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  1. Article ; Online: Plasma Neurofilaments: Potential Biomarkers of SPG11-Related Hereditary Spastic Paraplegia.

    Krumm, Laura / Winkler, Jürgen / Winner, Beate / Regensburger, Martin

    Movement disorders : official journal of the Movement Disorder Society

    2024  Volume 39, Issue 4, Page(s) 755–757

    MeSH term(s) Humans ; Spastic Paraplegia, Hereditary/genetics ; Spastic Paraplegia, Hereditary/blood ; Spastic Paraplegia, Hereditary/diagnosis ; Biomarkers/blood ; Male ; Adult ; Female ; Neurofilament Proteins/blood ; Proteins/genetics ; Middle Aged
    Chemical Substances SPG11 protein, human ; Biomarkers ; Neurofilament Proteins ; Proteins
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
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    Zs.MO 238: Show issues

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  2. Book ; Thesis: Der Einfluß von glykiert-oxidiertem Lipoprotein (a) auf die Vasomotorik von isolierten Kaninchenaorten

    Winner, Beate

    1999  

    Author's details vorgelegt von Beate Winner
    Language German
    Size IV, 53 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1999
    HBZ-ID HT012829094
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2000 D 1971 order for loan Magazin

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  3. Book ; Online ; Thesis: Axon-spezifische mitochondriale Pathologie in Alpha-Motoneuronen von SPG11-Patienten

    Güner, Fabian [Verfasser] / Winner, Beate [Akademischer Betreuer] / Winner, Beate [Gutachter]

    2022  

    Author's details Fabian Güner ; Gutachter: Beate Winner ; Betreuer: Beate Winner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Organoids in gastrointestinal diseases: from experimental models to clinical translation.

    Günther, Claudia / Winner, Beate / Neurath, Markus F / Stappenbeck, Thaddeus S

    Gut

    2022  Volume 71, Issue 9, Page(s) 1892–1908

    Abstract: We are entering an era of medicine where increasingly sophisticated data will be obtained from patients to determine proper diagnosis, predict outcomes and direct therapies. We predict that the most valuable data will be produced by systems that are ... ...

    Abstract We are entering an era of medicine where increasingly sophisticated data will be obtained from patients to determine proper diagnosis, predict outcomes and direct therapies. We predict that the most valuable data will be produced by systems that are highly dynamic in both time and space. Three-dimensional (3D) organoids are poised to be such a highly valuable system for a variety of gastrointestinal (GI) diseases. In the lab, organoids have emerged as powerful systems to model molecular and cellular processes orchestrating natural and pathophysiological human tissue formation in remarkable detail. Preclinical studies have impressively demonstrated that these organs-in-a-dish can be used to model immunological, neoplastic, metabolic or infectious GI disorders by taking advantage of patient-derived material. Technological breakthroughs now allow to study cellular communication and molecular mechanisms of interorgan cross-talk in health and disease including communication along for example, the gut-brain axis or gut-liver axis. Despite considerable success in culturing classical 3D organoids from various parts of the GI tract, some challenges remain to develop these systems to best help patients. Novel platforms such as organ-on-a-chip, engineered biomimetic systems including engineered organoids, micromanufacturing, bioprinting and enhanced rigour and reproducibility will open improved avenues for tissue engineering, as well as regenerative and personalised medicine. This review will highlight some of the established methods and also some exciting novel perspectives on organoids in the fields of gastroenterology. At present, this field is poised to move forward and impact many currently intractable GI diseases in the form of novel diagnostics and therapeutics.
    MeSH term(s) Bioprinting ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/metabolism ; Gastrointestinal Diseases/therapy ; Humans ; Models, Theoretical ; Organoids/metabolism ; Reproducibility of Results
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2021-326560
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    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models.

    Kaindl, Johanna / Winner, Beate

    Current topics in behavioral neurosciences

    2019  Volume 42, Page(s) 159–183

    Abstract: Human pluripotent stem (PS) cells are a relevant platform to model human-specific neurological disorders. In this chapter, we focus on human stem cell models for neuropsychiatric disorders including induced pluripotent stem (iPS) cell-derived neural ... ...

    Abstract Human pluripotent stem (PS) cells are a relevant platform to model human-specific neurological disorders. In this chapter, we focus on human stem cell models for neuropsychiatric disorders including induced pluripotent stem (iPS) cell-derived neural precursor cells (NPCs), neurons and cerebral organoids. We discuss crucial steps for planning human disease modeling experiments. We introduce the different strategies of human disease modeling including transdifferentiation, human embryonic stem (ES) cell-based models, iPS cell-based models and genome editing options. Analysis of disease-relevant phenotypes is discussed. In more detail, we provide exemplary insight into modeling of the neurodevelopmental defects in autism spectrum disorder (ASD) and the process of neurodegeneration in Alzheimer's disease (AD). Besides monogenic diseases, iPS cell-derived models also generated data from idiopathic and sporadic cases.
    MeSH term(s) Alzheimer Disease ; Autism Spectrum Disorder ; Cell Differentiation ; Humans ; Induced Pluripotent Stem Cells ; Neural Stem Cells ; Organoids
    Language English
    Publishing date 2019-08-06
    Publishing country Germany
    Document type Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2019_111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Intracellular Mechanisms of α-Synuclein Processing.

    Zunke, Friederike / Winner, Beate / Richter, Franziska / Caraveo, Gabriela

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 752378

    Language English
    Publishing date 2021-09-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.752378
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  7. Article ; Online: Th17 cells: a promising therapeutic target for Parkinson's disease?

