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  1. AU="Witberg, Guy"
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  1. Article ; Online: More on Myocarditis after BNT162b2 Vaccination in Israeli Adolescents. Reply.

    Witberg, Guy

    The New England journal of medicine

    2023  Volume 388, Issue 6, Page(s) 576

    MeSH term(s) Humans ; Adolescent ; Myocarditis/epidemiology ; Myocarditis/etiology ; BNT162 Vaccine ; Israel/epidemiology
    Chemical Substances BNT162 Vaccine
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2214450
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    Ua VI Zs.34: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Acute myocarditis caused by COVID-19 disease and following COVID-19 vaccination.

    Kornowski, Ran / Witberg, Guy

    Open heart

    2022  Volume 9, Issue 1

    Abstract: Myocarditis and pericarditis are inflammatory conditions of the heart that present a range of symptoms, often including chest pain, fatigue, breathlessness and palpitations that may be irregular due to cardiac rhythm disturbances. Myocarditis has been ... ...

    Abstract Myocarditis and pericarditis are inflammatory conditions of the heart that present a range of symptoms, often including chest pain, fatigue, breathlessness and palpitations that may be irregular due to cardiac rhythm disturbances. Myocarditis has been proposed to account for a fraction of cardiac injury among patients infected with SARS-CoV-2 and associated systemic inflammation; and it might be one of the reasons for the high mortality seen in COVID-19 patients. Furthermore, following vaccination with mRNA COVID-19 vaccines (ie, Comirnaty and Spikevax), myocarditis and pericarditis can develop within a few days of vaccination, particularly following the second dose. Based on recent reviewed data, the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have determined that the risk for both of these conditions is overall 'very rare' (~1 in 10 000 vaccinated people may be clinically affected), with the highest risk among younger males. Both EMA and FDA agree that the benefits of all authorised COVID-19 vaccines continue to outweigh their risks, given the threat of serious COVID-19 illness and related complications. Since myocarditis has a very wide clinical spectrum, ranging from mild to fulminant life-threatening disease, we present in this review a sum of the latest findings and considerations for the proper diagnosis and management of affected patients.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; Male ; Myocarditis/complications ; Myocarditis/etiology ; SARS-CoV-2 ; United States ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2021-001957
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  3. Article ; Online: A Tale of 2 mRNA Vaccines: The Spring of Hope, The Winter of Despair.

    Witberg, Guy / Richter, Ilan

    Journal of the American College of Cardiology

    2022  Volume 80, Issue 20, Page(s) 1909–1911

    MeSH term(s) Humans ; Adaptation, Psychological ; Myocarditis ; Pericarditis ; mRNA Vaccines
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2022.09.010
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  4. Article: A Case Series of Myocarditis Following Third (Booster) Dose of COVID-19 Vaccination: Magnetic Resonance Imaging Study.

    Shiyovich, Arthur / Witberg, Guy / Aviv, Yaron / Kornowski, Ran / Hamdan, Ashraf

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 839090

    Abstract: Background: Myocarditis has been reported following the first two doses of Pfizer-BNT162b2 messenger RNA (mRNA) COVID-19 vaccination. Administration of a third dose (booster) of the vaccine was initiated recently in Israel.: Objective: The aim of ... ...

    Abstract Background: Myocarditis has been reported following the first two doses of Pfizer-BNT162b2 messenger RNA (mRNA) COVID-19 vaccination. Administration of a third dose (booster) of the vaccine was initiated recently in Israel.
    Objective: The aim of this study was to describe the characteristics of patients referred for cardiac magnetic resonance (CMR) imaging with myocarditis following the booster.
    Methods: Patients referred for CMR imaging with a clinical diagnosis of myocarditis within 21 days following the booster, between July 13 and November 11, 2021, were analyzed.
    Results: Overall, 4 patients were included, 3/4 (75%) were men, and the mean age was 27 ± 10 years. The time from booster administration to the onset of symptoms was 5.75 ± 4.8 days (range 2-14). Obstructive coronary artery disease was excluded in 3 of the patients (75%). CMR was performed 34 ± 15 days (range 8-47 days) following the 3rd vaccination. The mean left ventricular ejection fraction was 61 ± 7% (range 53-71%), and regional wall motion abnormalities were present in one of the patients. Global T1 was increased in one of the patients, while focal T1 values were increased in 3 of the patients. Global T2 was increased in one of the patients, while focal T2 values were increased in all the patients. Global ECV was increased in 3 of the patients, while focal ECV was increased in all the patients. Median late gadolinium enhancement (LGE) was 4 ± 3% (range 1-9%), with the inferolateral segment as the most common location (3 of the 4 patients). All the patients met the Updated Lake Louise Criteria.
    Conclusions: Patient characteristics and CMR imaging findings of myocarditis following the administration of the booster vaccine are relatively mild and consistent with those observed with the first two doses. Although larger-scale prospective studies are necessary, these initial findings are somewhat reassuring.
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.839090
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  5. Article ; Online: A meta-analysis of randomized controlled trials comparing percutaneous coronary intervention with optimal medical therapy in stable obstructive coronary artery disease.

