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  1. Book ; Online: Actinobacteria and Myxobacteria : Important Resources for Novel Antibiotics

    Wink, Joachim

    2020  

    Keywords Research & information: general ; Biology, life sciences ; actinomycetes ; antibiotic biosynthesis ; silent biosynthetic pathways ; γ-butyrolactones ; HiTES ; translation inhibitors ; marine actinobacteria ; Streptomyces sp ; enzyme inhibition ; antimicrobial ; antioxidant ; cytotoxicity ; GC-MS ; pyrrolopyrazines ; myxobacteria ; antivirals ; secondary metabolites ; HIV ; Ebola ; hepatitis viruses ; diversity ; uncultured ; new antibiotics ; Streptomyces ; polyketides ; secondary metabolite ; polyketide synthases (PKSs)
    Size 1 electronic resource (270 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046434
    ISBN 9783039435302 ; 3039435302
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Special Issue: "Actinobacteria and Myxobacteria-Important Resources for Novel Antibiotics".

    Wink, Joachim

    Microorganisms

    2020  Volume 8, Issue 10

    Abstract: The history of our antibiotics is inseparably connected to microorganisms as producers [ ... ]. ...

    Abstract The history of our antibiotics is inseparably connected to microorganisms as producers [...].
    Language English
    Publishing date 2020-09-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8101464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Special Issue: “Actinobacteria and Myxobacteria—Important Resources for Novel Antibiotics”

    Wink, Joachim

    Microorganisms. 2020 Sept. 24, v. 8, no. 10

    2020  

    Abstract: The history of our antibiotics is inseparably connected to microorganisms as producers [ ... ] ...

    Abstract The history of our antibiotics is inseparably connected to microorganisms as producers [...]
    Keywords Actinobacteria ; antibiotics ; history ; microorganisms
    Language English
    Dates of publication 2020-0924
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8101464
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Special Issue

    Wink, Joachim

    8 ; 10 ; Microorganisms ; Switzerland

    "Actinobacteria and Myxobacteria-Important Resources for Novel Antibiotics".

    2020  

    Abstract: No abstract available] ...

    Abstract [[No abstract available]
    Language English
    Publishing date 2020-09-24
    Publisher MDPI
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Streptomyces iakyrus

    Charousová, Ivana / Hlebová, Miroslava / Hleba, Lukas / Medo, Juraj / Wink, Joachim

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 16

    Abstract: A wide range of bioactive compounds with potential medical applications are produced by members of the ... ...

    Abstract A wide range of bioactive compounds with potential medical applications are produced by members of the genus
    MeSH term(s) Phylogeny ; RNA, Ribosomal, 16S/genetics ; Quinones/pharmacology ; Streptomyces ; Anti-Bacterial Agents/pharmacology
    Chemical Substances gamma-rubromycin (27267-71-6) ; RNA, Ribosomal, 16S ; Quinones ; quinone (3T006GV98U) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28165977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Antimicrobial potential of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas (Bivalvia, Ostreidae).

    Cera, Guillermo / Risdian, Chandra / Pira, Hani / Wink, Joachim

    Journal of applied microbiology

    2022  Volume 133, Issue 2, Page(s) 1099–1114

    Abstract: Aims: Explore the diversity of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas with special emphasis on their antimicrobial activity.: Methods and results: For the characterization of the isolated actinobacteria, a ... ...

    Abstract Aims: Explore the diversity of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas with special emphasis on their antimicrobial activity.
    Methods and results: For the characterization of the isolated actinobacteria, a polyphasic approach was adopted and thereby phenotypic descriptions, phylogenetic analysis, evaluations of antimicrobial activities and chemical analyses of crude extracts through HPLC and LC-HRESIMS were performed. Five strains were isolated from C. gigas. The 16S rRNA gene analysis revealed that three of them were taxonomically affiliated to the genus Streptomyces and the other two strains were related to Micromonospora. High inhibition was detected against different test microorganisms such as Candida albicans, Staphylococcus aureus, Bacillus subtilis and Mycobacterium smegmatis. On the basis of the chemical analysis, 11 compounds from the active fractions of the crude extracts were determined, and 8 were related putatively to previously reported compounds.
    Conclusions: Actinobacteria isolated from C. gigas represent an interesting reservoir of antimicrobial compounds, and further study to uncover the full capacity of this source is encouraged.
    Significance and impact: At present, the study of actinobacteria and their antimicrobial potential from uncommon sources as C. gigas is vital to the development of new therapeutic agents to cope with the widespread resistance of human pathogens.
    MeSH term(s) Actinobacteria ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Complex Mixtures ; Crassostrea ; Humans ; Ostreidae ; Phylogeny ; RNA, Ribosomal, 16S/genetics
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Complex Mixtures ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1111/jam.15635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Isolation of Nannocystis species from Iran and exploring their natural products.

    Moradi, Azam / Yaghoubi-Avini, Mohammad / Wink, Joachim

    Archives of microbiology

    2022  Volume 204, Issue 2, Page(s) 123

    Abstract: Several different techniques were employed for the isolation of Nannocystis from various sources. A polyphasic approach was used for identification. Twelve strains of N. pusilla, N. exedens, and N. konarekensis with distinctive distribution between ... ...

