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Article ; Online: Fertility-sparing approach for endometrial cancer: the role of office hysteroscopy.

Carugno, José / Wong, Adriana

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

2021 Volume 30, Issue 5, Page(s) 296–303

Abstract: Endometrial cancer is the most common gynecologic malignancy in developed countries, with increasing incidence among younger, nulliparous patients. These epidemiological shifts are attributed to increasing rates of obesity, in combination with delayed ... ...

Abstract	Endometrial cancer is the most common gynecologic malignancy in developed countries, with increasing incidence among younger, nulliparous patients. These epidemiological shifts are attributed to increasing rates of obesity, in combination with delayed childbearing. This highlights a need for fertility-sparing options for individuals who wish to delay standard surgical management with hysterectomy, bilateral salpingoophorectomy, and assessment of pelvic/para-aortic lymph nodes. Careful consideration should be taken to select which patients are suitable candidates for fertility-sparing methods. Typically, these are patients found to have FIGO grade 1 tumors of the endometrioid subtype without myometrial invasion. Currently, conservative treatment options include the use of oral progestins and levonorgestrel-releasing intrauterine devices, with an emerging role for hysteroscopy for direct visualization of the uterine cavity, targeted tissue sampling, and tumor resection. This paper aims to highlight the role of office hysteroscopy for diagnosis, hysteroscopic tumor resection, and follow-up in suitable endometrial cancer patients who wish to preserve their uterus until childbearing is complete.
MeSH term(s)	Antineoplastic Agents, Hormonal/therapeutic use ; Endometrial Neoplasms/surgery ; Female ; Fertility ; Fertility Preservation ; Humans ; Hysteroscopy ; Pregnancy
Chemical Substances	Antineoplastic Agents, Hormonal
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1317160-4
ISSN	1365-2931 ; 1364-5706
ISSN (online)	1365-2931
ISSN	1364-5706
DOI	10.1080/13645706.2021.1949353
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Zs.A 3467: Show issues

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Article ; Online: Live Birth with or without Preimplantation Genetic Testing for Aneuploidy.

Wong, Adriana J / DeCherney, Alan H

The New England journal of medicine

2022 Volume 386, Issue 7, Page(s) 703

MeSH term(s)	Aneuploidy ; Female ; Genetic Testing ; Humans ; Live Birth ; Pregnancy
Language	English
Publishing date	2022-02-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2119856
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Article ; Online: Diagnosis and Management of Uterine Perforation with Omental Incarceration after Dilation and Curettage.

Sedrati, Adel / Wong, Adriana J / Alonso, Luis / Carugno, Jose

Journal of minimally invasive gynecology

2022 Volume 29, Issue 9, Page(s) 1028–1029

MeSH term(s)	Curettage ; Dilatation ; Dilatation and Curettage/adverse effects ; Female ; Humans ; Omentum/surgery ; Uterine Perforation/diagnosis ; Uterine Perforation/etiology ; Uterine Perforation/surgery
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186934-0
ISSN	1553-4669 ; 1553-4650
ISSN (online)	1553-4669
ISSN	1553-4650
DOI	10.1016/j.jmig.2022.05.008
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Zs.A 4205: Show issues

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Article: Retreatment of chemotherapy-resistant metastatic choriocarcinoma with immunotherapy.

Wong, Adriana J / Finch, Lindsey / Pearson, Joseph Matt / Pinto, Andre / Huang, Marilyn

Gynecologic oncology reports

2022 Volume 40, Page(s) 100955

Abstract: Introduction: Recurrent metastatic choriocarcinoma is a rare disease with historically limited guidance in the literature regarding standardized treatment protocols. In this case report, we review the course of a patient with recurrent metastatic ... ...

Abstract	Introduction: Recurrent metastatic choriocarcinoma is a rare disease with historically limited guidance in the literature regarding standardized treatment protocols. In this case report, we review the course of a patient with recurrent metastatic choriocarcinoma re-treated with single agent pembrolizumab.Our patient was initially diagnosed with metastatic choriocarcinoma (FIGO Stage IV, WHO Score 13) after presenting for evaluation of amenorrhea. She received standard treatment with etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine (EMA-CO), with a complete response. However, she recurred one year later. Molecular profiling of a chest wall tumor demonstrated strong expression of programmed cell death ligand 1 (PD-L1), and she was started on treatment with single agent pembrolizumab achieving a complete response. Unfortunately, she recurred again 6 months following completion of treatment. She was re-treated with pembrolizumab for 2 years with complete response after 25 cycles and is currently without evidence of disease. She has been followed on surveillance, with no evidence of disease for more than 24 months following treatment. Conclusion: This case represents the first to our knowledge to discuss re-treatment with pembrolizumab for relapsed choriocarcinoma after achieving a complete response.
Language	English
Publishing date	2022-03-09
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2818505-5
ISSN	2352-5789
ISSN	2352-5789
DOI	10.1016/j.gore.2022.100955
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Article ; Online: Management of placenta percreta in a Jehovah's Witness patient.

