LIVIVO - Search results -

Search results

Result 1 - 8 of total 8

Search options

Article ; Online: Aging in Autism Spectrum Disorder.

Wise, Elizabeth A

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

2019 Volume 28, Issue 3, Page(s) 339–349

Abstract: Most research on autism spectrum disorder (ASD) has focused on younger individuals, but there is increasing awareness that more must be known about the clinical needs and outcomes of older adults with ASD. This article reviews what is known about ... ...

Abstract	Most research on autism spectrum disorder (ASD) has focused on younger individuals, but there is increasing awareness that more must be known about the clinical needs and outcomes of older adults with ASD. This article reviews what is known about barriers to recognition in the elderly, the prevalence of ASD over the lifespan, outcomes in adulthood in comparison to the general population, co-occurring psychiatric diagnoses, and healthcare needs in this population.
MeSH term(s)	Aging/psychology ; Autism Spectrum Disorder/epidemiology ; Comorbidity ; Health Services Needs and Demand/statistics & numerical data ; Humans ; Mental Disorders/epidemiology ; Outcome Assessment, Health Care ; Prevalence
Language	English
Publishing date	2019-12-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1278145-9
ISSN	1545-7214 ; 1064-7481
ISSN (online)	1545-7214
ISSN	1064-7481
DOI	10.1016/j.jagp.2019.12.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4443: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Graphical methods for understanding changes in states: Understanding medication use pathways.

Wise, Elizabeth A / Adams, Roy J / Lyketsos, Constantine G / Leoutsakos, Jeannie-Marie

International journal of methods in psychiatric research

2022 Volume 31, Issue 4, Page(s) e1932

Abstract: Objectives: As epidemiological studies become longer and larger, the field needs novel graphical methods to visualize complex longitudinal data. The aim of this study was to present the Slinkyplot, a longitudinal crosstabulation, to illustrate patterns ... ...

Abstract	Objectives: As epidemiological studies become longer and larger, the field needs novel graphical methods to visualize complex longitudinal data. The aim of this study was to present the Slinkyplot, a longitudinal crosstabulation, to illustrate patterns of antidepressant use in a large prospective cohort of older adults with mild cognitive impairment. Methods: Data from the National Alzheimer's Coordinating Center are used to track switches between different states and types of antidepressant use. A Slinkyplot is populated with rows representing the state of medication use at each timepoint and columns representing the state at each subsequent visit. Results: The constructed Slinkyplots display the common practice of switching on and off different antidepressants over time, with citalopram, sertraline, and bupropion most commonly used followed by switching to another SSRI or SNRI as second-line treatment. Conclusions: Slinkyplots are an innovative graphical means of visualizing complex patterns of transitions between different states over time for large longitudinal studies.
MeSH term(s)	Humans ; Aged ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Prospective Studies ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Citalopram/therapeutic use ; Sertraline/pharmacology ; Sertraline/therapeutic use
Chemical Substances	Serotonin Uptake Inhibitors ; Antidepressive Agents ; Citalopram (0DHU5B8D6V) ; Sertraline (QUC7NX6WMB)
Language	English
Publishing date	2022-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1078002-6
ISSN	1557-0657 ; 1049-8931
ISSN (online)	1557-0657
ISSN	1049-8931
DOI	10.1002/mpr.1932
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3262: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Correlates of daily functioning in older adults with autism spectrum disorder.

Wise, Elizabeth A / Smith, Marcia D / Rabins, Peter V

Aging & mental health

2019 Volume 24, Issue 10, Page(s) 1754–1762

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Activities of Daily Living ; Aged ; Autism Spectrum Disorder ; Cross-Sectional Studies ; Humans ; Occupations ; Surveys and Questionnaires
Language	English
Publishing date	2019-07-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1474804-6
ISSN	1364-6915 ; 1360-7863
ISSN (online)	1364-6915
ISSN	1360-7863
DOI	10.1080/13607863.2019.1647138
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5081: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Time course of neuropsychiatric symptoms and cognitive diagnosis in National Alzheimer's Coordinating Centers volunteers.

