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  1. Book ; Thesis: Analyse orthopädischer Gutachten aus den Jahren 1985 - 1992 unter besonderer Berücksichtigung der Begutachtung von Meniskusveränderungen

    Wissing, Martin

    2000  

    Author's details vorgelegt von: Martin Wissing
    Language German
    Size III, 82 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 2000
    HBZ-ID HT012840419
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Preemptive Antibody Therapy for Vaccine Breakthrough SARS-CoV-2 Infection in Immunocompromised Patients.

    Catalano, Concetta / Servais, Sophie / Bonvoisin, Catherine / Couturier, Bruno / Hildebrand, Marc / Etienne, Isabelle / Meuris, Christelle / Goffard, Jean-Christophe / Wissing, Martin / Goldman, Michel / Le Moine, Alain

    Transplantation

    2021  Volume 105, Issue 12, Page(s) e282

    MeSH term(s) COVID-19 ; Humans ; Immunocompromised Host ; SARS-CoV-2 ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000003942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Analyse orthopädischer Gutachten aus den Jahren 1985 - 1992 unter besonderer Berücksichtigung der Begutachtung von Meniskusveränderungen

    Wissing, Martin

    2000  

    Author's details vorgelegt von: Martin Wissing
    Language German
    Size 1 Mikrofiche, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Münster (Westfalen), 2000
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article ; Online: Ticlopidine and clopidogrel, sometimes combined with aspirin, only minimally increase the surgical risk in renal transplantation: a case-control study.

    Benahmed, Ahmed / Kianda, Mireille / Ghisdal, Lidia / Broeders, Nilufer / Massart, Annick / Lemy, Anne / Mikhalski, Dimitri / Hoang, Anh Dung / Donckier, Vincent / Sadis, Claude / Le Moine, Alain / Madhoun, Philippe / Racapé, Judith / Wissing, Martin / Abramowicz, Daniel

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2014  Volume 29, Issue 2, Page(s) 463–466

    Abstract: Background: Patients undergoing kidney transplantation are sometimes being treated with antiplatelet agents such as ticlopidine or clopidogrel. Some teams refuse to wait-list these patients for fear of bleeding during transplant surgery.: Methods: We ...

    Abstract Background: Patients undergoing kidney transplantation are sometimes being treated with antiplatelet agents such as ticlopidine or clopidogrel. Some teams refuse to wait-list these patients for fear of bleeding during transplant surgery.
    Methods: We retrospectively reviewed the records of 702 adult patients with a kidney transplant alone between 2000 and 2010. Nineteen (2.7%) patients were taking clopidogrel or ticlopidine when called in for transplantation. Furthermore, 10 of these 19 patients were also taking low-dose aspirin (ASA). We compared the risk of bleeding peri- and postoperatively, and the occurrence of cardiovascular complications within 30 days after renal transplantation between 19 cases and 39 controls randomly selected within the cohort.
    Results: Platelets were administered to 7 cases (37%) versus 0 controls (P<0.001). A single case (5.3%) presented with significant bleeding during surgery following an implantation biopsy, and required 4 red bood cell (RBC) units. During the first day, 3 of the 19 cases (16%) and 1 of the 39 controls required RBC (P=0.1). No reoperation was performed for bleeding. After the transplant, clopidogrel or ticlopidine was resumed in only two patients. The platelet count and haemoglobin were similar between cases and controls at Day 30. No cardiovascular event occurred in cases or controls during the first month post-transplantation. At 5 years, graft and patient survival was similar in cases and controls.
    Conclusions: Clopidogrel and ticlopidine, sometimes in combination with ASA, are associated with a low risk of bleeding during renal transplantation and does not seem to be a contraindication for renal transplant surgery.
    MeSH term(s) Aspirin/administration & dosage ; Blood Loss, Surgical/prevention & control ; Case-Control Studies ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Graft Survival ; Humans ; Incidence ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/administration & dosage ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Prognosis ; Retrospective Studies ; Risk ; Risk Factors ; Survival Rate/trends ; Ticlopidine/administration & dosage ; Ticlopidine/analogs & derivatives ; Time Factors
    Chemical Substances Platelet Aggregation Inhibitors ; clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gft385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Efficacy and cardiovascular safety of daclizumab, mycophenolate mofetil, tacrolimus, and early steroid withdrawal in renal transplant recipients: a multicenter, prospective, pilot trial.

