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  1. Book: Atopic dermatitis - when the skin window is open

    Wollenberg, Andreas

    (British journal of dermatology ; 170, Suppl. 1)

    2014  

    Author's details guest ed.: Andreas Wollenberg
    Series title British journal of dermatology ; 170, Suppl. 1
    The British journal of dermatology
    Collection The British journal of dermatology
    Language English
    Size 48 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018344758
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui VI Zs 23 -170,Suppl.1- verfügbar in Königswinter Königswinter

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  2. Article ; Online: How to Understand Personalized Medicine in Atopic Dermatitis Nowadays?

    Mesjasz, Alicja / Kołkowski, Karol / Wollenberg, Andreas / Trzeciak, Magdalena

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: Atopic dermatitis (AD) is a heterogeneous disease in terms of its phenotypical, barrier, and immunological presentation. Emerging therapies are undoubtedly contributing to a new chapter in the treatment of AD, bringing an excellent possibility of ... ...

    Abstract Atopic dermatitis (AD) is a heterogeneous disease in terms of its phenotypical, barrier, and immunological presentation. Emerging therapies are undoubtedly contributing to a new chapter in the treatment of AD, bringing an excellent possibility of individualization, and thereby creating a tailored approach. The two most promising substance groups are biological drugs (dupilumab, tralokinumab, lebrikizumab, nemolizumab) and Janus kinase inhibitors (JAKis) (baricitinib, upadacitinib, and abrocitinib). The vision that certain well-defined phenotypes and endotypes, as well as personal preferences, may guide the future treatment of AD is both tempting and appealing, but not yet reality. The accessibility of new drugs such as biologics and small molecules has opened up the discussion regarding personalized medicine, referring to the complex nature of AD as well as the experiences from clinical trials and real-world evidence. We have now reached the point of creating new strategies and AD treatment goals by increasing the amount of new information concerning the efficacy and safety of new drugs. This article has reviewed the novel treatment options for AD in the light of the heterogeneity of this disease and proposes a broader vision on the strategy of personalized treatment of AD.
    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Precision Medicine ; Janus Kinase Inhibitors/therapeutic use
    Chemical Substances Janus Kinase Inhibitors
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Real-world effectiveness and tolerability of a cream containing postbiotic Aquaphilus dolomiae extract-G3 in subjects with sensitive facial skin.

    Wollenberg, Andreas / Giménez-Arnau, Ana Maria / Stennevin, Aline / Ortiz-Brugués, Ariadna

    European journal of dermatology : EJD

    2024  Volume 34, Issue 1, Page(s) 79–88

    Abstract: Previous studies indicate that a postbiotic extract from Aquaphilus dolomiae (ADE-G3) improves skin barrier function and relieves neuroinflammation. Evaluation of an ADE-G3-based soothing cream for managing sensitive facial skin. This real-world, ... ...

    Abstract Previous studies indicate that a postbiotic extract from Aquaphilus dolomiae (ADE-G3) improves skin barrier function and relieves neuroinflammation. Evaluation of an ADE-G3-based soothing cream for managing sensitive facial skin. This real-world, international, pre-post comparative study involved adults with sensitive facial skin who used the study product once or twice daily for two to three months according to usual practice. Subjects reported changes in perceived clinical symptoms using self-administered questionnaires. Physicians assessed changes in xerosis severity, overall product effectiveness and tolerability. User satisfaction and quality of life (QoL) assessments, and subgroup analyses according to the factors triggering sensitive skin were also conducted. In total, 2,382 subjects with sensitive facial skin (female: 79%; median age: 40 years) were included. An immediate skin soothing effect after the first ADE-G3-based cream application was reported by 93% of subjects, and improvements in symptoms were reported in 94% after a mean of nine days of product use. After several months of use (mean: 71±21 days), xerosis severity and dermatological-related QoL significantly improved in the whole study population and in the subgroups (p<0.001). At the end of the study, 92% of users were satisfied with the product and 95% reported improvements in their overall skin condition. Physicians found the cream to be effective and well tolerated in 92% and 98% of subjects, respectively. Regular use of the ADE-G3-based cream was shown to be effective in real-world management of sensitive facial skin, regardless of the factors involved in triggering skin sensitivity.
    MeSH term(s) Adult ; Humans ; Female ; Quality of Life ; Skin ; Skin Diseases/drug therapy ; Neisseriaceae ; Skin Cream ; Treatment Outcome
    Language English
    Publishing date 2024-04-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2024.4637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3484: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The Burden of Pediatric Atopic Dermatitis: Quality of Life of Patients and Their Families.

