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  1. Book ; Online ; Thesis: Structural and functional characterization of multiple system atrophy and promyelinogenic repair strategies

    Mészáros, Lisa [Verfasser] / Winkler, Jürgen [Akademischer Betreuer] / Winkler, Jürgen [Gutachter]

    2024  

    Author's details Lisa Mészáros ; Gutachter:  Jürgen Winkler ; Betreuer:  Jürgen Winkler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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    Inter-library loan at ZB MED

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  2. Article ; Online: Plasma Neurofilaments: Potential Biomarkers of SPG11-Related Hereditary Spastic Paraplegia.

    Krumm, Laura / Winkler, Jürgen / Winner, Beate / Regensburger, Martin

    Movement disorders : official journal of the Movement Disorder Society

    2024  Volume 39, Issue 4, Page(s) 755–757

    MeSH term(s) Humans ; Spastic Paraplegia, Hereditary/genetics ; Spastic Paraplegia, Hereditary/blood ; Spastic Paraplegia, Hereditary/diagnosis ; Biomarkers/blood ; Male ; Adult ; Female ; Neurofilament Proteins/blood ; Proteins/genetics ; Middle Aged
    Chemical Substances SPG11 protein, human ; Biomarkers ; Neurofilament Proteins ; Proteins
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

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  3. Book ; Online ; Thesis: Generation and characterization of human oligodendroglia as cellular model for Multiple System Atrophy

    Wihan, Jeanette [Verfasser] / Winkler, Jürgen [Akademischer Betreuer] / Winkler, Jürgen [Gutachter]

    2023  

    Author's details Jeanette Wihan ; Gutachter: Jürgen Winkler ; Betreuer: Jürgen Winkler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  4. Book ; Online ; Thesis: Compensatory mechanisms and therapeutic approaches in neuronal protein aggregation disorders

    Stemick, Judith [Verfasser] / Winkler, Jürgen [Akademischer Betreuer] / Winkler, Jürgen [Gutachter]

    2023  

    Author's details Judith Stemick ; Gutachter: Jürgen Winkler ; Betreuer: Jürgen Winkler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  5. Article ; Online: The Bidirectional Interplay of α-Synuclein with Lipids in the Central Nervous System and Its Implications for the Pathogenesis of Parkinson's Disease.

    Battis, Kristina / Xiang, Wei / Winkler, Jürgen

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: The alteration and aggregation of alpha-synuclein (α-syn) play a crucial role in neurodegenerative diseases collectively termed as synucleinopathies, including Parkinson's disease (PD). The bidirectional interaction of α-syn with lipids and biomembranes ... ...

    Abstract The alteration and aggregation of alpha-synuclein (α-syn) play a crucial role in neurodegenerative diseases collectively termed as synucleinopathies, including Parkinson's disease (PD). The bidirectional interaction of α-syn with lipids and biomembranes impacts not only α-syn aggregation but also lipid homeostasis. Indeed, lipid composition and metabolism are severely perturbed in PD. One explanation for lipid-associated alterations may involve structural changes in α-syn, caused, for example, by missense mutations in the lipid-binding region of α-syn as well as post-translational modifications such as phosphorylation, acetylation, nitration, ubiquitination, truncation, glycosylation, and glycation. Notably, different strategies targeting the α-syn-lipid interaction have been identified and are able to reduce α-syn pathology. These approaches include the modulation of post-translational modifications aiming to reduce the aggregation of α-syn and modify its binding properties to lipid membranes. Furthermore, targeting enzymes involved in various steps of lipid metabolism and exploring the neuroprotective potential of lipids themselves have emerged as novel therapeutic approaches. Taken together, this review focuses on the bidirectional crosstalk of α-syn and lipids and how alterations of this interaction affect PD and thereby open a window for therapeutic interventions.
    MeSH term(s) Humans ; alpha-Synuclein ; Central Nervous System ; Lipids ; Parkinson Disease ; Synucleinopathies
    Chemical Substances alpha-Synuclein ; Lipids
    Language English
    Publishing date 2023-08-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Das gastrointestinale Mikrobiom beim idiopathischen Parkinson-Syndrom: Zentrale Rolle von Kovariaten

    Cosma-Grigorov, Alexandra [Verfasser] / Winkler, Jürgen [Akademischer Betreuer] / Winkler, Jürgen [Gutachter]

    2023  

    Author's details Alexandra Cosma-Grigorov ; Gutachter: Jürgen Winkler ; Betreuer: Jürgen Winkler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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    Inter-library loan at ZB MED

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  7. Article ; Online: Transcription factor Olig2 is a major downstream effector of histone demethylase Phf8 during oligodendroglial development.

