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Article ; Online: Editorial for the Special Issue "Benefits of Supplementation with L-arginine, Citrulline and Watermelon on Vascular and Metabolic Health".

Figueroa, Arturo / Wong, Alexei

2023 Volume 15, Issue 6

Abstract: The endothelium is crucial in controlling blood pressure and preventing cardiovascular diseases [ ... ]. ...

Abstract	The endothelium is crucial in controlling blood pressure and preventing cardiovascular diseases [...].
MeSH term(s)	Dietary Supplements ; Citrulline/metabolism ; Citrullus/metabolism ; Blood Pressure ; Arginine
Chemical Substances	Citrulline (29VT07BGDA) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2023-03-20
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15061491
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Article ; Online: Effects of exercise training on inflammatory and cardiometabolic health markers in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials.

Hejazi, Keyvan / Wong, Alexei

The Journal of sports medicine and physical fitness

2022 Volume 63, Issue 2, Page(s) 345–359

Abstract: Introduction: The improvements in inflammation and cardiometabolic health play an important role in the prevention and treatment of obesity. However, the interactions between different exercise training (ET) modalities with inflammatory and ... ...

Abstract	Introduction: The improvements in inflammation and cardiometabolic health play an important role in the prevention and treatment of obesity. However, the interactions between different exercise training (ET) modalities with inflammatory and cardiometabolic biomarkers are not completely understood. This systematic review and meta-analysis investigated the effects of ET on inflammatory and cardiometabolic health markers in overweight and obese adults. Evidence acquisition: A systematic search was conducted in PubMed, CINAHL, MEDLINE, Cochrane, Google Scholar, Scopus and Web of Science up to December 15, 2021. Thirty-five studies including 2752 participants were included and analyzed using a random-effects model to estimate weighted mean differences (MD) with 95% confidence intervals (CI). Evidence synthesis: The meta-analysis found that ET significantly (P<0.05) increased adiponectin (WMD: 0.72 µg/mL; 95% CI: 0.60 to 0.84; SMD=0.65) and maximal oxygen consumption levels (WMD: 5.26 mL.kg.min; 95% CI: 3.84, 6.69; SMD=1.21). Moreover, ET significantly (P<0.05) reduced fasting insulin (WMD: -2.40 μIU/mL; 95% CI: -3.43 to -1.37; SMD=-0.87), fasting blood glucose (WMD: -5.41 mg/dL; 95% CI: -7.91, -2.91; SMD=-0.66), insulin resistance (WMD: -0.66; 95% CI: -1.08, -0.24; SMD=-0.66) and triglyceride levels (WMD: -10.88 mg/dL; 95% CI: -17.61, -4.15; SMD=-0.91). No significant changes were observed in interleukin-6, tumor necrosis factor-α, leptin, C-reactive protein and cholesterol concentrations. Subgroup analysis by type of training indicated that aerobic and resistance exercise had the most consistent beneficial effects as compared to other modalities. Conclusions: Our findings suggest that ET may improve inflammation and cardiometabolic health in overweight and obese adults. Aerobic and resistance training appear to be more beneficial for improving adiponectin, fasting insulin, fasting blood glucose, insulin resistance index and triglyceride levels as compared to other exercise modalities. Further long-term studies are required to confirm and expand on these findings.
MeSH term(s)	Adult ; Humans ; Overweight/therapy ; Insulin Resistance ; Blood Glucose/metabolism ; Adiponectin ; Randomized Controlled Trials as Topic ; Obesity/therapy ; Exercise ; Insulin ; Inflammation ; Cardiovascular Diseases/prevention & control ; Triglycerides
Chemical Substances	Blood Glucose ; Adiponectin ; Insulin ; Triglycerides
Language	English
Publishing date	2022-07-11
Publishing country	Italy
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.22.14103-4
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Article ; Online: The effect of dietary carbohydrate restriction and aerobic exercise on retinol binding protein 4 (RBP4) and fatty acid binding protein 5 (FABP5) in middle-aged men with metabolic syndrome - CORRIGENDUM.