    Lerman, Tsahi T / Witberg, Guy / Kornowski, Ran

    Coronary artery disease

    2021  Volume 32, Issue 7, Page(s) 618–624

    Abstract: Background: The optimal treatment for patients suffering from stable obstructive coronary artery disease (SOCAD) is controversial. Many studies have examined the value of performing percutaneous coronary intervention (PCI) in these patients but so far ... ...

    Abstract Background: The optimal treatment for patients suffering from stable obstructive coronary artery disease (SOCAD) is controversial. Many studies have examined the value of performing percutaneous coronary intervention (PCI) in these patients but so far no study has been able to demonstrate an improvement in outcomes by performing PCI in addition to optimal medical therapy (OMT). This study aimed to examine the added value of performing PCI plus OMT vs. OMT alone regarding cardiovascular outcomes.
    Methods and results: We performed a systematic search and a meta-analysis for randomized controlled trials comparing PCI plus OMT vs. OMT in SOCAD patients. We included six trials (N = 11 144) with follow-up ranges 2.2-11.4 years. The pooled analysis showed no significant difference between PCI + OMT vs. OMT group regarding all-cause mortality, odds ratio (OR) = 0.98 [confidence interval (CI) 0.86-1.12, P = 0.79, I2 = 0%]. In addition, we have found no difference between the two groups regarding cardiovascular mortality, OR = 0.91 (CI 0.76-1.08, P = 0.27, I2 = 24%). Moreover, there was no difference in the incidence of myocardial infarction, OR = 0.92 (CI 0.81-1.04, P = 0.18, I2 = 49%).
    Conclusion: Our results suggest that there is no improvement in cardiovascular outcomes of patients with SOCAD by performing PCI plus OMT vs. OMT alone. This study provides an insight that should be taken under consideration in the management of SOCAD patients.
    MeSH term(s) Coronary Artery Disease/classification ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/therapy ; Humans ; Percutaneous Coronary Intervention/methods ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Randomized Controlled Trials as Topic/statistics & numerical data
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000001022
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    Zs.A 3039: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The pros and cons of the Heart Team.

    Kornowski, Ran / Witberg, Guy

    Future cardiology

    2019  Volume 15, Issue 4, Page(s) 255–258

    MeSH term(s) Cardiologists ; Clinical Decision-Making ; Humans ; Interprofessional Relations ; Patient Care Team ; Practice Guidelines as Topic ; Surgeons
    Language English
    Publishing date 2019-07-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca-2019-0018
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  7. Article ; Online: Reply to the letter to the editor "Is transcatheter aortic valve implantation feasible in patients with chronic kidney disease?"

    Steinmetz, Tali / Witberg, Guy

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2019  Volume 14, Issue 17, Page(s) 1792

    MeSH term(s) Aortic Valve ; Aortic Valve Stenosis ; Heart Valve Prosthesis Implantation ; Humans ; Renal Insufficiency, Chronic ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2019-04-25
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-D-18-00500R
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    Zs.A 6680: Show issues Location:
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    Zs.MO 571: Show issues

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  8. Article ; Online: Association of socioeconomic status measures with physical activity and subsequent frailty in older adults.

