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  1. Article ; Online: Myomodulation Using Botulinum Toxin in Septorhinoplasty for Crooked Noses: Introducing the Concept and Application of Nasal Muscle Imbalance Theory.

    Wong, Eugene Hung Chih / D'Souza, Alwyn

    Facial plastic surgery : FPS

    2023  Volume 40, Issue 1, Page(s) 52–60

    Abstract: The role of septorhinoplasty for adequate correction of deviated nose is well documented, but the rationales and patterns for recurrences after proper rhinoplasty remain unclear. There has also been little attention given to the influence of nasal ... ...

    Abstract The role of septorhinoplasty for adequate correction of deviated nose is well documented, but the rationales and patterns for recurrences after proper rhinoplasty remain unclear. There has also been little attention given to the influence of nasal musculatures on the stability of nasal structures after septorhinoplasty. The aim of this article is to propose our nasal muscle imbalance theory, which may explain the potential reason for redeviation of the noses in the initial period after septorhinoplasty. We postulate that in a chronically deviated nose, the nasal muscles on the convex side will be stretched and develop hypertrophy after prolonged period of increased contractile activity. On the contrary, the nasal muscles on the concave side will undergo atrophy due to reduced load requirement. In the initial period of recovery after a septorhinoplasty to bring the nose back to midline, this muscle imbalance is still uncorrected with unequal pulling forces on the nasal structure because the stronger nasal muscles on the previously convex side is still hypertrophied and exert stronger forces compared with the previously concave side, therefore increasing the risk of redeviation of the nose back to the preoperative side until muscle atrophy occurs in the convex side and a balanced nasal muscle pull is achieved. We believe that postseptorhinoplasty botulinum toxin injections can be used as an adjunct in rhinoplasty surgery to effectively block the pulling actions of the stronger or overacting nasal muscles by speeding up the atrophy process while allowing patient's nose to heal and stabilize in the desired position. However, further studies to objectively confirm this hypothesis is required, which include comparing topographic measurements, imaging and electromyography signals before and after injections in postseptorhinoplasty patients. The authors have already planned a multicenter study to further evaluate this theory.
    MeSH term(s) Humans ; Atrophy ; Botulinum Toxins ; Facial Muscles/surgery ; Nasal Septum/surgery ; Nose/surgery ; Rhinoplasty/adverse effects ; Rhinoplasty/methods ; Treatment Outcome
    Chemical Substances Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/a-2047-7179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Primary nasopharyngeal amyloidosis with nasal polyposis: Case report of a diagnostic challenge.

    Jamarun, Stacy A / Wong, Eugene Hung Chih

    International journal of surgery case reports

    2022  Volume 94, Page(s) 107056

    Abstract: Background: Primary nasopharyngeal amyloidosis is a rare entity of localised amyloidosis. Patients usually present with symptoms that mimic other common nasal diseases. We report an unusual case of nasopharyngeal amyloidosis that co-exist with nasal ... ...

    Abstract Background: Primary nasopharyngeal amyloidosis is a rare entity of localised amyloidosis. Patients usually present with symptoms that mimic other common nasal diseases. We report an unusual case of nasopharyngeal amyloidosis that co-exist with nasal polyposis at the same time.
    Case presentation: We described a 72-year-old gentleman who presented with left-sided nasal obstruction, rhinorrhoea and hyposmia and right-sided hearing loss. Examination revealed bilateral intranasal polyposis with right lobular swelling at torus tubarius and right sided middle ear effusion. Biopsy revealed inflammatory nasal polyps with nasopharyngeal amyloidosis. Patient was treated successfully with functional endoscopic sinus surgery (FESS) for nasal polyposis and an en bloc wide local excision of the torus tubarius with no signs of recurrence at one year follow-up.
    Conclusion: Clinicians should have raised index of suspicion of a possible primary nasopharyngeal amyloidosis in patients presenting with nasopharyngeal mass with co-existing nasal polyposis to avoid delay in diagnosis and treatment.
    Language English
    Publishing date 2022-04-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.107056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Myomodulation Using Botulinum Toxin in Septorhinoplasty for Crooked Noses: Introducing the Concept and Application of Nasal Muscle Imbalance Theory

    Wong, Eugene Hung Chih / D'Souza, Alwyn

    Facial Plastic Surgery

    (Facial Plastic Surgery Original Research)

    2023  Volume 40, Issue 01, Page(s) 52–60

    Abstract: The role of septorhinoplasty for adequate correction of deviated nose is well documented, but the rationales and patterns for recurrences after proper rhinoplasty remain unclear. There has also been little attention given to the influence of nasal ... ...