Wise, Elizabeth A / Rosenberg, Paul B / Lyketsos, Constantine G / Leoutsakos, Jeannie-Marie

Alzheimer's & dementia (Amsterdam, Netherlands)

2019 Volume 11, Page(s) 333–339

Abstract: Introduction: Neuropsychiatric symptoms (NPSs) are nearly universal in cognitive disorders. The mild behavioral impairment construct postulates that NPS may be the first symptom of impending dementia.: Methods: Participants were cognitively normal ... ...

Abstract	Introduction: Neuropsychiatric symptoms (NPSs) are nearly universal in cognitive disorders. The mild behavioral impairment construct postulates that NPS may be the first symptom of impending dementia. Methods: Participants were cognitively normal volunteers followed up approximately annually at Alzheimer's Disease Centers, who were assessed on the Neuropsychiatric Inventory and had at least one follow-up visit during which they were diagnosed with mild cognitive impairment (MCI) or dementia. Descriptive statistics were used to determine sequencing of NPS presence with cognitive diagnoses. Results: Data were available for 1998 participants who progressed to MCI or dementia. Over 59% developed NPS before the diagnosis of any cognitive disorder. Depression and irritability were the most common NPSs to precede cognitive diagnoses (24 and 21%, respectively). Discussion: NPSs precede a cognitive diagnosis in most people who develop cognitive decline, both MCI and dementia. These individuals are an important group to focus clinical and research efforts.
Language	English
Publishing date	2019-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1016/j.dadm.2019.02.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Aging and Autism Spectrum Disorder: A Naturalistic, Longitudinal Study of the Comorbidities and Behavioral and Neuropsychiatric Symptoms in Adults with ASD.

Wise, Elizabeth A / Smith, Marcia D / Rabins, Peter V

Journal of autism and developmental disorders

2017 Volume 47, Issue 6, Page(s) 1708–1715

Abstract: Little is known about Autism Spectrum Disorder (ASD) in persons over age 50. In a retrospective, naturalistic review of 74 individuals aged 30 and older meeting DSM-5 criteria for ASD, the point prevalence of behavioral and neuropsychiatric symptoms ( ... ...

Abstract	Little is known about Autism Spectrum Disorder (ASD) in persons over age 50. In a retrospective, naturalistic review of 74 individuals aged 30 and older meeting DSM-5 criteria for ASD, the point prevalence of behavioral and neuropsychiatric symptoms (BNPS) declined significantly for 12 of 13 BNPS over a mean of 25 years while many other features of ASD remained stable. GI disorders (68.9%) and seizure disorders (23%) were common, and 25.7% of the sample had a BMI >30. Females were more likely to engage in screaming (p < 0.05) and oppositional behavior (p < 0.05). Current age did not have a significant effect on BNPS prevalence.
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-017-3095-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 765: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Trajectories of neuropsychiatric symptoms over time in healthy volunteers and risk of MCI and dementia.

Leoutsakos, Jeannie-Marie S / Wise, Elizabeth A / Lyketsos, Constantine G / Smith, Gwenn S

International journal of geriatric psychiatry

2019 Volume 34, Issue 12, Page(s) 1865–1873

Abstract: Objectives: To identify subtypes of neuropsychiatric symptom (NPS) course among cognitively normal individuals and to assess the association between these subtypes and hazard of later mild cognitive impairment (MCI) or dementia diagnosis.: Methods: ... ...