Ghorbanian, Bahloul / Wong, Alexei / Iranpour, Asgar

The British journal of nutrition

2023 Volume 130, Issue 12, Page(s) 2208

MeSH term(s)	Humans ; Male ; Middle Aged ; Metabolic Syndrome ; Dietary Carbohydrates ; Exercise ; Fatty Acid-Binding Proteins ; Insulin Resistance ; Retinol-Binding Proteins, Plasma
Chemical Substances	Dietary Carbohydrates ; Fatty Acid-Binding Proteins ; FABP5 protein, human ; RBP4 protein, human ; Retinol-Binding Proteins, Plasma
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114523001320
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Article ; Online: Acute Hemodynamic, Metabolic, and Hormonal Responses to a Boxing Exergame with and without Blood Flow Restriction in Non-Athlete Young Individuals.

Karimi, Zohreh / Mousavi, Zeynabalsadat / Nordvall, Michael / Wong, Alexei / Bagheri, Reza / Dutheil, Frederic

Sports (Basel, Switzerland)

2024 Volume 12, Issue 3

Abstract: Background: This study aimed to compare acute hemodynamic, metabolic (glucose and blood lactate concentrations), hormonal (growth hormone and normetanephrine), heart rate variability (HRV), and rating of perceived exertion (RPE) responses before and ... ...

Abstract	Background: This study aimed to compare acute hemodynamic, metabolic (glucose and blood lactate concentrations), hormonal (growth hormone and normetanephrine), heart rate variability (HRV), and rating of perceived exertion (RPE) responses before and after bouts of a boxing exergame with and without blood flow restriction (BFR) in non-athlete young individuals. Methods: Fourteen participants (age: 30 ± 10 y; BMI: 21 ± 3 kg.m Results: Playing exergame led to a significant increase in hemodynamic variables (except for diastolic blood pressure) regardless of BFR condition with no between-group differences. Regarding HRV, significant reductions in total power (TP) and low-frequency (LF) waves were identified in the non-BFR group ( Conclusions: We observed similar hemodynamic, hormonal, and metabolic responses after an acute boxing exergame session in young individuals, whether conducted with or without BFR. However, notable differences were observed in certain HRV markers and RPE. Specifically, the inclusion of BFR resulted in an elevation of VLF and a heightened perceived exertion. These findings suggest that BFR may alter cardiac autonomic and perceptual responses during exergaming. Further research is warranted to understand the long-term implications and potential benefits of incorporating BFR into exergaming routines.
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704239-X
ISSN	2075-4663 ; 2075-4663
ISSN (online)	2075-4663
ISSN	2075-4663
DOI	10.3390/sports12030068
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Article ; Online: Comparison of enjoyment and energy expenditure of exergame with and without blood flow restriction in men and women.

Mousavi, Zeynabalsadat / Karimi, Zohreh / Wong, Alexei / Cheraghloo, Neda / Bagheri, Hessan / Bagheri, Reza

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9030

Abstract: This study compared the effects of blood flow restriction (BFR) on intensity and perceived enjoyment during an exergame. Fourteen healthy young participants engaged in a boxing exergame for 20 min, with or without BFR, across two sessions. Perceived ... ...

Abstract	This study compared the effects of blood flow restriction (BFR) on intensity and perceived enjoyment during an exergame. Fourteen healthy young participants engaged in a boxing exergame for 20 min, with or without BFR, across two sessions. Perceived enjoyment levels were assessed using the Physical Activity Enjoyment Scale. Heart rate was monitored, and energy expenditure (EE) during exercise was calculated. A mixed model analysis of variance with repeated measures was used to evaluate differences in EE and enjoyment between exergame conditions (with and without BFR) as well as the interaction effects of these protocols with gender. Although not statistically significant, perceived enjoyment decreased with BFR inclusion for both genders. No significant differences were observed between men and women for both protocols. Regarding EE, there was no significant difference between the two groups (with and without BFR). However, a significant main effect of gender was found, with men exhibiting higher EE values in both protocols compared to women. In conclusion, exergames incorporating BFR impact perceptual responses, particularly perceived enjoyment. Furthermore, significant gender differences in EE were found, with men displaying higher values.
MeSH term(s)	Humans ; Female ; Male ; Pleasure ; Exergaming ; Hemodynamics ; Exercise/physiology ; Energy Metabolism/physiology
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59379-8
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Article: Association between dietary antioxidant quality score and severity of coronavirus infection: a case-control study.

Aghajani, Mobina / Wong, Alexei / Azimi, Mehdi / Harijani, Shadmehr Mirdar

Frontiers in nutrition

2023 Volume 10, Page(s) 1174113

Abstract: The purpose of this study was to examine the association between the dietary antioxidant quality score (DAQS) and the severity of Coronavirus disease 2019 (COVID-19). The present case-control study was carried out on 295 patients diagnosed with COVID-19 ( ...

