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  1. Article ; Online: Correction: Quake et al. Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study. Nutrients 2022, 14, 737

    Quake, Antonia Zoe / Liu, Taryn Audrey / D'Souza, Rachel / Jackson, Katherine G / Woch, Margaret / Tetteh, Afua / Sampath, Vanitha / Nadeau, Kari C / Sindher, Sayantani / Chinthrajah, R Sharon / Cao, Shu

    Nutrients

    2022  Volume 15, Issue 1

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2022-12-28
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15010135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Phase 2, randomized multi oral immunotherapy with omalizumab 'real life' study.

    Sindher, Sayantani B / Kumar, Divya / Cao, Shu / Purington, Natasha / Long, Andrew / Sampath, Vanitha / Zedeck, Stacey S / Woch, Margaret A / Garcia-Lloret, Maria / Chinthrajah, Rebecca Sharon

    Allergy

    2022  Volume 77, Issue 6, Page(s) 1873–1884

    Abstract: Background: Oral immunotherapy (OIT) is frequently discontinued due to adverse events (AEs) and current data suggests that lowering OIT doses can minimize severity and frequency of AEs. However, the minimum daily dose that can enable desensitization and ...

    Abstract Background: Oral immunotherapy (OIT) is frequently discontinued due to adverse events (AEs) and current data suggests that lowering OIT doses can minimize severity and frequency of AEs. However, the minimum daily dose that can enable desensitization and induce immune responses in multi-food OIT (mOIT) is unknown.
    Methods: Participants aged 2-25 years with multi-food allergies were pretreated with fixed-dose omalizumab (150 mg, 3 doses, every 4 weeks), and randomized 1:1 to receive mOIT to a total maintenance dose of either 300 or 1200 mg total protein, (total dose includes at least two and up to a max of five allergens) and then transitioned to real-food protein equivalents after 18 weeks of treatment. The primary endpoint was the proportion of subjects with increases in IgG4/IgE ratio of at least 2 allergens by ≥25% from baseline after 18 weeks of therapy. The primary efficacy and safety analyses were done in the intention-to-treat population.
    Results: Sixty participants were enrolled across two sites. Seventy percent of participants in both arms showed changes in sIgG4/sIgE ratio in at least 2 allergens with no difference between the treatment groups (OR [95% CI] = 1.00 [0.29, 3.49]). Overall, there were no differences in AEs between the 300 and 1200 mg groups (19% vs. 17%, p = .69), respectively.
    Conclusions: Our data suggest that plasma marker changes are induced early, even at a total protein dose of 300 mg inclusive of multiple allergens when mOIT is combined with fixed-dose omalizumab. Identification of optimal mOIT dosing with adjunct omalizumab is needed for the long-term success of OIT.
    Trial registration: ClinicalTrials.gov (NCT03181009).
    MeSH term(s) Administration, Oral ; Allergens ; Desensitization, Immunologic/adverse effects ; Humans ; Immunoglobulin E ; Immunologic Factors ; Omalizumab/adverse effects
    Chemical Substances Allergens ; Immunologic Factors ; Omalizumab (2P471X1Z11) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2022-01-24
    Publishing country Denmark
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study.

    Quake, Antonia Zoe / Liu, Taryn Audrey / D'Souza, Rachel / Jackson, Katherine G / Woch, Margaret / Tetteh, Afua / Sampath, Vanitha / Nadeau, Kari C / Sindher, Sayantani / Chinthrajah, R Sharon / Cao, Shu

    Nutrients

    2022  Volume 14, Issue 4

    Abstract: The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of ... ...