    Kisieliene, Inga / Mainelis, Antanas / Rudzeviciene, Odilija / Bylaite-Bucinskiene, Matilda / Wollenberg, Andreas

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: 1) Background: ...

    Abstract (1) Background:
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Über den Lymphozytentransformationstest bei Bienengift-Allergikern unter Schnellhyposensibilisierung

    Wollenberg, Andreas

    experimentelle Untersuchungen über den Einfluß von Mitogenen und Allergenen auf Thymidineinbau und Immunglobulinsekretion von peripheren

    1991  

    Author's details vorgelegt von Andreas Wollenberg
    Size 132 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1991
    HBZ-ID HT003941021
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    91 D 5634 order for loan Magazin

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  6. Book ; Online ; Thesis: Immunologische Veränderungen bei Patienten mit akneiformem Exanthem unter Cetuximab-Therapie

    Cyran, Carolin Anna Maria [Verfasser] / Wollenberg, Andreas [Akademischer Betreuer]

    2023  

    Author's details Carolin Anna Maria Cyran ; Betreuer: Andreas Wollenberg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Atopic Dermatitis in Children and Adults—Diagnosis and Treatment

    Wollenberg, Andreas / Werfel, Thomas / Ring, Johannes / Ott, Hagen / Gieler, Uwe / Weidinger, Stephan

    Deutsches Arzteblatt international

    2023  Volume 120, Issue 13, Page(s) 224–234

    Abstract: Background: Atopic dermatitis is a common, chronically recurring inflammatory skin disease. It gives rise to a high disease burden and is of major importance in social medicine.: Methods: This review is based on pertinent publications retrieved by a ... ...

    Abstract Background: Atopic dermatitis is a common, chronically recurring inflammatory skin disease. It gives rise to a high disease burden and is of major importance in social medicine.
    Methods: This review is based on pertinent publications retrieved by a selective search in PubMed, including the current German and European guidelines.
    Results: Basic therapy with drug-free topical agents markedly improves the barrier function of the skin. Adults should apply at least 250 g per week. Patient-specific trigger factors such as allergens, stress, microbial pathogens, or skin irritants should be eliminated or avoided. In mild and moderately severe forms, external treatment with topical glucocorticosteroids and topical calcineurin inhibitors usually suffices; proactive therapy is given to patients with frequent recurrences or a long course of disease. Systemic anti-inflammatory treatment with biological agents such as dupilumab and tralokinumab, Janus kinase inhibitors such as baricitinib, upadacitinib, and abrocitinib, or conventional immunosuppressant drugs is indicated particularly in severe cases. The patient should be actively involved in the choice and planning of treatment; the patient's age and the cutaneous findings should be taken into account. Interdisciplinary patient education yields a sustained benefit.
    Conclusion: A combination of baseline therapy, reactive and proactive anti-inflammatory therapy, and systemic therapy as needed is the foundation of successful interdisciplinary treatment for atopic dermatitis.
    MeSH term(s) Humans ; Adult ; Child ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/drug therapy ; Immunosuppressive Agents/therapeutic use ; Calcineurin Inhibitors/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents ; Calcineurin Inhibitors ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-01-23
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2023.0011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A detailed look at the European Medicines Agency's recommendations for use of Janus kinase inhibitors in patients with atopic dermatitis.

    Wollenberg, Andreas / Thyssen, Jacob P / Bieber, Thomas / Chan, Gary / Kerkmann, Urs

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 37, Issue 10, Page(s) 2041–2046

    Abstract: Background: Oral Janus kinase inhibitors (JAKi) have been approved for the treatment of several chronic inflammatory conditions, including rheumatoid arthritis (RA) and atopic dermatitis (AD). Prompted by new evidence, the Pharmacovigilance Risk ... ...

