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  1. Book: Twenty years of Nipah virus research

    Wit, Emmie de

    (The journal of infectious diseases ; volume 221, supplement 4 (1 June 2020))

    2020  

    Author's details editors: Emmie de Wit, Ph.D., Emily S. Gurley, Ph.D., and Christina F. Spiropoulou, Ph.D
    Series title The journal of infectious diseases ; volume 221, supplement 4 (1 June 2020)
    Collection
    Language English
    Size Seite S359-S498, Illustrationen, Diagramme
    Publisher Oxford University Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT020531805
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh II Zs 50 -221,Suppl.4- verfügbar in Königswinter Königswinter

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  2. Article ; Online: An Acute Immune Response to Middle East Respiratory Syndrome Coronavirus Replication Contributes to Viral Pathogenicity

    Baseler, Laura J. / Falzarano, Darryl / Scott, Dana P. / Rosenke, Rebecca / Thomas, Tina / Munster, Vincent J. / Feldmann, Heinz / Wit, Emmie de

    The American Journal of Pathology 186(3) 630--638

    2016  

    Abstract: textless}p{\textgreater}Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in a human with severe pneumonia in 2012. Since then, infections have been detected in {\textgreater}1500 individuals, with disease severity ranging ... ...

    Abstract {\textless}p{\textgreater}Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in a human with severe pneumonia in 2012. Since then, infections have been detected in {\textgreater}1500 individuals, with disease severity ranging from asymptomatic to severe, fatal pneumonia. To elucidate the pathogenesis of this virus and investigate mechanisms underlying disease severity variation in the absence of autopsy data, a rhesus macaque and common marmoset model of MERS-CoV disease were analyzed. Rhesus macaques developed mild disease, and common marmosets exhibited moderate to severe, potentially lethal, disease. Both nonhuman primate species exhibited respiratory clinical signs after inoculation, which were more severe and of longer duration in the marmosets, and developed bronchointerstitial pneumonia. In marmosets, the pneumonia was more extensive, with development of severe airway lesions. Quantitative analysis showed significantly higher levels of pulmonary neutrophil infiltration and higher amounts of pulmonary viral antigen in marmosets. Pulmonary expression of the MERS-CoV receptor, dipeptidyl peptidase 4, was similar in marmosets and macaques. These results suggest that increased virus replication and the local immune response to MERS-CoV infection likely play a role in pulmonary pathology severity. Together, the rhesus macaque and common marmoset models of MERS-CoV span the wide range of disease severity reported in MERS-CoV–infected humans, which will aid in investigating MERS-CoV disease pathogenesis.{\textless}/p{\textgreater}
    Keywords Coronaviridae ; Viridae ; corona viruses ; biotic associations ; CETAF-taskforce ; covid ; covid-19 ; pathogens ; biotic interaction ; virus-host ; biotic relations ; pathogen-host ; covid19
    Subject code 610
    Language English
    Publishing date 2016-03-31
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

    Williamson, Brandi N. / Feldmann, Friederike / Schwarz, Benjamin / Meade-White, Kimberly / Porter, Danielle P. / Schulz, Jonathan / Doremalen, Neeltje van / Leighton, Ian / Yinda, Claude Kwe / Pérez-Pérez, Lizzette / Okumura, Atsushi / Lovaglio, Jamie / Hanley, Patrick W. / Saturday, Greg / Bosio, Catharine M. / Anzick, Sarah / Barbian, Kent / Cihlar, Tomas / Martens, Craig /
    Scott, Dana P. / Munster, Vincent J. / Wit, Emmie de

    bioRxiv

    Abstract: Background: Effective therapeutics to treat COVID-19 are urgently needed. Remdesivir is a nucleotide prodrug with in vitro and in vivo efficacy against coronaviruses. Here, we tested the efficacy of remdesivir treatment in a rhesus macaque model of SARS- ... ...

