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Article ; Online: Particle physics experiments based on the AWAKE acceleration scheme.

Wing, M

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

2019 Volume 377, Issue 2151, Page(s) 20180185

Abstract: New particle acceleration schemes open up exciting opportunities, potentially providing more compact or higher-energy accelerators. The AWAKE experiment at CERN is currently taking data to establish the method of proton-driven plasma wakefield ... ...

Abstract	New particle acceleration schemes open up exciting opportunities, potentially providing more compact or higher-energy accelerators. The AWAKE experiment at CERN is currently taking data to establish the method of proton-driven plasma wakefield acceleration. A second phase aims to demonstrate that bunches of about 10
Language	English
Publishing date	2019-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	208381-4
ISSN	1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
ISSN (online)	1471-2962
ISSN	0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
DOI	10.1098/rsta.2018.0185
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Article ; Online: Video feedback in medical education: A student's perspective.

Wing, Michelle

Medical teacher

2020 Volume 43, Issue 2, Page(s) 239–240

MeSH term(s)	Education, Medical ; Feedback ; Humans ; Learning ; Medical Staff, Hospital ; Students, Medical
Language	English
Publishing date	2020-08-03
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	424426-6
ISSN	1466-187X ; 0142-159X
ISSN (online)	1466-187X
ISSN	0142-159X
DOI	10.1080/0142159X.2020.1800613
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Article ; Online: Delivering medical professionalism: A student's perspective.

Wing, Michelle

Medical teacher

2020 Volume 42, Issue 10, Page(s) 1196–1197

MeSH term(s)	Education, Medical ; Humans ; Medicine ; Professionalism ; Schools ; Singapore ; Students, Medical
Language	English
Publishing date	2020-03-19
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	424426-6
ISSN	1466-187X ; 0142-159X
ISSN (online)	1466-187X
ISSN	0142-159X
DOI	10.1080/0142159X.2020.1736276
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Article ; Online: Ocular adnexal trauma in the workplace despite the use of protective eyewear.

Holzer, Elad Y / Lee-Wing, Matthew

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2023 Volume 58, Issue 6, Page(s) e265–e266

MeSH term(s)	Humans ; Eye Injuries/diagnosis ; Eye Injuries/etiology ; Eye Injuries/prevention & control ; Workplace ; Working Conditions ; Face ; Eye Protective Devices
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Letter
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2023.06.010
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Article ; Online: Discrimination of consonants in quiet and in noise in Mandarin-speaking children with normal hearing.

Lena L N Wong / Shufeng Zhu / Yuan Chen / Xinxin Li / Wing M C Chan

PLoS ONE, Vol 18, Iss 3, p e

2023 Volume 0283198

Abstract: Objective Given the critical role of consonants in speech perception and the lack of knowledge on consonant perception in noise in Mandarin-speaking children, the current study aimed to investigate Mandarin consonant discrimination in normal-hearing ... ...

Abstract	Objective Given the critical role of consonants in speech perception and the lack of knowledge on consonant perception in noise in Mandarin-speaking children, the current study aimed to investigate Mandarin consonant discrimination in normal-hearing children, in relation to the effects of age and signal-to-noise ratios (S/N). Design A discrimination task consisting of 33 minimal pairs in monosyllabic words was designed to explore the development of consonant discrimination in five test conditions: 0, -5, -10, -15 dB S/Ns, and quiet. Study sample Forty Mandarin-speaking, normal-hearing children aged from 4;0 to 8;9 in one-year-age increment were recruited and their performance was compared to 10 adult listeners. Results A significant main effect of age, test conditions, and an interaction effect between these variables was noted. Consonant discrimination in quiet and in noise improved as children became older. Consonants that were difficult to discriminate in quiet and in noise were mainly velar contrasts. Noise seemed to have less effect on the discrimination of affricates and fricatives, and plosives appeared to be to be more difficult to discriminate in noise than in quiet. Place contrasts between alveolar and palato-alveolar consonants were difficult in quiet. Conclusions The findings were the first to reveal typical perceptual development of Mandarin consonant discrimination in children and can serve as a reference for comparison with children with disordered perceptual development, such as those with hearing loss.
Keywords	Medicine ; R ; Science ; Q
Subject code	410
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Discrimination of consonants in quiet and in noise in Mandarin-speaking children with normal hearing.

