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  1. Book ; Thesis: Simultane Herz- Nierentransplantation an der Medizinischen Hochschule Hannover in Zeiten des Organmangels

    Thies, Juliane Barbara / Winkler, Michael

    eine Analyse der Ergebnisse nach kombinierter Herz- Nierentransplantation im Vergleich zur isolierten Nierentransplantation

    2021  

    Institution Medizinische Hochschule Hannover
    Klinik für Allgemein-, Viszeral- und Transplantationschirurgie
    Author's details vorgelegt von Juliane Barbara Thies ; aus der Klinik der Allgemein-, Viszeral- und Transplantationschirurgie der Medizinischen Hochschule Hannover ; Betreuer der Arbeit: Prof. Dr. med. Michael Winkler
    Language German ; English
    Size 1 ungezähltes Blatt, 23 Blätter, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    Note Text auf Deutsch, Sonderabdruck auf Englisch ; Enthält 1 Zeitschriftenaufsatz aus „BMC Nephrology", Jg. 22 (2021)
    HBZ-ID HT021710297
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2023 E 213 order for loan Magazin

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  2. Book ; Thesis: Vergleich der affektiven Befindlichkeit vor und nach einer KMT/ SZT mit Analyse des emotionalen Distress sowie der Bewältigungsstrategien im Bezug auf die 1-Jahres-Überlebensrate

    Winkler, Michael

    2013  

    Author's details vorgelegt von Michael Winkler
    Language German
    Size 66 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2014
    HBZ-ID HT018727552
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 1373 order for loan Magazin

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  3. Article: IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms

    Wrensch, Florian / Winkler, Michael / Pöhlmann, Stefan

    Viruses, 6(9):3683-3698

    2014  

    Abstract: The interferon-inducible transmembrane (IFITM) proteins 1, 2 and 3 inhibit the host cell entry of several enveloped viruses, potentially by promoting the accumulation of cholesterol in endosomal compartments. IFITM3 is essential for control of influenza ... ...

    Institution Deutsches Primatenzentrum (Göttingen)
    Abstract The interferon-inducible transmembrane (IFITM) proteins 1, 2 and 3 inhibit the host cell entry of several enveloped viruses, potentially by promoting the accumulation of cholesterol in endosomal compartments. IFITM3 is essential for control of influenza virus infection in mice and humans. In contrast, the role of IFITM proteins in coronavirus infection is less well defined. Employing a retroviral vector system for analysis of coronavirus entry, we investigated the susceptibility of human-adapted and emerging coronaviruses to inhibition by IFITM proteins. We found that entry of the recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is sensitive to inhibition by IFITM proteins. In 293T cells, IFITM-mediated inhibition of cellular entry of the emerging MERS- and SARS-CoV was less efficient than blockade of entry of the globally circulating human coronaviruses 229E and NL63. Similar differences were not observed in A549 cells, suggesting that cellular context and/or IFITM expression levels can impact inhibition efficiency. The differential IFITM-sensitivity of coronaviruses observed in 293T cells afforded the opportunity to investigate whether efficiency of entry inhibition by IFITMs and endosomal cholesterol accumulation correlate. No such correlation was observed. Furthermore, entry mediated by the influenza virus hemagglutinin was robustly inhibited by IFITM3 but was insensitive to accumulation of endosomal cholesterol, indicating that modulation of cholesterol synthesis/transport did not account for the antiviral activity of IFITM3. Collectively, these results show that the emerging MERS-CoV is a target of the antiviral activity of IFITM proteins and demonstrate that mechanisms other than accumulation of endosomal cholesterol can contribute to viral entry inhibition by IFITMs.
    Keywords COVID-19 ; IFITM ; MERS ; SARS ; coronavirus
    Language English
    Document type Article
    Database Repository for Life Sciences

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  4. Book ; Thesis: Funktionelle Analyse des Regulatorproteins pUL69 des menschlichen Cytomegalovirus

    Winkler, Michael

    1997  

    Author's details vorgelegt von Michael Winkler
    Language German
    Size 99 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 1997
    HBZ-ID HT008281189
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Clinical significance of the hemodynamic gain index in patients undergoing exercise stress testing and coronary computed tomography angiography.

