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Book: Focus on statin research

Wong, B. A.

2006

Title variant	Statin research
Author's details	B. A. Wong, ed
Keywords	Hydroxymethylglutaryl-CoA Reductase Inhibitors / metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Language	English
Size	XI, 248 S. : Ill., graph. Darst.
Publisher	Nova Biomed. Books
Publishing place	New York
Publishing country	United States
Document type	Book
HBZ-ID	HT014813311
ISBN	1-59454-617-7 ; 978-1-59454-617-4
Database	Catalogue ZB MED Medicine, Health

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Article: Toxicity and human health assessment of an alcohol-to-jet (ATJ) synthetic kerosene developed under an international agreement with Sweden.

Mattie, D R / Wong, B A / Mumy, K L / McInturf, S M / Shafer, L M / Allen, R / Edwards, J T / Sibomana, I / Sterner, T R

Journal of toxicology and environmental health. Part A

2023 Volume 86, Issue 9, Page(s) 263–282

Abstract: Alcohol-to-jet (ATJ) Synthetic Kerosene with Aromatics (SKA) fuels are produced by dehydration and refining of alcohol feed stocks. ATJ SKA fuel known as SB-8 was developed by Swedish Biofuels as a cooperative agreement between Sweden and AFRL/RQTF. SB-8 ...

Abstract	Alcohol-to-jet (ATJ) Synthetic Kerosene with Aromatics (SKA) fuels are produced by dehydration and refining of alcohol feed stocks. ATJ SKA fuel known as SB-8 was developed by Swedish Biofuels as a cooperative agreement between Sweden and AFRL/RQTF. SB-8 including standard additives was tested in a 90-day toxicity study with male and female Fischer 344 rats exposed to 0, 200, 700, or 2000 mg/m
MeSH term(s)	Humans ; Rats ; Male ; Female ; Animals ; Kerosene/toxicity ; Sweden ; Semen ; Hydrocarbons/toxicity ; Rats, Inbred F344 ; Aerosols ; Ethanol
Chemical Substances	Kerosene ; JP5 jet fuel (8008-20-6) ; Hydrocarbons ; Aerosols ; Ethanol (3K9958V90M)
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1413345-3
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
DOI	10.1080/15287394.2023.2186295
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Book: Focus on statin research

Wong, B. A

2006

Author's details	B.A. Wong, editor
MeSH term(s)	Hydroxymethylglutaryl-CoA Reductase Inhibitors/metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
Language	English
Size	xi, 248 p. :, ill.
Publisher	Nova Biomedical Books
Publishing place	New York
Document type	Book
ISBN	9781594546174 ; 1594546177
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Development and use of a single-animal whole-body system for inhalation exposure

Wong, B.A / Ross, P.W / James, R.A

Lab animal. 2008 Jan., v. 37, no. 1

2008

Keywords	laboratory animals ; inhalation exposure ; toxicity testing
Language	English
Dates of publication	2008-01
Size	p. 33-40.
Document type	Article
ISSN	0093-7355
Database	NAL-Catalogue (AGRICOLA)

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Article: Semi-automatic scene generation using the Digital Anatomist Foundational Model.

Wong, B A / Rosse, C / Brinkley, J F

Proceedings. AMIA Symposium

1999 , Page(s) 637–641

Abstract: A recent survey shows that a major impediment to more widespread use of computers in anatomy education is the inability to directly manipulate 3-D models, and to relate these to corresponding textual information. In the University of Washington Digital ... ...

Abstract	A recent survey shows that a major impediment to more widespread use of computers in anatomy education is the inability to directly manipulate 3-D models, and to relate these to corresponding textual information. In the University of Washington Digital Anatomist Project we have developed a prototype Web-based scene generation program that combines the symbolic Foundational Model of Anatomy with 3-D models. A Web user can browse the Foundational Model (FM), then click to request that a 3-D scene be created of an object and its parts or branches. The scene is rendered by a graphics server, and a snapshot is sent to the Web client. The user can then manipulate the scene, adding new structures, deleting structures, rotating the scene, zooming, and saving the scene as a VRML file. Applications such as this, when fully realized with fast rendering and more anatomical content, have the potential to significantly change the way computers are used in anatomy education.
MeSH term(s)	Anatomy/education ; Anatomy, Cross-Sectional ; Computer Graphics ; Computer-Assisted Instruction ; Humans ; Image Processing, Computer-Assisted ; Internet ; Medical Illustration ; Models, Anatomic
Language	English
Publishing date	1999
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ISSN	1531-605X
ISSN	1531-605X
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Article: In vivo and in vitro kinetics of ethylene oxide metabolism in rats and mice.