Wong, Lena L N / Zhu, Shufeng / Chen, Yuan / Li, Xinxin / Chan, Wing M C

PloS one

2023 Volume 18, Issue 3, Page(s) e0283198

Abstract: Objective: Given the critical role of consonants in speech perception and the lack of knowledge on consonant perception in noise in Mandarin-speaking children, the current study aimed to investigate Mandarin consonant discrimination in normal-hearing ... ...

Abstract	Objective: Given the critical role of consonants in speech perception and the lack of knowledge on consonant perception in noise in Mandarin-speaking children, the current study aimed to investigate Mandarin consonant discrimination in normal-hearing children, in relation to the effects of age and signal-to-noise ratios (S/N). Design: A discrimination task consisting of 33 minimal pairs in monosyllabic words was designed to explore the development of consonant discrimination in five test conditions: 0, -5, -10, -15 dB S/Ns, and quiet. Study sample: Forty Mandarin-speaking, normal-hearing children aged from 4;0 to 8;9 in one-year-age increment were recruited and their performance was compared to 10 adult listeners. Results: A significant main effect of age, test conditions, and an interaction effect between these variables was noted. Consonant discrimination in quiet and in noise improved as children became older. Consonants that were difficult to discriminate in quiet and in noise were mainly velar contrasts. Noise seemed to have less effect on the discrimination of affricates and fricatives, and plosives appeared to be to be more difficult to discriminate in noise than in quiet. Place contrasts between alveolar and palato-alveolar consonants were difficult in quiet. Conclusions: The findings were the first to reveal typical perceptual development of Mandarin consonant discrimination in children and can serve as a reference for comparison with children with disordered perceptual development, such as those with hearing loss.
MeSH term(s)	Adult ; Humans ; Child ; Aged ; Noise ; Hearing Loss ; Deafness ; Speech Perception ; Hearing
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283198
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Article ; Online: Does cataract surgery in patients with concurrent lower lid malposition increase the risk of postoperative endophthalmitis?

Yarmak, Pavel / Lee-Wing, Matthew / Rocha, Guillermo

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2021 Volume 57, Issue 4, Page(s) 253–256

Abstract: Objective: To evaluate the safety of performing cataract surgery prior to eyelid (entropion/ectropion) surgery in patients with concurrent cataract and lower eyelid malposition.: Design: Retrospective case series.: Participants and methods: ... ...

Abstract	Objective: To evaluate the safety of performing cataract surgery prior to eyelid (entropion/ectropion) surgery in patients with concurrent cataract and lower eyelid malposition. Design: Retrospective case series. Participants and methods: Patients with concurrent lower eyelid malposition and cataract undergoing cataract surgery before lower eyelid repair from 2013 to 2020 were identified from two ophthalmologists (M.L.W., G.R.). Both surgeries were performed by the same ophthalmologist, with eyelid repair completed at least 1 month following cataract extraction. Data analysis was performed with two-parameter estimations. The primary outcome was the postoperative endophthalmitis rate in this cohort. Results: 129 cases in 90 patients were found (86 involutional entropion and 43 involutional ectropion). No cases of endophthalmitis were encountered. Statistical analysis using the 95% Jeffreys interval for one-sample binomial proportion revealed an upper limit of 1.9%. The Agresti-Caffo interval of the proportional difference between the study procedure and historical incidence data of postoperative endophthalmitis following cataract surgery alone yielded an estimate of 0.8% with an upper confidence limit of 2.2%. Conclusion: We present preliminary evidence on the endophthalmitis risk in patients with concurrent lower eyelid malposition and cataract who undergo cataract surgery prior to eyelid repair. We propose that this strategy may be a viable option to expedite vision restoration and reduce the risk of recurrent lower eyelid malposition in select patients. More data are required to reach statistically significant noninferiority and show that a malpositioned lower eyelid is not a risk factor for postoperative endophthalmitis following cataract surgery.
MeSH term(s)	Cataract/complications ; Cataract Extraction/adverse effects ; Ectropion/surgery ; Endophthalmitis/epidemiology ; Endophthalmitis/etiology ; Endophthalmitis/surgery ; Entropion/surgery ; Humans ; Postoperative Complications/etiology ; Retrospective Studies
Language	English
Publishing date	2021-05-29
Publishing country	England
Document type	Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2021.04.024
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Article ; Online: The emerging role of open technologies for community-based improvement of cryopreservation and quality management for repository development in aquatic species.

