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  1. Article ; Online: Multicenter Clinical Validation of a Cartridge-Based Real-Time PCR System for Detection of Coccidioides spp. in Lower Respiratory Specimens.

    Saubolle, Michael A / Wojack, Bette R / Wertheimer, Anne M / Fuayagem, Atehkeng Z / Young, Stephen / Koeneman, Brian A

    Journal of clinical microbiology

    2018  Volume 56, Issue 2

    Abstract: Available methods for the diagnosis of coccidioidomycosis have significant shortcomings relative to accuracy and timeliness. We retrospectively and prospectively evaluated the diagnostic performance and reproducibility of a new cartridge-based real-time ... ...

    Abstract Available methods for the diagnosis of coccidioidomycosis have significant shortcomings relative to accuracy and timeliness. We retrospectively and prospectively evaluated the diagnostic performance and reproducibility of a new cartridge-based real-time PCR assay for
    MeSH term(s) Bronchoalveolar Lavage Fluid/microbiology ; Coccidioides/genetics ; Coccidioides/isolation & purification ; Coccidioidomycosis/diagnosis ; Coccidioidomycosis/microbiology ; DNA, Fungal/genetics ; Humans ; Limit of Detection ; Molecular Diagnostic Techniques/methods ; Prospective Studies ; Real-Time Polymerase Chain Reaction/standards ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Southwestern United States ; Time Factors
    Chemical Substances DNA, Fungal
    Language English
    Publishing date 2018-01-24
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Validation Studies
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01277-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona.

    Bowers, Jolene R / Driebe, Elizabeth M / Nibecker, Jennifer L / Wojack, Bette R / Sarovich, Derek S / Wong, Ada H / Brzoska, Pius M / Hubert, Nathaniel / Knadler, Andrew / Watson, Lindsey M / Wagner, David M / Furtado, Manohar R / Saubolle, Michael / Engelthaler, David M / Keim, Paul S

    BMC microbiology

    2012  Volume 12, Page(s) 12

    Abstract: Background: Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them.! ...

    Abstract Background: Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them.
    Results: Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains.
    Conclusions: The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology ; Arizona/epidemiology ; Child ; Child, Preschool ; Cluster Analysis ; DNA Transposable Elements ; Drug Resistance, Multiple, Bacterial ; Female ; Genes, Bacterial ; Genotype ; Humans ; Infant ; Macrolides/pharmacology ; Male ; Middle Aged ; Molecular Epidemiology ; Multilocus Sequence Typing ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/microbiology ; Polymerase Chain Reaction ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/isolation & purification ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; DNA Transposable Elements ; Macrolides
    Language English
    Publishing date 2012-01-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1471-2180
    ISSN (online) 1471-2180
    DOI 10.1186/1471-2180-12-12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona

    Bowers Jolene R / Driebe Elizabeth M / Nibecker Jennifer L / Wojack Bette R / Sarovich Derek S / Wong Ada H / Brzoska Pius M / Hubert Nathaniel / Knadler Andrew / Watson Lindsey M / Wagner David M / Furtado Manohar R / Saubolle Michael / Engelthaler David M / Keim Paul S

    BMC Microbiology, Vol 12, Iss 1, p

    2012  Volume 12

    Abstract: Abstract Background Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef (E) and erm (B) genes and post-vaccine clonal expansion of strains that ... ...

    Abstract Abstract Background Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef (E) and erm (B) genes and post-vaccine clonal expansion of strains that carry them. Results Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef (E)/ erm (B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan 19F -14, mostly multilocus sequence type 320, carrying the recently described transposon Tn 2010 . The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef (E)-positive, and 9% erm (B)-positive strains. Conclusions The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.
    Keywords Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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