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  1. Article ; Online: Integrated Optical Deformation Measurement with TIR Prism Rods.

    Wolf, Alexander

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 2

    Abstract: In this paper, a novel optical measurement principle for deformation, especially torsion, is presented. A laser beam is guided via total internal reflection (TIR) in a prism rod. Every single reflection causes an increasing change in the beam path, which ...

    Abstract In this paper, a novel optical measurement principle for deformation, especially torsion, is presented. A laser beam is guided via total internal reflection (TIR) in a prism rod. Every single reflection causes an increasing change in the beam path, which can be measured by its effect on the outcoupling position of the laser. With a diameter of the prism rod of 10 mm and a length of 120 mm, the system achieves torsion sensitivities between 350 µm/° and more than 7000 µm/°, depending on the actual torsion angle φ. A decency level of sensitivity is defined for comparison, which is exceeded by a factor of ~55 at φ=0. The presented principle of TIR prism rods can be adapted to measure different load cases. Using two laser beams, bending and torsion can be distinguished and combined load cases analyzed. The resulting system can be integrated into machine elements, such as screws, to perform condition monitoring on mechanically loaded components.
    MeSH term(s) Light ; Biomechanical Phenomena
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23020943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Gezielter liposomaler Transfer von siRNA in Neuroblastomzellen

    Wolf, Alexander

    2013  

    Author's details vorgelegt von Alexander Wolf
    Language German
    Size 115 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2014
    HBZ-ID HT018583694
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: MtDNA mutations and aging-not a closed case after all?

    Wolf, Alexander M

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 56

    MeSH term(s) DNA, Mitochondrial/genetics ; Mutation
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2021-02-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00479-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The tumor suppression theory of aging.

    Wolf, Alexander M

    Mechanisms of ageing and development

    2021  Volume 200, Page(s) 111583

    Abstract: Despite continued increases in human life expectancy, the factors determining the rate of human biological aging remain unknown. Without understanding the molecular mechanisms underlying aging, efforts to prevent aging are unlikely to succeed. The tumor ... ...

    Abstract Despite continued increases in human life expectancy, the factors determining the rate of human biological aging remain unknown. Without understanding the molecular mechanisms underlying aging, efforts to prevent aging are unlikely to succeed. The tumor suppression theory of aging introduced here proposes somatic mutation as the proximal cause of aging, but postulates that oncogenic transformation and clonal expansion, not functional impairment, are the relevant consequences of somatic mutation. Obesity and caloric restriction accelerate and decelerate aging due to their effect on cell proliferation, during which most mutations arise. Most phenotypes of aging are merely tumor-suppressive mechanisms that evolved to limit malignant growth, the dominant age-related cause of death in early and middle life. Cancer limits life span for most long-lived mammals, a phenomenon known as Peto's paradox. Its conservation across species demonstrates that mutation is a fundamental but hard limit on mammalian longevity. Cell senescence and apoptosis and differentiation induced by oncogenes, telomere shortening or DNA damage evolved as a second line of defense to limit the tumorigenic potential of clonally expanding cells, but accumulating senescent cells, senescence-associated secretory phenotypes and stem cell exhaustion eventually cause tissue dysfunction and the majority, if not most, phenotypes of aging.
    MeSH term(s) Aging/physiology ; Caloric Restriction ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Self Renewal/physiology ; Cell Transformation, Neoplastic ; Clonal Evolution/physiology ; Humans ; Longevity/physiology ; Mutation Accumulation
    Language English
    Publishing date 2021-10-09
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2021.111583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rodent diet aids and the fallacy of caloric restriction.

    Wolf, Alexander M

    Mechanisms of ageing and development

    2021  Volume 200, Page(s) 111584

    Abstract: Understanding the molecular mechanisms of normal aging is a prerequisite to significantly improving human health span. Caloric restriction (CR) can delay aging and has served as a yardstick to evaluate interventions extending life span. However, mice ... ...