    Mansour, Mohamad Jihad / Chammas, Elie / Winkler, Michael / AlJaroudi, Wael

    BMC cardiovascular disorders

    2023  Volume 23, Issue 1, Page(s) 65

    Abstract: Background: Many hemodynamic parameters provide limited information regarding obstructive coronary artery disease (CAD) during exercise stress testing particularly when exercise is suboptimal. Hemodynamic gain index (HGI) is a recent sensitive indicator ...

    Abstract Background: Many hemodynamic parameters provide limited information regarding obstructive coronary artery disease (CAD) during exercise stress testing particularly when exercise is suboptimal. Hemodynamic gain index (HGI) is a recent sensitive indicator of ischemia and has been associated with increased mortality. This study evaluated the clinical impact of HGI in patients who underwent concomitant exercise stress testing and coronary computed tomography angiography (CCTA).
    Methods: A total of 284 consecutive patients from the executive health program between 2010 and 2018 were identified. Resting and peak heart rate (HR) as well as systolic blood pressure (SBP) measurements were recorded. Framingham risk score (FRS), Duke treadmill score (DTS) and HGI [Formula: see text] were calculated. The latter was divided into quartiles. CCTA was used as a reference test to detect any CAD. Multivariate analysis and artificial neural network were used to determine the independent predictors of obstructive CAD.
    Results: Mean age was 53 ± 12 years with 83% male. Mean HGI was 1.74 ± 0.67, with cut-off value of severely blunted HGI ≤ 1.25 (Quartile 4). Patients with severely blunted HGI were older, had higher FRS, and worse DTS. Patients with obstructive CAD had lower HGI when compared to those with normal CCTA/non-obstructive CAD (1.36 ± 0.53 vs. 1.77 ± 0.67, P = 0.005), and showed a higher prevalence of severely blunted HGI (44% vs. 22%, P = 0.019). After adjusting for traditional risk factors, HGI remained an independent predictor of obstructive CAD while severely blunted HGI was associated with threefold increased odds of having obstructive CAD (P = 0.05). Using artificial intelligence analysis, severely blunted HGI independently predicted obstructive CAD with an area under the curve of 0.83 and 0.96, and normalized importance of HGI of 100% and 63%, respectively for different models.
    Conclusions: Among patients who underwent concomitant exercise stress testing and CCTA, severely blunted HGI independently predicted obstructive CAD after multivariate adjustment for traditional risk factors.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Clinical Relevance ; Artificial Intelligence ; Coronary Artery Disease ; Hemodynamics ; Predictive Value of Tests
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03088-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Development of immortalized rhesus macaque kidney cells supporting infection with a panel of viruses.

    Reiter, Stefanie / Gärtner, Sabine / Decker, Katharina / Pöhlmann, Stefan / Winkler, Michael

    PloS one

    2023  Volume 18, Issue 5, Page(s) e0284048

    Abstract: Non-human primate (NHP)-based model systems faithfully reproduce various viral diseases including Ebola, influenza, AIDS and Zika. However, only a small number of NHP cell lines are available and generation of additional cell lines could help to refine ... ...