Liu, Yue / Todd Monroe, W / Belgodere, Jorge A / Choi, Jin-Woo / Teresa Gutierrez-Wing, M / Tiersch, Terrence R

Animal reproduction science

2021 Volume 246, Page(s) 106871

Abstract: Genetic resources of aquatic species are of tremendous value, but worldwide these are maintained almost exclusively as live populations. This is extremely expensive and insecure, and largely results from a pervasive lack of production capability, quality ...

Abstract	Genetic resources of aquatic species are of tremendous value, but worldwide these are maintained almost exclusively as live populations. This is extremely expensive and insecure, and largely results from a pervasive lack of production capability, quality management, and reproducibility in cryopreservation that are barriers in development of germplasm repositories. Community-based technology approaches are emerging that can stimulate research previously limited by a lack of affordable, customizable equipment. Open-access technologies can provide for custom design and fabrication not available through traditional manufacturing. This can assist repository development with robust sample production methods and strong quality management, and can greatly improve reproducibility and standardization. Open technologies can support establishment of new communities of users, makers, and developers that collectively strive to develop open hardware in a distributed (i.e., non-centralized) fashion that can yield aggregate throughput. This occurs through use of consumer-level tools, supplies, software, and equipment, free exchange of designs and modifications, and a shared sense of mission. For cryopreservation and repository development, we have identified 14 categories of open hardware for a processing pathway, and six categories for a quality management pathway. Open hardware offers economic incentives to develop repositories for aquatic species, something that has not occurred despite 70 years of research largely focused on protocol development rather than practical applications. Advanced development of custom scientific hardware enhancing open technologies will be facilitated by interdisciplinary collaboration across biological and engineering fields. This manuscript is a contribution to the Special Issue in memory of Dr. Duane Garner, a leader in the sperm biology.
MeSH term(s)	Male ; Animals ; Reproducibility of Results ; Semen ; Cryopreservation/veterinary ; Cryopreservation/methods ; Spermatozoa ; Technology
Language	English
Publishing date	2021-10-16
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	429674-6
ISSN	1873-2232 ; 0378-4320
ISSN (online)	1873-2232
ISSN	0378-4320
DOI	10.1016/j.anireprosci.2021.106871
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Article ; Online: Infection rate following elective oculoplastic surgery in a minor procedure setting: a single-centre retrospective study.

Doucet, Véronique / McKenzie, Marna / Lee-Wing, Matthew / Bellan, Lorne

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2021 Volume 58, Issue 1, Page(s) 34–38

Abstract: Objective: A surgical site infection after oculoplastic surgery is a serious complication that can lead to endophthalmitis and vision loss. Although performing these procedures in a minor-surgery setting is common, there is a lack of evidence in the ... ...