    Abstract Several different techniques were employed for the isolation of Nannocystis from various sources. A polyphasic approach was used for identification. Twelve strains of N. pusilla, N. exedens, and N. konarekensis with distinctive distribution between climates were identified. The bioactivity was examined against a panel of eight bacteria, two yeasts, and one fungus; cytotoxicity was tested on the L929 fibroblast cell line. Eleven strains mainly inhibit Gram-positive bacteria, and only one isolate was cytotoxic. The extract analyses by HPLC and LC-MS were compared to Myxobase, and eight different compounds were detected; a correlation was observed between compounds and producing species. 70% of strains had the potential to produce structurally diverse compounds. Nannochelins and althiomycin were the most abundant metabolites. The discovery of a new species of Nannocystis and the high potentiality of strains to produce secondary metabolites encourage further sampling and in-depth analysis of extracts to find new active metabolites.
    MeSH term(s) Antineoplastic Agents ; Bacteria ; Biological Products ; Iran ; Myxococcales
    Chemical Substances Antineoplastic Agents ; Biological Products
    Language English
    Publishing date 2022-01-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-021-02738-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Antimicrobial potential of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas (Bivalvia, Ostreidae)

    Cera, Guillermo / Risdian, Chandra / Pira, Hani / Wink, Joachim

    Journal of applied microbiology. 2022 Aug., v. 133, no. 2

    2022  

    Abstract: AIMS: Explore the diversity of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas with special emphasis on their antimicrobial activity. METHODS AND RESULTS: For the characterization of the isolated actinobacteria, a polyphasic ... ...

    Abstract AIMS: Explore the diversity of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas with special emphasis on their antimicrobial activity. METHODS AND RESULTS: For the characterization of the isolated actinobacteria, a polyphasic approach was adopted and thereby phenotypic descriptions, phylogenetic analysis, evaluations of antimicrobial activities and chemical analyses of crude extracts through HPLC and LC‐HRESIMS were performed. Five strains were isolated from C. gigas. The 16S rRNA gene analysis revealed that three of them were taxonomically affiliated to the genus Streptomyces and the other two strains were related to Micromonospora. High inhibition was detected against different test microorganisms such as Candida albicans, Staphylococcus aureus, Bacillus subtilis and Mycobacterium smegmatis. On the basis of the chemical analysis, 11 compounds from the active fractions of the crude extracts were determined, and 8 were related putatively to previously reported compounds. CONCLUSIONS: Actinobacteria isolated from C. gigas represent an interesting reservoir of antimicrobial compounds, and further study to uncover the full capacity of this source is encouraged. SIGNIFICANCE AND IMPACT: At present, the study of actinobacteria and their antimicrobial potential from uncommon sources as C. gigas is vital to the development of new therapeutic agents to cope with the widespread resistance of human pathogens.
    Keywords Bacillus subtilis ; Candida albicans ; Crassostrea gigas ; Micromonospora ; Mycobacterium smegmatis ; Staphylococcus aureus ; Streptomyces ; antimicrobial properties ; chemical analysis ; genes ; humans ; phenotype ; phylogeny ; therapeutics
    Language English
    Dates of publication 2022-08
    Size p. 1099-1114.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1111/jam.15635
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  9. Article: Isolation of Nannocystis species from Iran and exploring their natural products

    Moradi, Azam / Yaghoubi-Avini, Mohammad / Wink, Joachim

    Archives of microbiology. 2022 Feb., v. 204, no. 2

    2022  

    Abstract: Several different techniques were employed for the isolation of Nannocystis from various sources. A polyphasic approach was used for identification. Twelve strains of N. pusilla, N. exedens, and N. konarekensis with distinctive distribution between ... ...

    Abstract Several different techniques were employed for the isolation of Nannocystis from various sources. A polyphasic approach was used for identification. Twelve strains of N. pusilla, N. exedens, and N. konarekensis with distinctive distribution between climates were identified. The bioactivity was examined against a panel of eight bacteria, two yeasts, and one fungus; cytotoxicity was tested on the L929 fibroblast cell line. Eleven strains mainly inhibit Gram-positive bacteria, and only one isolate was cytotoxic. The extract analyses by HPLC and LC–MS were compared to Myxobase, and eight different compounds were detected; a correlation was observed between compounds and producing species. 70% of strains had the potential to produce structurally diverse compounds. Nannochelins and althiomycin were the most abundant metabolites. The discovery of a new species of Nannocystis and the high potentiality of strains to produce secondary metabolites encourage further sampling and in-depth analysis of extracts to find new active metabolites.
    Keywords cell lines ; cytotoxicity ; fibroblasts ; new species ; secondary metabolites ; Iran
    Language English
    Dates of publication 2022-02
    Size p. 123.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-021-02738-0
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 75/91: Show issues

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  10. Article ; Online: Exploring the Antibiotic Production Potential of Heterotrophic Bacterial Communities Isolated from the Marine Sponges

    Tareen, Sanaullah / Schupp, Peter J / Iqbal, Naveed / Wink, Joachim

    Marine drugs

    2022  Volume 20, Issue 7

    Abstract: The discovery of novel secondary metabolites is actively being pursued in new ecosystems. Sponge-associated bacteria have been in the limelight in recent years on account of their ability to produce bioactive compounds. In this study, heterotrophic ... ...

    Abstract The discovery of novel secondary metabolites is actively being pursued in new ecosystems. Sponge-associated bacteria have been in the limelight in recent years on account of their ability to produce bioactive compounds. In this study, heterotrophic bacteria associated with four sponge species were isolated, taxonomically identified, and subjected to screening for the production of bioactive entities against a panel of nine microorganisms, including Gram-positive and negative bacteria, as well as yeast and fungi. Of the 105 isolated strains, 66% were represented by
    MeSH term(s) Animals ; Anti-Bacterial Agents ; Bacteria/metabolism ; Genomics ; Microbiota ; Phylogeny ; Porifera/microbiology ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism
    Chemical Substances Anti-Bacterial Agents ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20070463
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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