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  1. Book ; Thesis: Die Proteine Neurofilament light chain und Progranulin im Liquor cerebrospinalis als Wegbereiter zur personalisierten Neurologie

    Körtvélyessy, Péter / Wiltfang, Jens / Flöel, Agnes / Bittner, Stefan

    2021  

    Institution Otto-von-Guericke-Universität Magdeburg
    Author's details von Péter Körtvélyessy ; Gutachter: Prof. Dr. Jens Wiltfang ; Prof. Dr. Agnes Flöel ; Prof. Dr. Stefan Bittner
    Keywords Nervenkrankheit ; Biomarker
    Subject Biochemischer Marker ; Biologischer Marker ; Nervenkrankheiten ; Neurologische Erkrankung ; Neurologische Krankheit ; Nervensystem ; Nervensystemkrankheit ; Nervous disease
    Language German
    Size verschiedene Seitenzählung, Illustrationen, Diagramme
    Publisher Otto-von-Guericke-Universität Magdeburg
    Publishing place Magdeburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitation, Universität Magdeburg, 2021
    HBZ-ID HT021714766
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 236 order for loan Magazin

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  2. Book ; Conference proceedings: 150 years of psychiatry at Göttingen University

    Wedekind, Dirk / Spitzer, Carsten / Wiltfang, Jens

    lectures given at the anniversary symposium

    2019  

    Title translation 150 Jahre Universitätspsychiatrie in Göttingen
    Event/congress 150 Jahre Universitätspsychiatrie Göttingen (2016, Göttingen)
    Author's details Dirk Wedekind/Carsten Spitzer/Jens Wiltfang (eds.)
    Keywords Göttingen ; Medizingeschichte ; Psychiatrie ; Psychiatrie-Enquète ; Niedersächsisches Landeskrankenhaus ; Ludwig Meyer ; Universität/Göttingen ; Klinik für Psychiatrie und Psychotherapie der Universitätsmedizin Göttingen ; Geschichte 1866-2016
    Subject code 616.89009435972
    Language English
    Size 126 Seiten, Illustrationen, 24 cm
    Publisher V & R unipress
    Publishing place Göttingen
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT020240455
    ISBN 978-3-8471-1034-7 ; 3-8471-1034-9 ; 9783847010340 ; 9783737010344 ; 3847010344 ; 373701034X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2019 A 1428 available for loan (reading room) Lesesaal EG

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  3. Book ; Conference proceedings: 150 Jahre Universitätspsychiatrie in Göttingen

    Wedekind, Dirk / Spitzer, Carsten / Wiltfang, Jens

    Beiträge zum Jubiläumssymposium

    2019  

    Event/congress 150 Jahre Universitätspsychiatrie Göttingen (2016, Göttingen)
    Author's details Dirk Wedekind/Carsten Spitzer/Jens Wiltfang (Hg.)
    Keywords MEDIZINGESCHICHTE: Medizingeschichte ; PSYCHIATRIE: Psychiatrie ; GÖTT: Göttingen/Universität ; GÖTTINGEN: Göttingen ; PSYCHIATRIE-ENQUÈTE: Psychiatrie-Enquète ; LANDESKRANKENHAUS: Niedersächsisches Landeskrankenhaus ; Klinik für Psychiatrie und Psychotherapie der Universitätsmedizin Göttingen ; Geschichte 1866-2016
    Subject code 616.89009435972
    Language German
    Size 126 Seiten, Illustrationen, 24 cm
    Publisher V & R unipress
    Publishing place Göttingen
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT020328060
    ISBN 978-3-8471-0901-3 ; 3-8471-0901-4 ; 9783847009016 ; 9783737009010 ; 384700901X ; 3737009015
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 42 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: Drug repurposing and new drug targets: perspectives for novel treatment options in mental health disorders.

