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  1. Article ; Online: Issues in the management of esophageal cancer and geriatric patients.

    Won, Elizabeth

    Chinese clinical oncology

    2017  Volume 6, Issue 5, Page(s) 51

    Abstract: Esophageal cancer is a disease occurring in older adults and given the aging population, the incidence of cancer in the elderly will continue to rise. However, older patients are less likely to receive treatment for their cancers based on age alone. ... ...

    Abstract Esophageal cancer is a disease occurring in older adults and given the aging population, the incidence of cancer in the elderly will continue to rise. However, older patients are less likely to receive treatment for their cancers based on age alone. There are limited data and guidelines for how to manage the older patient population but elderly patients can derive benefit from treatment. This review will describe issues specific to older patients with esophageal cancer with a focus on the utilization of geriatric assessment (GA) tools and how to apply geriatric principles to this cancer patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/therapy ; Geriatric Assessment ; Humans
    Language English
    Publishing date 2017-10
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2828547-5
    ISSN 2304-3873 ; 2304-3865
    ISSN (online) 2304-3873
    ISSN 2304-3865
    DOI 10.21037/cco.2017.10.05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Issues in the Management of Esophagogastric Cancer in Geriatric Patients.

    Won, Elizabeth

    Surgical oncology clinics of North America

    2017  Volume 26, Issue 2, Page(s) 335–346

    Abstract: Esophagogastric cancers predominantly affect older adults; however, older patients are less likely to be recommended for both curative and palliative treatment. Older patients have unique challenges that need to be addressed during their oncologic care. ... ...

    Abstract Esophagogastric cancers predominantly affect older adults; however, older patients are less likely to be recommended for both curative and palliative treatment. Older patients have unique challenges that need to be addressed during their oncologic care. Tools such as complete geriatric assessments may help to better identify fit older adults and stratify patients for aggressive treatment strategies. This review evaluates the current knowledge and the remaining challenges in optimally managing elderly patients with esophagogastric cancers.
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2016.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1339: Show issues Location:
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  3. Article: The imperative of state capacity in public health crisis: Asia's early COVID-19 policy responses.

    Yen, Wei-Ting / Liu, Li-Yin / Won, Eunji / Testriono

    Governance (Oxford, England)

    2022  Volume 35, Issue 3, Page(s) 777–798

    Abstract: Preexisting political institutions influence governments' responses to public health crises in different ways, creating national variations. This article investigates how state capacity, a country's fundamental ability to organize bureaucracy and ... ...

    Abstract Preexisting political institutions influence governments' responses to public health crises in different ways, creating national variations. This article investigates how state capacity, a country's fundamental ability to organize bureaucracy and allocate societal resources, affects the timing and configuration of governments' COVID-19 policy responses. Through comparative case study analysis of five of China's neighboring countries early in the COVID-19 crisis, the paper shows that more-capable states (Singapore, South Korea, Taiwan) initiated crisis response faster, mobilized national resources more extensively, and utilized diverse policy tools when the virus risk level was still low. In contrast, low-capacity states (Thailand and Indonesia) were more reactive in handling the crisis, limited their focus to border-related measures, and were more constrained in the types of tools they could employ. The paper points to the importance of studying the COVID-19 response process rather than the outcome (i.e., confirmed cases/deaths) when unpacking the impacts of political institutions in public health crises.
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1480738-5
    ISSN 1468-0491 ; 0952-1895
    ISSN (online) 1468-0491
    ISSN 0952-1895
    DOI 10.1111/gove.12695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neuroinflammation-Associated Alterations of the Brain as Potential Neural Biomarkers in Anxiety Disorders.

    Won, Eunsoo / Kim, Yong-Ku

    International journal of molecular sciences

    2020  Volume 21, Issue 18

    Abstract: Stress-induced changes in the immune system, which lead to neuroinflammation and consequent brain alterations, have been suggested as possible neurobiological substrates of anxiety disorders, with previous literature predominantly focusing on panic ... ...

