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  1. Article ; Online: Potential role of pregabalin in the treatment of episodic breathlessness.

    Gaertner, Jan / Witte, Klaus K

    Annals of palliative medicine

    2023  Volume 13, Issue 1, Page(s) 200–201

    MeSH term(s) Humans ; Pregabalin/therapeutic use ; Dyspnea/drug therapy ; Time Factors
    Chemical Substances Pregabalin (55JG375S6M)
    Language English
    Publishing date 2023-11-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-23-547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Remote monitoring in heart failure: it's the data you collect

    Straw, Sam / Witte, Klaus K

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 11, Page(s) 810–811

    MeSH term(s) Humans ; Heart Failure/diagnosis ; Heart Failure/therapy ; Remote Sensing Technology ; Monitoring, Physiologic
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-322137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 112: Show issues

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  3. Article ; Online: It's a Matter of Fat: The Obesity Paradox in Heart Failure.

    Smith, Hannah R / Roberts, Lee D / Witte, Klaus K

    The American journal of cardiology

    2023  Volume 209, Page(s) 247–249

    MeSH term(s) Humans ; Obesity Paradox ; Heart Failure/epidemiology ; Obesity/complications ; Obesity/epidemiology
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.09.117
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    Ui IV Zs.73: Show issues Location:
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  4. Article ; Online: Cardiac resynchronisation therapy with or without a defibrillator: individualising device prescription.

    Straw, Sam / Mullens, Wilfried / Witte, Klaus K

    Heart (British Cardiac Society)

    2022  Volume 108, Issue 15, Page(s) 1164–1166

    MeSH term(s) Cardiac Resynchronization Therapy ; Defibrillators, Implantable ; Heart Failure/therapy ; Humans ; Prescriptions
    Language English
    Publishing date 2022-07-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-320909
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    Ui IV Zs.40: Show issues Location:
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    Zs.MO 112: Show issues

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  5. Article ; Online: Designing clinical trials in heart failure with preserved ejection fraction: quality over quantity?

    Straw, Sam / Gierula, John / Witte, Klaus K

    European journal of heart failure

    2022  Volume 24, Issue 5, Page(s) 851–854

    MeSH term(s) Heart Failure/drug therapy ; Hospitalization ; Humans ; Stroke Volume
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2510
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    Zs.A 5299: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: 'Acute Heart Failure': Should We Abandon the Term Altogether?

    Straw, Sam / Napp, Andreas / Witte, Klaus K

    Current heart failure reports

    2022  Volume 19, Issue 6, Page(s) 425–434

    Abstract: Purpose of review: The distinction between 'acute' and 'chronic' heart failure persists. Our review aims to explore whether reclassifying heart failure decompensation more accurately as an event within the natural history of chronic heart failure has ... ...

    Abstract Purpose of review: The distinction between 'acute' and 'chronic' heart failure persists. Our review aims to explore whether reclassifying heart failure decompensation more accurately as an event within the natural history of chronic heart failure has the potential to improve outcomes.
    Recent findings: Although hospitalisation for worsening heart failure confers a poor prognosis, much of this reflects chronic disease severity. Most patients survive hospitalisation with most deaths occurring in the post-discharge 'vulnerable phase'. Current evidence supports four classes of medications proven to reduce cardiovascular mortality for those who have heart failure with a reduced ejection fraction, with recent trials suggesting worsening heart failure events are opportunities to optimise these therapies. Abandoning the term 'acute heart failure' has the potential to give greater priority to initiating proven pharmacological and device therapies during decompensation episodes, in order to improve outcomes for those who are at the greatest risk.
    MeSH term(s) Humans ; Heart Failure/drug therapy ; Aftercare ; Patient Discharge ; Hospitalization ; Chronic Disease ; Stroke Volume
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-022-00576-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5936: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Closing the loop: Delivering personalised care for patients with cryptogenic stroke.

    Straw, Sam / Witte, Klaus K

    International journal of cardiology

    2020  Volume 327, Page(s) 100–101

    MeSH term(s) Atrial Fibrillation ; Electrocardiography, Ambulatory ; Humans ; Ischemic Stroke ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/therapy
    Language English
    Publishing date 2020-11-19
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2020.11.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Observational data during the COVID-19 pandemic: opportunity with uncertainty.

    Straw, Sam / Witte, Klaus K

    Heart (British Cardiac Society)

    2020  Volume 106, Issue 19, Page(s) 1461–1462

    MeSH term(s) Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Uncertainty
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2020-317486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 112: Show issues

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  9. Article: Development of algorithms for determining heart failure with reduced and preserved ejection fraction using nationwide electronic healthcare records in the UK.

    Sundaram, Varun / Zakeri, Rosita / Witte, Klaus K / Quint, Jennifer Kathleen

    Open heart

    2022  Volume 9, Issue 2

    Abstract: Background: Determining heart failure (HF) phenotypes in routine electronic health records (EHR) is challenging. We aimed to develop and validate EHR algorithms for identification of specific HF phenotypes, using Read codes in combination with selected ... ...

    Abstract Background: Determining heart failure (HF) phenotypes in routine electronic health records (EHR) is challenging. We aimed to develop and validate EHR algorithms for identification of specific HF phenotypes, using Read codes in combination with selected patient characteristics.
    Methods: We used The Healthcare Improvement Network (THIN). The study population included a random sample of individuals with HF diagnostic codes (HF with reduced ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and non-specific HF) selected from all participants registered in the THIN database between 1 January 2015 and 30 September 2017. Confirmed diagnoses were determined in a randomly selected subgroup of 500 patients via GP questionnaires including a review of all available cardiovascular investigations. Confirmed diagnoses of HFrEF and HFpEF were based on four criteria. Based on these data, we calculated a positive predictive value (PPV) of predefined algorithms which consisted of a combination of Read codes and additional information such as echocardiogram results and HF medication records.
    Results: The final cohort from which we drew the 500 patient random sample consisted of 10 275 patients. Response rate to the questionnaire was 77.2%. A small proportion (18%) of the overall HF patient population were coded with specific HF phenotype Read codes. For HFrEF, algorithms achieving over 80% PPV included definite, possible or non-specific HF HFrEF codes when combined with at least two of the drugs used to treat HFrEF. Only in non-specific HF coding did the use of three drugs (rather than two) contribute to an improvement of the PPV for HFrEF. HFpEF was only accurately defined with specific codes. In the absence of specific coding for HFpEF, the PPV was consistently below 50%.
    Conclusions: Prescription for HF medication can reliably be used to find HFrEF patients in the UK, even in the absence of a specific Read code for HFrEF. Algorithms using non-specific coding could not reliably find HFpEF patients.
    MeSH term(s) Humans ; Stroke Volume/physiology ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/epidemiology ; Delivery of Health Care ; Algorithms ; Electronics ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-11-02
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2022-002142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Four pillars of heart failure: contemporary pharmacological therapy for heart failure with reduced ejection fraction.

    Straw, Sam / McGinlay, Melanie / Witte, Klaus K

    Open heart

    2021  Volume 8, Issue 1

    MeSH term(s) Cardiovascular Agents/therapeutic use ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Stroke Volume/drug effects ; Stroke Volume/physiology
    Chemical Substances Cardiovascular Agents
    Language English
    Publishing date 2021-02-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2021-001585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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