    Abstract The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of allergens that can be safely introduced to infants, particularly in those at high or low risk of atopy, are still unclear. This 1-year pilot study evaluated the safety of the early introduction of single foods (milk, egg, or peanut) vs. two foods (milk/egg, egg/peanut, milk/peanut) vs. multiple foods (milk/egg/peanut/cashew/almond/shrimp/walnut/wheat/salmon/hazelnut at low, medium, or high doses) vs. no early introduction in 180 infants between 4-6 months of age. At the end of the study, they were evaluated for plasma biomarkers associated with food reactivity via standardized blood tests. Two to four years after the start of the study, participants were evaluated by standardized food challenges. The serving sizes for the single, double, and low dose mixtures were 300 mg total protein per day. The serving sizes for the medium and high dose mixtures were 900 mg and 3000 mg total protein, respectively. Equal parts of each protein were used for double or mixture foods. All infants were breastfed until at least six months of age. The results demonstrate that infants at either high or low risk for atopy were able to tolerate the early introduction of multiple allergenic foods with no increases in any safety issues, including eczema, FA, or food protein induced enterocolitis. The mixtures of foods at either low, medium, or high doses demonstrated trends for improvement in food challenge reactivity and plasma biomarkers compared to single and double food introductions. The results of this study suggest that the early introduction of foods, particularly simultaneous mixtures of many allergenic foods, may be safe and efficacious for preventing FA and can occur safely. These results need to be confirmed by larger randomized controlled studies.
    MeSH term(s) Allergens ; Arachis ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/prevention & control ; Humans ; Hypersensitivity, Immediate ; Infant ; Pilot Projects
    Chemical Substances Allergens
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14040737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study

    Quake, Antonia Zoe / Liu, Taryn Audrey / D’Souza, Rachel / Jackson, Katherine G. / Woch, Margaret / Tetteh, Afua / Sampath, Vanitha / Nadeau, Kari C. / Sindher, Sayantani / Chinthrajah, R. Sharon / Cao, Shu

    Nutrients. 2022 Feb. 09, v. 14, no. 4

    2022  

    Abstract: The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of ... ...

    Abstract The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of allergens that can be safely introduced to infants, particularly in those at high or low risk of atopy, are still unclear. This 1-year pilot study evaluated the safety of the early introduction of single foods (milk, egg, or peanut) vs. two foods (milk/egg, egg/peanut, milk/peanut) vs. multiple foods (milk/egg/peanut/cashew/almond/shrimp/walnut/wheat/salmon/hazelnut at low, medium, or high doses) vs. no early introduction in 180 infants between 4–6 months of age. At the end of the study, they were evaluated for plasma biomarkers associated with food reactivity via standardized blood tests. Two to four years after the start of the study, participants were evaluated by standardized food challenges. The serving sizes for the single, double, and low dose mixtures were 300 mg total protein per day. The serving sizes for the medium and high dose mixtures were 900 mg and 3000 mg total protein, respectively. Equal parts of each protein were used for double or mixture foods. All infants were breastfed until at least six months of age. The results demonstrate that infants at either high or low risk for atopy were able to tolerate the early introduction of multiple allergenic foods with no increases in any safety issues, including eczema, FA, or food protein induced enterocolitis. The mixtures of foods at either low, medium, or high doses demonstrated trends for improvement in food challenge reactivity and plasma biomarkers compared to single and double food introductions. The results of this study suggest that the early introduction of foods, particularly simultaneous mixtures of many allergenic foods, may be safe and efficacious for preventing FA and can occur safely. These results need to be confirmed by larger randomized controlled studies.
    Keywords allergenicity ; almonds ; atopy ; biomarkers ; breast feeding ; dietary protein ; eczema ; eggs ; enterocolitis ; food allergies ; hazelnuts ; milk ; peanuts ; protein content ; risk ; salmon ; shrimp ; walnuts ; wheat
    Language English
    Dates of publication 2022-0209
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14040737
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Retail Food Equivalents for Post-Oral Immunotherapy Dosing in the Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy in Food-Allergic Children and Adults (OUtMATCH) Clinical Trial.

    Groetch, Marion / Mudd, Kim / Woch, Margaret / Schaible, Allison / Gray, Brianna E / Babineau, Denise C / Bird, J Andrew / Jones, Stacie / Kim, Edwin H / Lanser, Bruce J / Poyser, Julian / Rogers, Nicole / Shreffler, Wayne / Sicherer, Scott / Spergel, Amanda K Rudman / Spergel, Jonathan / Vickery, Brian P / Chinthrajah, R Sharon / Wood, Robert

    The journal of allergy and clinical immunology. In practice

    2022  Volume 11, Issue 2, Page(s) 572–580.e2

    Abstract: Background: Patients with food allergy may be advised to introduce specific foods into their diets, both to increase tolerance gradually and as next steps after completing oral immunotherapy or other therapeutic interventions. However, the safe use of ... ...

