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  1. Article ; Online: Relative age and persistence of ADHD diagnosis in young children.

    Wong, Ian C K

    The lancet. Psychiatry

    2023  Volume 10, Issue 12, Page(s) 910–911

    MeSH term(s) Humans ; Child ; Child, Preschool ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention ; Age Factors
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(23)00334-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Considerations Regarding Antipsychotic Drug Prescriptions Among People With Dementia During the COVID-19 Pandemic-Reply.

    Luo, Hao / Man, Kenneth K C / Wong, Ian C K

    JAMA psychiatry

    2023  Volume 80, Issue 7, Page(s) 753–754

    MeSH term(s) Humans ; Antipsychotic Agents/therapeutic use ; COVID-19 ; Pandemics ; Drug Prescriptions ; Dementia/drug therapy ; Dementia/epidemiology
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.1250
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  3. Article ; Online: Deciphering the Molecular Mechanism of Post-Acute Sequelae of COVID-19 through Comorbidity Network Analysis

    Tian, Lue / Wong, Ian C.K. / Zhang, Qingpeng

    bioRxiv

    Abstract: Introduction: The post-acute sequelae of COVID-19 presents a significant health challenge in the post-pandemic world. Our study aims to analyze longitudinal electronic health records to determine the impact of COVID-19 on disease progression, provide ... ...

    Abstract Introduction: The post-acute sequelae of COVID-19 presents a significant health challenge in the post-pandemic world. Our study aims to analyze longitudinal electronic health records to determine the impact of COVID-19 on disease progression, provide molecular insights into these mechanisms, and identify associated biomarkers. Method: We included 58,710 patients with COVID-19 records from 01/01/2020 to 31/08/2022 and at least one hospital admission before and after the acute phase of COVID-19 (28 days) as the treatment group. A healthy control group of 174,071 individuals was established for comparison using propensity score matching based on pre-existing diseases (before COVID-19). We built a comorbidity network using Pearson correlation coefficient differences between pairs of pre-existing disease and post-infection disease in both groups. Disease-protein mapping and protein-protein interaction network analysis revealed the impact of COVID-19 on disease trajectories through protein interactions in the human body. Results: The disparity in the weight of prevalent disease comorbidity patterns between the treatment and control groups highlights the impact of COVID-19. Certain specific comorbidity patterns show a more pronounced influence by COVID-19. For each comorbidity pattern, overlapping proteins directly associated with pre-existing diseases, post-infection diseases, and COVID-19 help to elucidate the biological mechanism of COVID-199s impact on each comorbidity pattern. Proteins essential for explaining the biological mechanism can be identified based on their weights. Conclusion: Disease comorbidity associations influenced by COVID-19, as identified through longitudinal electronic health records and disease-protein mapping, can help elucidate the biological mechanisms of COVID-19, discover intervention methods, and decode the molecular basis of comorbidity associations. This analysis can also yield potential biomarkers and corresponding treatments for specific disease patterns.
    Keywords covid19
    Language English
    Publishing date 2024-01-20
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2024.01.17.575851
    Database COVID19

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  4. Article: Antidepressant treatment and mortality in people with comorbid depression and type 2 diabetes: UK electronic health record study.

    Jeffery, Annie / Walters, Kate / Wong, Ian C K / Osborn, David / Hayes, Joseph F

    BJPsych open

    2024  Volume 10, Issue 3, Page(s) e79

    Abstract: Background: Depression is associated with higher rates of premature mortality in people with physical comorbidities, such as type 2 diabetes. Conceptually, the successful treatment of depression in people with type 2 diabetes could prevent premature ... ...

    Abstract Background: Depression is associated with higher rates of premature mortality in people with physical comorbidities, such as type 2 diabetes. Conceptually, the successful treatment of depression in people with type 2 diabetes could prevent premature mortality.
    Aims: To investigate the association between antidepressant prescribing and the rates of all-cause and cause-specific (endocrine, cardiovascular, respiratory, cancer, unnatural) mortality in individuals with comorbid depression and type 2 diabetes.
    Method: Using UK primary care records between years 2000 and 2018, we completed a nested case-control study in a cohort of people with comorbid depression and type 2 diabetes who were starting oral antidiabetic treatment for the first time. We used incident density sampling to identify cases who died and matched controls who remained alive after the same number of days observation. We estimated incidence rate ratios for the association between antidepressant prescribing and mortality, adjusting for demographic characteristics, comorbidities, medication use and health behaviours.
    Results: We included 5222 cases with a recorded date of death, and 18 675 controls, observed for a median of 7 years. Increased rates of all-cause mortality were associated with any antidepressant prescribing during the observation period (incidence rate ratio 2.77, 95% CI 2.48-3.10). These results were consistent across all causes of mortality that we investigated.
    Conclusions: Antidepressant prescribing was highly associated with higher rates of mortality. However, we suspect that this is not a direct causal effect, but that antidepressant treatment is a marker of more severe and unsuccessfully treated depression.
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2829557-2
    ISSN 2056-4724
    ISSN 2056-4724
    DOI 10.1192/bjo.2024.33
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  5. Article ; Online: Innovative methodologies in paediatric drug development: A conect4children (c4c) special issue.

