 1-h recommendation in the Sepsis Kills pathway. There was non-significant trend in faster overall time performances with successive higher triage category allocation.
    Conclusion: This study highlights an opportunity to consider alternative triage methods or fast-track of patients with acute abdomen to promote early surgical assessment, resuscitation, antibiotic therapy and definitive intervention.
    MeSH term(s) Abdomen, Acute ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Clinical Audit ; Emergency Service, Hospital ; Emergency Treatment ; Female ; Humans ; Male ; Middle Aged ; Preoperative Care ; Retrospective Studies ; Time Factors ; Triage/methods ; Young Adult
    Language English
    Publishing date 2019-05-21
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.15255
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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