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  1. Article ; Online: Cardiac Transplantation and Mechanical Circulatory Support in Amyloidosis.

    Witteles, Ronald M

    JACC. CardioOncology

    2021  Volume 3, Issue 4, Page(s) 516–521

    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-0873
    ISSN (online) 2666-0873
    DOI 10.1016/j.jaccao.2021.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ESC Cardio-Oncology Guidelines: A Triumph-But Are We Overscreening?

    Witteles, Ronald M / Reddy, Sunil A

    JACC. CardioOncology

    2022  Volume 5, Issue 1, Page(s) 133–136

    Language English
    Publishing date 2022-12-06
    Publishing country United States
    Document type Editorial
    ISSN 2666-0873
    ISSN (online) 2666-0873
    DOI 10.1016/j.jaccao.2022.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Doxycycline and Ursodiol for ATTR Amyloidosis: Not Ready for Prime Time.

    Witteles, Ronald M

    Journal of cardiac failure

    2019  Volume 25, Issue 3, Page(s) 154–155

    MeSH term(s) Amyloid Neuropathies, Familial ; Doxycycline ; Heart Failure ; Humans ; Prealbumin ; Ursodeoxycholic Acid
    Chemical Substances Prealbumin ; Ursodeoxycholic Acid (724L30Y2QR) ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2019-02-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2019.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4340: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Avoiding Catastrophe: Understanding Free Light Chain Testing in the Evaluation of ATTR Amyloidosis.

    Witteles, Ronald M / Liedtke, Michaela

    Circulation. Heart failure

    2021  Volume 14, Issue 4, Page(s) e008225

    MeSH term(s) Biomarkers/blood ; Cardiomyopathies/blood ; Cardiomyopathies/diagnostic imaging ; Humans ; Immunoglobulin Light Chains/blood ; Immunoglobulin Light-chain Amyloidosis/blood ; Immunoglobulin Light-chain Amyloidosis/diagnostic imaging ; Radionuclide Imaging/methods
    Chemical Substances Biomarkers ; Immunoglobulin Light Chains
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.120.008225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6745: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Global Longitudinal Strain in Cardio-Oncology.

    Moslehi, Javid J / Witteles, Ronald M

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 4, Page(s) 402–404

    MeSH term(s) Cardiotoxicity/etiology ; Humans ; Medical Oncology ; Neoplasms/epidemiology ; Neoplasms/therapy
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

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  6. Article ; Online: Reply: Should We Be for ASCT?: If Yes, Then When?

    Witteles, Ronald M / Barrett, Christopher D

    JACC. Heart failure

    2020  Volume 8, Issue 8, Page(s) 696–697

    MeSH term(s) Amyloidosis ; Heart Failure ; Heart Transplantation ; Humans ; Stem Cell Transplantation ; Transplantation, Autologous
    Language English
    Publishing date 2020-09-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2020.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bone Scintigraphy Imaging for Transthyretin Cardiac Amyloidosis: Still Much to Learn.

    Alexander, Kevin M / Witteles, Ronald M

    JACC. Cardiovascular imaging

    2020  Volume 13, Issue 6, Page(s) 1322–1324

    MeSH term(s) Amyloid Neuropathies, Familial/diagnostic imaging ; Humans ; Mutation ; Prealbumin/genetics ; Radionuclide Imaging
    Chemical Substances Prealbumin
    Language English
    Publishing date 2020-01-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2019.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Biomarkers as Predictors of Cardiac Toxicity From Targeted Cancer Therapies.

    Witteles, Ronald M

    Journal of cardiac failure

    2016  Volume 22, Issue 6, Page(s) 459–464

    Abstract: Background: Cardiac biomarkers have been extensively investigated as early detectors of cardiac toxicity from cancer therapies. Whereas the role of biomarkers in monitoring anthracycline toxicity is generally well understood, substantial uncertainty ... ...