    Series title Facial Plastic Surgery Original Research
    Abstract The role of septorhinoplasty for adequate correction of deviated nose is well documented, but the rationales and patterns for recurrences after proper rhinoplasty remain unclear. There has also been little attention given to the influence of nasal musculatures on the stability of nasal structures after septorhinoplasty. The aim of this article is to propose our nasal muscle imbalance theory, which may explain the potential reason for redeviation of the noses in the initial period after septorhinoplasty. We postulate that in a chronically deviated nose, the nasal muscles on the convex side will be stretched and develop hypertrophy after prolonged period of increased contractile activity. On the contrary, the nasal muscles on the concave side will undergo atrophy due to reduced load requirement. In the initial period of recovery after a septorhinoplasty to bring the nose back to midline, this muscle imbalance is still uncorrected with unequal pulling forces on the nasal structure because the stronger nasal muscles on the previously convex side is still hypertrophied and exert stronger forces compared with the previously concave side, therefore increasing the risk of redeviation of the nose back to the preoperative side until muscle atrophy occurs in the convex side and a balanced nasal muscle pull is achieved. We believe that postseptorhinoplasty botulinum toxin injections can be used as an adjunct in rhinoplasty surgery to effectively block the pulling actions of the stronger or overacting nasal muscles by speeding up the atrophy process while allowing patient's nose to heal and stabilize in the desired position. However, further studies to objectively confirm this hypothesis is required, which include comparing topographic measurements, imaging and electromyography signals before and after injections in postseptorhinoplasty patients. The authors have already planned a multicenter study to further evaluate this theory.
    Keywords septorhinoplasty ; botulinum toxin ; deviated nose ; nasal muscle imbalance
    Language English
    Publishing date 2023-03-06
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/a-2047-7179
    Database Thieme publisher's database

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  4. Article ; Online: Monophasic synovial sarcoma of the pyriform fossa.

    Ng, Chun Tau / Wong, Eugene Hung Chih / Prepageran, Narayanan

    BMJ case reports

    2020  Volume 13, Issue 11

    Abstract: Head and neck synovial sarcoma is rare. We report the case of a 71-year-old man who presented with progressive dysphagia, odynophagia, shortness of breath on exertion and hoarseness of voice. Nasendoscopy revealed a smooth, non-fungating, non-ulcerative ... ...

    Abstract Head and neck synovial sarcoma is rare. We report the case of a 71-year-old man who presented with progressive dysphagia, odynophagia, shortness of breath on exertion and hoarseness of voice. Nasendoscopy revealed a smooth, non-fungating, non-ulcerative mass arising from the left lateral pharyngeal wall. CT showed a well-defined, heterogenous enhancing lesion arising from the left pyriform fossa. Initial biopsy taken was inconclusive and patient underwent a transcervical complete excision of the tumour, where histopathological analysis confirmed the diagnosis of monophasic synovial sarcoma of the left pyriform fossa. This patient also received adjuvant radiotherapy postoperatively and remained disease free 1 year after completion of treatment.
    MeSH term(s) Aged ; Biopsy ; Diagnosis, Differential ; Head and Neck Neoplasms/diagnosis ; Humans ; Hypopharyngeal Neoplasms/diagnosis ; Hypopharyngeal Neoplasms/diagnostic imaging ; Male ; Pyriform Sinus/diagnostic imaging ; Pyriform Sinus/pathology ; Sarcoma, Synovial/diagnosis ; Sarcoma, Synovial/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-11-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Objective and subjective changes in voice after endoscopic sinus surgeries in patients with and without nasal polyps.

