Article ; Online: Exercise Training Induced Changes In Nuclear Magnetic Resonance-Measured Lipid Particles In Mild Cognitively Impaired Elderly African American Volunteers: A Pilot Study.
Clinical interventions in aging
2019 Volume 14, Page(s) 2115–2123
Abstract: Purpose: Poor cardiorespiratory fitness (CRF) is linked to cognitive deterioration, but its effects on lipid heterogeneity and functional properties in older African American (AA) subjects with mild cognitive impairment (MCI) need elucidation. This ... ...
Abstract | Purpose: Poor cardiorespiratory fitness (CRF) is linked to cognitive deterioration, but its effects on lipid heterogeneity and functional properties in older African American (AA) subjects with mild cognitive impairment (MCI) need elucidation. This study determined whether exercise training-induced changes in blood lipid particle sizes (LPS) were associated with CRF determined by VO Methods: This analysis included 17 of the 29 randomized elderly AAs with MCI who had NMR data at baseline and after a 6-month training. We used Generalized Linear Regression (GLM) models to examine cardiorespiratory fitness (VO Results: Collectively, mean VO Conclusion: Promotion of stretch and aerobic exercise to increase CRF in elderly AA volunteers with MCI may also promote beneficial changes in lipoprotein particle profile. Because high BDNF concentration may reduce CVD risk, training-related improvements in BDNF levels are likely advantageous. Large randomized studies are needed to confirm our observations and to further elucidate the role for exercise therapy in reducing CVD risk in elderly AAs with MCI. |
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MeSH term(s) | African Americans ; Aged ; Brain-Derived Neurotrophic Factor ; Cardiovascular Diseases ; Cognitive Dysfunction ; Exercise ; Female ; Humans ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/physiology ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Pilot Projects ; Triglycerides/blood |
Chemical Substances | Brain-Derived Neurotrophic Factor ; Lipoproteins, LDL ; Triglycerides ; BDNF protein, human (7171WSG8A2) |
Language | English |
Publishing date | 2019-12-05 |
Publishing country | New Zealand |
Document type | Journal Article ; Randomized Controlled Trial |
ZDB-ID | 2364924-0 |
ISSN | 1178-1998 ; 1176-9092 |
ISSN (online) | 1178-1998 |
ISSN | 1176-9092 |
DOI | 10.2147/CIA.S195878 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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