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  1. Article: Proximale Spinale Muskelatrophien (SMA).

    Fujak, A / Wollinsky, K H / Forst, R

    Zeitschrift fur Orthopadie und Unfallchirurgie

    2007  Volume 145, Issue 2, Page(s) 233–252

    Title translation Proximal spinal muscular atrophy (SMA).
    MeSH term(s) Humans ; Muscular Atrophy, Spinal/diagnosis ; Muscular Atrophy, Spinal/therapy ; Physical Therapy Modalities ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Reconstructive Surgical Procedures/methods
    Language German
    Publishing date 2007-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/s-2007-964871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Proximale Spinale Muskelatrophien (SMA)

    Fujak, A. / Wollinsky, K. H. / Forst, R.

    Zeitschrift für Orthopädie und Unfallchirurgie

    2007  Volume 145, Issue 02, Page(s) 233–252

    Language German
    Publishing date 2007-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/s-2007-964871
    Database Thieme publisher's database

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  3. Article: Unfälle durch elektrischen Strom und Blitzschlag.

    Wollinsky, K H / Mehrkens, H H

    Deutsche Krankenpflegezeitschrift

    1993  Volume 46, Issue 6, Page(s) 397–403

    Title translation Accidents by electric current and lightning.
    MeSH term(s) Burns, Electric/nursing ; Electric Countershock ; Humans ; Lightning Injuries/nursing ; Male
    Language German
    Publishing date 1993-06
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 80299-2
    ISSN 0012-074X
    ISSN 0012-074X
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    Zs.A 314: Show issues Location:
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  4. Article: Neurologische Intensivmedizin.

    Westarp, M E / Wollinsky, K H

    Krankenpflege Journal

    1991  Volume 29, Issue 11, Page(s) 509

    Title translation Neurologic intensive care units.
    MeSH term(s) Humans ; Intensive Care Units/organization & administration ; Nervous System Diseases/nursing ; Nervous System Diseases/therapy
    Language German
    Publishing date 1991-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603227-8
    ISSN 0174-108X ; 0048-9549
    ISSN 0174-108X ; 0048-9549
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  5. Article: Diagnostik und Therapie der Osteogenesis imperfecta. Konsensus-Statement der 30. Jahrestagung 2014 der Deutschen Gesellschaft für Osteogenesis imperfecta Betroffene e.V. Diagnostics and treatment of osteogenesis imperfecta. Consensus statement of the 30th annual conference 2014 of the German Society for Persons with Osteogenesis Imperfecta

    Hoyer-Kuhn, H. / Bartz-Seel, J. / Blickheuser, R. / Deimling, U. v. / Stücker, R. / Wirth, T. / Wolf, J. / Wollinsky, K. H. / Semler, O.

    Monatsschrift Kinderheilkunde

    2017  Volume 165, Issue 4, Page(s) 333

    Language German
    Document type Article
    ZDB-ID 137102-2
    ISSN 0026-9298
    Database Current Contents Medicine

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  6. Article: An endogenous pentapeptide acting as a sodium channel blocker in inflammatory autoimmune disorders of the central nervous system.

    Brinkmeier, H / Aulkemeyer, P / Wollinsky, K H / Rüdel, R

    Nature medicine

    2000  Volume 6, Issue 7, Page(s) 808–811

    Abstract: Reversible blockade of sodium channels by endogenous substances has been claimed to account for the fast exacerbations and relapses commonly seen in demyelinating autoimmune diseases. Evidence has been provided that in the cerebrospinal fluid of patients ...

    Abstract Reversible blockade of sodium channels by endogenous substances has been claimed to account for the fast exacerbations and relapses commonly seen in demyelinating autoimmune diseases. Evidence has been provided that in the cerebrospinal fluid of patients with multiple sclerosis or Guillain-Barré syndrome, a sodium-channel-blocking factor exists that has properties of local anesthetic agents. This factor could contribute to the nerve conduction block and paresis seen in these disorders. We describe here a previously unknown endogenous substance in human cerebrospinal fluid with distinct channel-blocking properties even at very low (0.00001 M) concentrations. The pentapeptide with the sequence Gln-Tyr-Asn-Ala-Asp exerted its blocking action by shifting the steady-state inactivation curve of the sodium channels to more-negative potentials, as most local anesthetics do. In the cerebrospinal fluid of healthy individuals, its concentration was about 3 microM, whereas in patients with multiple sclerosis and Guillain-Barré syndrome, it increased 300-1,400%. At these concentrations, the peptide's blocking efficacy was higher than that of 50 microM lidocaine. At a concentration of 10 microM, lidocaine is able to 'unmask' subclinical lesions in multiple sclerosis; thus, the endogenous pentapeptide may well contribute to the fast changes of symptoms. Furthermore, it may become valuable as a marker of disease activity.
    MeSH term(s) Cerebrospinal Fluid/chemistry ; Guillain-Barre Syndrome/cerebrospinal fluid ; Humans ; Multiple Sclerosis/cerebrospinal fluid ; Neurons/drug effects ; Oligopeptides/isolation & purification ; Oligopeptides/pharmacology ; Sequence Analysis, Protein ; Sodium Channel Blockers ; Tumor Cells, Cultured
    Chemical Substances Oligopeptides ; Sodium Channel Blockers
    Language English
    Publishing date 2000-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/77543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The human endogenous local anesthetic-like factor (ELLF) is functionally neutralized by serum albumin.

