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  1. Book: Stem cells

    Wobus, Anna M. / Alison, M. R.

    [with 24 tables]

    (Handbook of experimental pharmacology ; 174)

    2006  

    Author's details ed. Anna M. Wobus ... Contributors: M. R. Alison
    Series title Handbook of experimental pharmacology ; 174
    Collection
    Keywords Stammzelle
    Subject Stem cell
    Language English
    Size X, 414 S. : Ill., 235 mm x 155 mm
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014583309
    ISBN 978-3-540-26133-9 ; 3-540-26133-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 6733 order for loan Magazin
    2006 A 681 order for loan Magazin

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  2. Article ; Online: The Janus face of pluripotent stem cells--connection between pluripotency and tumourigenicity.

    Wobus, Anna M

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2010  Volume 32, Issue 11, Page(s) 993–1002

    Abstract: Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. ...

    Abstract Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. Here three types of in vitro cultured pluripotent stem cells (embryonic carcinoma, embryonic stem and induced pluripotent stem cells) are compared in their historical context with respect to their different origin and properties. It became evident that tumourigenicity is an inherent property of pluripotent cells based on p53 down-regulation, expression of tumour-related genes and high telomerase activity that allow unlimited proliferation. In addition, culture-adapted genetic and epigenetic changes may induce tumourigenicity of pluripotent cells. The use of stem cells in regenerative medicine, however, requires non-malignant cell types and strategies that circumvent stages of malignancy.Reprogramming strategies of adult somatic cells that avoid the tumourigenic state of pluripotency may offer alternatives for future biomedical application.
    MeSH term(s) Embryonic Stem Cells/metabolism ; Embryonic Stem Cells/pathology ; Humans ; Induced Pluripotent Stem Cells/pathology ; Neoplasms/pathology ; Pluripotent Stem Cells/pathology
    Language English
    Publishing date 2010-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201000065
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2024: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Book ; Conference proceedings: Die Verfügbarkeit des Lebendigen

    Wobus, Anna M.

    am 28. und 29. Mai 1999 ; mit 6 Tabellen

    (Nova acta Leopoldina ; N.F., Nr. 315 : Bd. 82)

    2000  

    Institution Institut für Pflanzengenetik und Kulturpflanzenforschung
    Event/congress Gaterslebener Begegnung (8, 1999, Gatersleben)
    Author's details Gaterslebener Begegnung 1999. Gemeinsam veranst. vom Institut für Pflanzengenetik und Kulturpflanzenforschung Gatersleben und von der Deutschen Akademie der Naturforscher Leopoldina. Hrsg. von Anna M. Wobus
    Series title Nova acta Leopoldina ; N.F., Nr. 315 : Bd. 82
    Collection
    Keywords Gentechnologie
    Subject Gentechnik ; Genchirurgie ; Genetic engineering ; Genetische Manipulation ; Genetische Technik ; Genmanipulation
    Language German
    Size 285 S. : Ill., graph. Darst.
    Publisher Barth
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT012798215
    ISBN 3-8304-5085-0 ; 978-3-8304-5085-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 1/20 -395- verfügbar in Königswinter Königswinter

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  4. Book ; Conference proceedings: Der Begriff der Natur

    Wobus, Anna M

    Wandlungen unseres Naturverständnisses und seine Folgen ; Gaterslebener Begegnung 2009 ; ... vom 7. bis 9. Mai 2009 ; mit 1 Tabelle

    (Nova acta Leopoldina ; N.F., 376 = Bd. 109)

    2010  

    Title variant Gaterslebener Begegnung 2009
    Institution Deutsche Akademie der Naturforscher Leopoldina
    Gaterslebener Begegnung
    Institut für Pflanzengenetik und Kulturpflanzenforschung
    Event/congress Gaterslebener Begegnung (11, 2009.05.07-09, Gatersleben)
    Author's details gemeinsam veranst. vom Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung Gatersleben und von der Deutschen Akademie der Naturforscher Leopoldina. Hrsg. von Anna M. Wobus
    Series title Nova acta Leopoldina ; N.F., 376 = Bd. 109
    Keywords Umweltethik ; Natur ; Begriff
    Language German
    Size 266 S., Ill., graph. Darst., Kt.
    Publisher Wiss. Verl.-Ges
    Publishing place Stuttgart
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 3804728014 ; 9783804728011
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Book ; Conference proceedings: Der Begriff der Natur

    Wobus, Anna M

    Wandlungen unseres Naturverständnisses und seine Folgen ; Gaterslebener Begegnung 2009 ; ... vom 7. bis 9. Mai 2009 ; mit 1 Tabelle

    (Nova acta Leopoldina ; N.F., 376 = Bd. 109)

    2010  

    Title variant Gaterslebener Begegnung 2009
    Institution Deutsche Akademie der Naturforscher Leopoldina
    Gaterslebener Begegnung
    Institut für Pflanzengenetik und Kulturpflanzenforschung
    Event/congress Gaterslebener Begegnung (11, 2009.05.07-09, Gatersleben)
    Author's details gemeinsam veranst. vom Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung Gatersleben und von der Deutschen Akademie der Naturforscher Leopoldina. Hrsg. von Anna M. Wobus
    Series title Nova acta Leopoldina ; N.F., 376 = Bd. 109
    Keywords Umweltethik ; Natur ; Begriff
    Language German
    Size 266 S., Ill., graph. Darst., Kt.
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 3804728014 ; 9783804728011
    Database Leibniz Institute of Plant Genetics and Crop Plant Research

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  6. Article ; Online: Stem cell research within the Priority Program 1109 of the German Research Foundation, 2001-2007.