Abstract	The purpose of this study was to examine the association between the dietary antioxidant quality score (DAQS) and the severity of Coronavirus disease 2019 (COVID-19). The present case-control study was carried out on 295 patients diagnosed with COVID-19 (≥18 years old), including 104 critical patients (Intensive care unit [ICU] admission) and 191 COVID-19 patients without severe complications (Non-intensive care unit [Non-ICU] patients) as cases. Dietary intake was assessed by a 147-item, semi-quantitative food frequency questionnaire (FFQ). Logistic regression was performed to calculate the odds ratio (OR) and 95% confidence interval (CI) for the considered risk factors. Our outcomes (after multivariate adjustment) suggested that higher adherence to DAQS was significantly associated with a decreased risk of COVID-19 infection severity (OR = 0.12; 95% CI: 0.04-0.29,
Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1174113
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Article ; Online: The effect of dietary carbohydrate restriction and aerobic exercise on retinol binding protein 4 (RBP4) and fatty acid binding protein 5 (FABP5) in middle-aged men with metabolic syndrome.

Ghorbanian, Bahloul / Wong, Alexei / Iranpour, Asgar

The British journal of nutrition

2022 Volume 130, Issue 4, Page(s) 553–563

Abstract: Exercise and dietary interventions have been described to positively affect metabolic syndrome (MetS) via molecular-induced changes. The purpose of this study was to investigate the effects of dietary carbohydrate restriction and aerobic exercise (AE) on ...

Abstract	Exercise and dietary interventions have been described to positively affect metabolic syndrome (MetS) via molecular-induced changes. The purpose of this study was to investigate the effects of dietary carbohydrate restriction and aerobic exercise (AE) on retinol binding protein 4 (RBP4) and fatty acid binding protein 5 (FABP5) in middle-aged men with MetS. The study had a randomised, double-blinded, parallel-controlled design. Forty middle-aged men with MetS (age: 53·97 ± 2·85 years, BMI = 31·09 ± 1·04 kg/m
MeSH term(s)	Male ; Middle Aged ; Humans ; Metabolic Syndrome/therapy ; Metabolic Syndrome/metabolism ; Insulin Resistance ; Dietary Carbohydrates ; Body Mass Index ; Fatty Acid-Binding Proteins ; Retinol-Binding Proteins ; Retinol-Binding Proteins, Plasma/metabolism
Chemical Substances	Dietary Carbohydrates ; Fatty Acid-Binding Proteins ; Retinol-Binding Proteins ; FABP5 protein, human ; RBP4 protein, human ; Retinol-Binding Proteins, Plasma
Language	English
Publishing date	2022-11-14
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114522003580
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Article: Effects of l-citrulline supplementation on nitric oxide and antioxidant markers after high-intensity interval exercise in young men: a randomised controlled trial

Valaei, Kosar / Mehrabani, Javad / Wong, Alexei

British journal of nutrition. 2022 May 14, v. 127, no. 9

2022

Abstract: l-Citrulline (l-Cit) is a non-essential amino acid that stimulates nitric oxide (NO) production and improves exercise performance by reducing muscle damage indices; however, the direct benefits of l-Cit on antioxidant markers are unclear. The aim of this ...

Abstract	l-Citrulline (l-Cit) is a non-essential amino acid that stimulates nitric oxide (NO) production and improves exercise performance by reducing muscle damage indices; however, the direct benefits of l-Cit on antioxidant markers are unclear. The aim of this study was to examine antioxidant responses to high-intensity interval exercise following acute l-Cit supplementation. Nine young men (21 (sd 1) years) participated in a double-blind crossover study in which they received 12 g of l-Cit and placebo (PL) an hour prior to high-intensity interval exercise on two occasions, separated by a 7-d washout period. Blood samples were obtained before (PRE), immediately after (IP), 10 (10P) and 30 min after exercise (30P) from the cubital vein using standard procedures. Serum concentrations of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and NO metabolites (NOx) were measured. The exercise protocol significantly elevated SOD (P = 0·01) and GPx (P = 0·048) from PRE to 10P in the l-Cit group with greater changes than the PL group. CAT concentrations increased IP (P = 0·014) and remained elevated at 10P (P = 0·03) and 30P (P = 0·015) in both the l-Cit and PL conditions. NOx concentrations increased IP (P = 0·05) in the l-Cit group with greater changes than PL group in PRE to IP, PRE to 10P and PRE to 30P (P < 0·05). Our data indicate that l-Cit supplementation (single 12 g dose pre-exercise) induces improvements in antioxidant markers following a session of high-intensity interval exercise in young men.
Keywords	antioxidants ; athletic performance ; blood serum ; catalase ; citrulline ; cross-over studies ; exercise ; glutathione peroxidase ; metabolites ; muscles ; nitric oxide ; nutrition ; placebos ; randomized clinical trials ; superoxide dismutase
Language	English
Dates of publication	2022-0514
Size	p. 1303-1312.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114521002178
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Article ; Online: Effects of Acute Stretching Exercise and Training on Heart Rate Variability: A Review.