Abstract	Objectives: To identify subtypes of neuropsychiatric symptom (NPS) course among cognitively normal individuals and to assess the association between these subtypes and hazard of later mild cognitive impairment (MCI) or dementia diagnosis. Methods: We modeled neuropsychiatric inventory questionnaire (NPI-Q) scores from 4184 volunteers over approximately 4 years using growth mixture models, generating latent classes of trajectory. We then fit Cox proportional hazard models to determine if membership in trajectory classes was associated with increased hazard of diagnosis of MCI or dementia. Results: We identified four trajectory classes: the majority of the sample (65%) would be expected to belong to a class with consistently low or zero NPS. The next most prevalent class, (16%) showed a decrease over time in NPI-Q total score but, compared with the majority class had an almost threefold increase in hazard of MCI or dementia (HR: 2.92; 95% CI: 1.82-4.68). Another class (14%) showed an increase in NPS over time and was also associated with greater hazard of MCI or dementia (HR: 3.96; CI: 2.61-6.03). The smallest class (5%) had high and fluctuating NPI-Q total scores and had the greatest hazard (HR: 4.57; CI: 2.72-7.63). Conclusion: We have demonstrated that it is possible to identify meaningful groups of NPS trajectories and that trajectory of NPS can convey information beyond a single cross-sectional measure. While even those whose NPS improved were at increased hazard of MCI or dementia, hazard increased as a function of the severity of the NPS trajectory.
MeSH term(s)	Aged ; Aged, 80 and over ; Cognitive Dysfunction/psychology ; Cross-Sectional Studies ; Dementia/psychology ; Disease Progression ; Female ; Humans ; Male ; Mental Disorders/classification ; Mental Disorders/diagnosis ; Neuropsychological Tests ; Prevalence ; Proportional Hazards Models
Language	English
Publishing date	2019-09-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5203
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2208: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: An injectable capillary-like microstructured alginate hydrogel improves left ventricular function after myocardial infarction in rats.

Rocca, Domenico G Della / Willenberg, Bradley J / Qi, Yanfei / Simmons, Chelsey S / Rubiano, Andres / Ferreira, Leonardo F / Huo, Tianyao / Petersen, John W / Ruchaya, Prashant J / Wate, Prateek S / Wise, Elizabeth A / Handberg, Eileen M / Cogle, Christopher R / Batich, Christopher D / Byrne, Barry J / Pepine, Carl J

International journal of cardiology

2016 Volume 220, Page(s) 149–154

Abstract: Background: A new post-myocardial infarction (MI) therapy is injection of high-water-content polymeric biomaterial gels (hydrogels) into damaged myocardium to modulate cardiac negative remodeling and preserve heart function.: Methods: We investigated ...

Abstract	Background: A new post-myocardial infarction (MI) therapy is injection of high-water-content polymeric biomaterial gels (hydrogels) into damaged myocardium to modulate cardiac negative remodeling and preserve heart function. Methods: We investigated the therapeutic potential of a novel gelatinized alginate hydrogel with a unique microstructure of uniform capillary-like channels (termed Capgel). Shortly (48h) after induced anterior MI, Sprague Dawley rats received intramyocardial injection of Capgel directly into the antero-septal wall at the infarct border zone (n=12) or no injection (n=10, controls). Echocardiograms were performed at 48h (week 0) and 4weeks (week 4) to evaluate left ventricular function. Results: Echocardiograms showed 27% improvement of left ventricular systolic function over time with gel injection: fractional shortening increased from 26±3% at week 0 to 33±2% at week 4 (p=0.001). Capgel was present at the injection site after 4weeks, but was minimal at 8weeks. The remaining gel was heavily populated by CD68(+) macrophages with CD206(+) clusters and blood vessels. An in vitro experiment was performed to assess Angiotensin-(1-7) released from Capgel. Angiotensin-(1-7) was released from the Capgel in a sustained manner for 90days. Conclusions: Use of Capgel, a degradable, bioactive hydrogel composed of gelatinized capillary-alginate gel, appears safe for intramyocardial injection, is associated with improved left ventricular function after MI in rats, and may provide a long-term supply of Angiotensin-(1-7).
MeSH term(s)	Alginates/chemistry ; Alginates/pharmacology ; Angiotensin I/chemistry ; Angiotensin I/pharmacology ; Animals ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Disease Models, Animal ; Echocardiography/methods ; Gelatin/pharmacology ; Glucuronic Acid/chemistry ; Glucuronic Acid/pharmacology ; Hexuronic Acids/chemistry ; Hexuronic Acids/pharmacology ; Hydrogels/pharmacology ; Injections, Intralesional/methods ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Peptide Fragments/chemistry ; Peptide Fragments/pharmacology ; Rats ; Rats, Sprague-Dawley ; Treatment Outcome ; Ventricular Function, Left/physiology ; Ventricular Remodeling/drug effects
Chemical Substances	Alginates ; Biocompatible Materials ; Hexuronic Acids ; Hydrogels ; Peptide Fragments ; Glucuronic Acid (8A5D83Q4RW) ; alginic acid (8C3Z4148WZ) ; Gelatin (9000-70-8) ; Angiotensin I (9041-90-1) ; angiotensin I (1-7) (IJ3FUK8MOF)
Language	English
Publishing date	2016-10-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2016.06.158
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1673: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A genomics-informed computational biology platform prospectively predicts treatment responses in AML and MDS patients.