Wong, Adriana J / Schlumbrecht, Matthew / Huang, Marilyn

BMJ case reports

2018 Volume 2018

Abstract: Placenta percreta is increasing in incidence and is associated with the risk of life-threatening haemorrhage. Patients who do not accept blood products present a unique challenge to obstetrician-gynaecologists. In this case report, we present the case of ...

Abstract	Placenta percreta is increasing in incidence and is associated with the risk of life-threatening haemorrhage. Patients who do not accept blood products present a unique challenge to obstetrician-gynaecologists. In this case report, we present the case of a 42-year-old pregnant Jehovah's Witness with a complete placenta previa and confirmed percreta at 26 weeks' gestation. Due to her religious beliefs against the use of blood products, she was managed with a stepwise surgical approach which involved caesarean delivery with internal iliac (hypogastric) artery ligation, weekly methotrexate and delayed hysterectomy 6 weeks later. Non-traditional, alternative approaches to the management of abnormal placentation in patients declining blood products warrant exploration.
MeSH term(s)	Adult ; Blood Transfusion/psychology ; Cesarean Section, Repeat ; Erythropoietin/administration & dosage ; Female ; Humans ; Hysterectomy ; Jehovah's Witnesses ; Magnetic Resonance Imaging ; Methotrexate/adverse effects ; Placenta Accreta/diagnostic imaging ; Placenta Accreta/therapy ; Placenta Previa/diagnostic imaging ; Placenta Previa/therapy ; Pregnancy ; Treatment Refusal ; Ultrasonography, Prenatal ; Uterine Hemorrhage/prevention & control
Chemical Substances	Erythropoietin (11096-26-7) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2018-06-11
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2018-225260
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Article: Trends in Social Media Topics During COVID-19 Among Women Undergoing Assisted Reproductive Technology Treatments.

Perone, Hanna R / Stump, Hannah / Herweck, Alexandra / Levine, Hannah / Wong, Adriana J / Carugno, Jose

Cureus

2020 Volume 12, Issue 10, Page(s) e11049

Abstract: Patients undergoing fertility treatments, such as in-vitro fertilization (IVF), face unique challenges both physically and mentally. With the emergence of the COVID-19 global pandemic, IVF patients began to face additional obstacles as hospitals and ... ...

Abstract	Patients undergoing fertility treatments, such as in-vitro fertilization (IVF), face unique challenges both physically and mentally. With the emergence of the COVID-19 global pandemic, IVF patients began to face additional obstacles as hospitals and clinics shut down in compliance with recommendations for limiting exposure risk. In order to assess the impact of COVID-19 on IVF patients, we conducted a qualitative analysis using 563 public Instagram posts collected from three randomly selected days in March 2020. After the exclusion of 354 posts, thematic coding was used to analyze 209 posts. Five major themes were identified including (1) the medical and physical experience of IVF, (2) emotional spectrum, (3) sources of social support, (4) coping mechanisms, and (5) education on social media. Posts were categorized based on whether COVID-19 was discussed and theme frequencies were compared. The majority of patients impacted by the pandemic discussed setbacks to care, such as clinic closures. In addition, posts authored by those impacted by COVID-19 contained more negative emotions and fewer positive emotions compared to unaffected users. Despite an increase in setbacks and negative emotions, posts offering support nearly tripled in frequency highlighting the resilience of the IVF community. Our thematic analysis supports the need for careful consideration of the psychological and social effects of cycle cancellations on the IVF community. Experiences and sentiments revealed by this study should be considered when a successive pandemic or global emergency threatens IVF treatment protocols.
Keywords	covid19
Language	English
Publishing date	2020-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.11049
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Article ; Online: Tracking the Development of Cerebrovascular Risk Factors Following Pregnancy With Preeclampsia.

Lederer, Madeline / Wong, Adriana / Diego, Daniela / Nguyen, Desiree / Verma, Usha / Chaturvedi, Seemant

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2020 Volume 29, Issue 6, Page(s) 104720

Abstract: Objective: To evaluate the development and management of cerebrovascular risk factors following a pregnancy with preeclampsia.: Methods: This is a retrospective chart review including women diagnosed with preeclampsia between 2012 and 2013 with later ...

