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  1. Book ; Thesis: Langzeitergebnisse nach Implantation einer Ahmed-Glaukomdrainage zur Senkung des intraokularen Druckes

    Strobel, Claudia / Pillunat, Karin Roswitha / Wimberger, Pauline

    2022  

    Institution Klinik und Poliklinik für Augenheilkunde
    Author's details von Claudia Strobel, geb. Klingstedt aus Dresden ; Klinik und Poliklinik für Augenheilkunde [Dresden]
    Language German
    Size X, 119 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030654174
    Database Catalogue ZB MED Medicine, Health

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    2024 E 368 order for loan Magazin

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  2. Book ; Thesis: Zusammenhang zwischen der proliferativen Aktivität von Endometriosezellen und dem klinischen Beschwerdebild sowie dem Schweregrad der Erkrankung

    Wetzk, Michelle / Wimberger, Pauline / Distler, Marius

    2021  

    Institution Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
    Author's details von Michelle Wetzk aus Forst ; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe [Dresden]
    Language German
    Size VII, 125 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021268847
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: Topographie der intracutanen Muskulatur des weiblichen Beckenbodens

    Heimann, Claudia / May, Christian Albrecht / Wimberger, Pauline

    2022  

    Institution Technische Universität Dresden / Institut für Anatomie
    Author's details von Claudia Heimann aus Meißen ; Institut für Anatomie [Dresden]
    Language German
    Size 45 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030693373
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Thesis: Klinische und forensische Bedeutung des Methamphetaminkonsums in der Schwangerschaft

    Capek, Claudia / Erfurt, Christine / Wimberger, Pauline

    eine Analyse der Behandlungsunterlagen der Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe des Universitätsklinikums Carl Gustav Carus in Dresden und der Labordaten des Instituts für Rechtsmedizin der TU Dresden von 2010-2015

    2019  

    Institution Institut für Rechtsmedizin
    Author's details von Claudia Capek
    Language German
    Size 91 Blätter, Illustrationen, 30 cm
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, 2020
    HBZ-ID HT020886511
    Database Catalogue ZB MED Medicine, Health

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  5. Book ; Thesis: Schwankungen des Augeninnendruckes im Tages- und Nachtverlauf vor und nach Selektiver Lasertrabekuloplastik

    Kocket, Greta Annette Sibylle Gerda / Pillunat, Karin Roswitha / Wimberger, Pauline

    2020  

    Institution Klinik und Poliklinik für Augenheilkunde
    Author's details von Greta Annette Sibylle Gerda Kocket aus Berlin ; Klinik und Poliklinik für Augenheilkunde [Dresden]
    Language German
    Size 86 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021694315
    Database Catalogue ZB MED Medicine, Health

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  6. Book: Blickdiagnosen Gynäkologie Geburtshilfe

    Fehm, Tanja / Aktaş, Bahriye / Banys-Paluchowski, Maggie / Schmalfeldt, Barbara / Wimberger, Pauline

    2022  

    Author's details Tanja Fehm, Bahriye Aktas, Maggie Banys-Paluchowski, Barbara Schmalfeldt, Pauline Wimberger (Hrsg.) ; mit Beiträgen von: Prof. Dr. med. Bahriye Aktas [und weiteren]
    Keywords Blickdiagnostik ; Differenzialdiagnose ; visuelle Leitsymptome ; visuelle Diagnostik ; Laparaskopie ; Entzündungen ; Infektionen ; gynäkologische Onkologie ; Endokrinologie ; Endometriose ; Urogynäkologie ; Pränataldiagnostik ; Frauenkrankheit ; Visuelle Diagnostik ; Schwangerschaft ; Geburtshilfe
    Subject Blickdiagnostik ; Blickdiagnose ; Obstetrik ; Gestation ; Gravidität ; Frauenleiden
    Language German
    Size XX, 275 Seiten, Illustrationen, 22.9 cm x 15.2 cm
    Edition 1. Auflage
    Publisher Elsevier
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT021384005
    ISBN 978-3-437-23805-5 ; 3-437-23805-1 ; 9783437062674 ; 3437062670
    Database Catalogue ZB MED Medicine, Health

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    2022 A 665 available for loan (reading room) Lesesaal EG

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  7. Article: Correction: Continuous Body Temperature Monitoring to Improve the Diagnosis of Female Infertility.

    Goeckenjan, Maren / Schiwek, Esther / Wimberger, Pauline

    Geburtshilfe und Frauenheilkunde

    2023  Volume 80, Issue 7, Page(s) e291

    Abstract: This corrects the article DOI: 10.1055/a-1191-7888.]. ...

    Abstract [This corrects the article DOI: 10.1055/a-1191-7888.].
    Language English
    Publishing date 2023-08-24
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/a-2154-8645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A predictive and prognostic model for surgical outcome and prognosis in ovarian cancer computed by clinico-pathological and serological parameters (CA125, HE4, mesothelin).