    Kheifets, Mark / Goshen, Abigail / Goldbourt, Uri / Witberg, Guy / Eisen, Alon / Kornowski, Ran / Gerber, Yariv

    BMC geriatrics

    2022  Volume 22, Issue 1, Page(s) 439

    Abstract: Background: Despite increased recognition, frailty remains a significant public health challenge.: Objective: we aimed to assess the role of education and income, as well as neighborhood socioeconomic status, on physical activity and subsequent ... ...

    Abstract Background: Despite increased recognition, frailty remains a significant public health challenge.
    Objective: we aimed to assess the role of education and income, as well as neighborhood socioeconomic status, on physical activity and subsequent frailty in older adults.
    Methods: Using a population-based cohort of older adults, this study examined the relationship between socioeconomic status (SES) factors, physical activity and frailty. The study included 1,799 participants (mean [SD], 74.6 (6.2), 53.3% female) from the "National Health and Nutrition Survey of Older Adults Aged 65 and Over in Israel", conducted in 2005-2006. A follow-up interview was performed 12-14 years later in a subgroup of 601 subjects (mean [SD], age 84[4]; 56% women). Self-reported leisure-time physical activity (LTPA) was measured at both baseline and follow-up. SES measures were assessed at baseline. Frailty was measured at follow-up, using the Fried's Phenotype Model.
    Results: All SES measures were strongly and positively associated with LTPA (all p < 0.001). Eighty-two participants (14%) were classified as frail at follow-up. After age and sex adjustment and accounting for attrition bias using inverse probability weighting, baseline LTPA (OR = 2.77, 95% CI: 1.57-4.90, for inactivity; OR = 1.41, 95% CI: 0.75-2.68, for insufficient activity, compared with sufficient activity, P
    Conclusion: Among older individuals, multiple SES measures were positively associated with LTPA, which was a strong predictor of lower subsequent frailty risk.
    MeSH term(s) Aged ; Exercise ; Female ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Humans ; Male ; Residence Characteristics ; Social Class ; Socioeconomic Factors
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-022-03108-1
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  9. Article ; Online: Myocarditis Following COVID-19 Vaccination: A Follow-up Magnetic Resonance Imaging Study.

    Shiyovich, Arthur / Plakht, Ygal / Witberg, Guy / Aviv, Yaron / Shafir, Gideon / Kornowski, Ran / Hamdan, Ashraf

    JACC. Cardiovascular imaging

    2022  Volume 15, Issue 11, Page(s) 2006–2007

    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Follow-Up Studies ; Magnetic Resonance Imaging/methods ; Myocarditis/diagnostic imaging ; Myocarditis/etiology ; Myocarditis/pathology ; Predictive Value of Tests ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Letter
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2022.05.017
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  10. Article ; Online: Current perspectives on revascularization in multivessel ST elevation myocardial infarction.

    Witberg, Guy / Kornowski, Ran

    Coronary artery disease

    2017  Volume 28, Issue 6, Page(s) 498–506

    Abstract: Up to 50% of patients presenting with ST elevation myocardial infarction (STEMI) are found to have multivessel coronary artery disease. These patients have a worse prognosis compared with the overall STEMI population. Two revascularization strategies are ...

    Abstract Up to 50% of patients presenting with ST elevation myocardial infarction (STEMI) are found to have multivessel coronary artery disease. These patients have a worse prognosis compared with the overall STEMI population. Two revascularization strategies are possible for these patients: treating the infarct-related artery percutaneous coronary intervention (IRA-PCI) only or achieving Complete revascularization (CR), either through an immediate multivessel PCI during the index angiography or during a second-staged procedure. Until recently, most clinical data on this issue were derived from observational studies - which all showed a clear advantage to the IRA-PCI over the CR approach. Over the past few years, several groundbreaking randomized trials have suggested that the CR approach may be at least equivalent, and perhaps superior, to the IRA-PCI strategy. This has caused a paradigm shift reflected in the recent US and European guidelines. However, there is still uncertainty on the optimal timing for achieving CR (immediate/during the index admission/during a subsequent elective admission) and several other important issues in terms of revascularization: the extent of revascularization needed to achieve maximal benefit, the optimal means to evaluate the significance of intermediate coronary stenosis in the context of acute myocardial infarction, and the best approach to treat chronic total occlusions have not been thoroughly examined, and are the subject of an ongoing debate.
    Language English
    Publishing date 2017-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000000496
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