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Book ; Thesis: Real-time detection of bone-invasive oral cancer with laser-induced breakdown spectroscopy: a proof-of-principle study

Winnand, Philipp

2023

Author's details	vorgelegt von Dr.med. Philipp Winnand
Size	8 Seiten, Illustrationen, Diagramme
Publishing place	Aachen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2023
Note	Die Dissertation besteht aus einem Aufsatz, der zuvor in der Zeitschrift "Oral Oncology" (2023; 138:106308 ) veröffentlicht wurde; DOI: 10.1016/j.oraloncology.2023.106308
HBZ-ID	HT030073546
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Book ; Thesis: Molekulare Analyse der Leberregeneration im Rahmen des "In-situ Split"-Verfahrens

Winnand, Philipp

2020

Author's details	vorgelegt von Philipp Winnand
Language	German
Size	87 Seiten, Illustrationen, Diagramme
Publishing place	Aachen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2020
HBZ-ID	HT020572611
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Assessment of the Electrolyte Heterogeneity of Tissues in Mandibular Bone-Infiltrating Head and Neck Cancer Using Laser-Induced Breakdown Spectroscopy.

Winnand, Philipp / Boernsen, Klaus Olaf / Ooms, Mark / Heitzer, Marius / Vohl, Nils / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Laser-induced breakdown spectroscopy (LIBS) was recently introduced as a rapid bone analysis technique in bone-infiltrating head and neck cancers. Research efforts on laser surgery systems with controlled tissue feedback are currently limited to animal ... ...

Abstract	Laser-induced breakdown spectroscopy (LIBS) was recently introduced as a rapid bone analysis technique in bone-infiltrating head and neck cancers. Research efforts on laser surgery systems with controlled tissue feedback are currently limited to animal specimens and the use of nontumorous tissues. Accordingly, this study aimed to characterize the electrolyte composition of tissues in human mandibular bone-infiltrating head and neck cancer. Mandible cross-sections from 12 patients with bone-invasive head and neck cancers were natively investigated with LIBS. Representative LIBS spectra (n = 3049) of the inferior alveolar nerve, fibrosis, tumor stroma, and cell-rich tumor areas were acquired and histologically validated. Tissue-specific differences in the LIBS spectra were determined by receiver operating characteristics analysis and visualized by principal component analysis. The electrolyte emission values of calcium (Ca) and potassium (K) significantly (
MeSH term(s)	Animals ; Humans ; Spectrum Analysis/methods ; Lasers ; Head and Neck Neoplasms ; Electrolytes ; Mandible ; Fibrosis
Chemical Substances	Electrolytes
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052607
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Article ; Online: A Biodegradable Tissue Adhesive for Post-Extraction Alveolar Bone Regeneration under Ongoing Anticoagulation-A Microstructural Volumetric Analysis in a Rodent Model.

Heitzer, Marius / Winnand, Philipp / Ooms, Mark / Magnuska, Zuzanna / Kiessling, Fabian / Buhl, Eva Miriam / Hölzle, Frank / Modabber, Ali

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive ... ...

Abstract	In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive effect on soft tissue regeneration and hemostasis. However, the regenerative potential of VIVO in terms of bone regeneration has not yet been explored. The present rodent study compared the post-extraction bone healing of a collagen sponge (COSP) and VIVO in the context of ongoing anticoagulation therapy. According to a split-mouth design, a total of 178 extraction sockets were generated under rivaroxaban treatment, of which 89 extraction sockets were treated with VIVO and 89 with COSP. Post-extraction bone analysis was conducted via in vivo micro-computed tomography (µCT), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) after 5, 10, and 90 days. During the observation time of 90 days, µCT analysis revealed that VIVO and COSP led to significant increases in both bone volume and bone density (
MeSH term(s)	Animals ; Bone Regeneration/drug effects ; Tooth Extraction/adverse effects ; Rats ; X-Ray Microtomography ; Male ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Tissue Adhesives/pharmacology ; Alveolar Bone Loss/etiology ; Alveolar Bone Loss/diagnostic imaging ; Alveolar Bone Loss/drug therapy ; Collagen/metabolism
Chemical Substances	Anticoagulants ; Tissue Adhesives ; Collagen (9007-34-5)
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084210
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Article ; Online: Real-time detection of bone-invasive oral cancer with laser-induced breakdown spectroscopy: A proof-of-principle study.