Brown, C D / Wong, B A / Fennell, T R

Toxicology and applied pharmacology

1996 Volume 136, Issue 1, Page(s) 8–19

Abstract: Ethylene oxide (EO) is a direct-acting mutagen and animal carcinogen used as an industrial intermediate and sterilant with a high potential for human exposure. Kinetics of EO metabolism in rodents can be used to develop human EO dosimetry models. This ... ...

Abstract	Ethylene oxide (EO) is a direct-acting mutagen and animal carcinogen used as an industrial intermediate and sterilant with a high potential for human exposure. Kinetics of EO metabolism in rodents can be used to develop human EO dosimetry models. This study examined the kinetics of EO metabolism in vivo and in vitro in male and female F-344 rats and B6C3F1 mice. In vivo studies measured blood and tissue EO levels during and 2-20 min following whole-body inhalation exposure (4 hr, 100 or 330 ppm EO). At 100 ppm EO, the half-life of elimination (t1/2) in rats was 13.8 +/- 0.3 (mean +/- SD) and 10.8 +/- 2.4 min for males and females, respectively, compared to a t1/2 in mice of 3.12 +/- 0.2 and 2.4 +/- 0.2 min in males and females, respectively. On exposure to 330 ppm EO, the t1/2 in mice increased approx twofold, while no change in t1/2 was observed in rats. In vitro kinetic parameters (Vmax and KM) of EO metabolism were determined using tissue cytosol and microsomes. EO metabolism in vitro occurred primarily via cytosolic glutathione S-transferase-mediated EO-GSH conjugation (cGST-EO), with highest activity in the liver. Liver cGST-EO activity (Vmax) was 258 +/- 86.9 and 287 +/- 49.0 nmol/mg protein/min (mean +/- SD) in male and female mice, respectively, compared to 52.7 +/- 10.8 and 29.3 +/- 4.9 in male and female rats, respectively. In rats, but not mice, there was a statistically significant (p < 0.05) gender difference in the Vmax for liver cGST. The KM for liver cGST-EO was approximately 10 mM in both species. The higher Vmax values observed in mice are consistent with the more rapid elimination of EO observed for this species in vivo compared to rats.
MeSH term(s)	Administration, Inhalation ; Animals ; Brain/metabolism ; Cytosol/drug effects ; Cytosol/enzymology ; Cytosol/metabolism ; Environmental Exposure ; Ethylene Oxide/administration & dosage ; Ethylene Oxide/pharmacokinetics ; Ethylene Oxide/toxicity ; Female ; Glutathione Transferase/metabolism ; Half-Life ; Hydrolysis ; In Vitro Techniques ; Kidney/metabolism ; Liver/drug effects ; Liver/enzymology ; Liver/metabolism ; Magnetic Resonance Spectroscopy ; Male ; Mice ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Muscles/metabolism ; Mutagens/administration & dosage ; Mutagens/metabolism ; Mutagens/toxicity ; Rats ; Rats, Inbred F344 ; Species Specificity ; Testis/metabolism ; Tissue Distribution
Chemical Substances	Mutagens ; Glutathione Transferase (EC 2.5.1.18) ; Ethylene Oxide (JJH7GNN18P)
Language	English
Publishing date	1996-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1006/taap.1996.0002
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Article: Pharmacokinetics of inhaled manganese phosphate in male Sprague-Dawley rats following subacute (14-day) exposure.

Vitarella, D / Wong, B A / Moss, O R / Dorman, D C

Toxicology and applied pharmacology

2000 Volume 163, Issue 3, Page(s) 279–285

Abstract: Methylcyclopentadienyl manganese tricarbonyl (MMT) is used as a gasoline octane enhancer. Manganese phosphate is the primary respirable (PM(2.5)) MMT-combustion product emitted from the automobile tailpipe. The goal of this study was to determine the ... ...