    Wong, Eugene Hung Chih / Chong, Aun Wee

    American journal of otolaryngology

    2019  Volume 41, Issue 2, Page(s) 102367

    Abstract: Background: Many studies have looked at the effect of functional endoscopic sinus surgeries (FESS) on nasalance, nasal consonant and nasalized vowels. Only two studies investigated the effect of FESS on vocal sound quality and have not found ... ...

    Abstract Background: Many studies have looked at the effect of functional endoscopic sinus surgeries (FESS) on nasalance, nasal consonant and nasalized vowels. Only two studies investigated the effect of FESS on vocal sound quality and have not found statistically significant changes before and after operations. The aim of this study was to examine the short-term and long-term objective and subjective changes in the vocal quality of patients after FESS, comparing patients with and without nasal polyps.
    Methods: Sixteen patients were recruited for voice analysis during pre-operative, within two weeks and at least three months post-operatively. Subjective questionnaire was used to assess perception of voice changes.
    Results: There were no statistically significant changes in the acoustic parameters of patients with nasal polyposis. In patients with CRS without polyps, there was a statistically significant increase in fundamental frequency (F
    Conclusions: Clinicians should inform all patients, especially voice professionals about the possible effects of endoscopic sinus surgeries on their voice quality.
    MeSH term(s) Endoscopy/adverse effects ; Endoscopy/methods ; Humans ; Nasal Polyps ; Paranasal Sinuses/surgery ; Voice/physiology
    Language English
    Publishing date 2019-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2019.102367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Can bone wax cause cholesterol granuloma in the petrous apex? A case report.

    Wong, Eugene Hung Chih / Lim, Chee Chean / Ong, Cheng Ai / Narayanan, Prepageran

    International journal of surgery case reports

    2020  Volume 72, Page(s) 587–589

    Abstract: Background: Cholesterol granuloma (CG) is a rare entity but is the commonest lesion in the petrous apex. They are associated with chronic ear disease and previous temporal bone surgery. While bone wax has been known to cause foreign body reaction due to ...

    Abstract Background: Cholesterol granuloma (CG) is a rare entity but is the commonest lesion in the petrous apex. They are associated with chronic ear disease and previous temporal bone surgery. While bone wax has been known to cause foreign body reaction due to its non-resorbable property in the mastoid, it has not been documented to cause CG formation.
    Case presentation: We described a 43 years old male who presented with a right mastoid swelling, nine years after a right retro-sigmoid craniotomy and excision for a cerebellopontine angle meningioma. He also had multiple cranial neuropathies involving trigeminal, facial and vestibulocochlear nerves. Temporal bone CT and MRI showed features suggestive of cholesterol granuloma with extensive bony erosions. He was treated with surgical excision and drainage where bone wax residues were found intraoperatively. Histopathological analysis of the lesion confirmed the diagnosis of cholesterol granuloma. Post-operatively, the mastoid swelling resolved and his recovery was uneventful.
    Conclusion: Our case showed that CG could manifest as a complication of bone wax usage in a neurosurgical procedure. Even though further study is needed to draw a definitive conclusion on this theory, we believe this paper will contribute to the current literature as it is the only reported case of cholesterol granuloma with bone wax as the possible causative agent. This is important so that surgeons are aware of this potential complication and use this haemostatic agent more judiciously.
    Language English
    Publishing date 2020-06-26
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.06.086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: An unusual first presentation of hypopharyngeal carcinoma as thyroid abscess: Case report of a diagnostic challenge.

    Tan, Heng Yao / Sanudin, Siti Hajar / Lum, Sai Guan / Wong, Eugene Hung Chih

    International journal of surgery case reports

    2021  Volume 81, Page(s) 105723

    Abstract: Background: Hypopharyngeal carcinoma can involve thyroid gland due to their close proximity. However, an initial presentation as a thyroid abscess is rare in this malignancy. To our knowledge, this is the second reported case in the English literature.!# ...

    Abstract Background: Hypopharyngeal carcinoma can involve thyroid gland due to their close proximity. However, an initial presentation as a thyroid abscess is rare in this malignancy. To our knowledge, this is the second reported case in the English literature.
    Case presentation: We described a 45-year-old female who presented with dysphagia, hoarseness and anterior neck swelling. The initial CT scan revealed a right thyroid abscess which was incised and drained with no malignancy found in the biopsy of the thyroid tissue. Patient presented one month later with worsening dysphagia, weight loss and a fungating anterior neck mass. Further investigation revealed a locally advanced hypopharyngeal squamous cell carcinoma extending to the right thyroid, upper oesophagus, prevertebral muscles and bilateral cervical lymph nodes (T4bN2cM0). Unfortunately, the patient passed away prior to initiation of treatment.
    Conclusion: Clinicians should have raised index of suspicion of a possible underlying hypopharyngeal carcinoma in patients presenting with thyroid abscess and proceed to further investigations in order to ensure early diagnosis and treatment of the malignancy.
    Language English
    Publishing date 2021-03-05
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2021.105723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The First Report on Incidence of Nasopharyngeal Carcinoma in Sabah, Borneo.

    Wong, Eugene Hung Chih / Tan, Heng Yao / Dompok, Tracey May / Mohamad Ishak, Luqman Afiq / Loong, Siow Ping

    ORL; journal for oto-rhino-laryngology and its related specialties

    2021  Volume 83, Issue 4, Page(s) 258–262

    Abstract: Background: Nasopharyngeal carcinoma (NPC) is the fourth common cancer in Malaysia. A few studies have looked into the incidence of NPC in Malaysia in general, but there has been no published data on its incidence in Sabah specifically, where NPC is ... ...

    Abstract Background: Nasopharyngeal carcinoma (NPC) is the fourth common cancer in Malaysia. A few studies have looked into the incidence of NPC in Malaysia in general, but there has been no published data on its incidence in Sabah specifically, where NPC is very common among the population. The aim of this study is to present the first report on the incidence of NPC in the state of Sabah, Borneo.
    Methods: Data of all patients diagnosed with NPC over a 5-year period from January 2015 to December 2019 inclusive were collected from the NPC registry of 3 main hospitals in Sabah. Age-standardized rates (ASRs) for different genders, ethnicities, and districts of origin were calculated.
    Results: 215 NPC patients were identified with a mean age at diagnosis of 49 (range 9-82). The ASR of NPC was 7.9/100,000 where the average age-adjusted male-to-female ratio was 2.4. The highest ASR was found in Dusun ethnicity in both male (3.19/100,000) and female (1.69/100,000) individuals, followed by Chinese (both genders), and Kadazan (for male individuals) and Bajau (for female individuals). The highest ASR was found in patients originating from Sandakan, Kota Kinabalu, Keningau, and Tawau.
    Conclusion: This is the first report on the incidence of NPC in Sabah, Borneo. The data suggest high ASRs among the population, especially in male Dusun and Chinese ethnic groups. Further research looking into NPC in this state, especially on risk factors and ways to improve diagnosis and prevention among the population, is recommended.
    MeSH term(s) Borneo ; Female ; Humans ; Incidence ; Malaysia/epidemiology ; Male ; Nasopharyngeal Carcinoma/epidemiology ; Nasopharyngeal Neoplasms/epidemiology
    Language English
    Publishing date 2021-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 121482-2
    ISSN 1423-0275 ; 0301-1569
    ISSN (online) 1423-0275
    ISSN 0301-1569
    DOI 10.1159/000516597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Five-year Survival Data on the Role of Endoscopic Endonasal Nasopharyngectomy in Advanced Recurrent rT3 and rT4 Nasopharyngeal Carcinoma.

    Wong, Eugene Hung Chih / Liew, Yew Toong / Loong, Siow Ping / Prepageran, Narayanan

    The Annals of otology, rhinology, and laryngology

    2019  Volume 129, Issue 3, Page(s) 287–293

    Abstract: Aim: Endoscopic endonasal nasopharyngectomy (EEN) for recurrent nasopharyngeal carcinoma (rNPC) is being increasingly used due to the added high magnification, reduced morbidities associated with open procedures and good survival outcomes. Most studies ... ...

    Abstract Aim: Endoscopic endonasal nasopharyngectomy (EEN) for recurrent nasopharyngeal carcinoma (rNPC) is being increasingly used due to the added high magnification, reduced morbidities associated with open procedures and good survival outcomes. Most studies looked at usage of EEN in patients with lower recurrent staging (rT1 and rT2) although more and more surgeons are studying the outcome of EEN in advanced rNPC (rT3 and rT4). The aims of this study were to report the long-term 5-year survival outcome of EEN performed in patients with advanced rNPC, and to determine any prognostic factors for patients' survival.
    Methods: All patients who underwent EEN for advanced rNPC between January 2003 and December 2015 inclusive were analyzed. All surgeries were performed in University Malaya Medical Centre in Kuala Lumpur and Queen Elizabeth Hospital in Sabah. We reported the 5-year overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS) and any related complications and significant prognostic factors.
    Results: Twelve patients with rNPC (2 rT3 and 10 rT4) were followed-up over a mean duration of 44.8 months (range, 40-440 weeks). The 5-year OS was 50.0% (mean 44.75 months), DFS was 25.0% (mean 35.25 months) and the DSS was 58.3% (mean 43.33 months). No severe operative complications were encountered and no independent prognostic factors for survival outcome were identified.
    Conclusion: This is the first report in English that exclusively described the long-term 5-year survival data in patients with both rT3 and rT4 recurrent NPC after EEN. The data suggest that EEN is a feasible treatment to improve survival with minimal morbidities in patients with rT3 and rT4 recurrent NPC. However, more studies with larger patient size is recommended.
    MeSH term(s) Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma/mortality ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Carcinoma/surgery ; Nasopharyngeal Neoplasms/mortality ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/surgery ; Natural Orifice Endoscopic Surgery ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Pharyngectomy/methods ; Reoperation ; Salvage Therapy
    Language English
    Publishing date 2019-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/0003489419887410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acoustic neuroma with orofacial paresthesia: description of an atypical presentation.

    Lim, Chee Chean / Misron, Khairunnisak / Liew, Yew Toong / Wong, Eugene Hung Chih

    BMJ case reports

    2019  Volume 12, Issue 11

    Abstract: Acoustic neuroma (AN) usually manifests with asymmetric hearing loss, tinnitus, dizziness and sense of disequilibrium. About 10% of patients complain of atypical symptoms, which include facial numbness or pain and sudden onset of hearing loss. Patients ... ...

    Abstract Acoustic neuroma (AN) usually manifests with asymmetric hearing loss, tinnitus, dizziness and sense of disequilibrium. About 10% of patients complain of atypical symptoms, which include facial numbness or pain and sudden onset of hearing loss. Patients with atypical symptoms also tend to have larger tumours due to the delay in investigation. We report a particularly interesting case of a patient presented to us with numbness over her right hemifacial region after a dental procedure without significant acoustic and vestibular symptoms. Physical examination and pure tone audiometry revealed no significant findings but further imaging revealed a cerebellopontine angle mass. The changing trends with easier access to further imaging indicate that the presentation of patients with AN are also changing. Atypical symptoms which are persistent should raise clinical suspicion of this pathology among clinicians.
    MeSH term(s) Audiometry, Pure-Tone ; Cerebellar Neoplasms/complications ; Cerebellar Neoplasms/pathology ; Cerebellar Neoplasms/surgery ; Cerebellopontine Angle/pathology ; Facial Pain/etiology ; Facial Pain/physiopathology ; Female ; Hearing Loss/etiology ; Hearing Loss/physiopathology ; Humans ; Middle Aged ; Neuroma, Acoustic/complications ; Neuroma, Acoustic/pathology ; Neuroma, Acoustic/surgery ; Postoperative Period ; Treatment Outcome
    Language English
    Publishing date 2019-11-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-232275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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