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  1. Article ; Online: Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury.

    Bohnert, Simone / Wirth, Christoph / Schmitz, Werner / Trella, Stefanie / Monoranu, Camelia-Maria / Ondruschka, Benjamin / Bohnert, Michael

    International journal of legal medicine

    2021  Volume 135, Issue 4, Page(s) 1525–1535

    Abstract: The aim of this study was to investigate if the biomarkers myelin basic protein (MBP) and neurofilament-H (NF-H) yielded informative value in forensic diagnostics when examining cadaveric cerebrospinal fluid (CSF) biochemically via an enzyme-linked ... ...

    Abstract The aim of this study was to investigate if the biomarkers myelin basic protein (MBP) and neurofilament-H (NF-H) yielded informative value in forensic diagnostics when examining cadaveric cerebrospinal fluid (CSF) biochemically via an enzyme-linked immunosorbent assay (ELISA) and comparing the corresponding brain tissue in fatal traumatic brain injury (TBI) autopsy cases by immunocytochemistry versus immunohistochemistry. In 21 trauma and 19 control cases, CSF was collected semi-sterile after suboccipital puncture and brain specimens after preparation. The CSF MBP (p = 0.006) and NF-H (p = 0.0002) levels after TBI were significantly higher than those in cardiovascular controls. Immunohistochemical staining against MBP and against NF-H was performed on cortical and subcortical samples from also biochemically investigated cases (5 TBI cases/5 controls). Compared to the controls, the TBI cases showed a visually reduced staining reaction against MBP or repeatedly ruptured neurofilaments against NF-H. Immunocytochemical tests showed MBP-positive phagocytizing macrophages in CSF with a survival time of > 24 h. In addition, numerous TMEM119-positive microglia could be detected with different degrees of staining intensity in the CSF of trauma cases. As a result, we were able to document that elevated levels of MBP and NF-H in the CSF should be considered as useful neuroinjury biomarkers of traumatic brain injury.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Autopsy ; Biomarkers/cerebrospinal fluid ; Brain Injuries, Traumatic/diagnosis ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunohistochemistry/methods ; Male ; Middle Aged ; Myelin Basic Protein/cerebrospinal fluid ; Neurofilament Proteins/cerebrospinal fluid
    Chemical Substances Biomarkers ; Myelin Basic Protein ; Neurofilament Proteins ; neurofilament protein H (108688-71-7)
    Language English
    Publishing date 2021-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-021-02606-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of age and sex on the concentrations of glutamate and glutamine in the human brain.

    Hädel, Sven / Wirth, Christoph / Rapp, Michael / Gallinat, Jürgen / Schubert, Florian

    Journal of magnetic resonance imaging : JMRI

    2013  Volume 38, Issue 6, Page(s) 1480–1487

    Abstract: Purpose: To determine the effects of age and sex on cerebral glutamate and glutamine concentrations in a large sample of healthy humans using a dedicated measuring and evaluation procedure. Exploratory examinations of other brain metabolites were also ... ...

    Abstract Purpose: To determine the effects of age and sex on cerebral glutamate and glutamine concentrations in a large sample of healthy humans using a dedicated measuring and evaluation procedure. Exploratory examinations of other brain metabolites were also conducted.
    Materials and methods: In 118 healthy subjects aged 19 to 55 years (59 female) absolute concentrations of glutamate, glutamine, N-acetylaspartate (NAA), total creatine, and total choline (tCho) in voxels comprising the left hippocampus (HC) and the anterior cingulate cortex (ACC) were investigated using point-resolved spectroscopy with an echo time of 80 ms at 3 Tesla in combination with a reliable quantification procedure. Special care was taken to correct for multiple comparisons.
    Results: An age-related decline of the concentrations of glutamate in both regions studied was observed whereas glutamine levels in ACC increased with age. Statistically significant sex-related differences were detected for glutamate in the HC and for tCho in the ACC. NAA decreased with age in both regions, the significance not surviving Bonferroni correction.
    Conclusion: The results demonstrate effects of age and gender on glutamate, glutamine, choline containing compounds, and NAA in healthy human brain. They add to the growing evidence for gender-specific differences in cerebral neurotransmission, metabolism, and structure across the lifespan.
    MeSH term(s) Adult ; Aging/metabolism ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Choline/metabolism ; Female ; Glutamic Acid/metabolism ; Glutamine/metabolism ; Gyrus Cinguli/metabolism ; Hippocampus/metabolism ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy/methods ; Male ; Neurotransmitter Agents/metabolism ; Reproducibility of Results ; Sensitivity and Specificity ; Sex Factors ; Young Adult
    Chemical Substances Neurotransmitter Agents ; Glutamine (0RH81L854J) ; Aspartic Acid (30KYC7MIAI) ; Glutamic Acid (3KX376GY7L) ; N-acetylaspartate (997-55-7) ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.24123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3648: Show issues Location:
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    Zs.MO 236: Show issues

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  3. Article ; Online: Diffusion- and reaction-limited growth of carbon nanotube forests.

