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Book ; Online ; Thesis: Entwicklung von Nanopartikeln für Targeted Drug Delivery Systeme

Witt, Sandra [Verfasser]

2020

Author's details	Sandra Witt
Keywords	Technische Chemie ; Technical Chemistry
Subject code	sg660
Language	German
Publisher	Gottfried Wilhelm Leibniz Universität Hannover
Publishing place	Hannover
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Macrodontia in guinea pigs (Cavia porcellus)–Radiological findings and localization in 131 patients

Köstlinger, Saskia / Witt, Sandra / Fehr, Michael

Journal of exotic pet medicine. 2021 Oct., v. 39

2021

Abstract: Guinea pigs with dental disease usually present with nonspecific signs such as reduced food intake, difficulty eating and poor general condition. It is assumed that deficient dental attrition is the cause for overlong teeth. Giant teeth, or Macrodonts, ... ...

Abstract	Guinea pigs with dental disease usually present with nonspecific signs such as reduced food intake, difficulty eating and poor general condition. It is assumed that deficient dental attrition is the cause for overlong teeth. Giant teeth, or Macrodonts, have been mentioned as an occasionally occurring pathology.Guinea pigs with clinically and radiologically confirmed dental disease presented between 2011 and 2014 and with complete sets of radiographs of the skull (laterolateral, dorsoventral, oblique and isolated views of the mandible and maxilla) were included in this retrospective study (n = 131). Every tooth was radiologically assessed and documented as changed, if an alteration in tooth width, tooth structure, periodontal ligament space, alveolar bone lamina dura and, in the incisors, pulp cavity was present. Special focus was placed on macrodonts and their additional alterations besides increase in width.The majority (89% = 116/131) of all guinea pigs had at least one macrodont; more than half (58% = 246/422) of all abnormal teeth were macrodonts. In total, 246 teeth (54 incisors, 192 cheek teeth) were diagnosed as macrodonts by means of radiography based on the presence of tooth expansion. Mandibular incisors were much more often affected by macrodontia (87%, 47/54). Furthermore, 91% (175/192) of cheek teeth macrodonts were found in the last two tooth positions. In the present study 97% of all macrodonts (238/246) showed both expansion and structural loss. Alterations to the periodontal ligament space were found in 76% (118/246) of macrodonts. The lamina dura of alveolar bone was changed in 46% (113/246) of cases. Abnormalities of the pulp cavity were present in 80% (43/54) of incisor macrodonts.In conclusion, macrodonts occur much more often than previously documented and present a common diagnostic finding in guinea pigs with dental disease. Macrodontia is radiologically characterised by expansion of the tooth and structural loss.
Keywords	food intake ; guinea pigs ; ligaments ; medicine ; pulp ; radiography ; retrospective studies ; skull ; tooth diseases ; Guinea
Language	English
Dates of publication	2021-10
Size	p. 68-75.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2228614-7
ISSN	1557-5063
ISSN	1557-5063
DOI	10.1053/j.jepm.2021.08.002
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Extraktion erkrankter Unterkieferinzisivi beim Meerschweinchen (Cavia porcellus) via ventraler Mandibulatrepanation.

Witt, Sandra / Köstlinger, Saskia / Fehr, Michael

Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere

2021 Volume 49, Issue 6, Page(s) 415–424

Abstract: Objective: This retrospective study describes the use of ventral mandibular trepanation for extraction of diseased mandibular incisors in guinea pigs and evaluates the clinical outcome.: Material and methods: In 40 guinea pigs with abnormal feed ... ...