    Abramowicz, Daniel / Vanrenterghem, Yves / Squifflet, Jean-Paul / Kuypers, Dirk / Mourad, Michel / Meurisse, Michel / Wissing, Martin

    Clinical transplantation

    2005  Volume 19, Issue 4, Page(s) 475–482

    Abstract: This single-arm, open-label, pilot study was designed to assess the efficacy and cardiovascular safety profile of daclizumab, a humanized monoclonal interleukin (IL)-2Ralpha antibody, in combination with mycophenolate mofetil (MMF), tacrolimus, and early ...

    Abstract This single-arm, open-label, pilot study was designed to assess the efficacy and cardiovascular safety profile of daclizumab, a humanized monoclonal interleukin (IL)-2Ralpha antibody, in combination with mycophenolate mofetil (MMF), tacrolimus, and early corticosteroid withdrawal in renal transplant recipients. Seventy-nine renal allograft recipients were treated with daclizumab (1 mg/kg; five doses starting on the day before transplant and then every two weeks), MMF (1 g b.i.d.), tacrolimus (0.2 mg/kg/d), and low-dose prednisolone, which was withdrawn at day 150 after transplant. The rate of acute rejection was determined at 12 months. Lipid profile, oral glucose tolerance, and adverse events were monitored. Of the 76 patients eligible for analysis, eight (10.5%) developed biopsy-proven acute rejection (BPAR). Ten (13.2%) experienced clinical and/or BPAR. Corticosteroids were withdrawn completely in 91% of patients at 12 months. Graft and patient survival were 97.5% and 98.7% respectively. Mean total cholesterol and triglycerides were significantly lower at 12 months post-transplant than at baseline (201 +/- 47.5 vs. 190.8 +/- 43.6 mg/dL, p = 0.005 and 196.2 +/- 133.2 vs. 144.5 +/- 76.8 mg/dL, p < 0.001, respectively). Mean hemoglobin A1c levels did not differ between baseline (5.54%) and 12 months (5.48%). New-onset post-transplant diabetes mellitus occurred in 6.6% of the non-diabetic transplanted patients. The proportion of patients with abnormal oral glucose tolerance test (OGTT) was 47% at 3 months and 39% at 12 months (p = NS). Daclizumab induction in combination with MMF, tacrolimus, and low-dose (followed by withdrawal) prednisolone appears to be effective and safe in patients receiving renal allografts. The regimen appears to be associated with a favorable cardiovascular profile.
    MeSH term(s) Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Cardiovascular System/drug effects ; Cholesterol/blood ; Drug Administration Schedule ; Female ; Glycated Hemoglobin A/analysis ; Graft Rejection ; Humans ; Immunoglobulin G/administration & dosage ; Immunoglobulin G/adverse effects ; Immunoglobulin G/therapeutic use ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Male ; Middle Aged ; Mycophenolic Acid/administration & dosage ; Mycophenolic Acid/adverse effects ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/therapeutic use ; Pilot Projects ; Prednisolone/administration & dosage ; Prospective Studies ; Steroids/administration & dosage ; Tacrolimus/administration & dosage ; Tacrolimus/adverse effects ; Tacrolimus/therapeutic use ; Triglycerides/blood
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Glycated Hemoglobin A ; Immunoglobulin G ; Immunosuppressive Agents ; Steroids ; Triglycerides ; Cholesterol (97C5T2UQ7J) ; Prednisolone (9PHQ9Y1OLM) ; daclizumab (CUJ2MVI71Y) ; Mycophenolic Acid (HU9DX48N0T) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2005-08
    Publishing country Denmark
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/j.1399-0012.2005.00369.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Acute arterio-venous fistula occlusion decreases sympathetic activity and improves baroreflex control in kidney transplanted patients.

    Velez-Roa, Sonia / Neubauer, Jolanta / Wissing, Martin / Porta, Alberto / Somers, Virend K / Unger, Philippe / van de Borne, Philippe

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2004  Volume 19, Issue 6, Page(s) 1606–1612

    Abstract: Background: The acute bradycardia induced by the occlusion of an arteriovenous fistula (AVF), known as the Nicoladoni-Branham sign, is considerably larger than that which occurs during carotid sinus massage. This suggests increased arterial baroreflex ... ...