Abstract	Methylcyclopentadienyl manganese tricarbonyl (MMT) is used as a gasoline octane enhancer. Manganese phosphate is the primary respirable (PM(2.5)) MMT-combustion product emitted from the automobile tailpipe. The goal of this study was to determine the exposure-response relationship for inhaled manganese phosphate in adult male CD rats. Rats were exposed 6-h/day for either 5 days/week (10 exposures) or 7 days/week (14 exposures) to manganese phosphate at 0, 0.03, 0.3, or 3 mg Mn/m(3) (MMAD congruent with 1.5 micrometer). The following tissues collected at the end of the 2-week exposure: plasma, erythrocytes, olfactory bulb, striatum, cerebellum, lung, liver, femur, and skeletal muscle (n = 6 rats/exposure group) were analyzed for manganese content by neutron activation analysis. Intravenous (54)MnCl(2) tracer studies were also conducted following the 14th exposure (n = 6 rats/concentration), and whole-body gamma spectrometry was performed immediately after injection and at 1, 2, 4, 8, 12, and 16 weeks after (54)MnCl(2) administration. Increased manganese concentrations were observed in olfactory bulb, lung, femur, and skeletal muscle following exposure to 3 mg Mn/m(3) (10 or 14 exposures). Increased manganese concentrations were also observed in olfactory bulb, striatum, and lung following exposure to 0.3 mg Mn/m(3) (14 exposures only). Red blood cell and plasma manganese concentrations were increased only in rats exposed to 3 mg Mn/m(3) (10 exposures). Rats exposed to 3 mg Mn/m(3) also had an increased whole-body manganese clearance rate when compared to air-exposed control animals. Our results suggest that the rat olfactory bulb may accumulate more manganese than other brain regions following inhalation exposure.
MeSH term(s)	Administration, Inhalation ; Air/analysis ; Animals ; Male ; Manganese/administration & dosage ; Manganese/pharmacokinetics ; Organometallic Compounds/administration & dosage ; Organometallic Compounds/toxicity ; Radioisotopes ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution
Chemical Substances	Organometallic Compounds ; Radioisotopes ; Manganese (42Z2K6ZL8P) ; manganese phosphate (VZ3U1H7Q5B)
Language	English
Publishing date	2000-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1006/taap.1999.8874
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Article: Respirable particulates generated by pressurized consumer products. II. Influence of experimental conditions

Wong, B. A.

American Industrial Hygiene Association J.

1979 Volume 40, Issue 4, Page(s) 339–347

Abstract: The many products available in pressurized packages produce appreciable concentrations of particulates that may be deposited in the deep lung of human users. We have reported the size and concentration characteristics of these aerosols under carefully ... ...

Institution	Waller Ferry Road, USA Lenoir City, TN 37771 Shell Oil Company
Abstract	The many products available in pressurized packages produce appreciable concentrations of particulates that may be deposited in the deep lung of human users. We have reported the size and concentration characteristics of these aerosols under carefully standardized conditions in a previous paper. These standard conditions have been varied to determine the influence of product discharge conditions on observed aerosol characteristics. The size characteristics are relatively insensitive to a wide range of changes in the discharge conditions; the only significant effect observed followed changing the target of the spray from a steel plate to a wig. The aerosol concentrations were changed by several experimental factors, but the relative changes were less than the estimated relative range of human exposure.
Keywords	Druckluft ; Kwst. heterohalogeniert ; Atmung ; Dampf ; Aerosol ; Exposition ; Kosmetisches Mittel
Language	English
Document type	Article
ZDB-ID	210659-0
ISSN	1542-8125 ; 0002-8894 ; 0096-820X ; 1529-8663 ; 1542-8117
ISSN (online)	1542-8125
ISSN	0002-8894 ; 0096-820X ; 1529-8663 ; 1542-8117
Database	Social Medicine (SOMED)

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Article: Respirable particulates generated by pressurized consumer products. I. Experimental method and general characteristics

Wong, B. A.

American Industrial Hygiene Association J.