    Prots, Iryna / Winner, Beate

    Expert opinion on therapeutic targets

    2019  Volume 23, Issue 4, Page(s) 309–314

    Abstract: Introduction: Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused by the progressive loss of neurons in the midbrain and other brain regions. Only symptomatic treatment is currently available. Mounting evidence ... ...

    Abstract Introduction: Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused by the progressive loss of neurons in the midbrain and other brain regions. Only symptomatic treatment is currently available. Mounting evidence suggests that T cells are a key contributor to PD pathogenesis and neurodegeneration by a mechanism that requires further elucidation. Areas covered: We discuss the evidence of imbalanced activation of effector T cell populations in PD and summarize the data of Th17 involvement and Th17-regulated mechanisms in PD pathology. Moreover, possible Th17-related molecular targets as possible neuroprotective immunomodulatory therapeutic targets for PD are examined. Expert Opinion: Existing data show that Th17 cells, their effector molecules, and signaling pathways are potentially effective therapeutic targets for neuroprotective immunomodulation in PD treatment. However, specificity of action within Th17-mediated signaling pathways for PD requires careful consideration.
    MeSH term(s) Animals ; Antiparkinson Agents/pharmacology ; Humans ; Immunologic Factors/pharmacology ; Molecular Targeted Therapy ; Neurons/pathology ; Neuroprotective Agents/pharmacology ; Parkinson Disease/drug therapy ; Parkinson Disease/immunology ; Parkinson Disease/physiopathology ; Th17 Cells/immunology
    Chemical Substances Antiparkinson Agents ; Immunologic Factors ; Neuroprotective Agents
    Language English
    Publishing date 2019-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2019.1590336
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
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  8. Book ; Online ; Thesis: Role of T cells subsets in alpha-synuclein aggregation in Parkinson's disease

    Brendler, Anna Irene [Verfasser] / Prots, Iryna [Akademischer Betreuer] / Prots, Iryna [Gutachter] / Winner, Beate [Gutachter]

    2024  

    Author's details Anna Irene Brendler ; Gutachter:  Iryna Prots,  Beate Winner ; Betreuer:  Iryna Prots
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
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  9. Article ; Online: Decoding Parkinson's disease - iPSC-derived models in the OMICs era.

    Krach, Florian / Bogiongko, Marios-Evangelos / Winner, Beate

    Molecular and cellular neurosciences

    2020  Volume 106, Page(s) 103501

    Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain. In recent years, researchers have started studying PD using induced pluripotent stem cell (iPSC) models of the disease. ... ...

    Abstract Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain. In recent years, researchers have started studying PD using induced pluripotent stem cell (iPSC) models of the disease. Surprisingly, few studies have combined iPSC-technology with the so-called powerful 'omics' approaches. Here, we review the current state of omics applications used in combination with iPSC-derived models to study PD. Our focus is on studies investigating transcriptional changes and publications using proteomics applications. Lastly, we discuss current caveats in the field and identify potential future directions to obtain novel insights into PD pathology.
    MeSH term(s) Animals ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Models, Biological ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Proteomics
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1046640-x
    ISSN 1095-9327 ; 1044-7431
    ISSN (online) 1095-9327
    ISSN 1044-7431
    DOI 10.1016/j.mcn.2020.103501
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    Zs.A 3035: Show issues Location:
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  10. Article ; Online: The Gut-Brain Axis in Inflammatory Bowel Disease-Current and Future Perspectives.

    Günther, Claudia / Rothhammer, Veit / Karow, Marisa / Neurath, Markus / Winner, Beate

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: The gut-brain axis is a bidirectional communication system driven by neural, hormonal, metabolic, immunological, and microbial signals. Signaling events from the gut can modulate brain function and recent evidence suggests that the gut-brain axis may ... ...

    Abstract The gut-brain axis is a bidirectional communication system driven by neural, hormonal, metabolic, immunological, and microbial signals. Signaling events from the gut can modulate brain function and recent evidence suggests that the gut-brain axis may play a pivotal role in linking gastrointestinal and neurological diseases. Accordingly, accumulating evidence has suggested a link between inflammatory bowel diseases (IBDs) and neurodegenerative, as well as neuroinflammatory diseases. In this context, clinical, epidemiological and experimental data have demonstrated that IBD predisposes a person to pathologies of the central nervous system (CNS). Likewise, a number of neurological disorders are associated with changes in the intestinal environment, which are indicative for disease-mediated gut-brain inter-organ communication. Although this axis was identified more than 20 years ago, the sequence of events and underlying molecular mechanisms are poorly defined. The emergence of precision medicine has uncovered the need to take into account non-intestinal symptoms in the context of IBD that could offer the opportunity to tailor therapies to individual patients. The aim of this review is to highlight recent findings supporting the clinical and biological link between the gut and brain, as well as its clinical significance for IBD as well as neurodegeneration and neuroinflammation. Finally, we focus on novel human-specific preclinical models that will help uncover disease mechanisms to better understand and modulate the function of this complex system.
    MeSH term(s) Animals ; Brain/metabolism ; Brain/pathology ; Central Nervous System Diseases/etiology ; Central Nervous System Diseases/metabolism ; Central Nervous System Diseases/pathology ; Humans ; Inflammatory Bowel Diseases/complications
    Language English
    Publishing date 2021-08-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168870
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