    Malchow, Berend / Wiltfang, Jens

    Journal of neural transmission (Vienna, Austria : 1996)

    2023  Volume 130, Issue 8, Page(s) 987–988

    MeSH term(s) Humans ; Drug Repositioning ; Mental Health ; Mental Disorders/drug therapy
    Language English
    Publishing date 2023-07-15
    Publishing country Austria
    Document type Editorial
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-023-02671-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Onset matters in dementia with Lewy bodies.

    Müller, Sebastian Johannes / Wiltfang, Jens / Hansen, Niels

    Aging

    2023  Volume 15, Issue 9, Page(s) 3228–3229

    MeSH term(s) Humans ; Lewy Body Disease ; Alzheimer Disease ; Lewy Bodies
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Editorial
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Blutbasierte Biomarker zur Optimierung der Früh- und Differentialdiagnostik der Alzheimer-Demenz.

    Hansen, Niels / Rauter, Carolin / Wiltfang, Jens

    Fortschritte der Neurologie-Psychiatrie

    2022  Volume 90, Issue 7-08, Page(s) 326–335

    Abstract: Aim: Dementia in Alzheimer´s disease is a global challenge. There is growing evidence that investigating blood biomarkers to diagnose Alzheimer´s disease is a promising fast, minimally invasive, and less costly method. The aim of this study was to ... ...

    Title translation Blood Based Biomarker for Optimization of Early and Differential Diagnosis of Alzheimer's Dementia.
    Abstract Aim: Dementia in Alzheimer´s disease is a global challenge. There is growing evidence that investigating blood biomarkers to diagnose Alzheimer´s disease is a promising fast, minimally invasive, and less costly method. The aim of this study was to review available studies on promising biomarkers for Alzheimer´s disease.
    Method: The latest studies were collated for this review.
    Results: Immunoassays followed by mass spectrometry and immunomagnetic reduction were reported to be highly relevant methods for detecting amyloid-ß 42 (Aß42) and amyloid-ß 40 (Aß40) to calculate the Aß42/Aß40 ratio, thereby improving the early diagnosis of Alzheimer´s disease. Amyloid-ß (Aß) peptides in blood plasma were considered as potential markers, as they correlated with the brain's Aß pathology. Phosphorylated tau protein 181 (p-tau181), phosphorylated tau protein 217 (p-tau217) and phosphorylated tau protein 231 (p-tau231) in blood samples assessed via Simoa technology served as parameters for the early and differential diagnosis of AD, and were markers of tau pathology in the brain. Neurofilament light chain (Nfl) and glial fibrillary acid protein (GFAP) were additional markers possibly facilitating the assessment of axonal and astroglial brain damage in Alzheimer´s disease. GFAP in blood was useful as an additional marker to detect early and to predict the time course of Alzheimer´s disease.
    Conclusions: Determining blood biomarkers represents less invasive and less costly diagnostics for Alzheimer´s disease. The investigation of blood biomarkers such as the Aß42/Aß40 ratio, p-tau217, p-tau231, Nfl and GFAP have been promising in establishing the AT(N) classification for Alzheimer´s disease. High-throughput methods should be evaluated in large patient cohort studies and via meta-analyses of studies. Consensus criteria with standard protocols for measuring these biomarkers while considering ethical issues and Alzheimer´s phenotype should unify normative values from different laboratories. The AT(N) classification of Alzheimer´s disease in blood would be a key element towards the implementation of minimally-invasive precision medicine.
    MeSH term(s) Alzheimer Disease/diagnosis ; Amyloid beta-Peptides ; Biomarkers ; Diagnosis, Differential ; Humans ; tau Proteins
    Chemical Substances Amyloid beta-Peptides ; Biomarkers ; tau Proteins
    Language German
    Publishing date 2022-07-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/a-1839-6237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.110: Show issues Location:
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  7. Article: Liquorbiomarker zur Frühdiagnostik der Alzheimerdemenz.

    Wiltfang, Jens

    Therapeutische Umschau. Revue therapeutique

    2015  Volume 72, Issue 4, Page(s) 271–278

    Abstract: Cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) is meanwhile validated on S3 evidence level and international dementia guidelines like those of the German neuropsychiatric associations (DGPPN, DGN; http://www.DGPPN.de) recommend ... ...