Title translation	Extraction of diseased mandibular incisors in the guinea pig (Cavia porcellus) via ventral mandibular trepanation.
Abstract	Objective: This retrospective study describes the use of ventral mandibular trepanation for extraction of diseased mandibular incisors in guinea pigs and evaluates the clinical outcome. Material and methods: In 40 guinea pigs with abnormal feed intake, at least one mandibular incisor was extracted via ventral mandibular trepanation. The diagnosis of primary mandibular incisor disease was based on the findings of the clinical general examination and intraoral and radiographic examination under general anesthesia. Following the procedure radiographs were taken and the patients were monitored and cared for as inpatients until discharge. Regular re-examinations were undertaken in order to assess and treat the surgical sites. Results: A total of 42 altered mandibular incisors were extracted via ventral mandibular trepanation. Macrodonts (25/42) and periapical and alveolar changes (8/42) were the main reasons for extraction. Tooth residuals of unknown etiology (4/42) as well as such resulting from failed conventional extraction attempt using luxators (3/42) and traumatically loosened incisors (2/42) were also extracted. Tooth-associated jaw abscesses were found in 40 % of the guinea pigs. In addition, 40 % of the animals presented secondary elongation of the molars requiring occlusal equilibration. In all patients, it was possible to completely remove the altered incisors or residuals. On average, independent feed intake was observed 2 days after surgery and the animals were discharged. Complete healing of the surgical site was observed on average after 39 days (minimum 9 days, maximum 98 days). A total of 22 animals were evaluated 6 months following surgery and showed no further tooth-associated complaints. Conclusion and clinical relevance: Ventral mandibular trepanation allows diseased mandibular incisors in guinea pigs to be removed entirely within one surgery and thus represents a curative procedure. Unlike the conventional extraction with luxators, it does not bear the risk of tooth fractures resulting in tooth fragments remaining in the alveolus.
MeSH term(s)	Animals ; Guinea Pigs ; Incisor/diagnostic imaging ; Incisor/surgery ; Mandible/surgery ; Retrospective Studies ; Trephining/veterinary
Language	German
Publishing date	2021-12-03
Publishing country	Germany
Document type	Journal Article
ISSN	2567-5842
ISSN (online)	2567-5842
DOI	10.1055/a-1617-5180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Aptamer-Modified Nanoparticles in Medical Applications.

Eilers, Alina / Witt, Sandra / Walter, Johanna

Advances in biochemical engineering/biotechnology

2020 Volume 174, Page(s) 161–193

Abstract: Since aptamers have been selected against a broad range of target structures of medical interest and nanoparticles are available with diverse properties, aptamer-modified nanoparticles can be used in various diagnostic and therapeutic applications. While ...

Abstract	Since aptamers have been selected against a broad range of target structures of medical interest and nanoparticles are available with diverse properties, aptamer-modified nanoparticles can be used in various diagnostic and therapeutic applications. While the aptamer is responsible for specificity and affinity of the conjugate, the nanoparticles' function varies from signal generation in diagnostic approaches to drug loading in drug delivery systems. Within this chapter different medical applications of aptamer-modified nanoparticles will be summarized and underlying principles will be described.
MeSH term(s)	Aptamers, Nucleotide/chemistry ; Aptamers, Nucleotide/therapeutic use ; Drug Delivery Systems ; Humans ; Nanoparticles/chemistry ; Nanoparticles/therapeutic use
Chemical Substances	Aptamers, Nucleotide
Language	English
Publishing date	2020-03-10
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	0724-6145
ISSN	0724-6145
DOI	10.1007/10_2020_124
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Extraktion erkrankter Unterkieferinzisivi beim Meerschweinchen (Cavia porcellus) via ventraler Mandibulatrepanation

Witt, Sandra / Köstlinger, Saskia / Fehr, Michael

Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere

2021 Volume 49, Issue 06, Page(s) 415–424

Abstract: Gegenstand und Ziel: Diese retrospektive Studie beschreibt die Methode der ventralen Mandibulatrepanation zur Extraktion erkrankter Unterkieferinzisivi beim Meerschweinchen und evaluiert das klinische Outcome.: Material und Methoden: Bei 40 ... ...