    Abstract Background: Cardiac biomarkers have been extensively investigated as early detectors of cardiac toxicity from cancer therapies. Whereas the role of biomarkers in monitoring anthracycline toxicity is generally well understood, substantial uncertainty remains regarding their role in monitoring newer targeted cancer therapies.
    Methods and results: This review article examines all major published studies using cardiac troponins and/or N-terminal pro-B-type natriuretic peptide (NT-proBNP) in monitoring for cardiac toxicity with trastuzumab, tyrosine kinase inhibitors, and mammalian target of rapamycin (mTOR) inhibitors. There is substantial variability among studies regarding biomarker assays used, sensitivity of the assays, and definitions of abnormal results. In general, troponin I predicts early but not late cardiac events when trastuzumab is administered after anthracyclines, but troponin increases likely reflect anthracycline injury rather than trastuzumab injury. NT-proBNP detects cardiac toxicity with tyrosine kinase inhibitors and mTOR inhibitors, but not independently from echocardiography.
    Conclusions: Troponin I can serve as a marker for susceptibility to cardiac toxicity during early trastuzumab treatment in patients who have received recent anthracyclines. NT-proBNP can serve as a useful marker of cardiac toxicity in patients treated with tyrosine kinase inhibitors or mTOR inhibitors if echocardiographic screening is not being used.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Biomarkers/blood ; Cardiomyopathies/blood ; Cardiomyopathies/chemically induced ; Cardiotoxicity ; Humans ; Natriuretic Peptide, Brain/blood ; Neoplasms/drug therapy ; Troponin I/blood
    Chemical Substances Antineoplastic Agents ; Biomarkers ; Troponin I ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2016.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4340: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Development and validation of a rapid visual technique for left ventricular hypertrophy detection from the electrocardiogram.

    Somani, Sulaiman / Hughes, J Weston / Ashley, Euan A / Witteles, Ronald M / Perez, Marco V

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1251511

    Abstract: Introduction: Left ventricular hypertrophy (LVH) detection techniques on by electrocardiogram (ECG) are cumbersome to remember with modest performance. This study validated a rapid technique for LVH detection and measured its performance against other ... ...

    Abstract Introduction: Left ventricular hypertrophy (LVH) detection techniques on by electrocardiogram (ECG) are cumbersome to remember with modest performance. This study validated a rapid technique for LVH detection and measured its performance against other techniques.
    Methods: This was a retrospective cohort study of patients at Stanford Health Care who received ECGs and resting transthoracic echocardiograms (TTE) from 2006 through 2018. The novel technique, Witteles-Somani (WS), assesses for S- and R-wave overlap on adjacent precordial leads. The WS, Sokolow-Lyon, Cornell, and Peguero-Lo Presti techniques were algorithmically implemented on ECGs. Classification metrics, receiver-operator curves, and Pearson correlations measured performance. Age- and sex-adjusted Cox proportional hazard models evaluated associations between incident cardiovascular outcomes and each technique.
    Results: A total of 53,333 ECG-TTE pairs from 18,873 patients were identified. Of all ECG-TTE pairs, 21,638 (40.6%) had TTE-diagnosed LVH. The WS technique had a sensitivity of 0.46, specificity of 0.66, and AUROC of 0.56, compared to Sokolow-Lyon (AUROC 0.55), Cornell (AUROC 0.63), and Peguero-Lo Presti (AUROC 0.63). Patients meeting LVH by WS technique had a higher risk of cardiovascular mortality [HR 1.18, 95% CI (1.12, 1.24),
    Conclusions: The WS criteria is a rapid visual technique for LVH detection with performance like other LVH detection techniques and is associated with incident cardiovascular outcomes.
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1251511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: AL Amyloidosis for the Cardiologist and Oncologist: Epidemiology, Diagnosis, and Management.

    Witteles, Ronald M / Liedtke, Michaela

    JACC. CardioOncology

    2019  Volume 1, Issue 1, Page(s) 117–130

    Abstract: AL amyloidosis results from clonal production of immunoglobulin light chains, most commonly arising from a clonal plasma cell disorder. Once considered a nearly uniformly fatal disease, prognosis has improved markedly over the past 15 years, ... ...

    Abstract AL amyloidosis results from clonal production of immunoglobulin light chains, most commonly arising from a clonal plasma cell disorder. Once considered a nearly uniformly fatal disease, prognosis has improved markedly over the past 15 years, predominantly because of advances in light chain suppressive therapies. Cardiac deposition of amyloid fibrils is common, and the severity of cardiac involvement remains the primary driver of prognosis. Improvements in chemotherapy/immunotherapy have prompted a reassessment of the role of advanced cardiac therapies previously considered contraindicated in most patients, including the role of implantable cardioverter-defibrillators and cardiac transplantation. This state-of-the-art review highlights the current state of the field, including diagnosis, prognosis, and hematologic- and cardiac-specific therapies.
    Language English
    Publishing date 2019-09-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-0873
    ISSN (online) 2666-0873
    DOI 10.1016/j.jaccao.2019.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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