    Aulkemeyer, P / Brinkmeier, H / Wollinsky, K H / Rüdel, R

    Neuroscience letters

    1996  Volume 216, Issue 1, Page(s) 37–40

    Abstract: The cerebrospinal fluid (CSF) of patients with multiple sclerosis or Guillain-Barré syndrome contains a factor that inhibits excitation of nerve and muscle cells like local anesthetics. CSF samples containing the endogenous local anesthetic-like factor ( ... ...

    Abstract The cerebrospinal fluid (CSF) of patients with multiple sclerosis or Guillain-Barré syndrome contains a factor that inhibits excitation of nerve and muscle cells like local anesthetics. CSF samples containing the endogenous local anesthetic-like factor (ELLF) were analyzed by gel filtration chromatography and ultraviolet (UV) absorption at 210 nm. The active component was in a single peak corresponding to a molecular weight of 600-800 Da. This peak was decreased and the Na+ channel blocking activity was neutralized by the addition of 40 g/l human serum albumin to the CSF. When the albumin was separated from the CSF/albumin mixture by acetonitrile treatment, the Na+ channel blocking activity reappeared. The ELLF and its neutralization may be of relevance for the clinical fluctuations known with these diseases.
    MeSH term(s) Cerebrospinal Fluid ; Chromatography, Gel ; Demyelinating Diseases/cerebrospinal fluid ; Humans ; Polyradiculoneuropathy/cerebrospinal fluid ; Protein Binding/physiology ; Serum Albumin/physiology ; Sodium Channels/metabolism ; Spectrophotometry, Ultraviolet ; Tumor Cells, Cultured
    Chemical Substances Serum Albumin ; Sodium Channels
    Language English
    Publishing date 1996-09-20
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/0304-3940(96)12997-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: On the nature of endogenous antiexcitatory factors in the cerebrospinal fluid of patients with demyelinating neurological disease.

    Brinkmeier, H / Seewald, M J / Wollinsky, K H / Rüdel, R

    Muscle & nerve

    1996  Volume 19, Issue 1, Page(s) 54–62

    Abstract: The cerebrospinal fluid (CSF) of patients with demyelinating neurological disease, such as Guillain-Barré syndrome or multiple sclerosis, contains factors that inhibit the excitatory Na+ current. Such antiexcitatory factors are occasionally also ... ...

    Abstract The cerebrospinal fluid (CSF) of patients with demyelinating neurological disease, such as Guillain-Barré syndrome or multiple sclerosis, contains factors that inhibit the excitatory Na+ current. Such antiexcitatory factors are occasionally also detectable in CSF from patients with other neurological diseases but were absent from an artificial CSF containing all major CSF constituents (electrolytes, amino acids, vitamins, metabolites, albumin). In an attempt to characterize these factors, unphysiological pCa or pH values were excluded by the application of the Ca2+ chelator EGTA and the use of buffers. Heating the CSF for 10 min to 95 degrees C or digesting it with proteases did not destroy the antiexcitatory potency. Fractionation of the CSF contents according to molecular weight showed that the factors have a molecular weight < 3 kD. This excludes proteins, such as antibodies or cytokines, as candidates. Small peptides are known to be resistant to some proteases and heating.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anesthetics, Local/cerebrospinal fluid ; Calcium/cerebrospinal fluid ; Cerebrospinal Fluid/physiology ; Electrophysiology ; Excitatory Amino Acid Antagonists/cerebrospinal fluid ; Female ; Hot Temperature ; Humans ; Inflammation Mediators/pharmacology ; Interleukin-2/physiology ; Male ; Multiple Sclerosis/cerebrospinal fluid ; Neurons/metabolism ; Peptide Fragments/physiology ; Polyradiculoneuropathy/cerebrospinal fluid ; Sodium Channel Blockers ; Sodium Channels/drug effects ; Sodium Channels/physiology ; Tumor Cells, Cultured
    Chemical Substances Anesthetics, Local ; Excitatory Amino Acid Antagonists ; Inflammation Mediators ; Interleukin-2 ; Peptide Fragments ; Sodium Channel Blockers ; Sodium Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1996-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/(SICI)1097-4598(199601)19:1<54::AID-MUS7>3.0.CO;2-7
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  9. Article: Liquorpheresis eliminates blocking factors from cerebrospinal fluid in polyradiculoneuritis (Guillain-Barré syndrome).

