LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 171

Search options

  1. Book: Langzeittherapie der Schizophrenie

    Wobrock, Thomas / Pajonk, Frank-Gerald

    (Uni-Med science)

    2004  

    Author's details [Hrsg.: Frank-Gerald Pajonk ... Autoren: Thomas Wobrock ...]
    Series title Uni-Med science
    Keywords Schizophrenie ; Langzeittherapie
    Subject Langzeit ; Long-term therapy ; Langzeitbehandlung ; Spaltungsirresein ; Schizophrene Psychose
    Language German
    Size 157 S. : graph. Darst., 25 cm
    Edition 1. Aufl.
    Publisher UNI-MED-Verl
    Publishing place Bremen u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT014284065
    ISBN 3-89599-823-0 ; 978-3-89599-823-2
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 571 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Thesis: AIDS-Encephalopathie

    Wobrock, Thomas

    vergleichende klinische und neuropathologische Beobachtungen bei mit Zidovudin (AZT) behandelten und nicht-behandelten Patienten

    1994  

    Title variant AIDS-Enzephalopathie
    Author's details vorgelegt von Thomas Wobrock
    Language German
    Size 265 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 1996
    HBZ-ID HT007384611
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    97 D 30 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Online ; Thesis: Veränderung der kortikalen Erregbarkeit durch mehrmonatige transkutane Vagus-Nerv-Stimulation bei Patienten mit einer chronischen Schizophrenie

    Gruhn, Philipp [Verfasser] / Wobrock, Thomas [Akademischer Betreuer] / Wobrock, Thomas [Gutachter] / Sommer, Martin [Gutachter]

    2022  

    Author's details Philipp Gruhn ; Gutachter: Thomas Wobrock, Martin Sommer ; Betreuer: Thomas Wobrock
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Online ; Thesis: Veränderung der kortikalen Inhibition und Fazilitation bei Patienten mit einem Risikostadium für eine Schizophrenie im Vergleich mit Schizophrenie-Ersterkrankten und gesunden Kontrollprobanden.

    Labusga, Marcin Lukasz [Verfasser] / Wobrock, Thomas [Akademischer Betreuer] / Zilles-Wegner, David [Gutachter] / Sennhenn-Kirchner, Sabine [Gutachter]

    2023  

    Author's details Marcin Lukasz Labusga ; Gutachter: David Zilles-Wegner, Sabine Sennhenn-Kirchner ; Betreuer: Thomas Wobrock
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Multimodal workflows optimally predict response to repetitive transcranial magnetic stimulation in patients with schizophrenia: a multisite machine learning analysis.

    Dong, Mark Sen / Rokicki, Jaroslav / Dwyer, Dominic / Papiol, Sergi / Streit, Fabian / Rietschel, Marcella / Wobrock, Thomas / Müller-Myhsok, Bertram / Falkai, Peter / Westlye, Lars Tjelta / Andreassen, Ole A / Palaniyappan, Lena / Schneider-Axmann, Thomas / Hasan, Alkomiet / Schwarz, Emanuel / Koutsouleris, Nikolaos

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 196

    Abstract: The response variability to repetitive transcranial magnetic stimulation (rTMS) challenges the effective use of this treatment option in patients with schizophrenia. This variability may be deciphered by leveraging predictive information in structural ... ...

    Abstract The response variability to repetitive transcranial magnetic stimulation (rTMS) challenges the effective use of this treatment option in patients with schizophrenia. This variability may be deciphered by leveraging predictive information in structural MRI, clinical, sociodemographic, and genetic data using artificial intelligence. We developed and cross-validated rTMS response prediction models in patients with schizophrenia drawn from the multisite RESIS trial. The models incorporated pre-treatment sMRI, clinical, sociodemographic, and polygenic risk score (PRS) data. Patients were randomly assigned to receive active (N = 45) or sham (N = 47) rTMS treatment. The prediction target was individual response, defined as ≥20% reduction in pre-treatment negative symptom sum scores of the Positive and Negative Syndrome Scale. Our multimodal sequential prediction workflow achieved a balanced accuracy (BAC) of 94% (non-responders: 92%, responders: 95%) in the active-treated group and 50% in the sham-treated group. The clinical, clinical + PRS, and sMRI-based classifiers yielded BACs of 65%, 76%, and 80%, respectively. Apparent sadness, inability to feel, educational attainment PRS, and unemployment were most predictive of non-response in the clinical + PRS model, while grey matter density reductions in the default mode, limbic networks, and the cerebellum were most predictive in the sMRI model. Our sequential modelling approach provided superior predictive performance while minimising the diagnostic burden in the clinical setting. Predictive patterns suggest that rTMS responders may have higher levels of brain grey matter in the default mode and salience networks which increases their likelihood of profiting from plasticity-inducing brain stimulation methods, such as rTMS. The future clinical implementation of our models requires findings to be replicated at the international scale using stratified clinical trial designs.
    MeSH term(s) Humans ; Schizophrenia/therapy ; Schizophrenia/diagnostic imaging ; Schizophrenia/physiopathology ; Transcranial Magnetic Stimulation/methods ; Machine Learning ; Female ; Male ; Adult ; Magnetic Resonance Imaging ; Workflow ; Treatment Outcome ; Middle Aged ; Young Adult
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Randomized Controlled Trial ; Multicenter Study
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02903-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Online ; Thesis: Veränderung der motorkortikalen Exzitabilität durch eine kontrollierte Sportintervention bei Menschen mit einer Schizophrenie und gesunden Teilnehmern

