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  1. Article ; Online: Manuscript best practices: Takeaways from a community conversation.

    Wong, Carmen Chak-Lui / Tapper, Elliot B / Malhi, Harmeet / Gores, Gregory J

    Hepatology (Baltimore, Md.)

    2024  

    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1660: Show issues Location:
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  2. Article ; Online: The future of Hepatology Communications.

    Tapper, Elliot B / Wong, Carmen Chak-Lui

    Hepatology communications

    2023  Volume 7, Issue 4

    MeSH term(s) Gastroenterology ; Forecasting
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Editorial
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1097/HC9.0000000000000085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of Metabolism in Adoptive T Cell Therapy: Strategies and Challenges.

    Tan, Ge Hui / Wong, Carmen Chak-Lui

    Antioxidants & redox signaling

    2022  Volume 37, Issue 16-18, Page(s) 1303–1324

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Cell- and Tissue-Based Therapy
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2022.0037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5488: Show issues Location:
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  4. Article ; Online: Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer.

    Bao, Macus Hao-Ran / Wong, Carmen Chak-Lui

    Cells

    2021  Volume 10, Issue 7

    Abstract: Hypoxia, low oxygen ( ... ...

    Abstract Hypoxia, low oxygen (O
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cellular Reprogramming/drug effects ; Cellular Reprogramming/genetics ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia/drug therapy ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immune Checkpoint Inhibitors/therapeutic use ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Metabolic Networks and Pathways/drug effects ; Metabolic Networks and Pathways/genetics ; Nivolumab/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase/genetics ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase/metabolism ; Sorafenib/therapeutic use ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Immune Checkpoint Inhibitors ; PDK1 protein, human ; Protein Kinase Inhibitors ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; Nivolumab (31YO63LBSN) ; Sorafenib (9ZOQ3TZI87) ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10071715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanistic Rationales Guiding Combination Hepatocellular Carcinoma Therapies Involving Immune Checkpoint Inhibitors.

    Cheu, Jacinth Wing-Sum / Wong, Carmen Chak-Lui

    Hepatology (Baltimore, Md.)

    2021  Volume 74, Issue 4, Page(s) 2264–2276

    Abstract: Hepatocellular carcinoma (HCC) is one of the deadliest cancers because of late symptom manifestation leading to delayed diagnosis, which limits patients with HCC in terms of receiving curative surgical treatment. There are only a few therapeutic options ... ...

    Abstract Hepatocellular carcinoma (HCC) is one of the deadliest cancers because of late symptom manifestation leading to delayed diagnosis, which limits patients with HCC in terms of receiving curative surgical treatment. There are only a few therapeutic options for patients with advanced HCC. The emergence of immune checkpoint inhibitors (ICIs) brings HCC treatment to a stage at which nivolumab, an anti-programmed cell death protein 1 monoclonal antibody, achieves a 20% response rate. However, the large proportion of unresponsive patients drives the exploration of therapeutic strategies to improve ICIs' efficacy. Recent preclinical and clinical studies have suggested that ICIs, when used in combinations or when used with other cancer therapies, might elicit synergistic antitumor effects. However, the mechanistic rationales guiding different drug combinations to maximize this synergy remain largely ambiguous. In this review, we discuss different drug combinations used in HCC and the underlying mechanistic rationales, aiming to enhance the understanding of how these treatments can achieve synergy. This knowledge sets the foundation for the development of more effective and promising combination therapies for HCC.
    MeSH term(s) Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/pathology ; Drug Therapy, Combination/methods ; Drug Therapy, Combination/trends ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/immunology ; Liver Neoplasms/pathology ; Treatment Outcome
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1660: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Hypoxia-inducible factors and innate immunity in liver cancer.

    Yuen, Vincent Wai-Hin / Wong, Carmen Chak-Lui

    The Journal of clinical investigation

    2020  Volume 130, Issue 10, Page(s) 5052–5062

    Abstract: The liver has strong innate immunity to counteract pathogens from the gastrointestinal tract. During the development of liver cancer, which is typically driven by chronic inflammation, the composition and biological roles of the innate immune cells are ... ...

    Abstract The liver has strong innate immunity to counteract pathogens from the gastrointestinal tract. During the development of liver cancer, which is typically driven by chronic inflammation, the composition and biological roles of the innate immune cells are extensively altered. Hypoxia is a common finding in all stages of liver cancer development. Hypoxia drives the stabilization of hypoxia-inducible factors (HIFs), which act as central regulators to dampen the innate immunity of liver cancer. HIF signaling in innate immune cells and liver cancer cells together favors the recruitment and maintenance of pro-tumorigenic immune cells and the inhibition of anti-tumorigenic immune cells, promoting immune evasion. HIFs represent attractive therapeutic targets to inhibit the formation of an immunosuppressive microenvironment and growth of liver cancer.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/immunology ; Cell Hypoxia/immunology ; Humans ; Hypoxia/complications ; Hypoxia/immunology ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1/antagonists & inhibitors ; Hypoxia-Inducible Factor 1/immunology ; Immunity, Innate ; Liver/immunology ; Liver/metabolism ; Liver Neoplasms/etiology ; Liver Neoplasms/immunology ; Liver Neoplasms/metabolism ; Models, Immunological ; Signal Transduction ; Tumor Microenvironment/immunology
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Hypoxia-Inducible Factor 1
    Language English
    Publishing date 2020-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI137553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The folate cycle is a new metabolic weakness of cancer.

    Lee, Derek / Wong, Carmen Chak-Lui

    Molecular & cellular oncology

    2017  Volume 4, Issue 6, Page(s) e1327004

    Abstract: Cancer cells harness nutrients to support its rapid proliferation through metabolic reprogramming. Our report identified folate cycle as a metabolic target in hepatocellular carcinoma. Folate cycle stagnation via inhibition of its mitochondrial folate ... ...

    Abstract Cancer cells harness nutrients to support its rapid proliferation through metabolic reprogramming. Our report identified folate cycle as a metabolic target in hepatocellular carcinoma. Folate cycle stagnation via inhibition of its mitochondrial folate enzyme methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) greatly induced oxidative stress improving HCC cells' response to sorafenib.
    Language English
    Publishing date 2017-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2017.1327004
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  8. Article ; Online: Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals.

    Malhi, Harmeet / Brown, Robert S / Lim, Joseph K / Reau, Nancy / Tapper, Elliot B / Wong, Carmen Chak-Lui / Gores, Gregory J

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2023  Volume 29, Issue 12, Page(s) 1262–1263

    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals.

    Malhi, Harmeet / Brown, Robert S / Lim, Joseph K / Reau, Nancy / Tapper, Elliot B / Wong, Carmen Chak-Lui / Gores, Gregory J

    Hepatology (Baltimore, Md.)

    2023  Volume 78, Issue 6, Page(s) 1680–1681

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Motivation ; Periodicals as Topic
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Precipitous changes in nomenclature and definitions-NAFLD becomes SLD: Implications for and expectations of AASLD journals.

    Malhi, Harmeet / Brown, Robert S / Lim, Joseph K / Reau, Nancy / Tapper, Elliot B / Wong, Carmen Chak-Lui / Gores, Gregory J

    Hepatology communications

    2023  Volume 7, Issue 11

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Motivation ; Periodicals as Topic
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1097/HC9.0000000000000318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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