    Abstract Background: Oral Janus kinase inhibitors (JAKi) have been approved for the treatment of several chronic inflammatory conditions, including rheumatoid arthritis (RA) and atopic dermatitis (AD). Prompted by new evidence, the Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) recently reassessed the benefit-risk balance of oral JAKi. The PRAC recommended that oral JAKi should be used only if no suitable alternatives are available in patients ≥65 years of age, or who have a history of atherosclerotic cardiovascular (CV) disease, other CV risk factors (e.g. history of long-term smoking) or have malignancy risk factors, and used with caution in patients at risk of pulmonary embolism or deep vein thrombosis. The European Commission's final decision was issued in March 2023.
    Objectives: Our goal was to highlight the PRAC recommendations, especially in the context of oral JAKi use in AD.
    Methods: Authors summarized the PRAC recommendations, the new clinical evidence on oral JAKi safety and key differences between patients with RA and AD.
    Results: Risk of developing adverse events of special interest (e.g. cardiovascular events, malignancy) is higher in patients with RA than in patients with AD, because of the higher prevalence of the underlying risk factors.
    Conclusions: The benefit-risk profile of JAKi approved for AD remains favourable, including use as first-line systemic therapy for patients with AD <65 years of age and without CV or malignancy risk factors.
    MeSH term(s) Humans ; Janus Kinase Inhibitors/adverse effects ; Dermatitis, Atopic/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Risk Assessment ; Pharmacovigilance ; Antirheumatic Agents/therapeutic use
    Chemical Substances Janus Kinase Inhibitors ; Antirheumatic Agents
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  9. Article ; Online: Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review.

    Demessant-Flavigny, Anne-Laure / Connétable, Sophie / Kerob, Delphine / Moreau, Magali / Aguilar, Luc / Wollenberg, Andreas

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 37 Suppl 5, Page(s) 3–17

    Abstract: A dysfunctional epidermal barrier, which may be associated with mutations in the filaggrin gene in genetically predisposed individuals or harmful effects of environmental agents and allergens, contributes to the development of atopic dermatitis (AD) due ... ...

    Abstract A dysfunctional epidermal barrier, which may be associated with mutations in the filaggrin gene in genetically predisposed individuals or harmful effects of environmental agents and allergens, contributes to the development of atopic dermatitis (AD) due to an interplay between the epithelial barrier, immune defence and the cutaneous microbiome. The skin of patients with AD is frequently over-colonized by biofilm-growing Staphylococcus aureus, especially during flares, causing dysbiosis of the cutaneous microbiota and a decrease in bacterial diversity that inversely correlates with AD severity. Specific changes in the skin microbiome can be present before clinical AD onset in infancy. Additionally, local skin anatomy, lipid content, pH, water activity and sebum secretion differ between children and adults and generally correlate with the predominant microbiota. Considering the importance of S. aureus in AD, treatments aimed at reducing over-colonization to rebalance microbial diversity may help manage AD and reduce flares. Anti-staphylococcal interventions in AD will contribute to a decrease in S. aureus superantigens and proteases that cause damage and inflammation of the skin barrier while concomitantly increasing the proportion of commensal bacteria that secrete antimicrobial molecules that protect healthy skin from invading pathogens. This review summarizes the latest data on targeting skin microbiome dysbiosis and S. aureus over-colonization to treat AD in adults and children. Indirect AD therapies, including emollients 'plus', anti-inflammatory topicals and monoclonal antibodies, may have an impact on S. aureus and help control bacterial diversity. Direct therapies, including antibacterial treatments (antiseptics/topical or systemic antibiotics), and innovative treatments specifically targeting S. aureus (e.g. anti-S. aureus endolysin, and autologous bacteriotherapy), may be effective alternatives to mitigate against an increase in microbial resistance and allow a proportionate increase in the commensal microbiota.
    MeSH term(s) Humans ; Child ; Adult ; Dermatitis, Atopic/drug therapy ; Staphylococcus aureus ; Dysbiosis/complications ; Skin/microbiology ; Staphylococcal Infections ; Microbiota ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Bacteria
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  10. Article ; Online: NOD/Scid IL2Rγ

    Schindler, Marietta / Schuster-Winkelmann, Paula / Weß, Veronika / Czell, Sophia / Rueff, Franziska / Wollenberg, Andreas / Siebeck, Matthias / Gropp, Roswitha

    JID innovations : skin science from molecules to population health

    2024  Volume 4, Issue 3, Page(s) 100268

    Abstract: NSG (NOD/Scid ... ...

    Abstract NSG (NOD/Scid IL2Rγ
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-0267
    ISSN (online) 2667-0267
    DOI 10.1016/j.xjidi.2024.100268
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