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  1. Article ; Online: Response to Letter to the editor from Kirk & Stebbings: The Impact of Gender-Affirming Hormone Therapy on Physical Performance.

    Cheung, Ada S / Zwickl, Sav / Miller, Kirsti / Nolan, Brendan J / Wong, Alex Fang Qi / Jones, Patrice / Eynon, Nir

    The Journal of clinical endocrinology and metabolism

    2024  

    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Impact of Gender-Affirming Hormone Therapy on Physical Performance.

    Cheung, Ada S / Zwickl, Sav / Miller, Kirsti / Nolan, Brendan J / Wong, Alex Fang Qi / Jones, Patrice / Eynon, Nir

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 2, Page(s) e455–e465

    Abstract: Context: The inclusion of transgender people in elite sport has been a topic of debate. This narrative review examines the impact of gender-affirming hormone therapy (GAHT) on physical performance, muscle strength, and markers of endurance.: Evidence ... ...

    Abstract Context: The inclusion of transgender people in elite sport has been a topic of debate. This narrative review examines the impact of gender-affirming hormone therapy (GAHT) on physical performance, muscle strength, and markers of endurance.
    Evidence acquisition: MEDLINE and Embase were searched using terms to define the population (transgender), intervention (GAHT), and physical performance outcomes.
    Evidence synthesis: Existing literature comprises cross-sectional or small uncontrolled longitudinal studies of short duration. In nonathletic trans men starting testosterone therapy, within 1 year, muscle mass and strength increased and, by 3 years, physical performance (push-ups, sit-ups, run time) improved to the level of cisgender men. In nonathletic trans women, feminizing hormone therapy increased fat mass by approximately 30% and decreased muscle mass by approximately 5% after 12 months, and steadily declined beyond 3 years. While absolute lean mass remains higher in trans women, relative percentage lean mass and fat mass (and muscle strength corrected for lean mass), hemoglobin, and VO2 peak corrected for weight was no different to cisgender women. After 2 years of GAHT, no advantage was observed for physical performance measured by running time or in trans women. By 4 years, there was no advantage in sit-ups. While push-up performance declined in trans women, a statistical advantage remained relative to cisgender women.
    Conclusion: Limited evidence suggests that physical performance of nonathletic trans people who have undergone GAHT for at least 2 years approaches that of cisgender controls. Further controlled longitudinal research is needed in trans athletes and nonathletes.
    MeSH term(s) Male ; Humans ; Female ; Cross-Sectional Studies ; Transsexualism/drug therapy ; Testosterone/therapeutic use ; Transgender Persons ; Physical Functional Performance
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pelvic Pain in Transgender People Using Testosterone Therapy.

    Zwickl, Sav / Burchill, Laura / Wong, Alex Fang Qi / Leemaqz, Shalem Y / Cook, Teddy / Angus, Lachlan M / Eshin, Kalen / Elder, Charlotte V / Grover, Sonia R / Zajac, Jeffrey D / Cheung, Ada S

    LGBT health

    2023  Volume 10, Issue 3, Page(s) 179–190

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Infant, Newborn ; Humans ; Female ; Adult ; Transgender Persons ; Testosterone ; Cross-Sectional Studies ; Pelvic Pain ; Sexual Behavior
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2727303-9
    ISSN 2325-8306 ; 2325-8292
    ISSN (online) 2325-8306
    ISSN 2325-8292
    DOI 10.1089/lgbt.2022.0187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Factors associated with suicide attempts among Australian transgender adults.

    Zwickl, Sav / Wong, Alex Fang Qi / Dowers, Eden / Leemaqz, Shalem Yiner-Lee / Bretherton, Ingrid / Cook, Teddy / Zajac, Jeffrey D / Yip, Paul S F / Cheung, Ada S

    BMC psychiatry

    2021  Volume 21, Issue 1, Page(s) 81

    Abstract: Background: Transgender, including gender diverse and non-binary people, henceforth referred to collectively as trans people, are a highly marginalised population with alarming rates of suicidal ideation, attempted suicide and self-harm. We aimed to ... ...

    Abstract Background: Transgender, including gender diverse and non-binary people, henceforth referred to collectively as trans people, are a highly marginalised population with alarming rates of suicidal ideation, attempted suicide and self-harm. We aimed to understand the risk and protective factors of a lifetime history of attempted suicide in a community sample of Australian trans adults to guide better mental health support and suicide prevention strategies.
    Methods: Using a non-probability snowball sampling approach, a total of 928 trans adults completed a cross-sectional online survey between September 2017 and January 2018. The survey assessed demographic data, mental health morbidity, a lifetime history of intentional self-harm and attempted suicide, experiences of discrimination, experiences of assault, access to gender affirming healthcare and access to trans peer support groups. Logistic regression was used to examine the risk or protective effect of participant characteristics on the odds of suicide.
    Results: Of 928 participants, 85% self-reported a lifetime diagnosis of depression, 63% reported previous self-harm, and 43% had attempted suicide. Higher odds of reporting a lifetime history of suicide attempts were found in people who were; unemployed (adjusted odds ratio (aOR) 1.55 (1.05, 2.29), p = 0.03), had a diagnosis of depression (aOR 3.70 (2.51, 5.45), p < 0.001), desired gender affirming surgery in the future (aOR 1.73 (1.14, 2.61), p = 0.01), had experienced physical assault (aOR 2.01 (1.37, 2.95), p < 0.001) or experienced institutional discrimination related to their trans status (aOR 1.59 (1.14, 2.23), p = 0.007).
    Conclusion: Suicidality is associated with barriers to gender affirming care, gender based victimisation and institutionalised cissexism. Interventions to increase social inclusion, reduce transphobia and enable timely access to gender affirming care, particularly surgical interventions, are potential areas of intervention.
    MeSH term(s) Adult ; Australia/epidemiology ; Cross-Sectional Studies ; Humans ; Risk Factors ; Suicidal Ideation ; Suicide, Attempted ; Transgender Persons
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-244X
    ISSN (online) 1471-244X
    DOI 10.1186/s12888-021-03084-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction to: Factors associated with suicide attempts among Australian transgender adults.

    Zwickl, Sav / Wong, Alex Fang Qi / Dowers, Eden / Leemaqz, Shalem Yiner-Lee / Bretherton, Ingrid / Cook, Teddy / Zajac, Jeffrey D / Yip, Paul S F / Cheung, Ada S

    BMC psychiatry

    2021  Volume 21, Issue 1, Page(s) 551

    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Published Erratum
    ISSN 1471-244X
    ISSN (online) 1471-244X
    DOI 10.1186/s12888-021-03491-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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