Winnand, Philipp / Ooms, Mark / Heitzer, Marius / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

Oral oncology

2023 Volume 138, Page(s) 106308

Abstract: Objectives: Intraoperative definition of resection margin status in bone-invasive oral cancer is a fundamental problem in oncologic surgery due to the lack of rapid bone analysis methods. Laser-induced breakdown spectroscopy (LIBS) provides direct ... ...

Abstract	Objectives: Intraoperative definition of resection margin status in bone-invasive oral cancer is a fundamental problem in oncologic surgery due to the lack of rapid bone analysis methods. Laser-induced breakdown spectroscopy (LIBS) provides direct measurement with real-time examination of a minimal tissue sample. This proof-of-principle study aimed to evaluate the possibility of distinguishing tumorous and healthy areas with LIBS. Materials and methods: LIBS experiments were executed on native segmental mandibulectomy specimens from 15 patients with bone-invasive oral cancer. Normalized and intensity-matched spectra were compared. Under biological derivation, peak area calculation and principal component analysis (PCA) were applied. The discriminatory power of the PCAs was correlated with the architectural and cytological characteristics of the lasered tumor tissue. Receiver operating characteristics analysis was used to evaluate the performance of LIBS in the real-time detection of bone-invasive cancer. Results: Calcium (Ca), which is high in healthy bone, is replaced by potassium (K) and sodium (Na) in bone-invasive cancer. The degree of stromal induction is significantly correlated with the discriminatory power between healthy and tumorous spectra. In this study, LIBS ensured an overall sensitivity of 95.51% and a specificity of 98.64% via the intracellular detection of K and Na. Conclusion: This study demonstrated robust real-time detection of bone-invasive oral cancer with LIBS, which may lay the foundation for establishing LIBS as a rapid bone analysis method. Further development of a LIBS-guided assessment of bone tumor resection margins might reduce the extent of bony resection without compromising oncologic safety.
MeSH term(s)	Humans ; Spectrum Analysis/methods ; Lasers ; Mouth Neoplasms ; Bone Neoplasms
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2023.106308
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Article ; Online: Evaluation of electrolyte element composition in human tissue by laser-induced breakdown spectroscopy (LIBS).

Winnand, Philipp / Boernsen, K Olaf / Bodurov, Georgi / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

Scientific reports

2022 Volume 12, Issue 1, Page(s) 16391

Abstract: Laser-induced breakdown spectroscopy (LIBS) enables the direct measurement of cell electrolyte concentrations. The utility of LIBS spectra in biomarker studies is limited because these studies rarely consider basic physical principles. The aim of this ... ...

Abstract	Laser-induced breakdown spectroscopy (LIBS) enables the direct measurement of cell electrolyte concentrations. The utility of LIBS spectra in biomarker studies is limited because these studies rarely consider basic physical principles. The aim of this study was to test the suitability of LIBS spectra as an analytical method for biomarker assays and to evaluate the composition of electrolyte elements in human biomaterial. LIBS as an analytical method was evaluated by establishing KCl calibration curves to demonstrate linearity, by the correct identification of emission lines with corresponding reference spectra, and by the feasibility to use LIBS in human biomaterial, analyzing striated muscle tissues from the oral regions of two patients. Lorentzian peak fit and peak area calculations resulted in better linearity and reduced shot-to-shot variance. Correct quantitative measurement allowed for differentiation of human biomaterial between patients, and determination of the concentration ratios of main electrolytes within human tissue. The clinical significance of LIBS spectra should be evaluated using peak area rather than peak intensity. LIBS might be a promising tool for analyzing a small group of living cells. Due to linearity, specificity and robustness of the proposed analytical method, LIBS could be a component of future biomarker studies.
MeSH term(s)	Biocompatible Materials ; Calibration ; Electrolytes ; Humans ; Lasers ; Spectrum Analysis/methods
Chemical Substances	Biocompatible Materials ; Electrolytes
Language	English
Publishing date	2022-09-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20825-0
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Article ; Online: Influence of microvascular mandibular bony reconstruction on the posterior airway space: A retrospective cohort study.