    Wirth, Christoph Tobias / Zhang, Can / Zhong, Guofang / Hofmann, Stephan / Robertson, John

    ACS nano

    2009  Volume 3, Issue 11, Page(s) 3560–3566

    Abstract: We present a systematic study of the temperature and pressure dependence of the growth rate of vertically aligned small diameter (single- and few-walled) carbon nanotube forests grown by thermal chemical vapor deposition over the temperature range 560- ... ...

    Abstract We present a systematic study of the temperature and pressure dependence of the growth rate of vertically aligned small diameter (single- and few-walled) carbon nanotube forests grown by thermal chemical vapor deposition over the temperature range 560-800 degrees C and 10(-5) to 14 mbar partial pressure range, using acetylene as the feedstock and Al(2)O(3)-supported Fe nanoparticles as the catalyst. We observe a pressure dependence of P(0.6) and activation energies of <1 eV. We interpret this as a growth rate limited by carbon diffusion in the catalyst, preceded by a pre-equilibrium of acetylene dissociation on the catalyst surface. The carbon nanotube forest growth was recorded by high-resolution real-time optical imaging.
    Language English
    Publishing date 2009-11-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/nn900613e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: On the mechanisms of Ni-catalysed graphene chemical vapour deposition.

    Weatherup, Robert S / Bayer, Bernhard C / Blume, Raoul / Baehtz, Carsten / Kidambi, Piran R / Fouquet, Martin / Wirth, Christoph T / Schlögl, Robert / Hofmann, Stephan

    Chemphyschem : a European journal of chemical physics and physical chemistry

    2012  Volume 13, Issue 10, Page(s) 2544–2549

    Language English
    Publishing date 2012-07-16
    Publishing country Germany
    Document type Journal Article
    ISSN 1439-7641
    ISSN (online) 1439-7641
    DOI 10.1002/cphc.201101020
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  5. Book ; Thesis: Experimentelle Untersuchungen des Ausflussverhaltens rohrbruchähnlicher Querschnitte

    Wirth, Christoph

    1983  

    Author's details von Christoph Wirth
    Language German
    Size VII, 101 S, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Darmstadt, 1983
    Database Former special subject collection: coastal and deep sea fishing

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  6. Book ; Thesis: Experimentelle Untersuchungen des Ausflussverhaltens rohrbruchähnlicher Querschnitte

    Wirth, Christoph

    1983  

    Author's details von Christoph Wirth
    Language German
    Size VII, 101 S, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Darmstadt, 1983
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex.

    Gallinat, Jürgen / Schubert, Florian / Brühl, Rüdiger / Hellweg, Rainer / Klär, Andreas A / Kehrer, Colin / Wirth, Christoph / Sander, Thomas / Lang, Undine E

    NeuroImage

    2010  Volume 49, Issue 1, Page(s) 767–771

    Abstract: Decreased levels of N-acetylaspartate (NAA) and brain-derived neurotrophic factor (BDNF) in the anterior cingulate cortex (ACC) have been linked to neuronal loss and psychiatric disorders like schizophrenia and bipolar disorder. We previously found that ... ...

    Abstract Decreased levels of N-acetylaspartate (NAA) and brain-derived neurotrophic factor (BDNF) in the anterior cingulate cortex (ACC) have been linked to neuronal loss and psychiatric disorders like schizophrenia and bipolar disorder. We previously found that BDNF serum concentration was predicted by the concentration of NAA in the ACC, indicating that neuronal integrity and vitality of a cortical region like the ACC, as reflected by a high concentration of NAA, might be related to high concentrations of BDNF in serum. Moreover, our recent finding that Val66Met genotype appears to predict the BDNF serum level in healthy human volunteers suggests the Met allele to be connected to higher concentrations of BDNF in serum. We examined absolute NAA concentrations in the ACC and hippocampus of 40 male and 42 female healthy volunteers (age: 33.3+/-9 years). We found NAA in the ACC to be significantly increased in Met carriers (F=5.2, df=1, p=0.025). On the other hand, the concentration of creatine+phosphocreatine in the hippocampus was significantly decreased in Met carriers. We hypothesize that higher NAA levels in the ACC might contribute to the protection of Met allele carriers against major psychiatric disorders as schizophrenia and bipolar disorder.
    MeSH term(s) Adult ; Amino Acid Substitution ; Analysis of Variance ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Brain Chemistry/genetics ; Brain Chemistry/physiology ; Brain-Derived Neurotrophic Factor/genetics ; Cerebral Cortex/metabolism ; Choline/metabolism ; Creatine/metabolism ; Female ; Genotype ; Heterozygote ; Hippocampus/metabolism ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Methionine/genetics ; Methionine/physiology ; Neurons/physiology ; Polymorphism, Single Nucleotide ; Valine/genetics ; Valine/physiology
    Chemical Substances Brain-Derived Neurotrophic Factor ; Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7) ; Methionine (AE28F7PNPL) ; Valine (HG18B9YRS7) ; Creatine (MU72812GK0) ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2010-01-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2009.08.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3664: Show issues Location:
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    Zs.MO 7: Show issues

