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  1. Article: Liquid profiling for tumor load monitoring in blood plasma using personalized droplet digital PCR assays detecting tumor-specific chromosomal rearrangements

    Winter, Christof

    Klinische Chemie

    2016  Volume 47, Issue Beil. Juni "HJ. Staudinger Symp., Page(s) 36

    Language German
    Document type Article
    ZDB-ID 841078-1
    ISSN 0173-6647
    Database Current Contents Medicine

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  2. Book ; Thesis: DIE ANWENDUNG DES BUNDESSEUCHENGESETZES AUF DIE SALMONELLOSE-ERKRANKUNG

    Winter, Christof

    BESTANDSAUFNAHME U. EMPFEHLUNGEN

    1977  

    Title variant ANWENDUNG DES BUNDESSEUCHENGESETZES AUF DIE SALMONELLOSE-ERKRANKUNG
    Size 82 S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis FRANKFURT (MAIN), UNIV., FACHBEREICH 19 - HUMANMEDIZIN, DISS., 1977
    HBZ-ID HT002590998
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    77 D 2336 order for loan Magazin

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  3. Article ; Online: The role of extended coagulation screening in adult cranial neurosurgery.

    Wagner, Arthur / Wostrack, Maria / Hartz, Frederik / Heim, Johannes / Hameister, Erik / Hildebrandt, Martin / Meyer, Bernhard / Winter, Christof

    Brain & spine

    2023  Volume 3, Page(s) 101756

    Abstract: Introduction: Postoperative hemorrhage after adult cranial neurosurgery is a serious complication with substantial morbidity and mortality.: Research question: We investigated if an extended preoperative screening and an early treatment of previously ...

    Abstract Introduction: Postoperative hemorrhage after adult cranial neurosurgery is a serious complication with substantial morbidity and mortality.
    Research question: We investigated if an extended preoperative screening and an early treatment of previously undetected coagulopathies may decrease the risk of postoperative hemorrhage.
    Methods: A prospective study cohort of patients undergoing elective cranial surgery and receiving the extended coagulatory work-up were compared to a propensity matched historical control cohort. The extended work-up included a standardized questionnaire on the patient's bleeding history as well as coagulatory tests of Factor XIII, von-Willebrand-Factor and PFA-100®. Deficiencies were substituted perioperatively. The primary outcome was determined as the surgical revision rate due to postoperative hemorrhage.
    Results: The study cohort and the control cohort included 197 cases each, without any significant difference in the preoperative intake of anticoagulant medication (p ​= ​.546). Most common interventions were resections of malignant tumors (41%), benign tumors (27%) and neurovascular surgeries (9%) in both cohorts. Imaging revealed postoperative hemorrhage in 7 cases (3.6%) in the study cohort and 18 cases (9.1%) in the control cohort (p ​= ​.023). Of these, revision surgeries were significantly more common in the control cohort with 14 cases (9.1%) compared to 5 cases (2.5%) in the study cohort (p ​= ​.034). Differences in mean intraoperative blood loss were not significant with 528 ​ml in the study cohort and 486 ​ml in the control cohort (p ​= ​.376).
    Conclusion: Preoperative extended coagulatory screening may allow for revealing previously undiagnosed coagulopathies with subsequent preoperative substitution and thereby reduction of risk for postoperative hemorrhage in adult cranial neurosurgery.
    Language English
    Publishing date 2023-05-11
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2023.101756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Junges Labor meets "Operation Karriere"

    Biemann, Ronald / Winter, Christof

    Klinische Chemie

    2019  Volume 51, Issue 1, Page(s) 144

    Language German
    Document type Article
    ZDB-ID 841078-1
    ISSN 0173-6647
    Database Current Contents Medicine

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  5. Article ; Online: Head and neck cancer of unknown primary: unveiling primary tumor sites through machine learning on DNA methylation profiles.

    Stark, Leonhard / Kasajima, Atsuko / Stögbauer, Fabian / Schmidl, Benedikt / Rinecker, Jakob / Holzmann, Katharina / Färber, Sarah / Pfarr, Nicole / Steiger, Katja / Wollenberg, Barbara / Ruland, Jürgen / Winter, Christof / Wirth, Markus

    Clinical epigenetics

    2024  Volume 16, Issue 1, Page(s) 47

    Abstract: Background: The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most common histologic subtype, squamous ... ...

    Abstract Background: The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most common histologic subtype, squamous cell carcinoma, can stem from various tumor primary sites, including the oral cavity, oropharynx, larynx, head and neck skin, lungs, and esophagus. DNA methylation profiles are highly tissue-specific and have been successfully used to classify tissue origin. We therefore developed a support vector machine (SVM) classifier trained with publicly available DNA methylation profiles of commonly cervically metastasizing squamous cell carcinomas (n = 1103) in order to identify the primary tissue of origin of our own cohort of squamous cell hnCUP patient's samples (n = 28). Methylation analysis was performed with Infinium MethylationEPIC v1.0 BeadChip by Illumina.
    Results: The SVM algorithm achieved the highest overall accuracy of tested classifiers, with 87%. Squamous cell hnCUP samples on DNA methylation level resembled squamous cell carcinomas commonly metastasizing into cervical lymph nodes. The most frequently predicted cancer localization was the oral cavity in 11 cases (39%), followed by the oropharynx and larynx (both 7, 25%), skin (2, 7%), and esophagus (1, 4%). These frequencies concord with the expected distribution of lymph node metastases in epidemiological studies.
    Conclusions: On DNA methylation level, hnCUP is comparable to primary tumor tissue cancer types that commonly metastasize to cervical lymph nodes. Our SVM-based classifier can accurately predict these cancers' tissues of origin and could significantly reduce the invasiveness of hnCUP diagnostics and enable a more precise therapy after clinical validation.
    MeSH term(s) Humans ; DNA Methylation ; Neoplasms, Unknown Primary/diagnosis ; Neoplasms, Unknown Primary/genetics ; Neoplasms, Unknown Primary/pathology ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/genetics ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Machine Learning
    Language English
    Publishing date 2024-03-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-024-01657-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: R-Leuchtung? Einführung in die Biostatistik mit R

    Winter, Christof / Ramspott, Sabine

    Klinische Chemie

    2018  Volume 50, Issue 4, Page(s) 203

    Language German
    Document type Article
    ZDB-ID 841078-1
    ISSN 0173-6647
    Database Current Contents Medicine

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  7. Article: NOTCH1 Intracellular Domain and the Tumor Microenvironment as Prognostic Markers in HNSCC.

    Schmidl, Benedikt / Siegl, Michael / Boxberg, Melanie / Stögbauer, Fabian / Jira, Daniel / Winter, Christof / Stark, Leonhard / Pickhard, Anja / Wollenberg, Barbara / Wirth, Markus

    Cancers

    2022  Volume 14, Issue 4

    Abstract: 1) Background: NOTCH1 is the second most common mutated gene in whole-exome sequencing of HNSCC. The aim of this project was to gain further insight into the relevance of NOTCH1 in HNSCC, potentially establishing NOTCH1 as a prognostic marker or ... ...

    Abstract (1) Background: NOTCH1 is the second most common mutated gene in whole-exome sequencing of HNSCC. The aim of this project was to gain further insight into the relevance of NOTCH1 in HNSCC, potentially establishing NOTCH1 as a prognostic marker or therapeutic target; (2) Methods: NOTCH1 was silenced via RNA interference in six HNSCC cell lines and the impact was evaluated in migration and proliferation assays. Subsequently, the protein expression of NOTCH1 intracellular domain (NICD) and NOTCH1 mRNA expression were examined in 70 oropharyngeal squamous cell cancer tissue samples. Lastly, the NICD expression was compared with the local infiltration of lymphocytes, measured with the immunoscore; (3) Results: Knockdown of NOTCH1 decreased migration and proliferation. A high NICD expression was associated with lower OS. A high immunoscore resulted in significantly better OS. NICD expression was independent of the immunoscore and as a whole differentiated three distinct prognostic groups; (4) Conclusions: These data suggest that NOTCH1 is involved in migration and proliferation of HNSCC cell lines. In vivo, NICD expression was associated with overall survival and could, therefore, be used as a prognostic marker. NICD expression differs from NOTCH1 mRNA levels, potentially explaining the previously suggested bimodal role as an oncogene and tumor suppressor in HNSCC.
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14041080
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  8. Article ; Conference proceedings: The Tumor Immune Microenvironment (TIME) of SCCUP in comparison to oropharyngeal carcinoma

    Schmidl, Benedikt / Vossenkämper, Kim-Aylin / Stark, Leonhard / Stögbauer, Fabian / Boxberg, Melanie / Pickhard, Anja / Winter, Christof / Wollenberg, Barbara / Wirth, Markus

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767277
    Database Thieme publisher's database

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  9. Article ; Conference proceedings: Das Tumor Immune Microenvironment (TIME) des SCCUP im Vergleich zum Oropharynkarzinom

    Schmidl, Benedikt / Vossenkämper, Kim-Aylin / Stark, Leonhard / Stögbauer, Fabian / Boxberg, Melanie / Pickhard, Anja / Winter, Christof / Wollenberg, Barbara / Wirth, Markus

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766667
    Database Thieme publisher's database

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  10. Article ; Online: Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy.

    Vornholz, Larsen / Isay, Sophie E / Kurgyis, Zsuzsanna / Strobl, Daniel C / Loll, Patricia / Mosa, Mohammed H / Luecken, Malte D / Sterr, Michael / Lickert, Heiko / Winter, Christof / Greten, Florian R / Farin, Henner F / Theis, Fabian J / Ruland, Jürgen

    Science advances

    2023  Volume 9, Issue 11, Page(s) eadd8564

    Abstract: Immune checkpoint inhibitors (ICIs) enhance anticancer immunity by releasing repressive signals into tumor microenvironments (TMEs). To be effective, ICIs require preexisting immunologically "hot" niches for tumor antigen presentation and lymphocyte ... ...

    Abstract Immune checkpoint inhibitors (ICIs) enhance anticancer immunity by releasing repressive signals into tumor microenvironments (TMEs). To be effective, ICIs require preexisting immunologically "hot" niches for tumor antigen presentation and lymphocyte recruitment. How the mutational landscape of cancer cells shapes these immunological niches remains poorly defined. We found in human and murine colorectal cancer (CRC) models that the superior antitumor immune response of mismatch repair (MMR)-deficient CRC required tumor cell-intrinsic activation of cGAS-STING signaling triggered by genomic instability. Subsequently, we synthetically enforced STING signaling in CRC cells with intact MMR signaling using constitutively active STING variants. Even in MMR-proficient CRC, genetically encoded gain-of-function STING was sufficient to induce cancer cell-intrinsic interferon signaling, local activation of antigen-presenting cells, recruitment of effector lymphocytes, and sensitization of previously "cold" TMEs to ICI therapy in vivo. Thus, our results introduce a rational strategy for modulating cancer cell-intrinsic programs via engineered STING enforcement to sensitize resistant tumors to ICI responsiveness.
    MeSH term(s) Humans ; Animals ; Mice ; Signal Transduction ; Antigen Presentation ; Antigen-Presenting Cells ; Colonic Neoplasms ; Genomic Instability ; Tumor Microenvironment
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.add8564
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