Abstract	Objective: To evaluate the development and management of cerebrovascular risk factors following a pregnancy with preeclampsia. Methods: This is a retrospective chart review including women diagnosed with preeclampsia between 2012 and 2013 with later encounters within 2014-2016. For each subject that met inclusion criteria, the development of cerebrovascular risk factors was determined using ICD codes within the 2014-2016 electronic medical record (EMR). For subjects who developed risk factors, current treatment was determined from the EMR. Demographic data was also documented. Differences in the development and treatment of risk factors were compared among racial groups and age. Descriptive statistics were calculated using SAS statistical software. Results: Compared to prepregnancy health status, the incidence of hypertension increased by 1.7 times (P < .05), hyperlipidemia increased by 4.5 (P < .05), migraines increased by 2.2 (P < .05), and diabetes mellitus increased by 2 (P < .05) after a pregnancy with preeclampsia. Black non-Hispanics had highest rates of hypertension, obesity, and migraines (20.5%, 9.1%, and 6.8%, respectively.) Of hypertensives, 73.6% (42/57) were prescribed medication. Of diabetics, 88.9% (16/18) were prescribed medication. No patients with hyperlipidemia were prescribed a statin. Black non-Hispanics had higher rates of risk factor management (74.3% of hypertensives and 100% of diabetics treated) than white Hispanics (55% and 77.8%, respectively). Conclusions: This study shows a significant increased risk of the development of cerebrovascular risk factors such as hypertension, hyperlipidemia, migraines, and diabetes following a diagnosis of preeclampsia. Opportunities exist for the early treatment of these risk factors, which could reduce the long-term rate of stroke in these women.
MeSH term(s)	Adult ; Antihypertensive Agents/therapeutic use ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/epidemiology ; Cerebrovascular Disorders/prevention & control ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Electronic Health Records ; Female ; Florida/epidemiology ; Health Status ; Humans ; Hyperlipidemias/diagnosis ; Hyperlipidemias/epidemiology ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypoglycemic Agents/therapeutic use ; Incidence ; Maternal Health ; Middle Aged ; Migraine Disorders/diagnosis ; Migraine Disorders/epidemiology ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Pregnancy ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Young Adult
Chemical Substances	Antihypertensive Agents ; Hypoglycemic Agents
Language	English
Publishing date	2020-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2020.104720
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Zs.A 3519: Show issues

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Article ; Online: Twitter Gynecologic Surgery Journal Club: Impact on Citation Scores and Social Media Attention.

Meyer, Raanan / Behbehani, Sadikah / Brooks, Kaylee / Valero, Cristobal R / Fox, Courtney / Layne, Alyssa N Small / Misal, Meenal / Movilla, Peter R / Lauer, Jacob K / Wong, Adriana J / Ackert, Kathleen / Truong, Mireille

Journal of minimally invasive gynecology

2023 Volume 30, Issue 8, Page(s) 635–641

Abstract: Study objective: To study the impact of a Twitter-based gynecologic surgery journal club of articles published in the Journal of Minimally Invasive Gynecology (JMIG) on their social media attention and citation scores.: Design: A cross-sectional ... ...

Abstract	Study objective: To study the impact of a Twitter-based gynecologic surgery journal club of articles published in the Journal of Minimally Invasive Gynecology (JMIG) on their social media attention and citation scores. Design: A cross-sectional study. Setting: N/A. Patients: N/A. Interventions: Comparison of citation and social media attention scores was conducted for all articles presented in the JMIG Twitter Journal Club (#JMIGjc), a monthly scientific discussion on Twitter of JMIG selected articles, between March 2018 and September 2021 (group A), with 2 matched control groups of other JMIG articles: group B, articles mentioned on social media but not promoted in any JMIG social media account, and group C, articles with no social media mentions and not presented in #JMIGjc. Matching was performed for publication year, design, and topic in a 1:1:1 ratio. Citation metrics included number of citations per year (CPY) and relative citation ratio (RCR). Altmetric Attention Score (AAS) was used to measure social media attention. This score tracks research articles' online activity from different sources such as social media platforms, blogs, and websites. We further compared group A with all JMIG articles published during the same period (group D). Measurements and main results: Thirty-nine articles were presented in the #JMIGjc (group A) and were matched to 39 articles in groups B and C. Median AAS was higher in group A than groups B and C (10.00 vs 3.00 vs 0, respectively, p <.001). CPY and RCR were similar among groups. Median AAS was higher in group A than group D (10.00 vs 1.00, p <.001), as were median CPY and RCR (3.00 vs 1.67, p = .001; 1.37 vs 0.89, p = .001, respectively). Conclusion: Although citation metrics were similar among groups, #JMIGjc articles had higher social media attention metrics than matched controls. Compared with all publications within the same journal, #JMIGjc articles resulted in higher citation metrics.
MeSH term(s)	Humans ; Female ; Journal Impact Factor ; Bibliometrics ; Social Media ; Cross-Sectional Studies ; Gynecologic Surgical Procedures
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186934-0
ISSN	1553-4669 ; 1553-4650
ISSN (online)	1553-4669
ISSN	1553-4650
DOI	10.1016/j.jmig.2023.04.002
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Zs.A 4205: Show issues