    Kremp, Marco / Aberle, Tim / Sock, Elisabeth / Bohl, Bettina / Hillgärtner, Simone / Winkler, Jürgen / Wegner, Michael

    Glia

    2024  

    Abstract: The plant homeodomain finger protein Phf8 is a histone demethylase implicated by mutation in mice and humans in neural crest defects and neurodevelopmental disturbances. Considering its widespread expression in cell types of the central nervous system, ... ...

    Abstract The plant homeodomain finger protein Phf8 is a histone demethylase implicated by mutation in mice and humans in neural crest defects and neurodevelopmental disturbances. Considering its widespread expression in cell types of the central nervous system, we set out to determine the role of Phf8 in oligodendroglial cells to clarify whether oligodendroglial defects are a possible contributing factor to Phf8-dependent neurodevelopmental disorders. Using loss- and gain-of-function approaches in oligodendroglial cell lines and primary cell cultures, we show that Phf8 promotes the proliferation of rodent oligodendrocyte progenitor cells and impairs their differentiation to oligodendrocytes. Intriguingly, Phf8 has a strong positive impact on Olig2 expression by acting on several regulatory regions of the gene and changing their histone modification profile. Taking the influence of Olig2 levels on oligodendroglial proliferation and differentiation into account, Olig2 likely acts as an important downstream effector of Phf8 in these cells. In line with such an effector function, ectopic Olig2 expression in Phf8-deficient cells rescues the proliferation defect. Additionally, generation of human oligodendrocytes from induced pluripotent stem cells did not require PHF8 in a system that relies on forced expression of Olig2 during oligodendroglial induction. We conclude that Phf8 may impact nervous system development at least in part through its action in oligodendroglial cells.
    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639414-0
    ISSN 1098-1136 ; 0894-1491
    ISSN (online) 1098-1136
    ISSN 0894-1491
    DOI 10.1002/glia.24538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2345: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  8. Book ; Thesis: Regeneration des cholinergen Systems im Zentralnervensystem

    Winkler, Jürgen

    potentielle Implikationen für die Therapie neurodegenerativer Erkrankungen

    1999  

    Author's details vorgelegt von Jürgen Winkler
    Language German
    Size getr. Zählung : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Habil.-Schr., Regensburg, 1999
    HBZ-ID HT013634295
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 E 1292 order to use in reading room Magazin

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  9. Book ; Online ; Thesis: Distinct neuroinflammatory pattern in multiple system atrophy

    Hoffmann, Alana [Verfasser] / Winkler, Jürgen [Akademischer Betreuer] / Winkler, Jürgen [Gutachter]

    2021  

    Author's details Alana Hoffmann ; Gutachter: Jürgen Winkler ; Betreuer: Jürgen Winkler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Validity of an inertial sensor-based system for the assessment of spatio-temporal parameters in people with multiple sclerosis.

    Zahn, Annalena / Koch, Veronika / Schreff, Lucas / Oschmann, Patrick / Winkler, Jürgen / Gaßner, Heiko / Müller, Roy

    Frontiers in neurology

    2023  Volume 14, Page(s) 1164001

    Abstract: Background: Gait variability in people with multiple sclerosis (PwMS) reflects disease progression or may be used to evaluate treatment response. To date, marker-based camera systems are considered as gold standard to analyze gait impairment in PwMS. ... ...

    Abstract Background: Gait variability in people with multiple sclerosis (PwMS) reflects disease progression or may be used to evaluate treatment response. To date, marker-based camera systems are considered as gold standard to analyze gait impairment in PwMS. These systems might provide reliable data but are limited to a restricted laboratory setting and require knowledge, time, and cost to correctly interpret gait parameters. Inertial mobile sensors might be a user-friendly, environment- and examiner-independent alternative. The purpose of this study was to evaluate the validity of an inertial sensor-based gait analysis system in PwMS compared to a marker-based camera system.
    Methods: A sample
    Results: All gait parameters highly correlated between both systems (
    Discussion: The inertial sensor-based system captured appropriately all examined gait parameters in comparison to a gold standard marker-based camera system. Stride time presented an excellent agreement. Furthermore, stride length and velocity presented also low errors. Whereas for stance and swing time, marginally worse results were observed.
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1164001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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