    Klotz, Daniel Martin / Link, Theresa / Wimberger, Pauline / Kuhlmann, Jan Dominik

    Clinical chemistry and laboratory medicine

    2023  Volume 62, Issue 3, Page(s) 530–539

    Abstract: Objectives: Numerous prognostic models have been proposed for ovarian cancer, extending from single serological factors to complex gene-expression signatures. Nonetheless, these models have not been routinely translated into clinical practice. We ... ...

    Abstract Objectives: Numerous prognostic models have been proposed for ovarian cancer, extending from single serological factors to complex gene-expression signatures. Nonetheless, these models have not been routinely translated into clinical practice. We constructed a robust and readily calculable model for predicting surgical outcome and prognosis of ovarian cancer patients by exploiting commonly available clinico-pathological factors and three selected serum parameters.
    Methods: Serum CA125, human epididymis protein 4 (HE4) and mesothelin (MSL) were quantified by Lumipulse
    Results: Detection of pre-operative HE4 and CA125 was the optimal marker combination for blood-based prediction of surgical outcome (AUC=0.86). We constructed a prognostic model, computed by serum levels of pre-operative CA125, post-operative HE4, post-operative MSL and surgical outcome. Prognostic performance of our model was superior to any of these parameters alone and was independent from
    Conclusions: We present a robust predictive/prognostic model for ovarian cancer, which could readily be implemented into routine diagnostics in order to identify ovarian cancer patients at high risk of recurrence.
    MeSH term(s) Humans ; Female ; Prognosis ; BRCA1 Protein ; Carcinoma, Ovarian Epithelial ; Mesothelin ; Proteins ; Biomarkers, Tumor ; Neoplasm Recurrence, Local ; BRCA2 Protein ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/surgery ; Ovarian Neoplasms/metabolism ; Treatment Outcome ; CA-125 Antigen
    Chemical Substances BRCA1 protein, human ; BRCA1 Protein ; Mesothelin (J27WDC343N) ; Proteins ; Biomarkers, Tumor ; BRCA2 protein, human ; BRCA2 Protein ; CA-125 Antigen
    Language English
    Publishing date 2023-10-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-0314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Fortgeschrittenes Ovarialkarzinom: "Wir empfehlen Bevacizumab in der First-Line-Situation einzusetzen". Interview mit Prof. Dr. med. Pauline Wimberger, Direktorin der Universitätsfrauenklinik Dresden

    Wimberger, Pauline

    Journal Onkologie

    2018  Volume 18, Issue 5, Page(s) 72

    Language German
    Document type Article
    ZDB-ID 2108287-X
    ISSN 1618-7687
    Database Current Contents Medicine

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    Zs.A 6162: Show issues Location:
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  10. Article ; Online: Overcoming PARP inhibitor resistance in ovarian cancer: what are the most promising strategies?

    Klotz, Daniel Martin / Wimberger, Pauline

    Archives of gynecology and obstetrics

    2020  Volume 302, Issue 5, Page(s) 1087–1102

    Abstract: Purpose: Ovarian cancer is the most lethal gynaecological malignancy. Despite the introduction of bevacizumab, standard chemotherapy has remained largely unchanged and the vast majority of patients will relapse within the first two years of diagnosis. ... ...

    Abstract Purpose: Ovarian cancer is the most lethal gynaecological malignancy. Despite the introduction of bevacizumab, standard chemotherapy has remained largely unchanged and the vast majority of patients will relapse within the first two years of diagnosis. However, results from recent clinical trials demonstrating clinical benefits of PARP inhibitor treatment are rapidly changing therapeutic options for many patients with ovarian cancer.
    Methods: Given the introduction of new therapeutic options in the treatment of ovarian cancer, we critically review key clinical trials, areas of scientific research and its clinical relevance.
    Results: Most notably, patients with BRCA1/2 mutant ovarian cancer benefit from maintenance treatment with PARP inhibitors after (complete or partial) response to platinum-based chemotherapy. Here, we discuss the mechanism of PARP inhibition, multiple drug resistance mechanisms, including BRCA reverse mutations, altered PARP expression, changes in DNA repair pathways, kinase activation and additional drug targets that may augment PARP inhibition.
    Conclusion: Although the use of PARP inhibitors is a huge step forward, it is apparent that patients, both with and without BRCA-mutant ovarian cancer, will eventually become resistant to PARP inhibitors. Therefore, novel combination therapies may enhance PARP inhibitor efficacy and overcome resistance mechanisms.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; BRCA1 Protein ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/genetics ; DNA Repair/drug effects ; Female ; Humans ; Mutation/drug effects ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use
    Chemical Substances Antineoplastic Agents ; BRCA1 Protein ; BRCA1 protein, human ; Poly(ADP-ribose) Polymerase Inhibitors
    Language English
    Publishing date 2020-08-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-020-05677-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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