    Abstract Non-human primate (NHP)-based model systems faithfully reproduce various viral diseases including Ebola, influenza, AIDS and Zika. However, only a small number of NHP cell lines are available and generation of additional cell lines could help to refine these models. We immortalized rhesus macaque kidney cells by lentiviral transduction with a vector encoding telomerase reverse transcriptase (TERT) and report the generation of three TERT-immortalized cell lines derived from rhesus macaque kidney. Expression of the kidney podocyte marker podoplanin on these cells was demonstrated by flow cytometry. Quantitative real-time PCR (qRT-PCR) was employed to demonstrate induction of MX1 expression upon stimulation with interferon (IFN) or viral infection, suggesting a functional IFN system. Further, the cell lines were susceptible to entry driven by the glycoproteins of vesicular stomatitis virus, influenza A virus, Ebola virus, Nipah virus and Lassa virus as assessed by infection with retroviral pseudotypes. Finally, these cells supported growth of Zika virus and the primate simplexviruses Cercopithecine alphaherpesvirus 2 and Papiine alphaherpesvirus 2. In summary, we developed IFN-responsive rhesus macaque kidney cell lines that allowed entry driven by diverse viral glycoproteins and were permissive to infection with Zika virus and primate simplexviruses. These cell lines will be useful for efforts to analyze viral infections of the kidney in macaque models.
    MeSH term(s) Animals ; Macaca mulatta ; Hemorrhagic Fever, Ebola ; Viruses ; Cell Line ; Virus Diseases ; Glycoproteins ; Kidney ; Zika Virus ; Zika Virus Infection
    Chemical Substances Glycoproteins
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: CT-guided microwave ablation of hepatic malignancies via transpulmonary approach without ancillary techniques.

    Raissi, Driss / Sanampudi, Sreeja / Yu, Qian / Winkler, Michael

    Journal of clinical imaging science

    2022  Volume 12, Page(s) 2

    Abstract: Objectives: The objectives of the study were to determine the safety and efficacy of computed tomography (CT)-guided transpulmonary percutaneous microwave ablation (MWA) for hepatic malignancies without the use of ancillary techniques.: Material and ... ...

    Abstract Objectives: The objectives of the study were to determine the safety and efficacy of computed tomography (CT)-guided transpulmonary percutaneous microwave ablation (MWA) for hepatic malignancies without the use of ancillary techniques.
    Material and methods: A retrospective review was performed on patients who underwent MWA for hepatic malignancy between January 2014 and February 2020 at a single tertiary center. Imaging was reviewed for each procedure to identify MWA showing transpleural transgression on CT scans. For these patients, demographics, ablation data, pulmonary complication rate, and predictors of pneumothorax were analyzed.
    Results: A total of 71 consecutive sessions (62.1 ± 11.3 years, 79% of males) of MWA were performed to treat 71 tumors (1.90 ± 0.96 cm) via transpulmonary approach under CT guidance. Technical success was achieved in all cases immediately after the procedure. At 1-month follow-up, 65/69 (94.2%) patients had no residual disease (two patients were lost to follow-up). Pulmonary complications occurred in 26/71 (36.6%) sessions, and 15/26 (57.7%) were minor requiring no intervention. Pneumothorax occurred in 14/71 (19.7%) sessions, and the rate of major pneumothorax requiring chest tube was 8/71 (11.3%). Lesions on the left side of the liver (segments I-IV) and intraprocedural probe adjustment were found to be independent predictors of developing major pneumothorax (
    Conclusion: CT-guided transpulmonary MWA is safe and effective in treating hepatic malignancies. Although it is associated with the risk of developing pulmonary complications, patients underwent successful ablation of their hepatic malignancies without life-threatening complications and mortality.
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601233-9
    ISSN 2156-5597 ; 2156-7514
    ISSN (online) 2156-5597
    ISSN 2156-7514
    DOI 10.25259/JCIS_152_2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Einsatz von Proteasen zur Verbesserung der Filtration und Stabilität des österreichischen Weines

    Mandl Karin / Suljic Jasmina / Scheiblhofer Harald / Winkler Michael / Schneider Michael

    Die Bodenkultur, Vol 72, Iss 2, Pp 93-

    2022  Volume 103

    Abstract: Weintrübung tritt häufig nach der Abfüllung aufgrund unzureichender Eiweißstabilisierung auf und wird oft als Qualitätsfehler von Kunden bezeichnet. Zur Vermeidung einer Weintrübung wird üblicherweise Bentonit verwendet, um bestimmte Proteinfraktionen zu ...