    Abstract Understanding the molecular mechanisms of normal aging is a prerequisite to significantly improving human health span. Caloric restriction (CR) can delay aging and has served as a yardstick to evaluate interventions extending life span. However, mice given unlimited access to food suffer severe obesity. Health gains from CR depend on control mice being sufficiently overweight and less obese mouse strains benefit far less from CR. Pharmacologic interventions that increase life span, including resveratrol, rapamycin, nicotinamide mononucleotide and metformin, also reduce body weight. In primates, CR does not delay aging unless the control group is eating enough to suffer from obesity-related disease. Human survival is optimal at a body mass index achievable without CR, and the above interventions are merely diet aids that shouldn't slow aging in healthy weight individuals. CR in humans of optimal weight can safely be declared useless, since there is overwhelming evidence that hunger, underweight and starvation reduce fitness, survival, and quality of life. Against an obese control, CR does, however, truly delay aging through a mechanism laid out in the following tumor suppression theory of aging.
    MeSH term(s) Aging/physiology ; Animals ; Caloric Restriction ; Energy Intake/physiology ; Healthy Aging/physiology ; Humans ; Longevity/drug effects ; Mice ; Obesity/diet therapy ; Obesity/drug therapy ; Obesity/metabolism ; Obesity/mortality ; Senotherapeutics/pharmacology ; Survival Analysis
    Chemical Substances Senotherapeutics
    Language English
    Publishing date 2021-10-18
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2021.111584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Leserbrief zum Beitrag: „Ondansetron: 5-HT3-Antagonist, kein notfallpharmakologisches Universalantiemetikum“

    Wolf, Alexander / Unterberg, Matthias

    NOTARZT

    2024  Volume 40, Issue 02, Page(s) 109–110

    Language German
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2039417-2
    ISSN 1438-8693 ; 0177-2309
    ISSN (online) 1438-8693
    ISSN 0177-2309
    DOI 10.1055/a-2218-1810
    Database Thieme publisher's database

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  7. Book ; Thesis: Mutationen im Gen der Schilddrüsenperoxidase bei Kindern mit konnataler Hypothyreose

    Wolf, Alexander

    2002  

    Author's details von Alexander Wolf
    Language German
    Size VII, 116 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2002
    HBZ-ID HT013650335
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Efficacy, safety, and side effects of oliceridine in acute postoperative pain, a protocol for a systematic review and meta-analysis.

    Wolf, Anne / Unterberg, Matthias / Witowski, Andrea / Adamzik, Michael / Wolf, Alexander

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0299320

    Abstract: This will be the first meta-analysis on the efficacy, safety, and side effects of oliceridine on postoperative pain. Our aim with this work is to evaluate the clinical utility of this relatively new substance in a broad postoperative context. Oliceridine ...

    Abstract This will be the first meta-analysis on the efficacy, safety, and side effects of oliceridine on postoperative pain. Our aim with this work is to evaluate the clinical utility of this relatively new substance in a broad postoperative context. Oliceridine is a new so-called bias opioid that is approved for severe pain requiring an opioid. Due to its biased agonism, it is said to have fewer side effects than conventional opioids. This systematic review and meta-analysis will analyze the efficacy, safety, and side effects of oliceridine compared to placebo or morphine in acute postoperative pain for up to 72 hours. In January 2024, an extensive search in various databases will be performed without restrictions for randomized controlled trials with at least single blinding. After data extraction, data will be pooled and meta-analytic calculations performed. A random-effects model will be used. Dichotomous data will be presented as risk ratio and continuous data as standardized mean difference. Dose-dependent side effects will be evaluated with meta-regression. Heterogeneity will be assessed via the Q statistic and prediction interval in case of a sufficient number of included studies. Publication bias will be examined using funnel plot and Duval and Tweedie's trim and fill method.
    MeSH term(s) Humans ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Meta-Analysis as Topic ; Pain, Postoperative/drug therapy ; Spiro Compounds/adverse effects ; Spiro Compounds/therapeutic use ; Systematic Reviews as Topic ; Thiophenes/adverse effects ; Thiophenes/therapeutic use
    Chemical Substances ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine ; Analgesics, Opioid ; Spiro Compounds ; Thiophenes
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Conformational, hydration, and protonation dynamics of cytochrome c oxidase and a tracking-free analysis method for diffusion in fluorescence microscopy

    Wolf, Alexander [Verfasser]

    2021  

    Author's details Alexander Wolf
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Book: Psychotherapy of the submerged personality

    Wolf, Alexander

    1991  

    Author's details ed. by Alexander Wolf
    Keywords Persönlichkeitsentwicklung
    Subject Persönlichkeit ; Persönlichkeitsbildung ; Persönlichkeitsentfaltung
    Size XX, 278 S.
    Publisher Aronson
    Publishing place Northvale, NJ u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004189281
    ISBN 0-87668-644-7 ; 978-0-87668-644-7
    Database Catalogue ZB MED Medicine, Health

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