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  1. Article ; Online: New targets for antimalarial drug discovery.

    Guerra, Francisco / Winzeler, Elizabeth A

    Current opinion in microbiology

    2022  Volume 70, Page(s) 102220

    Abstract: Phenotypic screening methods have placed numerous preclinical candidates into the antimalarial drug-discovery pipeline. As more chemically validated targets become available, efforts are shifting to target-based drug discovery. Here, we briefly review ... ...

    Abstract Phenotypic screening methods have placed numerous preclinical candidates into the antimalarial drug-discovery pipeline. As more chemically validated targets become available, efforts are shifting to target-based drug discovery. Here, we briefly review some of the most attractive targets that have been identified in recent years.
    MeSH term(s) Antimalarials/pharmacology ; Drug Discovery
    Chemical Substances Antimalarials
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2022.102220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A roadmap for malaria research.

    Winzeler, Elizabeth A

    Science (New York, N.Y.)

    2019  Volume 365, Issue 6455, Page(s) 753–754

    MeSH term(s) Animals ; Life Cycle Stages ; Malaria ; Parasites ; Plasmodium ; Transcriptome
    Language English
    Publishing date 2019-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aay5963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: New targets for antimalarial drug discovery

    Guerra, Francisco / Winzeler, Elizabeth A.

    Current opinion in microbiology. 2022 Sept. 10,

    2022  

    Abstract: Phenotypic screening methods have placed numerous preclinical candidates into the antimalarial drug discovery pipeline. As more chemically validated targets become available efforts are shifting to target-based drug discovery. Here we briefly review some ...

    Abstract Phenotypic screening methods have placed numerous preclinical candidates into the antimalarial drug discovery pipeline. As more chemically validated targets become available efforts are shifting to target-based drug discovery. Here we briefly review some of the most attractive targets that have been identified in recent years.
    Keywords antimalarials ; microbiology ; phenotype
    Language English
    Dates of publication 2022-0910
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2022.102220
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: A Sleeping Area of Malaria Research Awakes.

    Winzeler, Elizabeth A

    Cell host & microbe

    2018  Volume 23, Issue 3, Page(s) 292–295

    Abstract: Phenotypic screening methods have had a profound impact on antimalarial drug development, but assays that predict which compounds might provide a radical cure have remained elusive. In this issue of Cell Host & Microbe, Gural et al. (2018) report ... ...

    Abstract Phenotypic screening methods have had a profound impact on antimalarial drug development, but assays that predict which compounds might provide a radical cure have remained elusive. In this issue of Cell Host & Microbe, Gural et al. (2018) report hypnozoite culturing and systems to study these elusive, yet deadly, parasites.
    MeSH term(s) Animals ; Antimalarials ; Humans ; Malaria ; Parasites
    Chemical Substances Antimalarials
    Language English
    Publishing date 2018-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2018.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An improbable journey: Creativity helped me make the transition from art to curing malaria.

    Winzeler, Elizabeth A

    The Journal of biological chemistry

    2018  Volume 294, Issue 2, Page(s) 405–409

    Abstract: I was recently awarded the Alice and C. C. Wang Award in Molecular Parasitology for my contributions to antimalarial drug development, including laying the groundbreaking work that has led to two new molecular methods for curing malaria. This award means ...

    Abstract I was recently awarded the Alice and C. C. Wang Award in Molecular Parasitology for my contributions to antimalarial drug development, including laying the groundbreaking work that has led to two new molecular methods for curing malaria. This award means a great deal to me because I have spent much of my scientific career feeling like an imposter-one with the wrong sort of background and poor credentials. I am grateful for the recognition, and I am beginning to recognize that having an atypical background can be an advantage because it gives you a different perspective on a challenge. More generally, diversity in educational and cultural backgrounds is important because it can stimulate new ways of thinking and discovery.
    MeSH term(s) Antimalarials/therapeutic use ; Art/history ; Creativity ; History, 20th Century ; History, 21st Century ; Humans ; Malaria/drug therapy ; Malaria/history ; Malaria/parasitology ; Parasitology/history ; Plasmodium/drug effects ; Plasmodium/genetics ; Plasmodium/growth & development ; Plasmodium/physiology
    Chemical Substances Antimalarials
    Language English
    Publishing date 2018-11-06
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.AW118.005229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance.

    Winzeler, Elizabeth A

    Genome biology

    2017  Volume 18, Issue 1, Page(s) 79

    Abstract: A longitudinal analysis of malaria parasite genomes has revealed new markers that can be used in public health efforts to limit the spread of multidrug-resistant malaria. ...

    Abstract A longitudinal analysis of malaria parasite genomes has revealed new markers that can be used in public health efforts to limit the spread of multidrug-resistant malaria.
    MeSH term(s) Animals ; Antimalarials ; Artemisinins ; Drug Resistance/drug effects ; Genomics ; Longitudinal Studies ; Malaria, Falciparum ; Parasites/drug effects ; Plasmodium/drug effects ; Plasmodium falciparum/drug effects ; Protozoan Proteins
    Chemical Substances Antimalarials ; Artemisinins ; Protozoan Proteins
    Language English
    Publishing date 2017-04-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1465-6914 ; 1465-6906
    ISSN (online) 1474-760X ; 1465-6914
    ISSN 1465-6906
    DOI 10.1186/s13059-017-1219-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Glycophorin alleles link to malaria protection.