Winnand, Philipp / Ayoub, Nassim / König, Jan / Ooms, Mark / Heitzer, Marius / Peters, Florian / Hölzle, Frank / Modabber, Ali

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 88, Page(s) 414–424

Abstract: Introduction: The posterior airway space (PAS) is a common site of passive obstructions with high morbidity. Surgical changes to the craniomandibular system may affect the PAS. Data regarding the effects of mandibular reconstruction using vascularized ... ...

Abstract	Introduction: The posterior airway space (PAS) is a common site of passive obstructions with high morbidity. Surgical changes to the craniomandibular system may affect the PAS. Data regarding the effects of mandibular reconstruction using vascularized bone flaps on PAS are insufficient. This retrospective cohort study aimed to investigate changes in PAS after mandibular reconstruction. Materials and methods: Pre- and post-reconstructive computed tomography scans of 40 patients undergoing segmental mandibulectomy and mandibular reconstruction with deep circumflex iliac artery or fibula flaps were analyzed. Absolute differences in PAS geometry and relative trends of PAS volume changes were compared within the study population and between subgroups formed according to the extent of resection, timing and type of reconstruction, and presence of pre-reconstructive radiotherapy. Results: Irradiated patients were characterized by an increase in PAS volume after reconstruction. Absolute differences in total PAS volume after reconstruction were significantly different (p = 0.024) compared to non-irradiated patients. Reconstruction of central mandible segments resulted in decrease of the cross-sectional PAS areas. Absolute differences in middle cross-sectional PAS area after reconstruction were significantly different (p = 0.039) compared to non-central reconstructions. Patients who received radiotherapy were less likely to show a total PAS volume reduction after reconstruction (OR: 0.147; p = 0.007), with values adjusted for gender, age, body mass index, timing and type of reconstruction, and transplant length. Conclusions: Mandibular reconstruction causes changes in PAS geometry. Specifically, reconstructions of central mandibular segments can lead to a reduction in the cross-sectional areas of PAS, and mandibular reconstructions in irradiated sites may cause an increase in PAS volume.
MeSH term(s)	Humans ; Mandibular Reconstruction/methods ; Mandibular Neoplasms/diagnostic imaging ; Mandibular Neoplasms/surgery ; Retrospective Studies ; Bone Transplantation/methods ; Surgical Flaps/blood supply ; Mandible/diagnostic imaging ; Mandible/surgery ; Fibula ; Free Tissue Flaps
Language	English
Publishing date	2023-11-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.11.020
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Article: Evaluation of the Hemostatic Effect of an Innovative Tissue Adhesive during Extraction Therapy under Rivaroxaban in a Rodent Model.

Heitzer, Marius / Winnand, Philipp / Bock, Anna / Ooms, Mark / Katz, Marie Sophie / Kniha, Kristian / Grottke, Oliver / Hölzle, Frank / Modabber, Ali

Journal of functional biomaterials

2023 Volume 14, Issue 7

Abstract: An increase in rivaroxaban therapies is associated with increased numbers of postoperative bleeding despite the use of hemostatic sponges, which are currently the gold standard treatment. VIVO has shown promising hemostatic results, favorable tissue ... ...

Abstract	An increase in rivaroxaban therapies is associated with increased numbers of postoperative bleeding despite the use of hemostatic sponges, which are currently the gold standard treatment. VIVO has shown promising hemostatic results, favorable tissue properties, and ease of application, although it has not yet been used in the oral cavity. The aim of this study was to evaluate the hemostatic properties of VIVO in the extraction sockets of 31 rodents and compare this to gelatin sponge (GSP) therapy. At rivaroxaban concentrations of 264.10 ± 250.10 ng/mL, 62 extraction sockets were generated, of which 31 were treated with VIVO and 31 with GSP. The duration time, early and late bleeding events, and wound healing score were determined. Histologic examinations of the tissues were performed after 5 days. VIVO presented a longer procedure, 1.26 ± 0.06 min, but a significantly shorter bleeding time, 0.14 ± 0.03 min. There was no difference between the two groups in terms of the severity and timing of bleeding. More minor early bleeding events were observed for GSP. VIVO showed a significantly better healing score, with favorable histological results. In an animal study, VIVO showed promising hemostatic properties after tooth extraction under ongoing anticoagulative therapy.
Language	English
Publishing date	2023-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb14070333
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Article ; Online: Effect of systemic antiresorptive medication on the histopathological parameters of implant osseointegration in an in vivo rodent study.