    Levold, Katrin [Verfasser] / Wobrock, Thomas [Akademischer Betreuer] / Antal, Andrea [Gutachter] / Sennhenn-Kirchner, Sabine [Gutachter]

    2022  

    Author's details Katrin Levold ; Gutachter: Andrea Antal, Sabine Sennhenn-Kirchner ; Betreuer: Thomas Wobrock
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Book: Psychoedukation, Schizophrenie und Sucht

    D'Amelio, Roberto / Behrendt, Bernd / Wobrock, Thomas

    Manual zur Leitung von Patienten- und Angehörigengruppen ; mit 56 Folien, 30 Handouts, 9 Vordrucken und Suchtmittel-Kompendium im Ahang und als CD-ROM

    2007  

    Author's details R. D'Amelio ; B Behrendt ; T. Wobrock
    Keywords Schizophrenie ; Psychoedukation ; Sucht
    Subject Familie ; Familienangehöriger ; Psychoedukative Familienintervention ; Rezidivprophylaxe ; Suchtkrankheit ; Suchterkrankung ; Spaltungsirresein ; Schizophrene Psychose
    Language German
    Size XI, 401 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Urban & Fischer
    Publishing place München u.a.
    Publishing country Germany
    Document type Book
    Note Systemvoraussetzungen: Windows 98SE oder höher, CD-ROM, aktuelle Browser mit JavaScript Adobe Reader 5.0 oder höher; Mac OS9/OSX10.2.x, CD-ROM, Aktuelle Browser mit JavaScript Adobe Reader 5.0 oder höher; Linux, CD-ROM, Mozilla, Firefox, Netscape mit JavaScript Adobe Reader 5.0 oder höher
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT014834874
    ISBN 978-3-437-22756-1 ; 3-437-22756-4
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 MO 1146 <<[Begleitmaterial]>> order for loan Magazin
    2007 A 663 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes.

    Hasan, Alkomiet / Strube, Wolfgang / Palm, Ulrich / Wobrock, Thomas

    Schizophrenia bulletin

    2016  Volume 42 Suppl 1, Page(s) S95–S109

    Abstract: Despite many years of research, there is still an urgent need for new therapeutic options for the treatment of cognitive deficits in schizophrenia. Noninvasive brain stimulation (NIBS) has been proposed to be such a novel add-on treatment option. The ... ...

    Abstract Despite many years of research, there is still an urgent need for new therapeutic options for the treatment of cognitive deficits in schizophrenia. Noninvasive brain stimulation (NIBS) has been proposed to be such a novel add-on treatment option. The main objective of this review was to systematically evaluate the cognitive effects of repetitive NIBS in schizophrenia. As most studies have not been specifically designed to investigate cognition as primary outcome, we have focused on both, primary and secondary outcomes. The PubMed/MEDLINE database (1985-2015) was systematically searched for interventional studies investigating the effects of repetitive NIBS on schizophrenia symptoms. All interventional clinical trials using repetitive transcranial stimulation, transcranial theta burst stimulation, and transcranial direct current stimulation for the treatment of schizophrenia were extracted and analyzed with regard to cognitive measures as primary or secondary outcomes. Seventy-six full-text articles were assessed for eligibility of which 33 studies were included in the qualitative synthesis. Of these 33 studies, only 4 studies included cognition as primary outcome, whereas 29 studies included cognitive measures as secondary outcomes. A beneficial effect of frontal NIBS could not be clearly established. No evidence for a cognitive disruptive effect of NIBS (temporal lobe) in schizophrenia could be detected. Finally, a large heterogeneity between studies in terms of inclusion criteria, stimulation parameters, applied cognitive measures, and follow-up intervals was observed. This review provides the first systematic overview regarding cognitive effects of repetitive NIBS in schizophrenia.
    MeSH term(s) Cognitive Dysfunction/etiology ; Cognitive Dysfunction/therapy ; Humans ; Outcome Assessment (Health Care) ; Schizophrenia/complications ; Transcranial Direct Current Stimulation/methods ; Transcranial Magnetic Stimulation/methods
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbv158
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Online ; Thesis: Veränderung der kognitiven Funktionen durch körperliches Training bei Schizophrenie - Eine kontrollierte Studie

    Dörfler, Sebastian [Verfasser] / Wobrock, Thomas [Akademischer Betreuer] / Wobrock, Thomas [Gutachter] / Wilke, Melanie [Gutachter]

    2018  

    Author's details Sebastian Dörfler ; Gutachter: Thomas Wobrock, Melanie Wilke ; Betreuer: Thomas Wobrock
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Psychoedukation bei Schlafstörungen

    Wobrock, Thomas / Dörr, Roger

    (In: Bäuml, Josef; Behrendt, Bernd; Henningsen, Peter; Pitschel-Walz, Gabi (Ed.), Handbuch der Psychoedukation für Psychiatrie, Psychotherapie und Psychosomatische Medizin (S. 341-357). Stuttgart: Schattauer)

    2016  

    Series title In: Bäuml, Josef; Behrendt, Bernd; Henningsen, Peter; Pitschel-Walz, Gabi (Ed.), Handbuch der Psychoedukation für Psychiatrie, Psychotherapie und Psychosomatische Medizin (S. 341-357). Stuttgart: Schattauer
    Keywords Behavior Therapy ; Insomnia ; Psychoeducation ; Psychoedukativer Ansatz ; Schlaf-Wach-Störungen ; Schlaflosigkeit ; Sleep Wake Disorders ; Verhaltenstherapie
    Language German
    Document type Article
    Database PSYNDEX

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top