    Abstract Weintrübung tritt häufig nach der Abfüllung aufgrund unzureichender Eiweißstabilisierung auf und wird oft als Qualitätsfehler von Kunden bezeichnet. Zur Vermeidung einer Weintrübung wird üblicherweise Bentonit verwendet, um bestimmte Proteinfraktionen zu entfernen. Proteasen stellen möglicherweise eine Alternative zu Bentonit dar, vor allem Aspergillopepsin. Ziel dieser Arbeit war heraus zu finden, ob es Vorteile für den Winzer durch den Einsatz einer sauren Protease, im Bereich Filtrationsleistung und Prophylaxe für Eiweißtrübungen gibt. Dafür wurden die Produkte Lallzyme P1 und Lallzyme P2 von der Firma Lallemand GmbH an der Sorte „Grüner Veltliner“ getestet. Die Ergebnisse zeigten, dass es große Unterschiede in der Filtrationsleistung gab. Die Enzymzugabe erhöht die Filtrierbarkeit der Weine wohingegen die Erhitzung der Probe diese wiederum senkte. Die beste Filtrierbarkeit zeigte die Probe, die sowohl mit dem Enzym Lallzyme P1 und P2 sowie mit Pectinasen versetzt und erhitzt wurde. Der Verblockungswert war am höchsten, wo keine Enzympräparate zugesetzt wurden. In der Darstellung der Proteine mittels SDS-PAGE konnten Unterschiede der Bandenintensitäten vor und nach der Enzymbehandlung festgestellt werden. Sensorisch konnten die erhitzten Weine eindeutig von den nicht erhitzten Proben differenziert werden.
    Keywords aspergillopepsin ; eiweißtrübung ; grüner veltliner ; bentonitersatz ; erhitzung ; protein haze ; benonite replacement ; heating ; Environmental sciences ; GE1-350
    Subject code 630
    Language German
    Publishing date 2022-05-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: PySCIPOpt-ML

    Turner, Mark / Chmiela, Antonia / Koch, Thorsten / Winkler, Michael

    Embedding Trained Machine Learning Models into Mixed-Integer Programs

    2023  

    Abstract: A standard tool for modelling real-world optimisation problems is mixed-integer programming (MIP). However, for many of these problems there is either incomplete information describing variable relations, or the relations between variables are highly ... ...

    Abstract A standard tool for modelling real-world optimisation problems is mixed-integer programming (MIP). However, for many of these problems there is either incomplete information describing variable relations, or the relations between variables are highly complex. To overcome both these hurdles, machine learning (ML) models are often used and embedded in the MIP as surrogate models to represent these relations. Due to the large amount of available ML frameworks, formulating ML models into MIPs is highly non-trivial. In this paper we propose a tool for the automatic MIP formulation of trained ML models, allowing easy integration of ML constraints into MIPs. In addition, we introduce a library of MIP instances with embedded ML constraints. The project is available at https://github.com/Opt-Mucca/PySCIPOpt-ML.
    Keywords Mathematics - Optimization and Control ; Computer Science - Artificial Intelligence
    Publishing date 2023-12-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book: Emissionen ausgewählter Kohlenwasserstoffe aus Anwendungen flüssiger Kraft- und Brennstoffe im Verkehrswesen, im Off-Road-Bereich und in der Wärmeerzeugung in Deutschland

    Ettel, Siegfried / Winkler, Michael / Zellner, Reinhard

    (BUA-Stoffbericht ; 260)

    2006  

    Author's details hrsg. vom Beratergremium für Altstoffe (BUA) der Gesellschaft Deutscher Chemiker. [Autoren: S. Ettel, M. Winkler, R. Zellner]
    Series title BUA-Stoffbericht ; 260
    Collection
    Keywords Verkehr ; Kohlenwasserstoffemission ; Umweltbelastung ; Bewertung ; Wärmeerzeugung
    Subject Wertansatz ; Wertung ; Wertermittlung ; Ökologische Belastung ; Umweltbeeinträchtigung ; Umweltproblem ; Umwelt ; Kohlenwasserstoffe ; Verkehrswesen
    Language German
    Size Getr. Zählung
    Publisher Hirzel
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    Note Zsfassung in engl. Sprache
    HBZ-ID HT014856342
    ISBN 3-7776-1453-X ; 978-3-7776-1453-3
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    068/1390 available for loan (reading room) Freihandmagazin (U1)

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