    Abstract Background: Patients with food allergy may be advised to introduce specific foods into their diets, both to increase tolerance gradually and as next steps after completing oral immunotherapy or other therapeutic interventions. However, the safe use of retail foods depends on the ability to establish the specific allergen protein content of these foods.
    Objective: To develop a systematic approach to estimate the protein content of peanut, milk, egg, wheat, cashew, hazelnut, and walnut in a variety of retail food equivalents for each allergen and associated patient education materials.
    Method: We created an algorithm that used a multistep process with information from product food labels, nutrient databases, independent weighing and measuring of foods, and information provided by manufacturers, including certificates of analysis, and e-mail communication to estimate the allergen protein content of multiple retail foods for each of seven allergens. Once a variety of retail food equivalents for each allergen and allergen serving size was determined, we developed participant education handouts, which were reviewed by study teams at 10 food allergy centers, the National Institute of Allergy and Infectious Diseases, and the Consortium for Food Allergy Research coordinating center. After 1 year of use, multiple queries were addressed and the retail food equivalents and educational materials were reviewed and edited.
    Results: We identified a variety of retail food equivalents for seven allergens at six serving sizes, and created 48 unique patient education materials.
    Conclusion: Our results provide extensive guidance on a variety of retail equivalents for seven foods, and a method to estimate retail food protein equivalents systematically with ongoing reassessment.
    MeSH term(s) Adult ; Child ; Humans ; Allergens/therapeutic use ; Desensitization, Immunologic/methods ; Food Hypersensitivity/drug therapy ; Nuts ; Omalizumab/therapeutic use
    Chemical Substances Allergens ; Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.10.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Corrigendum: Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens.

    Sindher, Sayantani / Long, Andrew J / Purington, Natasha / Chollet, Madeleine / Slatkin, Sara / Andorf, Sandra / Tupa, Dana / Kumar, Divya / Woch, Margaret A / O'Laughlin, Katherine L / Assaad, Amal / Pongracic, Jacqueline / Spergel, Jonathan M / Tam, Jonathan / Tilles, Stephen / Wang, Julie / Galli, Stephen J / Nadeau, Kari C / Chinthrajah, R Sharon

    Frontiers in immunology

    2020  Volume 11, Page(s) 625796

    Abstract: This corrects the article DOI: 10.3389/fimmu.2018.02689.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2018.02689.].
    Language English
    Publishing date 2020-11-30
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.625796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges.

    Purington, Natasha / Chinthrajah, R Sharon / Long, Andrew / Sindher, Sayantani / Andorf, Sandra / O'Laughlin, Katherine / Woch, Margaret A / Scheiber, Alexandra / Assa'ad, Amal / Pongracic, Jacqueline / Spergel, Jonathan M / Tam, Jonathan / Tilles, Stephen / Wang, Julie / Galli, Stephen J / Desai, Manisha / Nadeau, Kari C

    Frontiers in immunology

    2018  Volume 9, Page(s) 2057

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Administration, Oral ; Adolescent ; Adult ; Allergens/immunology ; Arachis/immunology ; Asthma/diagnosis ; Asthma/epidemiology ; Child ; Child, Preschool ; Datasets as Topic ; Female ; Food/statistics & numerical data ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/epidemiology ; Humans ; Immunoglobulin E/blood ; Infant ; Male ; Mass Screening ; Middle Aged ; Prognosis ; Reference Standards ; Retrospective Studies ; Young Adult
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-09-21
    Publishing country Switzerland
    Document type Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens.

    Sindher, Sayantani / Long, Andrew J / Purington, Natasha / Chollet, Madeleine / Slatkin, Sara / Andorf, Sandra / Tupa, Dana / Kumar, Divya / Woch, Margaret A / O'Laughlin, Katherine L / Assaad, Amal / Pongracic, Jacqueline / Spergel, Jonathan M / Tam, Jonathan / Tilles, Stephen / Wang, Julie / Galli, Stephen J / Nadeau, Kari C / Chinthrajah, R Sharon

    Frontiers in immunology

    2018  Volume 9, Page(s) 2689

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adolescent ; Adult ; Allergens/immunology ; Child ; Child, Preschool ; Dermatitis, Atopic/immunology ; Double-Blind Method ; Female ; Food ; Food Hypersensitivity/immunology ; Humans ; Immunoglobulin E/immunology ; Infant ; Male ; Middle Aged ; Reference Standards ; Skin Tests/methods ; Young Adult
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-11-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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