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  1. Article: Severe Malaria in an Adult Patient from Low-Endemic Area in Flores Island, East Nusa Tenggara.

    Teressa, Maria / Purnama, Asep / Henrina, Joshua / Wiraatmadja, Agustinus / Boro, Angela M B / L Sam, Candida I / Dedang, Tersila A D / Cahyadi, Alius

    Case reports in medicine

    2023  Volume 2023, Page(s) 1239318

    Abstract: Malaria is an infection caused by protozoa of the ... ...

    Abstract Malaria is an infection caused by protozoa of the genus
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2502642-2
    ISSN 1687-9635 ; 1687-9627
    ISSN (online) 1687-9635
    ISSN 1687-9627
    DOI 10.1155/2023/1239318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Assessment of Circulating Tumor Cells in Colorectal Cancer as an Adjunctive Non-invasive Diagnostic Method.

    Nursyirwan, Saskia Aziza / Abdullah, Murdani / Sulaiman, Andri Sanityoso / Rinaldi, Ikhwan / Makmun, Dadang / Simadibrata, Marcellus / Noor, Dimas Ramadhian / Wiraatmadja, Agustinus / Jeo, Wifanto Saditya / Rahadiani, Nur / Handjari, Diah Rini / Shatri, Hamzah

    Acta medica Indonesiana

    2024  Volume 55, Issue 4, Page(s) 385–395

    Abstract: Background: Colorectal cancer (CRC) is a significant contributor to cancer-related morbidity and mortality. Biopsy remains the gold standard for CRC diagnosis, but invasive testing may not be preferred as an initial diagnostic procedure. Therefore, ... ...

    Abstract Background: Colorectal cancer (CRC) is a significant contributor to cancer-related morbidity and mortality. Biopsy remains the gold standard for CRC diagnosis, but invasive testing may not be preferred as an initial diagnostic procedure. Therefore, alternative non-invasive approaches are needed. Circulating tumor cells (CTC) present in the bloodstream have great potential as a non-invasive diagnostic marker for CRC patients. This study aimed to assess the diagnostic potential of CTC in CRC as an adjunctive diagnostic method using a subjective manual identification method and laser capture microdissection at 40x magnification.
    Methods: A cross-sectional study was conducted on adult patients suspected to have CRC at Dr. Cipto Mangunkusumo National General Hospital, Jakarta, between November 2020 and March 2021. CTC analysis was performed using the negative selection immunomagnetic method with Easysep™ and the CD44 mesenchymal tumor marker. The identification and quantification of CTC were conducted manually and subjectively, with three repetitions of cell counting per field of view at 40x magnification.
    Results: Of 80 subjects, 77.5% were diagnosed with CRC, while 7.5% and 15% exhibited adenomatous polyps and inflammatory/hyperplastic polyps, respectively. The diagnostic analysis of CTC for detecting CRC (compared to polyps) using a CTC cutoff point of >1.5 cells/mL suggested sensitivity, specificity, and positive predictive value (PPV) of 50%, 88.89%, and 93.94%. Additionally, the negative predictive value (NPV), as well as the positive and negative likelihood ratio (PLR and NLR) were 34.04%, 4.5, and 0.56, respectively. The subjective manual identification and quantification of CTC were performed at 40x magnification using laser capture microdissection.
    Conclusion: This study assessed the diagnostic potential of CTC examination in CRC as an adjunctive diagnostic method using the subjective manual identification method and laser capture microdissection at 40x magnification. Despite the limitations associated with subjective cell counting, the results showed 50% sensitivity and 88.89% specificity in diagnosing CRC. Further studies are needed to optimize the manual identification process and validate the clinical utility of CTC analysis in CRC patients.
    MeSH term(s) Adult ; Humans ; Colonography, Computed Tomographic/methods ; Neoplastic Cells, Circulating/pathology ; Cross-Sectional Studies ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Predictive Value of Tests
    Language English
    Publishing date 2024-01-12
    Publishing country Indonesia
    Document type Journal Article
    ZDB-ID 2474707-5
    ISSN 2338-2732 ; 0125-9326
    ISSN (online) 2338-2732
    ISSN 0125-9326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6834: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Gut Microbiota Profiles in Early- and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future.

    Abdullah, Murdani / Sukartini, Ninik / Nursyirwan, Saskia Aziza / Pribadi, Rabbinu Rangga / Maulahela, Hasan / Utari, Amanda Pitarini / Muzellina, Virly Nanda / Wiraatmadja, Agustinus / Renaldi, Kaka

    Digestion

    2021  Volume 102, Issue 6, Page(s) 823–832

    Abstract: Background: Researchers believe the role of gut microbiota dysbiosis in the raised incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be associated with microbiota dysbiosis either dependently or independently (combined ... ...

    Abstract Background: Researchers believe the role of gut microbiota dysbiosis in the raised incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be associated with microbiota dysbiosis either dependently or independently (combined with other risk factors).
    Summary: Recently, the rising of incidence and mortality of EOCRC have been noted. Some researchers are looking for risk factors influencing this fact. They hypothesize that it may be because of microbiota dysbiosis. Microbiota dysbiosis has been known to promote cancer development through immunity dysregulation and chronic inflammation. Microbiomes profile in late-onset colorectal cancer (LOCRC) among older patients has been documented, but there is still lack of data about microbial profiles among younger colorectal cancer (CRC) patients. This review tries to explain microbial profiles differences between EOCRC and LOCRC as a potential diagnostic biomarker in the future, and whether microbiota can have a role in EOCRC genesis. Key Messages: Microbiota does vary with age, and EOCRC may be associated with colonization of some specific bacteria. Further studies about gut microbiota profiles in EOCRC and LOCRC may provide a new insight on diagnostic biomarker of CRC.
    MeSH term(s) Biomarkers ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Dysbiosis ; Gastrointestinal Microbiome ; Humans ; Incidence
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000516689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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