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  1. Article ; Online: Self-Employed Canadians' Experiences with Cancer and Work: A Qualitative Study.

    Maheu, Christine / Parkinson, Maureen / Wong, Caitlin / Yashmin, Fatima / Longpré, Caroline

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 5, Page(s) 4586–4602

    Abstract: Self-employed individuals with cancer face unique challenges that have not been fully explored in previous research. For example, while some studies conducted in Europe have suggested that self-employed workers with cancer experience more adverse health ... ...

    Abstract Self-employed individuals with cancer face unique challenges that have not been fully explored in previous research. For example, while some studies conducted in Europe have suggested that self-employed workers with cancer experience more adverse health and work-related outcomes compared to salaried workers, the specific manners in which cancer affects the health, work, and businesses of self-employed individuals remain inadequately understood. This lack of understanding represents a crucial gap in the literature, as self-employed individuals make up a significant portion of the workforce in many countries, including Canada. To address this gap, a qualitative interpretive description study was undertaken to explore the experiences of 23 self-employed Canadians diagnosed with cancer from six provinces, with the aim of generating insights into the unique challenges faced by this population. The interviews were conducted in the language chosen by the participants from the two official languages of Canada, namely English and French. Using reflexive thematic analysis, four major themes and twelve subthemes were generated from the participants' shared accounts that reflected the impact of cancer on self-employed Canadians' physical, cognitive, and psychological function, affecting their work ability and their ability to maintain their business and financial well-being. Participants in the study also shared strategies they used to continue working and maintain their business during their cancer experience. This study sheds light on the impact of cancer on self-employed individuals and provides insight into the experiences of self-employed individuals with cancer that can inform the development of interventions to support this population.
    MeSH term(s) Humans ; Canada ; Employment ; Qualitative Research ; Neoplasms ; Europe
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30050347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Limb Laterality Recognition Score: A Reliable Clinical Measure Related to Phantom Limb Pain.

    Wong, Christopher Kevin / Wong, Caitlin Kimberly

    Pain medicine (Malden, Mass.)

    2017  Volume 19, Issue 4, Page(s) 753–756

    Abstract: Objective: To explore the usefulness of the limb laterality recognition score as a clinical measure of phantom limb pain, regarding test-retest reliability and association of limb laterality recognition scores with phantom limb pain measures.: Design!# ...

    Abstract Objective: To explore the usefulness of the limb laterality recognition score as a clinical measure of phantom limb pain, regarding test-retest reliability and association of limb laterality recognition scores with phantom limb pain measures.
    Design: Retrospective cohort.
    Setting: Community support group.
    Subjects: Eleven adults who averaged 4.8 years since lower limb amputation due to vascular pathologies (N = 9), trauma (N = 1), and cancer (N = 1).
    Methods: Subjects self-reported amputated limb pain using the sensation subsection of the Prosthetic Evaluation Questionnaire and back and sound limb pain. Using numbered iPads that corresponded to the self-reports, subjects played the Recognise Foot game to assess limb laterality recognition ability. Subjects identified the laterality of 20 foot images, within two seconds each. The software collected accuracy and speed scores in basic, vanilla, and context conditions for two rounds in random order. Basic showed feet against black backgrounds, vanilla showed feet with various monochromatic backgrounds, and context showed feet in clothed or environmental contexts. So that greater accuracy in less time meant a better score, accuracy scores were divided by completion speed. Intraclass correlation coefficient (ICC)3,1 assessed test-retest reliability. Correlations between accuracy/speed and phantom limb pain measures were assessed with Spearman's rho (categorical) and Pearson coefficients (continuous).
    Results: Accuracy/speed test-retest reliability was strong (ICC = 0.72) and inversely associated with phantom limb pain frequency (context rho = 0.72).
    Conclusions: Limb laterality recognition accuracy/speed in the context condition had good test-retest reliability and correlated strongly with phantom limb pain frequency. Accuracy/speed limb laterality recognition ability relates to phantom limb pain and may be a valid clinical or research measure.
    MeSH term(s) Cohort Studies ; Female ; Functional Laterality ; Humans ; Male ; Mobile Applications ; Pain Measurement/methods ; Phantom Limb ; Recognition (Psychology) ; Reproducibility of Results ; Retrospective Studies
    Language English
    Publishing date 2017-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnx179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: LATERAL ORGAN BOUNDARIES DOMAIN 25 functions as a key regulator of haustorium development in dodders.

    Jhu, Min-Yao / Ichihashi, Yasunori / Farhi, Moran / Wong, Caitlin / Sinha, Neelima R

    Plant physiology

    2021  Volume 186, Issue 4, Page(s) 2093–2110

    Abstract: Parasitic plants reduce crop yield worldwide. Dodder (Cuscuta campestris) is a stem parasite that attaches to its host, using haustoria to extract nutrients and water. We analyzed the transcriptome of six C. campestris tissues and identified a key gene, ... ...