Wong, Alexei / Figueroa, Arturo

Journal of strength and conditioning research

2020 Volume 35, Issue 5, Page(s) 1459–1466

Abstract: Abstract: Wong, A and Figueroa, A. Effects of acute stretching exercise and training on heart rate variability: A review. J Strength Cond Res 35(5): 1459-1466, 2021-Stretching (ST), an exercise modality widely used for flexibility improvement, has been ... ...

Abstract	Abstract: Wong, A and Figueroa, A. Effects of acute stretching exercise and training on heart rate variability: A review. J Strength Cond Res 35(5): 1459-1466, 2021-Stretching (ST), an exercise modality widely used for flexibility improvement, has been recently proposed as an effective adjunct therapy for declines in cardiovascular health, warranting research into the effects of ST exercise on cardiac autonomic function (CAF). Heart rate (HR) variability (HRV) is a reliable measure of CAF, mainly the sympathetic and parasympathetic modulations of HR. A low HRV has been associated to increased risk of cardiovascular events and mortality. Exercise interventions that enhance HRV are therefore seen as beneficial to cardiovascular health and are sought after. In this review, we discuss the effect of ST both acute and training on HRV. Stretching training seems to be a useful therapeutic intervention to improve CAF in different populations. Although the mechanisms by which ST training improves CAF are not yet well understood; increases in baroreflex sensitivity, relaxation, and nitric oxide bioavailability seem to play an important role.
MeSH term(s)	Autonomic Nervous System ; Baroreflex ; Exercise ; Exercise Therapy ; Heart Rate ; Humans
Language	English
Publishing date	2020-07-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0000000000003084
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Article ; Online: The Effects of Low Intensity Resistance Exercise on Cardiac Autonomic Function and Muscle Strength in Obese Postmenopausal Women.

Wong, Alexei / Figueroa, Arturo

Journal of aging and physical activity

2019 Volume 27, Issue 4, Page(s) 855–860

Abstract: The present study examined the effects of a 12-week low intensity resistance exercise training (LIRET) regimen on heart rate variability (HRV), strength and body composition in obese postmenopausal women. Participants were randomly assigned to 12 weeks ... ...

Abstract	The present study examined the effects of a 12-week low intensity resistance exercise training (LIRET) regimen on heart rate variability (HRV), strength and body composition in obese postmenopausal women. Participants were randomly assigned to 12 weeks of either LIRET (n= 10) or non-exercising control group (n= 10). HRV, leg muscle strength and body composition were measured before and after 12 weeks. There were significant decreases (P < 0.05) in sympathovagal balance (LnLF/LnHF) and sympathetic tone (nLF) as well as significant increases (P < 0.05) in parasympathetic tone (nHF) and strength following LIRET compared to no changes after control. There were no significant changes in body composition after LIRET or control. LIRET may be an effective therapeutic intervention for improving sympathovagal balance and strength in obese postmenopausal women. Since obese postmenopausal women are at increased risk of developing cardiovascular diseases and physical disability, they could potentially benefit from LIRET.
MeSH term(s)	Aged ; Autonomic Nervous System/physiopathology ; Body Composition ; Cardiovascular Diseases/prevention & control ; Female ; Heart Function Tests/methods ; Heart Rate/physiology ; Humans ; Middle Aged ; Muscle Strength/physiology ; Postmenopause/physiology ; Program Evaluation ; Resistance Training/methods ; Women's Health
Language	English
Publishing date	2019-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1543-267X
ISSN (online)	1543-267X
DOI	10.1123/japa.2018-0418
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