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  1. Book ; Online ; Thesis: Charakterisierung von Chondroitinsulfat-induzierten B-Zellen in vitro und in vivo

    Winter, Frederike [Verfasser] / Mack, Matthias [Akademischer Betreuer]

    2023  

    Author's details Frederike Winter ; Betreuer: Matthias Mack
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language German
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Donor-But Not Recipient-Derived Cells Produce Collagen-1 in Chronically Rejected Cardiac Allografts.

    Balam, Saidou / Buchtler, Simone / Winter, Frederike / Schmidbauer, Kathrin / Neumayer, Sophia / Talke, Yvonne / Renner, Kerstin / Geissler, Edward K / Mack, Matthias

    Frontiers in immunology

    2022  Volume 12, Page(s) 816509

    Abstract: Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin. Here, ... ...

    Abstract Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin. Here, we sought to determine whether tissue-resident donor-derived cells or allograft-infiltrating recipient-derived cells are responsible for allograft fibrosis, and whether hematopoietic cells contribute to collagen production. A fully MHC-mismatched mouse heterotopic heart transplantation model was used, with transient depletion of CD4
    MeSH term(s) Animals ; Biomarkers ; Chronic Disease ; Collagen Type I/biosynthesis ; Collagen Type I/immunology ; Disease Models, Animal ; Disease Susceptibility ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Graft Rejection/metabolism ; Heart Transplantation/adverse effects ; Heart Transplantation/methods ; Immunophenotyping ; Mice ; Mice, Transgenic ; Tissue Donors ; Transplantation, Homologous
    Chemical Substances Biomarkers ; Collagen Type I
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.816509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: B-cell modulation with anti-CD79b antibodies ameliorates experimental autoimmune encephalitis in mice.

    Renner, Kerstin / Neumayer, Sophia / Talke, Yvonne / Buchtler, Simone / Schmidbauer, Kathrin / Nimmerjahn, Falk / Lux, Anja / Winter, Frederike / Salewski, Jan-Nicklas / Mack, Matthias

    European journal of immunology

    2022  Volume 52, Issue 4, Page(s) 656–668

    Abstract: B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion ... ...

    Abstract B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion will also affect regulatory B cells that are known to suppress autoimmune responses. In our studies, we describe an alternative approach based on targeting CD79b that induces only partial B-cell depletion and achieves therapeutic effects by B-cell modulation. Prophylactic and therapeutic treatment with an antibody against CD79b and also a deglycosylated variant of this antibody, lacking effector function like antibody-dependent cellular cytotoxicity or complement activation, significantly reduced the development and progression of EAE in mice. Our data show that modulation of B cells via CD79b is equally effective as almost complete B-cell depletion with anti-CD20 antibodies and may constitute an alternative approach to treat MS.
    MeSH term(s) Animals ; Antibodies ; Antigens, CD20 ; Autoimmune Diseases ; Autoimmunity ; B-Lymphocytes ; Encephalitis/drug therapy ; Encephalitis/pathology ; Mice
    Chemical Substances Antibodies ; Antigens, CD20
    Language English
    Publishing date 2022-01-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  4. Article ; Online: IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils.

    Balam, Saidou / Schiechl-Brachner, Gabriela / Buchtler, Simone / Halbritter, Dagmar / Schmidbauer, Kathrin / Talke, Yvonne / Neumayer, Sophia / Salewski, Jan-Niklas / Winter, Frederike / Karasuyama, Hajime / Yamanishi, Yoshinori / Renner, Kerstin / Geissler, Edward K / Mack, Matthias

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 202, Issue 12, Page(s) 3514–3523

    Abstract: Chronic rejection is a major problem in transplantation medicine, largely resistant to therapy, and poorly understood. We have shown previously that basophil-derived IL-4 contributes to fibrosis and vasculopathy in a model of heart transplantation with ... ...