    Abstract Stress-induced changes in the immune system, which lead to neuroinflammation and consequent brain alterations, have been suggested as possible neurobiological substrates of anxiety disorders, with previous literature predominantly focusing on panic disorder, agoraphobia, and generalized anxiety disorder, among the anxiety disorders. Anxiety disorders have frequently been associated with chronic stress, with chronically stressful situations being reported to precipitate the onset of anxiety disorders. Also, chronic stress has been reported to lead to hypothalamic-pituitary-adrenal axis and autonomic nervous system disruption, which may in turn induce systemic proinflammatory conditions. Preliminary evidence suggests anxiety disorders are also associated with increased inflammation. Systemic inflammation can access the brain, and enhance pro-inflammatory cytokine levels that have been shown to precipitate direct and indirect neurotoxic effects. Prefrontal and limbic structures are widely reported to be influenced by neuroinflammatory conditions. In concordance with these findings, various imaging studies on panic disorder, agoraphobia, and generalized anxiety disorder have reported alterations in structure, function, and connectivity of prefrontal and limbic structures. Further research is needed on the use of inflammatory markers and brain imaging in the early diagnosis of anxiety disorders, along with the possible efficacy of anti-inflammatory interventions on the prevention and treatment of anxiety disorders.
    MeSH term(s) Anxiety Disorders/diagnosis ; Anxiety Disorders/metabolism ; Anxiety Disorders/physiopathology ; Biomarkers/analysis ; Brain/metabolism ; Cytokines/metabolism ; Humans ; Hypothalamo-Hypophyseal System/physiopathology ; Inflammation/metabolism ; Neuroimmunomodulation/immunology ; Neuroimmunomodulation/physiology ; Neurons/metabolism ; Pituitary-Adrenal System/physiopathology ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2020-09-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21186546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression.

    Won, Eunsoo / Na, Kyoung-Sae / Kim, Yong-Ku

    International journal of molecular sciences

    2021  Volume 23, Issue 1

    Abstract: Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent alterations in brain regions involved in emotional regulation have been suggested as an underlying mechanism for the pathophysiology of major depressive disorder (MDD). ... ...

    Abstract Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent alterations in brain regions involved in emotional regulation have been suggested as an underlying mechanism for the pathophysiology of major depressive disorder (MDD). A prominent feature of MDD is disruption of circadian rhythms, of which melatonin is considered a key moderator, and alterations in the melatonin system have been implicated in MDD. Melatonin is involved in immune system regulation and has been shown to possess anti-inflammatory properties in inflammatory conditions, through both immunological and non-immunological actions. Melatonin has been suggested as a highly cytoprotective and neuroprotective substance and shown to stimulate all stages of neuroplasticity in animal models. The ability of melatonin to suppress inflammatory responses through immunological and non-immunological actions, thus influencing neuroinflammation and neurotoxicity, along with subsequent alterations in brain regions that are implicated in depression, can be demonstrated by the antidepressant-like effects of melatonin. Further studies that investigate the associations between melatonin, immune markers, and alterations in the brain structure and function in patients with depression could identify potential MDD biomarkers.
    MeSH term(s) Animals ; Brain/pathology ; Depression/immunology ; Depression/pathology ; Humans ; Immune System/pathology ; Melatonin/metabolism ; Models, Biological ; Neuroinflammatory Diseases/immunology ; Neuroinflammatory Diseases/pathology
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2021-12-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23010305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neuroimaging in psychiatry: Steps toward the clinical application of brain imaging in psychiatric disorders.

    Won, Eunsoo / Kim, Yong-Ku

    Progress in neuro-psychopharmacology & biological psychiatry

    2018  Volume 80, Issue Pt B, Page(s) 69–70

    MeSH term(s) Brain/diagnostic imaging ; Humans ; Mental Disorders/diagnostic imaging ; Neuroimaging
    Language English
    Publishing date 2018-01-03
    Publishing country England
    Document type Editorial
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2017.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1342: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Association between Uncinate Fasciculus Integrity and Agoraphobia Symptoms in Female Patients with Panic Disorder.

    Kim, Sung Eun / Bang, Minji / Won, Eunsoo / Lee, Sang-Hyuk

    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

    2021  Volume 19, Issue 1, Page(s) 63–72

    Abstract: Objective: Although neural correlates of sub-clinical agoraphobia (AG) symptoms have been previously suggested, only a few studies evaluating structural changes of the brain have been conducted in agoraphobic patients with panic disorder (PD). We ... ...

    Abstract Objective: Although neural correlates of sub-clinical agoraphobia (AG) symptoms have been previously suggested, only a few studies evaluating structural changes of the brain have been conducted in agoraphobic patients with panic disorder (PD). We investigated and compared white matter (WM) micro-structural alterations between PD patients with AG (PD ＋ AG) and those without AG (PD - AG).
    Methods: Our study included 56 female PD patients, of which 25 were diagnosed with AG and 31 were diagnosed without AG. Diffusion tensor imaging was performed to investigate micro-structural changes in the WM tracts related to fronto-temporo-occipital areas (uncinate fasciculus, cingulum bundle, inferior longitudinal/fronto-occipital fasciculus, fornix column and body, and fornix/stria terminalis). All participants were subjected to the Anxiety Sensitivity Inventory-Revised (ASI-R), Beck Depression Inventory-II (BDI-II), and Albany Panic and Phobia questionnaires.
    Results: The fractional anisotropy values of the right uncinate fasciculus in PD ＋ AG were significantly lower than that of PD - AG and showed significant correlations with BDI-II and ASI-R total scores. Mean diffusivity and radial diffusivity values of the right uncinate fasciculus were significantly higher in PD ＋ AG as compared to PD - AG.
    Conclusion: Our findings suggest that the uncinate fasciculus may be associated with AG symptoms in PD, possibly through demyelination. Our findings may contribute to the neurobiological evidence regarding the association between AG and WM structural changes in PD.
    Language English
    Publishing date 2021-01-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2211550-X
    ISSN 1738-1088
    ISSN 1738-1088
    DOI 10.9758/cpn.2021.19.1.63
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6227: Show issues Location:
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  8. Article ; Online: Simulation of the optical system in the GroundBIRD telescope.