    Abstract Parasitic plants reduce crop yield worldwide. Dodder (Cuscuta campestris) is a stem parasite that attaches to its host, using haustoria to extract nutrients and water. We analyzed the transcriptome of six C. campestris tissues and identified a key gene, LATERAL ORGAN BOUNDARIES DOMAIN 25 (CcLBD25), as highly expressed in prehaustoria and haustoria. Gene coexpression networks from different tissue types and laser-capture microdissection RNA-sequencing data indicated that CcLBD25 could be essential for regulating cell wall loosening and organogenesis. We employed host-induced gene silencing by generating transgenic tomato (Solanum lycopersicum) hosts that express hairpin RNAs to target and down-regulate CcLBD25 in the parasite. Our results showed that C. campestris growing on CcLBD25 RNAi transgenic tomatoes transited to the flowering stage earlier and had reduced biomass compared with C. campestris growing on wild-type (WT) hosts, suggesting that parasites growing on transgenic plants were stressed due to insufficient nutrient acquisition. We developed an in vitro haustorium system to assay the number of prehaustoria produced on strands from C. campestris. Cuscuta campestris grown on CcLBD25 RNAi tomatoes produced fewer prehaustoria than those grown on WT tomatoes, indicating that down-regulating CcLBD25 may affect haustorium initiation. Cuscuta campestris haustoria growing on CcLBD25 RNAi tomatoes exhibited reduced pectin digestion and lacked searching hyphae, which interfered with haustorium penetration and formation of vascular connections. The results of this study elucidate the role of CcLBD25 in haustorium development and might contribute to developing parasite-resistant crops.
    MeSH term(s) Cuscuta/genetics ; Cuscuta/growth & development ; Gene Expression Regulation, Plant ; Organogenesis, Plant/genetics ; Plant Proteins/genetics
    Chemical Substances Plant Proteins
    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiab231
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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  4. Article ; Online: A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation.

    Ualiyeva, Saltanat / Lemire, Evan / Wong, Caitlin / Perniss, Alexander / Boyd, Amelia A / Avilés, Evelyn C / Minichetti, Dante G / Maxfield, Alice / Roditi, Rachel / Matsumoto, Ichiro / Wang, Xin / Deng, Wenjiang / Barrett, Nora A / Buchheit, Kathleen M / Laidlaw, Tanya M / Boyce, Joshua A / Bankova, Lora G / Haber, Adam L

    Science immunology

    2024  Volume 9, Issue 92, Page(s) eabq4341

    Abstract: The olfactory neuroepithelium serves as a sensory organ for odors and forms part of the nasal mucosal barrier. Olfactory sensory neurons are surrounded and supported by epithelial cells. Among them, microvillous cells (MVCs) are strategically positioned ... ...

    Abstract The olfactory neuroepithelium serves as a sensory organ for odors and forms part of the nasal mucosal barrier. Olfactory sensory neurons are surrounded and supported by epithelial cells. Among them, microvillous cells (MVCs) are strategically positioned at the apical surface, but their specific functions are enigmatic, and their relationship to the other specialized epithelial cells is unclear. Here, we establish that the family of MVCs comprises tuft cells and ionocytes in both mice and humans. Integrating analysis of the respiratory and olfactory epithelia, we define the distinct receptor expression of TRPM5
    MeSH term(s) Humans ; Mice ; Animals ; Tuft Cells ; Olfactory Mucosa/metabolism ; Nasal Mucosa ; Epithelial Cells/metabolism ; Cell Proliferation ; Doublecortin-Like Kinases
    Chemical Substances DCLK1 protein, human (EC 2.7.1.11) ; Doublecortin-Like Kinases (EC 2.7.1.11)
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abq4341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Novel Multidisciplinary Vascular Access Team Helps to Improve ICU Workflow Amidst Covid-19 Pandemic.

    Hackett, Anna K / Wells, Celia M / Gupta, Rohit / Zhang, Ziya / Brito, Amy / Kirton, Natalie B / Chan, Christy C / Brown, Kester / Wong, Caitlin / Leonardi, Kayla M / Shittu, Atinuke / Lay, Cappi / Kohli-Seth, Roopa

    Disaster medicine and public health preparedness

    2022  , Page(s) 1–3

    Abstract: Objective: The surge in critically ill patients has pressured hospitals to expand their intensive care unit capacities and critical care staff. This was difficult given the country's shortage of intensivists. This paper describes the implementation of a ...