Abstract	Gegenstand und Ziel: Diese retrospektive Studie beschreibt die Methode der ventralen Mandibulatrepanation zur Extraktion erkrankter Unterkieferinzisivi beim Meerschweinchen und evaluiert das klinische Outcome. Material und Methoden: Bei 40 Meerschweinchen mit veränderter Futteraufnahme wurde mindestens ein Unterkieferschneidezahn via ventraler Mandibulatrepanation extrahiert, nachdem Befunde der klinischen Allgemeinuntersuchung sowie der intraoralen und radiologischen Untersuchung in Allgemeinanästhesie die Diagnose einer primären mandibulären Inzisivuserkrankung ergeben hatten. Nach dem Eingriff wurden Röntgenaufnahmen angefertigt und die Patienten bis zur Entlassung stationär überwacht und versorgt. Zur Beurteilung und Behandlung der Wunden erfolgten regelmäßige Kontrollen. Ergebnisse: Bei den insgesamt 42 extrahierten Unterkieferinzisivi stellten Makrodonten (25/42) den häufigsten Extraktionsgrund dar, gefolgt von periapikalen und alveolären Veränderungen (8/42). Extrahiert wurden ferner Zahnresiduen unklarer Genese (4/42) sowie nach fehlgeschlagenem konventionellem Extraktionsversuch mittels Luxatoren (3/42) und traumatisch bedingt gelockerte Inzisivi (2/42). Bei jeweils 40 % (16/42) der Meerschweinchen lagen zahnassoziierte Kieferabszesse bzw. eine therapiebedürftige sekundäre Elongation der Backenzähne vor. Allen Patienten konnten die veränderten Inzisivi bzw. Residuen vollständig entfernt werden. Durchschnittlich 2 Tagen nach dem Eingriff nahmen die Tiere eigenständig Futter auf und konnten entlassen werden. Die Ausheilung der Wunde war nach durchschnittlich 39 Tagen (Minimum 9 Tage, Maximum 98 Tage) festzustellen. Die 22 Tiere, die 6 Monate nach dem Eingriff nachuntersucht werden konnten, wiesen keine erneuten zahnassoziierten Erkrankungen auf. Schlussfolgerung und klinische Relevanz: Die ventrale Mandibulatrepanation ermöglicht es, erkrankte Unterkieferinzisivi beim Meerschweinchen in toto in einer Operation zu entfernen und stellt somit einen kurativen Eingriff dar. Im Gegensatz zur klassischen Extraktion mit Luxatoren birgt sie nicht das Risiko von Zahnfrakturen mit der Folge verbleibender Zahnfragmente in der Alveole.
Keywords	Kleinsäuger ; Nager ; Makrodont ; Riesenzahn ; Zahnerkrankung ; Osteotomie ; Zahnheilkunde ; Small mammals ; rodents ; macrodont ; giant tooth ; dental disease ; osteotomy ; dentistry
Language	German
Publishing date	2021-12-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2567-5842 ; 1434-1239
ISSN (online)	2567-5842
ISSN	1434-1239
DOI	10.1055/a-1617-5180
Database	Thieme publisher's database

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Article: Production of polycaprolactone nanoparticles with hydrodynamic diameters below 100 nm.

Witt, Sandra / Scheper, Thomas / Walter, Johanna-Gabriela

Engineering in life sciences

2019 Volume 19, Issue 10, Page(s) 658–665

Abstract: Cancer is a worldwide increasing burden and its therapy is often challenging and causes severe side effects in healthy tissue. If drugs are loaded into nanoparticles, side effects can be reduced, and efficiency can be increased via the enhanced ... ...

Abstract	Cancer is a worldwide increasing burden and its therapy is often challenging and causes severe side effects in healthy tissue. If drugs are loaded into nanoparticles, side effects can be reduced, and efficiency can be increased via the enhanced permeability and retention effect. This effect is based on the fact that nanoparticles with sizes from 10 to 200 nm can accumulate in tumor tissue due to their leaky vasculature. In this work, we produced polycaprolactone (PCL) in the sizes 1.8, 5.4, and 13.6 kDa and were able to produce spherical shaped nanoparticles with mean diameters of 64 ± 19 nm out of the PCL
Language	English
Publishing date	2019-08-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2071199-2
ISSN	1618-2863 ; 1618-0240
ISSN (online)	1618-2863
ISSN	1618-0240
DOI	10.1002/elsc.201800214
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of a Novel Enzyme-Linked Immunosorbent Assay and Lateral Flow Test System for Improved Serodiagnosis of Visceral Leishmaniasis in Different Areas of Endemicity.