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  8. Book: Feinwerkelemente

    Ringhandt, Horst / Wirth, Christoph

    Verbindungen, Bauteile, Baugruppen ; mit einer Einführung in die Mikromechanik

    (Das Fachwissen der Technik)

    1992  

    Author's details Horst Ringhandt ; Christoph Wirth
    Series title Das Fachwissen der Technik
    Language German
    Size 311 S, Ill., zahlr. graph. Darst, 23 cm
    Edition 3., neubearb. Aufl.
    Publisher Hanser
    Publishing place München u.a.
    Document type Book
    Note Literaturverz. S. 304 - 305
    ISBN 3446160531 ; 9783446160538
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Journal: Das konzentrische Aluminium-Abgassystem als nachgeschalteter Waermetauscher

    Wirth, Christoph A. / Kesa, Juergen / Bretschneider, Peter

    Das Schornsteinfegerhandwerk : Das Magazin des Bundesverbandes

    1998  Volume 52, Page(s) 13–19, 21–24

    Abstract: Besonders bei Brennwert-, aber auch bei konventionellen Heizgeraeten sollte ein raumluftunabhaengiger Anschluss der Abgasanlage mit Verbrennungsluftzu- und Abgasabfuehrung im Gegenstrom eingesetzt werden, sofern diese Heizgeraete dafuer geeignet sind. ... ...

    Abstract Besonders bei Brennwert-, aber auch bei konventionellen Heizgeraeten sollte ein raumluftunabhaengiger Anschluss der Abgasanlage mit Verbrennungsluftzu- und Abgasabfuehrung im Gegenstrom eingesetzt werden, sofern diese Heizgeraete dafuer geeignet sind. Als Material fuer die Abgasleitung bietet sich aufgrund der guten Waermeuebertragung vor allem Aluminium an. Dieser raumluftunabhaengige Anschluss ermoeglicht eine effektive Energieausnutzung der gesamten Feuerstaette. Durch die Nutzung der Abgasleitung als Gegenstrom-Waermetauscher kann unter fast allen Betriebszustaenden eine Kondensationswaermenutzung im Gesamtsystem erreicht werden. Es wird davon ausgegangen, dass hiermit eine nicht unerhebliche Energieeinsparung erzielbar ist. Somit hat nun jeder Architekt bzw. Planer, jeder Bauherr, jeder Heizungsbauer und Schornsteinfeger die Moeglichkeit, mit seinem technischen Wissen, seiner fachlichen Beratung bzw. seiner persoenlichen Entscheidung aktiv seinen Beitrag zum verantwortungsbewussten und sparsamen Umgang mit Primaerenergie und damit zum Umweltschutz zu leisten.
    Keywords Waermetauscher ; Heizung ; Abgasableitung ; Aluminium ; Brennwertnutzung ; Energietechnik ; Feuerung ; Waermeerzeugung ; Warmwasserbereitung ; Lueftung ; Versuchsanlage ; Anlagenbeschreibung ; Einfamilienhaus ; Abgastemperatur ; Anlagenbetrieb ; Schornstein ; Rechenmodell ; Vergleichsuntersuchung ; Energieeinsparung ; Abgasstrahl ; Lufttemperatur ; Berechnungsverfahren ; Temperaturmessung ; Kamin ; Energieverbrauch ; Minderungspotenzial ; Wirkungsgradverbesserung ; Abwaermenutzung ; Waermetransport ; Zulassung
    Language German
    Document type Journal
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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  10. Article: Ledge-flow-controlled catalyst interface dynamics during Si nanowire growth.

    Hofmann, Stephan / Sharma, Renu / Wirth, Christoph T / Cervantes-Sodi, Felipe / Ducati, Caterina / Kasama, Takeshi / Dunin-Borkowski, Rafal E / Drucker, Jeff / Bennett, Peter / Robertson, John

    Nature materials

    2008  Volume 7, Issue 5, Page(s) 372–375

    Abstract: Self-assembled nanowires offer the prospect of accurate and scalable device engineering at an atomistic scale for applications in electronics, photonics and biology. However, deterministic nanowire growth and the control of dopant profiles and ... ...

    Abstract Self-assembled nanowires offer the prospect of accurate and scalable device engineering at an atomistic scale for applications in electronics, photonics and biology. However, deterministic nanowire growth and the control of dopant profiles and heterostructures are limited by an incomplete understanding of the role of commonly used catalysts and specifically of their interface dynamics. Although catalytic chemical vapour deposition of nanowires below the eutectic temperature has been demonstrated in many semiconductor-catalyst systems, growth from solid catalysts is still disputed and the overall mechanism is largely unresolved. Here, we present a video-rate environmental transmission electron microscopy study of Si nanowire formation from Pd silicide crystals under disilane exposure. A Si crystal nucleus forms by phase separation, as observed for the liquid Au-Si system, which we use as a comparative benchmark. The dominant coherent Pd silicide/Si growth interface subsequently advances by lateral propagation of ledges, driven by catalytic dissociation of disilane and coupled Pd and Si diffusion. Our results establish an atomistic framework for nanowire assembly from solid catalysts, relevant also to their contact formation.
    Language English
    Publishing date 2008-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/nmat2140
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