Abstract	Objective: A surgical site infection after oculoplastic surgery is a serious complication that can lead to endophthalmitis and vision loss. Although performing these procedures in a minor-surgery setting is common, there is a lack of evidence in the literature regarding the incidence of postoperative infections. The objective of this study was to determine the infection rate associated with elective outpatient oculoplastic procedures performed in a minor-surgery setting. Methods: A retrospective review was completed for all patients who underwent elective oculoplastic surgery in the minor-procedure room at the Misericordia Health Centre in Winnipeg between April and December 2018. Operations were performed by 2 senior oculoplastic surgeons. Data collected included the type of procedure, number of surgical incisions, type and number of sutures, use of prophylactic antibiotics, time to follow-up, complications, and presence of surgical site infection. Results: Review of 539 patients showed an infection rate of 0.37% (2 of 539). Infection cases were an exposed orbital implant using a temporalis fascia graft and ptosis repair using a frontalis sling. Thirteen complications were identified, corresponding to a complication rate of 2.41% (13 of 539). Conclusion: Study results show an infection rate of 0.37% for elective oculoplastic surgery in a minor-procedure setting.
MeSH term(s)	Humans ; Retrospective Studies ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control ; Blepharoplasty/adverse effects ; Blepharoplasty/methods ; Plastic Surgery Procedures ; Elective Surgical Procedures/adverse effects
Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2021.07.003
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Article ; Online: Clinical utility of cerebrospinal fluid biomarkers in the evaluation of cognitive impairment: a systematic review and meta-analysis.

Hazan, Jemma / Wing, Michelle / Liu, Kathy Y / Reeves, Suzanne / Howard, Robert

Journal of neurology, neurosurgery, and psychiatry

2022 Volume 94, Issue 2, Page(s) 113–120

Abstract: Background: The analytical and clinical validity of cerebrospinal (CSF) biomarkers has been extensively researched in dementia. Further work is needed to assess the ability of these biomarkers to improve diagnosis, management and health outcomes in the ... ...

Abstract	Background: The analytical and clinical validity of cerebrospinal (CSF) biomarkers has been extensively researched in dementia. Further work is needed to assess the ability of these biomarkers to improve diagnosis, management and health outcomes in the clinical setting OBJECTIVES: To assess the added value and clinical utility of CSF biomarkers in the diagnostic assessment of cognitively impaired patients under evaluation for Alzheimer's disease (AD). Methods: Systematic literature searches of Medline, EMBASE, PsycINFO and Web of Science research databases were conducted on 17 December 2022. Data from relevant studies were extracted and independently screened for quality using a tool for bias. Clinical utility was measured by clinicians' changes in diagnosis, diagnostic confidence and patient management (when available), after their examination of patients' CSF biomarkers. Cost-effectiveness was assessed by consideration of additional cost per patient and quality-adjusted life years. Results: Searches identified 17 studies comprising 2090 patient participants and 593 clinicians. The meta-analysis revealed that clinicians' use of CSF biomarkers resulted in a pooled percentage change in diagnosis of 25% (95% CI 14 to 37), an increase in diagnostic confidence of 14% (95% CI 9 to 18) and a pooled proportion of patients whose management changed of 31% (95% CI 12 to 50). CSF biomarkers were deemed cost-effective, particularly in memory services, where pre-test AD prevalence is higher compared with a primary care setting. Conclusions: CSF biomarkers can be a helpful additional diagnostic tool for clinicians assessing patients with cognitive impairment. In particular, CSF biomarkers consistently improved clinicians' confidence in diagnosing AD and influenced on diagnostic change and patient management. Further research is needed to study the clinical utility of blood-based biomarkers in the clinical setting.
MeSH term(s)	Humans ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/cerebrospinal fluid ; Alzheimer Disease/diagnosis ; Alzheimer Disease/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Mental Processes ; Amyloid beta-Peptides/cerebrospinal fluid
Chemical Substances	Biomarkers ; Amyloid beta-Peptides
Language	English
Publishing date	2022-09-12
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2022-329530
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