Kniha, Kristian / Hermanns-Sachweh, Benita / Möhlhenrich, Stephan Christian / Peters, Florian / Heitzer, Marius / Winnand, Philipp / Hölzle, Frank / Modabber, Ali

BMC oral health

2023 Volume 23, Issue 1, Page(s) 117

Abstract: Background: The purpose of this study was to evaluate the osseointegration of zirconia and titanium implants in the rat maxilla in specimens under systemic antiresorptive therapy.: Materials and methods: After 4 weeks of systematic medication ... ...

Abstract	Background: The purpose of this study was to evaluate the osseointegration of zirconia and titanium implants in the rat maxilla in specimens under systemic antiresorptive therapy. Materials and methods: After 4 weeks of systematic medication administration (either zoledronic acid or alendronic acid), 54 rats received one zirconia and one titanium implants that were immediately inserted in the rat maxilla after tooth extraction. Twelve weeks after implant placement, histopathological samples were evaluated for implant osteointegration parameters. Results: The bone-implant-contact (BIC) ratio revealed no significant inter-group or inter-material differences. The distance between the implant shoulder to the bone level was significantly greater around the titanium implants of the zoledronic acid group compared to the zirconia implants of the control group (p = 0.0005). On average, signs of new bone formation could be detected in all groups, although often without statistical differences. Signs of bone necrosis were only detected around the zirconia implants of the control group (p < 0.05). Conclusions: At the 3-month follow-up, no implant material was demonstrably better than the others in terms of osseointegration metrics under systemic antiresorptive therapy. Further studies are necessary to determine whether there are differences in the osseointegration behavior of the different materials.
MeSH term(s)	Rats ; Animals ; Osseointegration ; Dental Implants ; Zoledronic Acid ; Rodentia ; Titanium ; Dental Prosthesis Design ; Bone Density Conservation Agents ; Maxilla ; Surface Properties
Chemical Substances	Dental Implants ; zirconium oxide (S38N85C5G0) ; Zoledronic Acid (6XC1PAD3KF) ; Titanium (D1JT611TNE) ; Bone Density Conservation Agents
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-02763-z
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Article ; Online: Attached compared with unattached surface probes for monitoring flap perfusion in microvascular head and neck reconstruction: a feasibility study.

Ooms, Mark / Winnand, Philipp / Heitzer, Marius / Peters, Florian / Bock, Anna / Katz, Marie Sophie / Hölzle, Frank / Modabber, Ali

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15939

Abstract: Unattached surface probes are commonly used with the O2C analysis system (LEA Medizintechnik, Germany) to monitor microvascular free flap perfusion. This study compared attached and unattached surface probes for extraoral free flaps. The study included ... ...

Abstract	Unattached surface probes are commonly used with the O2C analysis system (LEA Medizintechnik, Germany) to monitor microvascular free flap perfusion. This study compared attached and unattached surface probes for extraoral free flaps. The study included 34 patients who underwent extraoral microvascular head and neck reconstruction between 2020 and 2022. Flap perfusion was monitored postoperatively using the O2C analysis system at 0, 12, 24, 36, and 48 h, with an attached surface probe at 3 mm tissue depth and an unattached surface probe at 2 mm and 8 mm tissue depths. Clinical complications, technical errors, and perfusion measurement values were compared. No clinical complications (attachment suture infections) or technical errors (probe detachment) occurred. Flap blood flow values of the probes were partially different (3 mm vs. 2 and 8 mm: p < 0.001; p = 0.308) and moderately correlated (3 mm with 2 and 8 mm: r = 0.670, p < 0.001; r = 0.638, p < 0.001). Hemoglobin concentration and oxygen saturation values were generally different (3 mm vs. 2 and 8 mm: all p < 0.001) and variably correlated (3 mm with 2 and 8 mm: r = 0.756, r = 0.645; r = 0.633, r = 0.307; all p < 0.001). Both probes are comparable in terms of technical feasibility and patient safety, with flap perfusion values dependent on tissue measurement depth.
MeSH term(s)	Humans ; Feasibility Studies ; Perfusion ; Head ; Neck ; Free Tissue Flaps
Language	English
Publishing date	2023-09-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43151-5
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