Drusbosky, Leylah M / Singh, Neeraj Kumar / Hawkins, Kimberly E / Salan, Cesia / Turcotte, Madeleine / Wise, Elizabeth A / Meacham, Amy / Vijay, Vindhya / Anderson, Glenda G / Kim, Charlie C / Radhakrishnan, Saumya / Ullal, Yashaswini / Talawdekar, Anay / Sikora, Huzaifa / Nair, Prashant / Khanna-Gupta, Arati / Abbasi, Taher / Vali, Shireen / Guha, Subharup /

Farhadfar, Nosha / Murthy, Hemant S / Horn, Biljana N / Leather, Helen L / Castillo, Paul / Tucker, Caitlin / Cline, Christina / Pettiford, Leslie / Lamba, Jatinder K / Moreb, Jan S / Brown, Randy A / Norkin, Maxim / Hiemenz, John W / Hsu, Jack W / Slayton, William B / Wingard, John R / Cogle, Christopher R

Blood advances

2019 Volume 3, Issue 12, Page(s) 1837–1847

Abstract: Patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) are generally older and have more comorbidities. Therefore, identifying personalized treatment options for each patient early and accurately is essential. To address this, we ... ...

Abstract	Patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) are generally older and have more comorbidities. Therefore, identifying personalized treatment options for each patient early and accurately is essential. To address this, we developed a computational biology modeling (CBM) and digital drug simulation platform that relies on somatic gene mutations and gene CNVs found in malignant cells of individual patients. Drug treatment simulations based on unique patient-specific disease networks were used to generate treatment predictions. To evaluate the accuracy of the genomics-informed computational platform, we conducted a pilot prospective clinical study (NCT02435550) enrolling confirmed MDS and AML patients. Blinded to the empirically prescribed treatment regimen for each patient, genomic data from 50 evaluable patients were analyzed by CBM to predict patient-specific treatment responses. CBM accurately predicted treatment responses in 55 of 61 (90%) simulations, with 33 of 61 true positives, 22 of 61 true negatives, 3 of 61 false positives, and 3 of 61 false negatives, resulting in a sensitivity of 94%, a specificity of 88%, and an accuracy of 90%. Laboratory validation further confirmed the accuracy of CBM-predicted activated protein networks in 17 of 19 (89%) samples from 11 patients. Somatic mutations in the
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Computational Biology/methods ; Computational Biology/statistics & numerical data ; DNA Copy Number Variations/genetics ; DNA Methylation/drug effects ; DNA-Binding Proteins/genetics ; Dioxygenases ; Enhancer of Zeste Homolog 2 Protein/genetics ; Female ; Genomics/instrumentation ; Humans ; Isocitrate Dehydrogenase/genetics ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Male ; Middle Aged ; Mutation ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Non-Randomized Controlled Trials as Topic ; Precision Medicine/instrumentation ; Predictive Value of Tests ; Prospective Studies ; Proto-Oncogene Proteins/genetics ; Repressor Proteins/genetics ; Sensitivity and Specificity ; Transcription Factors/genetics ; Treatment Outcome
Chemical Substances	ASXL1 protein, human ; DNA-Binding Proteins ; Proto-Oncogene Proteins ; Repressor Proteins ; Transcription Factors ; IDH2 protein, human (EC 1.1.1.41) ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.) ; Dioxygenases (EC 1.13.11.-) ; TET2 protein, human (EC 1.13.11.-) ; EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43)
Language	English
Publishing date	2019-06-12
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2018028316
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7153: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito