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  1. Book ; Online ; E-Book: Swept-source optical coherence tomography

    Teo, Kelvin Yi Chong / Wong, Chee Wai / Tsai, Andrew S. H. / Ting, Daniel S. W.

    a color atlas

    2015  

    Author's details edited by Kelvin Yi Chong Teo, Wong Chee Wai, Andrew Shih Hsiang Tsai, Daniel Shu Wei Ting
    Keywords Retinal Diseases / diagnosis ; Tomography, Optical Coherence / methods
    Language English
    Size 1 Online-Ressource (xii, 56 Seiten), Illustrationen
    Publisher World Scientific Publishing
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Note Includes index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019234184
    ISBN 978-981-4704-22-9 ; 9789814704212 ; 981-4704-22-9 ; 9814704210
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Pathologic myopia in highly myopic patients with high axial anisomyopia.

    Li, Jonathan / Dan, Yee Shan / Chua, Si Qi / Wong, Qiu Ying / Chong, Rachel S / Ang, Marcus / Wong, Chee Wai / Hoang, Quan V

    The British journal of ophthalmology

    2024  Volume 108, Issue 3, Page(s) 411–416

    Abstract: Purpose: To determine prevalence of anisomyopia (axial length (AL) difference ≥2.5 mm) among high myopes ((HMs), defined by spherical equivalent of ≤6.0 diopters or AL ≥ 26.5 mm). To characterise the shorter anisomyopic eye (SAE) and evaluate if ... ...

    Abstract Purpose: To determine prevalence of anisomyopia (axial length (AL) difference ≥2.5 mm) among high myopes ((HMs), defined by spherical equivalent of ≤6.0 diopters or AL ≥ 26.5 mm). To characterise the shorter anisomyopic eye (SAE) and evaluate if pathologic myopia (PM) in the longer anisomyopic eye (LAE) was associated with increased risk of PM in the SAE.
    Methods: 1168 HMs were recruited from Singapore National Eye Centre clinic for this cross-sectional study. Biometry, fundus photography and swept-source optical coherence tomography were performed. Patients with high axial anisomyopia were identified. Structural characteristics and presence of PM were described. Stepwise multivariate regression explored associations between PM in the LAE and pathology in the SAE, controlling for confounding variables.
    Results: Prevalence of anisomyopia was 15.8% (184 of 1168 patients). Anisomyopic patients (age 65.8±13.5 years) had mean AL of 30.6±2.0 mm and 26.2±2.3 mm in the LAE and SAE, respectively. 52.7% of SAEs had AL < 26.5 mm. Prevalence of myopic macular degeneration, macula-involving posterior staphyloma (PS), myopic traction maculopathy (MTM) and myopic choroidal neovascularisation (mCNV) in the SAE was 52.2%, 36.5%, 13.0% and 8.2%, respectively. Macular hole in the LAE was associated with increased risk of MTM in the SAE (OR=4.88, p=0.01). mCNV in the LAE was associated with mCNV in the SAE (OR=3.57, p=0.02). PS in the LAE was associated with PS in the SAE (OR=4.03, p<0.001).
    Conclusions: Even when controlled for AL, PM complications in the LAE predict similar PM complications in the SAE. Patients with high axial anisometropia with PM in the LAE should be monitored carefully for complications in the SAE.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Cross-Sectional Studies ; Myopia, Degenerative/complications ; Myopia, Degenerative/diagnosis ; Myopia, Degenerative/epidemiology ; Refraction, Ocular ; Vision Disorders/pathology ; Macular Degeneration/complications ; Choroidal Neovascularization/pathology ; Tomography, Optical Coherence ; Axial Length, Eye/pathology
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjo-2022-322285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Posterior segment drug delivery for the treatment of exudative age-related macular degeneration and diabetic macular oedema.

    Wong, Chee Wai / Wong, Tina T

    The British journal of ophthalmology

    2019  Volume 103, Issue 10, Page(s) 1356–1360

    Abstract: Inhibitors of vascular endothelial growth factors are used to treat a myriad of retinal conditions, including exudative age-related macular degeneration (AMD), diabetic macular oedema (DME) and diabetic retinopathy. Although effective, long-term efficacy ...

    Abstract Inhibitors of vascular endothelial growth factors are used to treat a myriad of retinal conditions, including exudative age-related macular degeneration (AMD), diabetic macular oedema (DME) and diabetic retinopathy. Although effective, long-term efficacy is limited by the need for frequent and invasive intravitreal injections. The quest for sustained action therapeutics that can be delivered to target tissue in the least invasive manner is an arduous endeavour that has ended in premature failure for several technologies in Phase II or III trials. Nevertheless, there have been promising preclinical studies, and more are on the horizon: port delivery systems for the treatment of exudative AMD have entered Phase III trials and a wide array of preclinical studies have demonstrated the potential for nanoparticles, such as liposomes, dendrimers and cell penetrating peptides to deliver therapeutics into the posterior segment via minimally invasive routes. In this review, we discuss the challenges posed by ocular barriers for drug penetration and present the recent advancements of the most pertinent drug delivery platforms with a focus on the treatment of exudative AMD and DME.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Cell-Penetrating Peptides/therapeutic use ; Dendrimers/therapeutic use ; Diabetic Retinopathy/drug therapy ; Drug Delivery Systems/methods ; Exudates and Transudates ; Humans ; Intravitreal Injections ; Liposomes/therapeutic use ; Macular Edema/drug therapy ; Posterior Eye Segment ; Visual Acuity ; Wet Macular Degeneration/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Cell-Penetrating Peptides ; Dendrimers ; Liposomes
    Language English
    Publishing date 2019-04-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2018-313462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A review of the clinical applications of drug delivery systems for the treatment of ocular anterior segment inflammation.

    Wong, Chee Wai / Metselaar, Josbert M / Storm, Gert / Wong, Tina T

    The British journal of ophthalmology

    2020  Volume 105, Issue 12, Page(s) 1617–1622

    Abstract: Ocular anterior segment inflammation is a medical problem that is seen in cases of cataract surgery and non-infectious anterior uveitis. Inadequately treated anterior segment inflammation can lead to sight-threatening conditions such as corneal oedema, ... ...

    Abstract Ocular anterior segment inflammation is a medical problem that is seen in cases of cataract surgery and non-infectious anterior uveitis. Inadequately treated anterior segment inflammation can lead to sight-threatening conditions such as corneal oedema, glaucoma and cystoid macular oedema. The mainstay of treatment for anterior segment inflammation is topical steroid eye-drops. However, several drawbacks limit the critical value of this treatment, including low bioavailability, poor patient compliance, relatively difficult administration manner and risk of blurring of vision and ocular irritation. A drug delivery system (DDS) that can provide increased bioavailability and sustained delivery while being specifically targeted towards inflamed ocular tissue can potentially replace daily eye-drops as the gold standard for management of anterior segment inflammation. The various DDS for anti-inflammatory drugs for the treatment of anterior segment inflammation are listed and summarised in this review, with a focus on commercially available products and those in clinical trials. Dextenza, INVELTYS, Dexycu and Bromsite are examples of DDS that have enjoyed success in clinical trials leading to FDA approval. Nanoparticles and ocular iontophoresis form the next wave of DDS that have the potential to replace topical steroids eye-drops as the treatment of choice for anterior segment inflammation. With the current relentless pace of ophthalmic drug delivery research, the pursuit of a new standard of treatment that eliminates the problems of low bioavailability and patient compliance may soon be realised.
    MeSH term(s) Drug Delivery Systems ; Eye ; Humans ; Inflammation/drug therapy ; Nanoparticles ; Ophthalmic Solutions ; Vision Disorders
    Chemical Substances Ophthalmic Solutions
    Language English
    Publishing date 2020-10-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2020-315911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply.

    Wong, Chee Wai / Lee, Shu Yen

    Retina (Philadelphia, Pa.)

    2016  Volume 36, Issue 6, Page(s) e54

    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000001083
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  6. Article ; Online: Reply.

    Wong, Chee Wai / Lee, Shu Yen

    Retina (Philadelphia, Pa.)

    2016  Volume 36, Issue 6, Page(s) e52–3

    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000001081
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  7. Article ; Online: Reply.

    Wong, Chee Wai / Lee, Shu Yen

    American journal of ophthalmology

    2016  Volume 173, Page(s) 147–148

    Language English
    Publishing date 2016-11-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2016.09.035
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  8. Article ; Online: Genotypic Homogeneity in Distinctive Transforming Growth Factor-Beta Induced (TGFBI) Protein Phenotypes.

    Han, Sang Beom / Anandalakshmi, Venkatraman / Wong, Chee Wai / Ng, Si Rui / Mehta, Jodhbir S

    International journal of molecular sciences

    2021  Volume 22, Issue 3

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/genetics ; Corneal Dystrophies, Hereditary/blood ; Corneal Dystrophies, Hereditary/genetics ; Corneal Dystrophies, Hereditary/metabolism ; Corneal Dystrophies, Hereditary/pathology ; DNA Mutational Analysis ; Exons ; Extracellular Matrix Proteins/blood ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Genetic Association Studies ; Genotype ; Humans ; Middle Aged ; Mutation ; Phenotype ; Transforming Growth Factor beta/blood ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
    Chemical Substances Extracellular Matrix Proteins ; Transforming Growth Factor beta ; betaIG-H3 protein (148710-76-3)
    Language English
    Publishing date 2021-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22031230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Liposomal drug delivery system for anti-inflammatory treatment after cataract surgery: a phase I/II clinical trial.

    Wong, Chee Wai / Wong, Edmund / Metselaar, Josbert M / Storm, Gert / Wong, Tina T

    Drug delivery and translational research

    2021  Volume 12, Issue 1, Page(s) 7–14

    Abstract: Liposomes as a drug delivery system may overcome the problems associated with non-compliance to eyedrops and inadequate control of inflammation after cataract surgery. We evaluated the safety and efficacy of a single subconjunctival injection of ... ...

    Abstract Liposomes as a drug delivery system may overcome the problems associated with non-compliance to eyedrops and inadequate control of inflammation after cataract surgery. We evaluated the safety and efficacy of a single subconjunctival injection of liposomal prednisolone phosphate (LPP) for the treatment of post-cataract surgery inflammation. This is a phase I/II, open-label non-comparative interventional trial of patients undergoing cataract surgery. All patients received a single injection of subconjunctival LPP intraoperatively. The primary outcome measure was the proportion of eyes with an anterior chamber cell count of 0 at postoperative month 1. Ocular and non-ocular adverse events, including elevated intraocular pressure, rebound iritis and pseudophakic macular edema were monitored. Five patients were enrolled in this study. The mean age was 66.6 ± 6.2 and 4 (80%) were male. The proportion of patients with AC cell grading of 0 was 0%, 80%, 80%, and 100% at day 1, week 1, month 1, and month 2 after cataract surgery, respectively. Mean laser flare photometry readings were significantly elevated at week 1 after cataract surgery (48.8 ± 18.9, p = 0.03) compared with baseline, decreasing to 25.8 ± 9.2 (p = 0.04) at month 1 and returned to baseline by month 2 (10.9 ± 5.1, p = 1.0). No ocular or non-ocular adverse events were observed. Liposomal prednisolone phosphate, administered as a single subconjunctival injection intraoperatively, can be a safe and effective treatment for post-cataract surgery inflammation. The delivery of steroids with a liposomal drug delivery system could potentially replace eyedrops as anti-inflammatory therapy following cataract surgery.
    MeSH term(s) Aged ; Anti-Inflammatory Agents/therapeutic use ; Cataract/chemically induced ; Drug Delivery Systems ; Female ; Humans ; Liposomes ; Male ; Middle Aged
    Chemical Substances Anti-Inflammatory Agents ; Liposomes
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-021-00912-x
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  10. Article: Advances in OCT Imaging in Myopia and Pathologic Myopia.

    Li, Yong / Zheng, Feihui / Foo, Li Lian / Wong, Qiu Ying / Ting, Daniel / Hoang, Quan V / Chong, Rachel / Ang, Marcus / Wong, Chee Wai

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 6

    Abstract: Advances in imaging with optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) technology, including the development of swept source OCT/OCTA, widefield or ultra-widefield systems, have greatly improved the understanding, ...

    Abstract Advances in imaging with optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) technology, including the development of swept source OCT/OCTA, widefield or ultra-widefield systems, have greatly improved the understanding, diagnosis, and treatment of myopia and myopia-related complications. Anterior segment OCT is useful for imaging the anterior segment of myopes, providing the basis for implantable collamer lens optimization, or detecting intraocular lens decentration in high myopic patients. OCT has enhanced imaging of vitreous properties, and measurement of choroidal thickness in myopic eyes. Widefield OCT systems have greatly improved the visualization of peripheral retinal lesions and have enabled the evaluation of wide staphyloma and ocular curvature. Based on OCT imaging, a new classification system and guidelines for the management of myopic traction maculopathy have been proposed; different dome-shaped macula morphologies have been described; and myopia-related abnormalities in the optic nerve and peripapillary region have been demonstrated. OCTA can quantitatively evaluate the retinal microvasculature and choriocapillaris, which is useful for the early detection of myopic choroidal neovascularization and the evaluation of anti-vascular endothelial growth factor therapy in these patients. In addition, the application of artificial intelligence in OCT/OCTA imaging in myopia has achieved promising results.
    Language English
    Publishing date 2022-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12061418
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