Mahdavi, Rouzbeh / Shams-Eldin, Hosam / Witt, Sandra / Latz, Andreas / Heinz, Daniela / Fresco-Taboada, Alba / Aira, Cristina / Hübner, Marc P / Sukyte, Dalia / Visekruna, Alexander / Teixeira, Henrique C / Abass, Elfadil / Steinhoff, Ulrich

Microbiology spectrum

2023 Volume 11, Issue 3, Page(s) e0433822

Abstract: Visceral leishmaniasis (VL) is caused by protozoan parasites of the Leishmania donovani complex and is one of the most prominent vector-borne infectious diseases with epidemic and mortality potential if not correctly diagnosed and treated. East African ... ...

Abstract	Visceral leishmaniasis (VL) is caused by protozoan parasites of the Leishmania donovani complex and is one of the most prominent vector-borne infectious diseases with epidemic and mortality potential if not correctly diagnosed and treated. East African countries suffer from a very high incidence of VL, and although several diagnostic tests are available for VL, diagnosis continues to represent a big challenge in these countries due to the lack of sensitivity and specificity of current serological tools. Based on bioinformatic analysis, a new recombinant kinesin antigen from Leishmania infantum (rKLi8.3) was developed. The diagnostic performance of rKLi8.3 was evaluated by enzyme-linked immunosorbent assay (ELISA) and lateral flow test (LFT) on a panel of sera from Sudanese, Indian, and South American patients diagnosed with VL or other diseases, including tuberculosis, malaria, and trypanosomiasis. The diagnostic accuracy of rKLi8.3 was compared with rK39 and rKLO8 antigens. The VL-specific sensitivity of rK39, rKLO8, and rKLi8.3 ranged from 91.2% over 92.4% to 97.1% and specificity ranged from 93.6% over 97.6% to 99.2%, respectively. In India, all tests showed a comparable specificity of 90.9%, while the sensitivity ranged from 94.7% to 100% (rKLi8.3). In contrast to commercial serodiagnostic tests, rKLi8.3-based ELISA and LFT showed improved sensitivity and no cross-reactivity with other parasitic diseases. Thus, rKLi8.3-based ELISA and LFT offer improved VL serodiagnostic efficiency in East Africa and other areas of endemicity.
MeSH term(s)	Humans ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/epidemiology ; Leishmaniasis, Visceral/parasitology ; Antigens, Protozoan ; Protozoan Proteins ; Kinesins ; Serologic Tests ; Enzyme-Linked Immunosorbent Assay
Chemical Substances	Antigens, Protozoan ; Protozoan Proteins ; Kinesins (EC 3.6.4.4)
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04338-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Studien zur Prävalenz der Makrodontie und Evaluation eines neuen Therapieansatzes bei mandibulären Inzisivus-Erkrankungen der Meerschweinchen (Cavia porcellus L.)

Witt, Sandra [Verfasser] / Fehr, Michael [Akademischer Betreuer] / Köstlinger, Saskia Akademischer Betreuer] / [Brehm, Ralph [Gutachter]

2021

Author's details	Sandra Witt ; Gutachter: Ralph Brehm ; Michael Fehr, Saskia Köstlinger
Keywords	Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
Subject code	sg630
Language	German
Publisher	Stiftung Tierärztliche Hochschule Hannover
Publishing place	Hannover
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Implementing microbubble contrast in the echocardiography laboratory: a sonographer's perspective.

Witt, Sandra

The American journal of cardiology

2002 Volume 90, Issue 10A, Page(s) 15J–16J

Abstract: The sonographer is instrumental in incorporating ultrasound contrast into routine clinical use. Optimization of the ultrasound settings and image capture is the primary responsibility of the sonographer, who is the point person of the main contrast team. ...

Abstract	The sonographer is instrumental in incorporating ultrasound contrast into routine clinical use. Optimization of the ultrasound settings and image capture is the primary responsibility of the sonographer, who is the point person of the main contrast team. The responsibilities of the sonographer are varied and include designing a guideline-compliant laboratory environment and being familiar with contrast agents and echocardiographic equipment settings.
MeSH term(s)	Artifacts ; Contrast Media ; Echocardiography ; Humans ; Microspheres
Chemical Substances	Contrast Media
Language	English
Publishing date	2002-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/s0002-9149(02)02860-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Die Rolle der DGDG-Synthase DGD1 bei der Galaktolipid Synthese in den Hüllmembranen von Chloroplasten

Witt, Sandra [Verfasser]

2009

Author's details	von Sandra Witt
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Language	German
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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