    de Wildt, Saskia N / Wong, Ian C K

    British journal of clinical pharmacology

    2022  Volume 88, Issue 12, Page(s) 4962–4964

    MeSH term(s) Child ; Humans ; Drug Development
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15355
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  6. Article ; Online: Prenatal Exposure to Antipsychotics-Handle With Caution-Reply.

    Wang, Zixuan / Wong, Ian C K / Man, Kenneth K C

    JAMA internal medicine

    2022  Volume 182, Issue 3, Page(s) 355–356

    MeSH term(s) Antipsychotic Agents/adverse effects ; Attention Deficit Disorder with Hyperactivity ; Autism Spectrum Disorder ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Pregnancy ; Premature Birth ; Prenatal Exposure Delayed Effects/chemically induced
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2021.7573
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  7. Article ; Online: Benefits v. risks of COVID-19 vaccination: an examination of vaccination policy impact on the occurrence of myocarditis and pericarditis.

    Carleton, Bruce C / Salmon, Daniel A / Ip, Patrick / Wong, Ian C K / Lai, Francicso T T

    The Lancet regional health. Western Pacific

    2023  , Page(s) 100797

    Abstract: Studies of myocarditis/pericarditis following mRNA COVID-19 vaccines in Hong Kong have been published. Data are consistent with data from other active surveillance or healthcare databases. The mRNA COVID-19 vaccines have been shown to rarely increase ... ...

    Abstract Studies of myocarditis/pericarditis following mRNA COVID-19 vaccines in Hong Kong have been published. Data are consistent with data from other active surveillance or healthcare databases. The mRNA COVID-19 vaccines have been shown to rarely increase risk of myocarditis, with the highest risk among males aged 12-17 after the second dose. An increased risk of pericarditis has also been shown after the second dose, though less common than myocarditis and more evenly distributed among different sex and age groups. Because of the increased risk of post-vaccine myocarditis, Hong Kong implemented a single dose mRNA COVID-19 vaccine policy on September 15, 2021 for adolescents (age 12-17 years). Post-policy, there were no cases of carditis. 40,167 first dose patients did not receive a second dose. This policy was highly successful in the reduction of carditis, but the trade-off is the potential risk of disease and cost to population-level immunity. This commentary brings forward some important global policy considerations.
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2023.100797
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  8. Article ; Online: WHO Essential Medicines List and methylphenidate for ADHD in children and adolescents - Authors' reply.

    Cortese, Samuele / Coghill, David / Mattingly, Gregory W / Rohde, Luis A / Wong, Ian C K / Faraone, Stephen V

    The lancet. Psychiatry

    2024  Volume 11, Issue 2, Page(s) 93–95

    MeSH term(s) Child ; Adolescent ; Humans ; Methylphenidate/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/therapeutic use ; World Health Organization
    Chemical Substances Methylphenidate (207ZZ9QZ49) ; Central Nervous System Stimulants
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Letter
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(23)00437-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Corrigendum: Concurrent use of oral anticoagulants and sulfonylureas in individuals with type 2 diabetes and risk of hypoglycemia: a UK population-based cohort study.

    Alwafi, Hassan / Wong, Ian C K / Naser, Abdallah Y / Banerjee, Amitava / Mongkhon, Pajaree / Whittlesea, Cate / Alsharif, Alaa / Wei, Li

    Frontiers in medicine

    2024  Volume 10, Page(s) 1337712

    Abstract: This corrects the article DOI: 10.3389/fmed.2022.893080.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmed.2022.893080.].
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1337712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Risk of drug-drug interactions in China's fight against COVID-19 and beyond.

    Zhang, Qingpeng / Yang, Jiannan / Zeng, Daniel Dajun / Feng, Yibin / Wong, Ian C K

    Pharmacological research

    2023  Volume 196, Page(s) 106903

    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106903
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