    Abstract Objective: The surge in critically ill patients has pressured hospitals to expand their intensive care unit capacities and critical care staff. This was difficult given the country's shortage of intensivists. This paper describes the implementation of a multidisciplinary central line placement team and its impact in reducing the vascular access workload of ICU physicians during the height of the COVID-19 pandemic.
    Methods: Vascular surgeons, interventionalists, and anesthesiologists, were redeployed to the ICU Access team to place central and arterial lines. Nurses with expertise in vascular access were recruited to the team to streamline consultation and assist with line placement.
    Results: While 51 central and arterial lines were placed per 100 ICU patients in 2019, there were 87 central and arterial lines placed per 100 COVID-19 ICU patients in the sole month of April, 2020. The ICU Access Team placed 107 of the 226 vascular access devices in April 2020, reducing the procedure-related workload of ICU treating teams by 46%.
    Conclusions: The ICU Access Team was able to complete a large proportion of vascular access insertions without reported complications. Given another mass casualty event, this ICU Access Team could be reassembled to rapidly meet the increased vascular access needs of patients.
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2022.111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Overcoming Weight Problems in Adults With Down Syndrome

    Wong, Caitlin / Dwyer, Johanna / Holland, Molly

    Nutrition today. 2014 , v. 49, no. 3

    2014  

    Abstract: Adults with Down syndrome often need help to keep their weights at healthy levels, and yet the prevention and treatment of overweight among them are rarely addressed. This article provides a brief review of the problem and recommendations to overcome the ...

    Abstract Adults with Down syndrome often need help to keep their weights at healthy levels, and yet the prevention and treatment of overweight among them are rarely addressed. This article provides a brief review of the problem and recommendations to overcome the many barriers to maintaining healthy weight and eating patterns encountered by persons with Down syndrome and their families. The primary causes of their weight problems are environmental; degree of intellectual disability and congenital conditions play lesser roles.
    Keywords Down syndrome ; adults ; eating habits ; human nutrition ; ideal body weight ; overweight
    Language English
    Dates of publication 2014-05
    Size p. 109-119.
    Publishing place Wolters Kluwer Health | Lippincott Williams & Wilkins
    Document type Article
    Note Affiliations: Caitlin Wong, MS, RD, is recent graduate of the Frances Stern Nutrition Center’s dietetic internship and the master’s degree program in Nutrition at Tufts University in Boston, Massachusetts, and is registered dietitian. Johanna Dwyer, DSc, RD, is professor of Medicine (Nutrition) and Community Health at Tufts University and is director of the Frances Stern Nutrition Center at Tufts Medical Center in Boston, Massachusetts. Molly Holland, MPH, RD, splits her time between Vermont Department of Health, Children With Special Health Needs, and as the metabolic dietitian at Fletcher Allen Health Care in Burlington, Vermont. She is a research associate at the Center for Disability and Community Inclusion at the University of Vermont.
    ZDB-ID 2053548-X
    ISSN 1538-9839 ; 0029-666X
    ISSN (online) 1538-9839
    ISSN 0029-666X
    DOI 10.1097/NT.0000000000000029
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation.

    Ualiyeva, Saltanat / Lemire, Evan / Aviles, Evelyn C / Wong, Caitlin / Boyd, Amelia A / Lai, Juying / Liu, Tao / Matsumoto, Ichiro / Barrett, Nora A / Boyce, Joshua A / Haber, Adam L / Bankova, Lora G

    Science immunology

    2021  Volume 6, Issue 66, Page(s) eabj0474

    Abstract: Aeroallergen sensing by airway epithelial cells triggers pathogenic immune responses leading to type 2 inflammation, the hallmark of chronic airway diseases such as asthma. Tuft cells are rare epithelial cells and the dominant source of interleukin-25 ( ... ...

    Abstract Aeroallergen sensing by airway epithelial cells triggers pathogenic immune responses leading to type 2 inflammation, the hallmark of chronic airway diseases such as asthma. Tuft cells are rare epithelial cells and the dominant source of interleukin-25 (IL-25), an epithelial cytokine, and cysteinyl leukotrienes (CysLTs), lipid mediators of vascular permeability and chemotaxis. How these two mediators derived from the same cell might cooperatively promote type 2 inflammation in the airways has not been clarified. Here, we showed that inhalation of the parent leukotriene C
    MeSH term(s) Animals ; Cysteine/immunology ; Epithelial Cells/immunology ; Interleukins/immunology ; Leukotrienes/immunology ; Mice ; Mice, Transgenic ; Pneumonia/immunology
    Chemical Substances Interleukins ; Leukotrienes ; Mydgf protein, mouse ; cysteinyl-leukotriene ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abj0474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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