    Hülser, P J / Wiethölter, H / Wollinsky, K H

    European archives of psychiatry and clinical neuroscience

    1991  Volume 241, Issue 2, Page(s) 69–72

    Abstract: Cerebrospinal fluid (CSF) derived from six patients with polyradiculoneuritis (Guillain-Barré syndrome, GBS) treated by liquorpheresis was injected into rat sciatic nerve. By measuring spinal evoked potentials after stimulation of the tibial nerve, we ... ...

    Abstract Cerebrospinal fluid (CSF) derived from six patients with polyradiculoneuritis (Guillain-Barré syndrome, GBS) treated by liquorpheresis was injected into rat sciatic nerve. By measuring spinal evoked potentials after stimulation of the tibial nerve, we observed slowing or dispersion of nerve conduction in those cases where the CSF had been taken before liquorpheresis. CSF of the same patient, sampled after liquorpheresis, showed minor effects only. Impairment of nerve conduction was seen between 5 and 20 min after injection, normal function being restored on the third day. These results suggest that liquorpheresis eliminates blocking factors from the CSF of patients with GBS. We postulate this as the effect by which liquorpheresis improves neurological symptoms in Guillain-Barré syndrome.
    MeSH term(s) Animals ; Autoimmune Diseases/cerebrospinal fluid ; Autoimmune Diseases/physiopathology ; Autoimmune Diseases/therapy ; Blood Component Removal/methods ; Cerebrospinal Fluid Proteins/physiology ; Electric Stimulation ; Humans ; Neural Conduction/physiology ; Polyradiculoneuropathy/cerebrospinal fluid ; Polyradiculoneuropathy/physiopathology ; Polyradiculoneuropathy/therapy ; Rats ; Reaction Time/physiology ; Sciatic Nerve/physiopathology ; Spinal Cord/physiopathology ; Tibial Nerve/physiopathology
    Chemical Substances Cerebrospinal Fluid Proteins
    Language English
    Publishing date 1991
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0940-1334 ; 0175-758X
    ISSN (online) 1433-8491
    ISSN 0940-1334 ; 0175-758X
    DOI 10.1007/bf02191142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A small sodium channel blocking factor in the cerebrospinal fluid is preferentially found in Guillain-Barré syndrome: a combined cell physiological and HPLC study.

    Weber, F / Brinkmeier, H / Aulkemeyer, P / Wollinsky, K H / Rüdel, R

    Journal of neurology

    1999  Volume 246, Issue 10, Page(s) 955–960

    Abstract: The cerebrospinal fluid (CSF) of patients with Guillain-Barré syndrome (GBS) contains a low molecular weight factor with sodium channel blocking activity. This study investigated whether such activity also exists in the CSF of patients with other ... ...

    Abstract The cerebrospinal fluid (CSF) of patients with Guillain-Barré syndrome (GBS) contains a low molecular weight factor with sodium channel blocking activity. This study investigated whether such activity also exists in the CSF of patients with other neurological diseases. Further, using high-performance liquid chromatography (HPLC) we tested whether the electrophysiological effect of the CSF is correlated with the size of the corresponding peak in the chromatograms. The existence of sodium channel blocking activity was tested in 27 native CSF samples of three groups of patients (group 1: GBS, n = 13; group 2: other inflammatory diseases, n = 8; group 3: controls, n = 6). NH15-CA2 neuroblastoma x glioma cells in the whole-cell recording configuration was used as a system for assaying the sodium channel blocking activity of CSF specimens. CSF shifted the steady-state inactivation curve of the sodium channels reversibly by -10.2 +/- 4.4 mV in group 1, -6.7 +/- 3.9 mV in group 2, and - 3.5 +/- 2.8 mV in group 3 (P < 0.01). The shift was greater in demyelinating (9.3 +/- 4.7 mV) than in nondemyelinating (5.6 +/- 3.9 mV) diseases (P < 0.04). HPLC analysis of CSFs showed a well separated peak containing the substance responsible for the electrophysiological effect at about 41 min elution time. The peak covered the molecular weight range of 600-800 Da. Sodium channel blocking activity of CSFs and areas of the corresponding peak in the chromatograms were well correlated. We conclude that sodium current inhibition by a low molecular weight factor is generally present but increased in GBS.
    MeSH term(s) Cerebrospinal Fluid/chemistry ; Cerebrospinal Fluid/physiology ; Chromatography, High Pressure Liquid ; Demyelinating Diseases/cerebrospinal fluid ; Demyelinating Diseases/metabolism ; Electrophysiology ; Guillain-Barre Syndrome/cerebrospinal fluid ; Guillain-Barre Syndrome/metabolism ; Guillain-Barre Syndrome/pathology ; Guillain-Barre Syndrome/physiopathology ; Humans ; Molecular Weight ; Nervous System Diseases/cerebrospinal fluid ; Nervous System Diseases/metabolism ; Neurons/metabolism ; Neurons/physiology ; Sodium Channel Blockers ; Tumor Cells, Cultured
    Chemical Substances Sodium Channel Blockers
    Language English
    Publishing date 1999-10-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s004150050490
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