    Jo, Yonggil / Choi, Jihoon / Hattori, Makoto / Honda, Shunsuke / Tanaka, Tomonaga / Tsuji, Miku / Won, Eunil / Lee, Kyungmin

    Applied optics

    2023  Volume 62, Issue 20, Page(s) 5369–5378

    Abstract: GroundBIRD is a ground-based telescope for measuring the polarization of cosmic microwave background radiation, and it is soon to be operational at the Teide Observatory. The GroundBIRD telescope employs Mizuguchi-Dragone dual reflectors and 161 kinetic ... ...

    Abstract GroundBIRD is a ground-based telescope for measuring the polarization of cosmic microwave background radiation, and it is soon to be operational at the Teide Observatory. The GroundBIRD telescope employs Mizuguchi-Dragone dual reflectors and 161 kinetic inductance detectors coupled with single polarization antennas as photon detectors. We present the results of our optical simulation on the pointing direction, stray light response, and influence of the blackbody radiation from the baffle. We also find that the power of the baffle radiation incident on the detectors is reduced by 99.95% when corrugated feed horns are coupled to the detectors.
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.488636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The influence of stress on neuroinflammation and alterations in brain structure and function in major depressive disorder.

    Kim, Yong-Ku / Won, Eunsoo

    Behavioural brain research

    2017  Volume 329, Page(s) 6–11

    Abstract: Major depressive disorder (MDD) is a condition which has often been associated with chronic stress. The sympathetic nervous system is continuously activated without the normal counteraction of the parasympathetic nervous system under the influence of ... ...

    Abstract Major depressive disorder (MDD) is a condition which has often been associated with chronic stress. The sympathetic nervous system is continuously activated without the normal counteraction of the parasympathetic nervous system under the influence of chronic stress. As a result, epinephrine and norepinephrine levels are increased, and acetylcholine levels are decreased, which in turn can increase the levels of pro-inflammatory cytokines. Peripheral inflammatory responses can access the brain, with neuroinflammation contributing to the increase in neurotoxic kynurenine pathway metabolites such as 3-hydroxykynurenine, 3-hydroxyanthranilic acid and quinolinic acid, and decrease in neuroprotective metabolites such as kynurenic acid. Pro-inflammatory cytokines can also exert direct neurotoxic effects on specific brain regions. Previous imaging studies have reported associations between pro-inflammatory states and alterations in brain regions involved in emotional regulation, including the hippocampus, amygdala and anterior cingulate cortex. Alterations in structure and function of such brain areas due to the neurotoxic effects of increased inflammation may be associated with the pathophysiology of depression. This review focuses the influence of stress on neuroinflammation which may cause alterations in brain structure and function in MDD.
    Language English
    Publishing date 2017-06-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2017.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: An Oldie but Goodie: Lithium in the Treatment of Bipolar Disorder through Neuroprotective and Neurotrophic Mechanisms.

    Won, Eunsoo / Kim, Yong-Ku

    International journal of molecular sciences

    2017  Volume 18, Issue 12

    Abstract: Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with more reliable designs and updated guidelines have recommended lithium to be the treatment of choice for acute manic, mixed and ... ...

    Abstract Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with more reliable designs and updated guidelines have recommended lithium to be the treatment of choice for acute manic, mixed and depressive episodes of BD, along with long-term prophylaxis. Lithium's specific mechanism of action in mood regulation is progressively being clarified, such as the direct inhibition on glycogen synthase kinase 3β, and its various effects on neurotrophic factors, neurotransmitters, oxidative metabolism, apoptosis, second messenger systems, and biological systems are also being revealed. Furthermore, lithium has been proposed to exert its treatment effects through mechanisms associated with neuronal plasticity. In this review, we have overviewed the clinical aspects of lithium use for BD, and have focused on the neuroprotective and neurotrophic effects of lithium.
    MeSH term(s) Bipolar Disorder/drug therapy ; Bipolar Disorder/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Lithium/pharmacology ; Lithium/therapeutic use ; Nerve Growth Factors/metabolism ; Neuronal Plasticity/drug effects ; Neuroprotection/drug effects
    Chemical Substances Nerve Growth Factors ; Lithium (9FN79X2M3F) ; GSK3B protein, human (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1)
    Language English
    Publishing date 2017-12-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms18122679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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