    Abstract Background: Effective therapeutics to treat COVID-19 are urgently needed. Remdesivir is a nucleotide prodrug with in vitro and in vivo efficacy against coronaviruses. Here, we tested the efficacy of remdesivir treatment in a rhesus macaque model of SARS-CoV-2 infection. Methods: To evaluate the effect of remdesivir treatment on SARS-CoV-2 disease outcome, we used the recently established rhesus macaque model of SARS-CoV-2 infection that results in transient lower respiratory tract disease. Two groups of six rhesus macaques were infected with SARS-CoV-2 and treated with intravenous remdesivir or an equal volume of vehicle solution once daily. Clinical, virological and histological parameters were assessed regularly during the study and at necropsy to determine treatment efficacy. Results: In contrast to vehicle-treated animals, animals treated with remdesivir did not show signs of respiratory disease and had reduced pulmonary infiltrates on radiographs. Virus titers in bronchoalveolar lavages were significantly reduced as early as 12hrs after the first treatment was administered. At necropsy on day 7 after inoculation, lung viral loads of remdesivir-treated animals were significantly lower and there was a clear reduction in damage to the lung tissue. Conclusions: Therapeutic remdesivir treatment initiated early during infection has a clear clinical benefit in SARS-CoV-2-infected rhesus macaques. These data support early remdesivir treatment initiation in COVID-19 patients to prevent progression to severe pneumonia.
    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2020.04.15.043166
    Database COVID19

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  4. Article: H5N1 Virus Attachment to Lower Respiratory Tract

    Riel, Debby van / Munster, Vincent J / Wit, Emmie de / Rimmelzwaan, Guus F / Fouchier, Ron A. M / Osterhaus, Ab D. M. E / Kuiken, Thijs

    Science. 2006 Apr. 21, v. 312, no. 5772

    2006  

    Abstract: Highly pathogenic avian influenza virus (H5N1) may cause severe lower respiratory tract (LRT) disease in humans. However, the LRT cells to which the virus attaches are unknown for both humans and other mammals. We show here that H5N1 virus attached ... ...

    Abstract Highly pathogenic avian influenza virus (H5N1) may cause severe lower respiratory tract (LRT) disease in humans. However, the LRT cells to which the virus attaches are unknown for both humans and other mammals. We show here that H5N1 virus attached predominantly to type II pneumocytes, alveolar macrophages, and nonciliated bronchiolar cells in the human LRT, and this pattern was most closely mirrored in cat and ferret tissues. These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion.
    Keywords Influenza A virus ; infection ; epithelium ; epithelial cells ; trachea (vertebrates) ; pulmonary alveoli ; humans ; mice ; ferrets ; cats ; Macaca ; cell lines
    Language English
    Dates of publication 2006-0421
    Size p. 399.
    Publishing place American Association for the Advancement of Science
    Document type Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/137: Show issues
    + C 27: Show issues
    Z50.00 SC01: Show issues
    Z 8.9: Show issues

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  5. Article ; Online: Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques

    Wit, Emmie de / Rasmussen, Angela L. / Falzarano, Darryl / Bushmaker, Trenton / Feldmann, Friederike / Brining, Douglas L. / Fischer, Elizabeth R. / Martellaro, Cynthia / Okumura, Atsushi / Chang, Jean / Scott, Dana / Benecke, Arndt G. / Katze, Michael G. / Feldmann, Heinz / Munster, Vincent J.

    Proceedings of the National Academy of Sciences 110(41) 16598--16603

    2013  

    Abstract: In 2012, a novel betacoronavirus, designated Middle East respiratory syndrome coronavirus or MERS-CoV and associated with severe respiratory disease in humans, emerged in the Arabian Peninsula. To date, 108 human cases have been reported, including cases ...

    Abstract In 2012, a novel betacoronavirus, designated Middle East respiratory syndrome coronavirus or MERS-CoV and associated with severe respiratory disease in humans, emerged in the Arabian Peninsula. To date, 108 human cases have been reported, including cases of human-to-human transmission. The availability of an animal disease model is essential for understanding pathogenesis and developing effective countermeasures. Upon a combination of intratracheal, ocular, oral, and intranasal inoculation with 7 × 106 50\% tissue culture infectious dose of the MERS-CoV isolate HCoV-EMC/2012, rhesus macaques developed a transient lower respiratory tract infection. Clinical signs, virus shedding, virus replication in respiratory tissues, gene expression, and cytokine and chemokine profiles peaked early in infection and decreased over time. MERS-CoV caused a multifocal, mild to marked interstitial pneumonia, with virus replication occurring mainly in alveolar pneumocytes. This tropism of MERS-CoV for the lower respiratory tract may explain the severity of the disease observed in humans and the, up to now, limited human-to-human transmission.
    Keywords covid ; virus-host ; covid-19 ; biotic associations ; pathogen-host ; pathogens ; emerging infectious disease ; CETAF-taskforce ; Coronaviridae ; Viridae ; biotic interaction ; DPP4 ; corona viruses ; biotic relations ; covid19
    Language English
    Publishing date 2013-10-31
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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