    Title translation Cerebrospinal fluid markers in early diagnosis of Alzheimer dementia.
    Abstract Cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) is meanwhile validated on S3 evidence level and international dementia guidelines like those of the German neuropsychiatric associations (DGPPN, DGN; http://www.DGPPN.de) recommend CSF-NDD for the improved early and differential diagnostics of multigenetic (sporadic) Alzheimer's Dementia (AD). CSF-NDD does also offer a predictive diagnosis of incipient AD for high-risk patients when they are still within the prodromal stage of mild cognitive impairment (MCI). But since currently no (secondary) preventive therapy of AD is available, the use of CSF-NDD for the predictive molecular diagnosis of AD is not recommended by the latter guidelines. However, molecular diagnostics of preclinical AD by CSF-NDD and/or [18F]Amyloid-PET has meanwhile gained high clinical relevance for therapeutic clinical research, as this novel clinical model allows to systematically screen for promising (secondary) preventive therapy options. Moreover, future blood based neurochemical diagnostics of preclinical or early AD by means of multiplex assays seems to be promising. However, so far blood assays were not consistently validated by independent research groups and in contrast to CSF-NDD a blood-based diagnosis of AD is not yet available.
    MeSH term(s) Aged ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnosis ; Alzheimer Disease/genetics ; Biomarkers/cerebrospinal fluid ; Diagnosis, Differential ; Early Diagnosis ; Genetic Markers/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Phenotype
    Chemical Substances Biomarkers ; Genetic Markers
    Language German
    Publishing date 2015-04
    Publishing country Switzerland
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a000675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Der Einsatz von Künstlicher Intelligenz bei Alzheimer-Krankheit – Personalisierte Diagnostik und Therapie.

    Wiltfang, Jens / Esselmann, Hermann / Barnikol, Utako B

    Psychiatrische Praxis

    2021  Volume 48, Issue S 01, Page(s) S31–S36

    Abstract: Using the example of dementia in Alzheimer's disease, it is shown which opportunities but also risks are posed by newer methodological approaches of artificial intelligence (AI) for the diagnosis and treatment of Alzheimer's dementia (AD). In addition, ... ...

    Title translation The Use of Artificial Intelligence in Alzheimer's Disease - Personalized Diagnostics and Therapy.
    Abstract Using the example of dementia in Alzheimer's disease, it is shown which opportunities but also risks are posed by newer methodological approaches of artificial intelligence (AI) for the diagnosis and treatment of Alzheimer's dementia (AD). In addition, AI is examined in the context of an ethical-philosophical critique of technology.
    MeSH term(s) Alzheimer Disease/diagnosis ; Alzheimer Disease/therapy ; Artificial Intelligence ; Germany ; Humans
    Language German
    Publishing date 2021-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-1369-3133
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  9. Article ; Online: Catatonic Schizophrenia Associated With Cerebrospinal GAD65 Autoantibodies: Case Report and Literature Review.

    Hansen, Niels / Bartels, Claudia / Teegen, Bianca / Wiltfang, Jens / Malchow, Berend

    Frontiers in immunology

    2022  Volume 13, Page(s) 829058

    Abstract: Background: GAD65 autoimmunity is reported to be associated with schizophrenia and bipolar disorder. However, there has been no evidence that glutamic acid decarboxylase 65 (GAD65) autoantibodies in cerebrospinal fluid (CSF) are associated with akinetic ...