    Winzeler, Elizabeth A

    Science (New York, N.Y.)

    2017  Volume 356, Issue 6343, Page(s) 1122–1123

    MeSH term(s) Alleles ; Erythrocytes ; Glycophorin/genetics ; Humans ; Malaria/genetics ; Malaria, Falciparum/genetics ; Plasmodium falciparum
    Chemical Substances Glycophorin
    Language English
    Publishing date 2017--16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aan4184
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  8. Article ; Online: SnapShot: Antimalarial Drugs.

    Luth, Madeline R / Winzeler, Elizabeth A

    Cell

    2020  Volume 183, Issue 2, Page(s) 554–554.e1

    Abstract: Malaria is a prominent vector-borne illness caused by Plasmodium parasites. Therapeutic intervention remains a critical component for disease eradication efforts but is complicated by the emergence of drug resistance. This SnapShot summarizes the human- ... ...

    Abstract Malaria is a prominent vector-borne illness caused by Plasmodium parasites. Therapeutic intervention remains a critical component for disease eradication efforts but is complicated by the emergence of drug resistance. This SnapShot summarizes the human-relevant stages of the P. falciparum life cycle and describes how licensed antimalarials, clinical candidates, and newly emerging compounds target each stage to prevent, treat, or block transmission of malaria. To view this SnapShot, open or download the PDF.
    MeSH term(s) Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Disease Eradication ; Drug Resistance ; Humans ; Malaria/drug therapy ; Malaria/parasitology ; Malaria, Falciparum/parasitology ; Plasmodium/drug effects ; Plasmodium falciparum/drug effects
    Chemical Substances Antimalarials
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The antimalarial resistome - finding new drug targets and their modes of action.

    Carolino, Krypton / Winzeler, Elizabeth A

    Current opinion in microbiology

    2020  Volume 57, Page(s) 49–55

    Abstract: To this day, malaria remains a global burden, affecting millions of people, especially those in sub-Saharan Africa and Asia. The rise of drug resistance to current antimalarial treatments, including artemisinin-based combination therapies, has made ... ...

    Abstract To this day, malaria remains a global burden, affecting millions of people, especially those in sub-Saharan Africa and Asia. The rise of drug resistance to current antimalarial treatments, including artemisinin-based combination therapies, has made discovering new small molecule compounds with novel modes of action an urgent matter. The concerted effort to construct enormous compound libraries and develop high-throughput phenotypic screening assays to find compounds effective at specifically clearing malaria-causing Plasmodium parasites at any stage of the life cycle has provided many antimalarial prospects, but does not indicate their target or mode of action. Here, we review recent advances in antimalarial drug discovery efforts, focusing on the following 'omics' approaches in mode of action studies: IVIEWGA, CETSA, metabolomic profiling.
    MeSH term(s) Animals ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Drug Discovery ; Drug Resistance ; Humans ; Malaria/drug therapy ; Malaria/parasitology ; Plasmodium/drug effects ; Plasmodium/physiology
    Chemical Substances Antimalarials
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2020.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genomic Approaches to Drug Resistance in Malaria.

    Rocamora, Frances / Winzeler, Elizabeth A

    Annual review of microbiology

    2020  Volume 74, Page(s) 761–786

    Abstract: Although the last two decades have seen a substantial decline in malaria incidence and mortality due to the use of insecticide-treated bed nets and artemisinin combination therapy, the threat of drug resistance is a constant obstacle to sustainable ... ...

    Abstract Although the last two decades have seen a substantial decline in malaria incidence and mortality due to the use of insecticide-treated bed nets and artemisinin combination therapy, the threat of drug resistance is a constant obstacle to sustainable malaria control. Given that patients can die quickly from this disease, public health officials and doctors need to understand whether drug resistance exists in the parasite population, as well as how prevalent it is so they can make informed decisions about treatment. As testing for drug efficacy before providing treatment to malaria patients is impractical, researchers need molecular markers of resistance that can be more readily tracked in parasite populations. To this end, much work has been done to unravel the genetic underpinnings of drug resistance in
    MeSH term(s) Alleles ; Antiprotozoal Agents/pharmacology ; Artemisinins/pharmacology ; Drug Resistance/genetics ; Genomics/methods ; Humans ; Malaria/parasitology ; Phenotype ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/genetics ; Protozoan Proteins/genetics
    Chemical Substances Antiprotozoal Agents ; Artemisinins ; Protozoan Proteins ; artemisinin (9RMU91N5K2)
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207931-8
    ISSN 1545-3251 ; 0066-4227
    ISSN (online) 1545-3251
    ISSN 0066-4227
    DOI 10.1146/annurev-micro-012220-064343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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