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Article: Trends in Social Media Topics During COVID-19 Among Women Undergoing Assisted Reproductive Technology Treatments

Perone, Hanna R. / Stump, Hannah Herweck Alexandra Levine Hannah Wong Adriana J. / Carugno, Jose

Cureus

Abstract: Patients undergoing fertility treatments, such as in-vitro fertilization (IVF), face unique challenges both physically and mentally With the emergence of the COVID-19 global pandemic, IVF patients began to face additional obstacles as hospitals and ... ...

Abstract	Patients undergoing fertility treatments, such as in-vitro fertilization (IVF), face unique challenges both physically and mentally With the emergence of the COVID-19 global pandemic, IVF patients began to face additional obstacles as hospitals and clinics shut down in compliance with recommendations for limiting exposure risk In order to assess the impact of COVID-19 on IVF patients, we conducted a qualitative analysis using 563 public Instagram posts collected from three randomly selected days in March 2020 After the exclusion of 354 posts, thematic coding was used to analyze 209 posts Five major themes were identified including (1) the medical and physical experience of IVF, (2) emotional spectrum, (3) sources of social support, (4) coping mechanisms, and (5) education on social media Posts were categorized based on whether COVID-19 was discussed and theme frequencies were compared The majority of patients impacted by the pandemic discussed setbacks to care, such as clinic closures In addition, posts authored by those impacted by COVID-19 contained more negative emotions and fewer positive emotions compared to unaffected users Despite an increase in setbacks and negative emotions, posts offering support nearly tripled in frequency highlighting the resilience of the IVF community Our thematic analysis supports the need for careful consideration of the psychological and social effects of cycle cancellations on the IVF community Experiences and sentiments revealed by this study should be considered when a successive pandemic or global emergency threatens IVF treatment protocols
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #902953
Database	COVID19

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Article ; Online: Low Perceived Anal Cancer Risk and Screening Utilization Among High-Risk Transgender Men and Women Living in an HIV / STI Epicenter.

Fein, Lydia A / Cunha, Isabella Rosa / Wong, Adriana / Schlumbrecht, Matthew P / Duthely, Lunthita M / Potter, JoNell E

AIDS and behavior

2021 Volume 25, Issue 7, Page(s) 2210–2218

Abstract: Although risk behaviors could place transgender people at increased risk of anal cancer, few studies have examined anal cancer knowledge and screening use among this population. This study assessed knowledge of anal cancer and associated screening tools, ...

Abstract	Although risk behaviors could place transgender people at increased risk of anal cancer, few studies have examined anal cancer knowledge and screening use among this population. This study assessed knowledge of anal cancer and associated screening tools, self-perceived risk for anal cancer, and willingness to undergo anal cytology testing among transgender persons in an HIV/sexually transmitted infection (STI)-dense region. Adult transgender persons were recruited locally and surveyed electronically. Descriptive statistics, student's t tests, ANOVA, and Pearson's chi-squared test were performed. Among 79 transgender persons, identified anal cancer risk factors included smoking, STI history, anoreceptive intercourse, and inconsistent condom use. Nearly half (43%) reported little to no knowledge of anal cancer. The vast majority (82%) had little to no perceived risk of developing anal cancer. Twenty-eight percent had heard of anal cytology, and few (17%) had undergone it. Despite susceptibility, transgender persons lack knowledge and have a low perception of personal risk of anal cancer, highlighting the need to increase awareness of anal cancer, risk factors, and screening methods among this population.
MeSH term(s)	Adult ; Anus Neoplasms/diagnosis ; Anus Neoplasms/epidemiology ; Anus Neoplasms/prevention & control ; Early Detection of Cancer ; Female ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; Homosexuality, Male ; Humans ; Male ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Transgender Persons
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-020-03149-w
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