    Wobus, Anna M

    Cells, tissues, organs

    2008  Volume 188, Issue 1-2, Page(s) 6–8

    MeSH term(s) Animals ; Cell Differentiation ; Congresses as Topic ; Embryonic Stem Cells/cytology ; Germany ; Humans ; Mice ; Research ; Research Support as Topic ; Stem Cells/cytology
    Language English
    Publishing date 2008
    Publishing country Switzerland
    Document type Introductory Journal Article
    ZDB-ID 1468141-9
    ISSN 1422-6421 ; 1422-6405
    ISSN (online) 1422-6421
    ISSN 1422-6405
    DOI 10.1159/000118785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Stammzellenbasierte Leberregeneration, Subprojekt No. II: Etablierung von effizienten in vitro-Protokollen für hepatische Differenzierung von ES-Zellen

    Wobus, Anna M

    Schlussbericht zum BMBF-Projekt ; Laufzeit: 01.09.2005 - 31.08.2008

    2009  

    Institution Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
    Author's details Projektleiter und durchführende Institution: Anna M. Wobus, Abt. Zytogenetik, Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)
    Language German
    Size [8] Bl.
    Publishing place Gatersleben
    Document type Book
    Note Förderkennzeichen BMBF 01GN0527. - Verbund-Nr. 01042052 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online: Stammzellenbasierte Leberregeneration, Subprojekt No. II: Etablierung von effizienten in vitro-Protokollen für hepatische Differenzierung von ES-Zellen

    Wobus, Anna M

    Schlussbericht zum BMBF-Projekt ; Laufzeit: 01.09.2005 - 31.08.2008

    2009  

    Institution Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
    Author's details Projektleiter und durchführende Institution: Anna M. Wobus, Abt. Zytogenetik, Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)
    Language German
    Size Online-Ressource (8 S., 33,1 KB)
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek
    Publishing place Hannover ; Gatersleben
    Document type Book ; Online
    Note Förderkennzeichen BMBF 01GN0527 ; Unterschiede zwischen der elektronischen Ressource und dem gedruckten Dokument können nicht ausgeschlossen werden. - Auch als gedr. Ausg. vorhanden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article: The Janus face of pluripotent stem cells - Connection between pluripotency and tumourigenicity

    Wobus, Anna M

    BioEssays. 2010 Nov., v. 32, no. 11

    2010  

    Abstract: Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. ...

    Abstract Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. Here three types of in vitro-cultured pluripotent stem cells (embryonic carcinoma, embryonic stem and induced pluripotent stem cells) are compared in their historical context with respect to their different origin and properties. It became evident that tumourigenicity is an inherent property of pluripotent cells based on p53 down-regulation, expression of tumour-related genes and high telomerase activity that allow unlimited proliferation. In addition, culture-adapted genetic and epigenetic changes may induce tumourigenicity of pluripotent cells. The use of stem cells in regenerative medicine, however, requires non-malignant cell types and strategies that circumvent stages of malignancy. Reprogramming strategies of adult somatic cells that avoid the tumourigenic state of pluripotency may offer alternatives for future biomedical application.
    Language English
    Dates of publication 2010-11
    Size p. 993-1002.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201000065
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2009/501: Show issues

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  10. Article: In vitro differentiation of embryonic stem cells into cardiomyocytes or skeletal muscle cells is specifically modulated by retinoic acid.

    Wobus, Anna M / Rohwedel, Jürgen / Maltsev, Victor / Hescheler, Jürgen

    Roux's archives of developmental biology : the official organ of the EDBO

    2017  Volume 204, Issue 1, Page(s) 36–45

    Abstract: Pluripotent embryonic stem cells (ES cells) differentiating via embryo-like aggregates (embryoid bodies) into derivatives of the primary germ layers were used as a model system to investigate the time- and concentration dependent effects of retinoic acid ...

    Abstract Pluripotent embryonic stem cells (ES cells) differentiating via embryo-like aggregates (embryoid bodies) into derivatives of the primary germ layers were used as a model system to investigate the time- and concentration dependent effects of retinoic acid (RA) on the in vitro differentiation pattern. When ES cells, cultivated normally under conditions resulting in cardiomyocyte differentiation, were treated during the first 2 days of embryoid body formation with high RA concentrations (10
    Language English
    Publishing date 2017-03-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 14096-x
    ISSN 0930-035X ; 0340-0794
    ISSN 0930-035X ; 0340-0794
    DOI 10.1007/BF00189066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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