    Abstract Background: The acute bradycardia induced by the occlusion of an arteriovenous fistula (AVF), known as the Nicoladoni-Branham sign, is considerably larger than that which occurs during carotid sinus massage. This suggests increased arterial baroreflex sensitivity during acute AVF occlusion. Moreover, the influence of acute AVF occlusion on muscle sympathetic nerve traffic (MSNA, by microneurography) is unknown. We therefore assessed the effects of acute AVF occlusion on baroreflex sensitivity and on MSNA in patients with stable functional kidney grafts and patent AVF.
    Methods: We measured blood pressure (BP), MSNA (n = 11), heart rate (HR), cardiac output (CO) and arterial baroreflex sensitivity (n = 18) at baseline and during acute, 30-s pneumatic AVF occlusions in 23 renal transplanted recipients.
    Results: During the first 5 s of the AVF occlusion, mean BP increased from 98+/-4 to 112+/-4 mmHg (P<0.0001) while MSNA decreased to 28+/-5% of baseline values (P<0.0001) and HR decreased from 71+/-3 to 61+/-3 b.p.m. (P<0.0001). The largest increases in BP were accompanied by the most marked decreases in MSNA (r = -0.79, P = 0.003) and HR (r = -0.49; P = 0.01) during the first 5 s of the AVF occlusion. During AVF occlusion baseline CO of 6.9+/-0.3 decreased to 5.6+/-0.3 l/min (P<0.0001) while baroreflex sensitivity increased from 10+/-1 to 17+/-2 ms/mm Hg (P<0.001).
    Conclusions: Arterial baroreceptor activation and increased arterial baroreflex sensitivity decrease heart rate during AVF occlusion. In addition, our study is the first to demonstrate that arterial baroreflex activation decreases sympathetic nerve traffic during the Nicoladoni-Branham sign.
    MeSH term(s) Arteriovenous Fistula ; Baroreflex/physiology ; Blood Pressure/physiology ; Bradycardia/physiopathology ; Cardiac Output/physiology ; Female ; Heart Rate/physiology ; Humans ; Kidney Transplantation/physiology ; Male ; Middle Aged ; Muscle, Smooth/innervation ; Muscle, Smooth/physiology ; Sympathetic Nervous System/physiology
    Language English
    Publishing date 2004-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfh124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Guidelines for the treatment and management of new-onset diabetes after transplantation.

    Wilkinson, Alan / Davidson, Jaime / Dotta, Francesco / Home, Philip D / Keown, Paul / Kiberd, Bryce / Jardine, Alan / Levitt, Naomi / Marchetti, Piero / Markell, Mariana / Naicker, Sarala / O'Connell, Philip / Schnitzler, Mark / Standl, Eberhard / Torregosa, Jose-Vicente / Uchida, Kazuharu / Valantine, Hannah / Villamil, Federico / Vincenti, Flavio /
    Wissing, Martin

    Clinical transplantation

    2005  Volume 19, Issue 3, Page(s) 291–298

    Abstract: Although graft and patient survival after solid organ transplantation have improved markedly in recent years, transplant recipients continue to experience an increased prevalence of cardiovascular disease (CVD) compared with the general population. A ... ...

    Abstract Although graft and patient survival after solid organ transplantation have improved markedly in recent years, transplant recipients continue to experience an increased prevalence of cardiovascular disease (CVD) compared with the general population. A number of factors are known to impact on the increased risk of CVD in this population, including hypertension, dyslipidemia and diabetes mellitus. Of these factors, new-onset diabetes after transplantation has been identified as one of the most important, being associated with reduced graft function and patient survival, and increased risk of graft loss. In 2003, International Consensus Guidelines on New-onset Diabetes after Transplantation were published, which aimed to establish a precise definition and diagnosis of the condition and recommend management strategies to reduce its occurrence and impact. These updated 2004 guidelines, developed in consultation with the International Diabetes Federation (IDF), extend the recommendations of the previous guidelines and encompass new-onset diabetes after kidney, liver and heart transplantation. It is hoped that adoption of these management approaches pre- and post-transplant will reduce individuals' risk of developing new-onset diabetes after transplantation as well as ameliorating the long-term impact of this serious complication.
    MeSH term(s) Cardiovascular Diseases/etiology ; Cardiovascular Diseases/therapy ; Diabetes Mellitus/etiology ; Diabetes Mellitus/therapy ; Humans ; Immunosuppressive Agents/adverse effects ; Organ Transplantation/adverse effects ; Practice Guidelines as Topic
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2005-06
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/j.1399-0012.2005.00359.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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