1979 Volume 40, Issue 4, Page(s) 330–338

Abstract: Many products and materials are available in the widely used pressurized package or "aerosol" form. A simulated breathing zone model approach has been developed and used to characterize the particles to which a user may be exposed. Some products ... ...

Institution	Waller Ferry Road, USA Lenoir City, TN 37771 Shell Oil Company
Abstract	Many products and materials are available in the widely used pressurized package or "aerosol" form. A simulated breathing zone model approach has been developed and used to characterize the particles to which a user may be exposed. Some products characterized under simulated "worst reasonable" conditions produced concentrations of particulates smaller than 6 mym aerodynamic diameter exceeding 50 mg/cbm.
Keywords	Druckluft ; Kwst. heterohalogeniert ; Atmung ; Dampf ; Aerosol ; Exposition ; Propan ; Kosmetisches Mittel
Language	English
Document type	Article
ZDB-ID	210659-0
ISSN	1542-8125 ; 0002-8894 ; 0096-820X ; 1529-8663 ; 1542-8117
ISSN (online)	1542-8125
ISSN	0002-8894 ; 0096-820X ; 1529-8663 ; 1542-8117
Database	Social Medicine (SOMED)

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Article: Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.

Moser, G J / Wolf, D C / Wong, B A / Goldsworthy, T L

Carcinogenesis

1997 Volume 18, Issue 5, Page(s) 1075–1083

Abstract: Unleaded gasoline (UG) vapor (2056 ppm) increased the incidence of liver tumors in a chronic bioassay and exhibited tumor-promoting activity in N-nitrosodiethylamine (DEN)-initiated female mouse liver. Estrogen inhibited mouse liver tumor development and ...

Abstract	Unleaded gasoline (UG) vapor (2056 ppm) increased the incidence of liver tumors in a chronic bioassay and exhibited tumor-promoting activity in N-nitrosodiethylamine (DEN)-initiated female mouse liver. Estrogen inhibited mouse liver tumor development and the hepatocarcinogenic and tumor-promoting dose of UG produced uterine changes suggestive of estrogen antagonism. To directly test the hypothesis that UG-induced tumor-promoting ability is secondary to its interaction with the mouse liver tumor inhibitor, estrogen, we compared the tumor-promoting ability of UG in ovariectomized (Ovex) mice with the hepatic tumor-promoting ability of UG in intact mice. Ovaries were surgically removed at 4 weeks of age. Exposure to wholly vaporized UG (2018 ppm) under bioassay and tumor-promoting conditions began at 8 weeks of age. After 4 months of exposure, UG increased relative liver weight and hepatic microsomal cytochrome P450 pentoxyresourfin-O-dealkylase and ethoxyresorufin-O-deethylase activity to a similar extent in intact and Ovex mice. Non-focal hepatocyte proliferation, as measured by the incorporation of bromo-deoxyuridine, was not changed by UG exposure and was similar in all treatment groups. After 4 months of exposure to DEN-initiated mice, UG significantly increased the volume fraction of liver occupied by foci (three-fold) as compared to control intact mice. As expected, volume of foci was elevated in DEN/Ovex/control mice as compared to DEN/intact/control mice. In DEN/Ovex mice UG did not significantly increase the focal volume fraction. Thus, the tumor promoting activity of UG, as demonstrated by increased volume fraction of liver occupied by hepatic foci in intact mice, is greatly attenuated in Ovex mice. The volume fraction data in Ovex mice support the hypothesis that the tumor promoting activity of UG is dependent upon the interaction of UG with ovarian hormones. These data also indicate that hepatic microsomal cytochrome P450 PROD and EROD induction, hepatomegaly and non-focal hepatic LI are not specific markers of hepatic tumor promoting activity of UG.
MeSH term(s)	Animals ; Body Weight ; Carcinogens ; Diethylnitrosamine ; Estrus ; Female ; Gasoline ; Liver Neoplasms/chemically induced ; Male ; Mice ; Mice, Inbred C3H ; Organ Size ; Ovariectomy
Chemical Substances	Carcinogens ; Gasoline ; Diethylnitrosamine (3IQ78TTX1A)
Language	English
Publishing date	1997-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/18.5.1075
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