    Abstract Background: GAD65 autoimmunity is reported to be associated with schizophrenia and bipolar disorder. However, there has been no evidence that glutamic acid decarboxylase 65 (GAD65) autoantibodies in cerebrospinal fluid (CSF) are associated with akinetic catatonia in schizophrenia patients.
    Methods: We report the case of a 28-year-old man who underwent diagnostics including brain MRI, neuropsychological testing, and electroencephalography (EEG) as well as a tumor search
    Results: Our patient presented catatonia that responded somewhat to benzodiazepines in combination with previously taken antipsychotics such as risperidone for prediagnosed paranoid schizophrenia. Diagnostics revealed GAD65 autoantibodies in his serum and CSF. MRI revealed no brain lesion, and the tumor search had no malignancy. We diagnosed catatonic schizophrenia. Furthermore, as he had not fully recovered, he was given immunotherapy entailing two cycles of intravenous immunoglobulins. Subsequent neuropsychological testing due to subjective cognitive complaints after immunotherapy revealed no objective cognitive deficits.
    Conclusions: We present the novel finding of an association between GAD65 autoantibodies in the serum and CSF with catatonia in a patient suffering from prediagnosed chronic schizophrenia. Due to the presence of CSF GAD65 antibodies and the catatonia factor in prediagnosed schizophrenia, we suspect that his catatonia has an autoimmune origin. Immunotherapy stabilized the catatonia that had initially responded to lorazepam treatment. Further research should be done to characterize patients' responses to immunotherapy and standard treatment in a large cohort of patients with GAD65 antibody-associated catatonia and schizophrenia.
    MeSH term(s) Adult ; Autoantibodies/therapeutic use ; Catatonia/diagnosis ; Catatonia/drug therapy ; Catatonia/etiology ; Humans ; Male ; Retrospective Studies ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Schizophrenia, Catatonic/complications
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Case Reports ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.829058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Impaired Verbal Memory Recall in Patients With Axonal Degeneration and Serum Glycine-Receptor Autoantibodies-Case Series.

    Hansen, Niels / Bartels, Claudia / Stöcker, Winfried / Wiltfang, Jens / Fitzner, Dirk

    Frontiers in psychiatry

    2022  Volume 12, Page(s) 778684

    Abstract: Background: Glycine receptor antibody-associated neuropsychiatric disease is currently known to be dominated by the phenotypes stiff-person syndrome and progressive encephalomyelitis entailing rigidity and myoclonus. In our case series we aim to depict ... ...

    Abstract Background: Glycine receptor antibody-associated neuropsychiatric disease is currently known to be dominated by the phenotypes stiff-person syndrome and progressive encephalomyelitis entailing rigidity and myoclonus. In our case series we aim to depict the less-often reported feature of cognitive impairment associated with glycine receptor antibodies.
    Methods: We investigated five patients with cognitive impairment varying from mild cognitive impairment to dementia associated with serum glycine receptor antibodies. Mild and major neurocognitive disorders were diagnosed according to the DSM-5 (fifth edition of the Diagnostic and Statistical Manual of Mental Disorders). Neuropsychology via Consortium to Establish a Registry for Alzheimer's Disease (CERAD) testing results, psychopathology data via the Manual for the Assessment and Documentation of Psychopathology in Psychiatry (AMDP), cerebrospinal fluid analysis and magnetic resonance imaging data were retrospectively analyzed from patient files.
    Results: We identified five patients with cognitive impairment as the main neuropsychiatric feature associated with serum glycine receptor antibodies. One patient also presented akinetic rigidity syndrome. The psychopathology comprised disorders of attention and memory, orientation, formal thought, and affect. In addition to suffering deficits in verbal memory function, figural recall, phonematic fluency, and globally deteriorated cognitive function, these patients presented seriously impaired memory recall in particular. Tau protein and phosphorylated tau protein 181 were elevated in 75% of patients.
    Conclusions: Our results suggest that axonal neurodegeneration and especially impaired verbal memory recall in addition to deficits in verbal and figural memory characterize patients with progressive cognitive impairment associated with glycine receptor antibodies. This unresolved issue should be clarified by researchers to discover whether axonal degeneration is merely an age-related phenomenon or one related to glycine-receptor autoantibodies in old age. Cognitive impairment as a neuropsychiatric syndrome of glycine-receptor antibody disease is a potential, conceivable, but so far unproven additional feature requiring deeper large-scale investigations and consideration during differential diagnosis in memory clinics.
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.778684
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