Article ; Online: CKD in Recipients of Nonkidney Solid Organ Transplants: A Review.
American journal of kidney diseases : the official journal of the National Kidney Foundation
2021 Volume 80, Issue 1, Page(s) 108–118
Abstract: Chronic kidney disease (CKD) after solid organ transplant is a common clinical presentation, affecting 10% to 20% of liver, heart, and lung transplant recipients and accounting for approximately 5% of the kidney transplant waiting list. The causes of CKD ...
| Abstract | Chronic kidney disease (CKD) after solid organ transplant is a common clinical presentation, affecting 10% to 20% of liver, heart, and lung transplant recipients and accounting for approximately 5% of the kidney transplant waiting list. The causes of CKD are different for different types of transplants and are not all, or even predominantly, due to calcineurin inhibitor toxicity, with significant heterogeneity particularly in liver transplant recipients. Many solid organ transplant recipients with advanced CKD benefit from kidney transplantation but have a higher rate of death while waitlisted and higher mortality after transplant than the general kidney failure population. Recent organ allocation policies and proposals have attempted to address the appropriate identification and prioritization of candidates in need of a kidney transplant, either simultaneous with or after nonkidney transplant. Future research should focus on predictive factors for individuals identified as being at high risk for progression to kidney failure and death and on strategies to preserve kidney function and minimize the CKD burden in this unique patient population. |
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| MeSH term(s) | Humans ; Kidney ; Kidney Transplantation/adverse effects ; Organ Transplantation ; Renal Insufficiency ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/surgery ; Risk Factors |
| Language | English |
| Publishing date | 2021-12-31 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 604539-x |
| ISSN | 1523-6838 ; 0272-6386 |
| ISSN (online) | 1523-6838 |
| ISSN | 0272-6386 |
| DOI | 10.1053/j.ajkd.2021.10.014 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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