    Abstract Chronic rejection is a major problem in transplantation medicine, largely resistant to therapy, and poorly understood. We have shown previously that basophil-derived IL-4 contributes to fibrosis and vasculopathy in a model of heart transplantation with depletion of CD4
    MeSH term(s) Animals ; Basophils/immunology ; Cell Movement ; Cells, Cultured ; Chronic Disease ; Disease Models, Animal ; Graft Rejection/immunology ; Heart Transplantation ; Humans ; Interleukin-3/genetics ; Interleukin-3/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Transplantation, Homologous ; Up-Regulation
    Chemical Substances Interleukin-3 ; Interleukin-6
    Language English
    Publishing date 2019-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1801269
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

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  5. Article ; Online: Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.

    Renner, Kerstin / Schwittay, Tobias / Chaabane, Sophia / Gottschling, Johanna / Müller, Christine / Tiefenböck, Charlotte / Salewski, Jan-Niklas / Winter, Frederike / Buchtler, Simone / Balam, Saidou / Malfertheiner, Maximilian V / Lubnow, Matthias / Lunz, Dirk / Graf, Bernhard / Hitzenbichler, Florian / Hanses, Frank / Poeck, Hendrik / Kreutz, Marina / Orsó, Evelyn /
    Burkhardt, Ralph / Niedermair, Tanja / Brochhausen, Christoph / Gessner, André / Salzberger, Bernd / Mack, Matthias

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 3006

    Abstract: Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and ... ...

    Abstract Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, associated with prolonged virus persistence and reversible with clinical recovery. COVID-19-induced T cell hyporeactivity is T cell extrinsic and caused by plasma components, independent of occasional immunosuppressive medication of the patients. Monocytes respond stronger in males than females and IL-2 partially restores T cell activation. Downstream markers of T cell hyporeactivity are also visible in fresh blood samples of ventilated patients. Based on our data we developed a score to predict fatal outcomes and identify patients that may benefit from strategies to overcome T cell hyporeactivity.
    MeSH term(s) Adult ; Aged ; Basophils/immunology ; COVID-19/immunology ; COVID-19/virology ; Cells, Cultured ; Dendritic Cells/immunology ; Female ; Humans ; Inflammation/immunology ; Lymphocyte Activation/immunology ; Male ; Middle Aged ; Monocytes/immunology ; Neutrophils/immunology ; Pneumonia/immunology ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; T-Lymphocytes/immunology ; Young Adult
    Language English
    Publishing date 2021-05-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-23334-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: T cell anergy in COVID-19 reflects virus persistence and poor outcomes

    Renner, Kerstin / Mueller, Christine / Tiefenboeck, Charlotte / Salewski, Jan-Niklas / Winter, Frederike / Buchtler, Simone / Malfertheiner, Maximilian V / Lubnow, Matthias / Lunz, Dirk / Graf, Bernhard / Hitzenbichler, Florian / Hanses, Frank / Poeck, Hendrik / Kreutz, Marina / Orso, Evelyn / Burkhardt, Ralph / Niedermair, Tanja / Brochhausen, Christoph / Gessner, Andre /
    Salzberger, Bernd / Mack, Matthias

    medRxiv

    Abstract: Coronavirus disease 2019 (COVID-19) can lead to severe pneumonia and hyperinflammation. So far, insufficient or excessive T cell responses were described in patients. We applied novel approaches to analyze T cell reactivity and showed that T anergy is ... ...

    Abstract Coronavirus disease 2019 (COVID-19) can lead to severe pneumonia and hyperinflammation. So far, insufficient or excessive T cell responses were described in patients. We applied novel approaches to analyze T cell reactivity and showed that T anergy is already present in non-ventilated COVID-19 patients, very pronounced in ventilated patients, strongly associated with virus persistence and reversible with clinical recovery. T cell activation was measured by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood and proved to be much more meaningful than classical readouts with PBMCs. Monocytes responded stronger in males than females and IL-2 partially reversed T cell anergy. Downstream markers of T cell anergy were also found in fresh blood samples of critically ill patients with severe T cell anergy. Based on our data we were able to develop a score to predict fatal outcomes and to identify patients that may benefit from strategies to overcome T cell anergy.
    Keywords covid19
    Language English
    Publishing date 2020-09-23
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.09.21.20198671
    Database COVID19

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