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  1. Article ; Online: Managing Dry Eye Disease with Novel Medications: Mechanism, Study Validity, Safety, Efficacy, and Practical Application.

    Wong, Jason C / Barak, Aselle

    Pharmacy (Basel, Switzerland)

    2024  Volume 12, Issue 1

    Abstract: Dry eye disease (DED) is a common condition that affects mainly older individuals and women. It is characterized by reduced tear production and increased tear evaporation. Symptoms include burning, irritation, tearing, and blurry vision. This paper ... ...

    Abstract Dry eye disease (DED) is a common condition that affects mainly older individuals and women. It is characterized by reduced tear production and increased tear evaporation. Symptoms include burning, irritation, tearing, and blurry vision. This paper reviews key trials of various new DED treatments, including their mechanism of action, study outcomes, safety, and efficacy. The paper also includes a critical assessment of the trial's validity and potential pharmacy applications of these new treatments. The literature search was conducted through PubMed, the Cochrane Central Register of Controlled Trials, and Google Scholar. The keywords "Dry Eye Disease", "lifitegrast", "cyclosporine", "loteprednol etabonate", "varenicline nasal spray", and "perfluorohexyloctane" were used to identify these medications' landmark trials. The articles deemed these medications safe and efficacious, with minimal side effects. Our randomized controlled trial validity comparison found the trials robust with predominantly low bias. Cyclosporine and loteprednol are effective when artificial tears fail, while perfluorohexyloctane reduces tear film evaporation and is preservative-free. Varenicline offers drug delivery via the nasal route and is appropriate for contact lens users. In conclusion, these FDA-approved novel medications exhibit safety and efficacy in managing DED. Further research is needed on long-term outcomes, efficacy, and side-effect comparisons, and combination therapy benefits.
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737194-3
    ISSN 2226-4787 ; 2226-4787
    ISSN (online) 2226-4787
    ISSN 2226-4787
    DOI 10.3390/pharmacy12010019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mental health and wellbeing for oral healthcare teams.

    Newton, Tim / Wong, Jason

    British dental journal

    2023  Volume 235, Issue 8, Page(s) 598–599

    MeSH term(s) Humans ; Mental Health ; Mental Health Services ; Health Personnel/psychology ; Patient Care Team
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type News
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-023-6439-8
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  3. Article ; Online: Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden.

    White, Maria C / Wong, Jason P / Damania, Blossom

    Cancer research communications

    2024  Volume 4, Issue 4, Page(s) 1024–1040

    Abstract: Non-Hodgkin lymphoma (NHL) is a common cancer in both men and women and represents a significant cancer burden worldwide. Primary effusion lymphoma (PEL) is a subtype of NHL infected with Kaposi sarcoma-associated herpesvirus (KSHV). PEL is an aggressive ...

    Abstract Non-Hodgkin lymphoma (NHL) is a common cancer in both men and women and represents a significant cancer burden worldwide. Primary effusion lymphoma (PEL) is a subtype of NHL infected with Kaposi sarcoma-associated herpesvirus (KSHV). PEL is an aggressive and lethal cancer with no current standard of care, owing largely to its propensity to develop resistance to current chemotherapeutic regimens. Here, we report a reliance of KSHV-positive PEL on the mitotic kinase, NEK2, for survival. Inhibition of NEK2 with the inhibitor, JH295, resulted in caspase 3-mediated apoptotic cell death of PEL. Furthermore, NEK2 inhibition significantly prolonged survival and reduced tumor burden in a PEL mouse model. We also demonstrate that the ABC transporter proteins, MDR1 and MRP, are most active in PEL and that inhibition of NEK2 in PEL reduced the expression and activity of these ABC transporter proteins, which are known to mediate drug resistance in cancer. Finally, we report that JH295 treatment sensitized lymphomas to other chemotherapeutic agents such as rapamycin, resulting in enhanced cancer cell death. Overall, these data offer important insight into the mechanisms underlying PEL survival and drug resistance, and suggest that NEK2 is a viable therapeutic target for PEL.
    Significance: The mitotic kinase, NEK2, is important for the survival of KSHV-positive PEL. NEK2 inhibition resulted in PEL apoptosis and reduced tumor burden in a mouse model. NEK2 inhibition also reduced drug resistance.
    MeSH term(s) Male ; Animals ; Mice ; Humans ; Female ; Herpesvirus 8, Human ; Lymphoma, Primary Effusion/drug therapy ; Lymphoma, Non-Hodgkin ; ATP-Binding Cassette Transporters ; Aggression ; Disease Models, Animal ; NIMA-Related Kinases/genetics
    Chemical Substances ATP-Binding Cassette Transporters ; NEK2 protein, human (EC 2.7.11.1) ; NIMA-Related Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-23-0430
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  4. Article ; Online: The prevalence of denture loss within community residential settings.

    Archer, Natalie / S Jayawardena, Don / Wong, Jason / Doshi, Mili

    British dental journal

    2024  

    Abstract: Introduction Denture loss prevalence in community settings is unknown and results in deteriorating residents' systemic and psychosocial wellbeing.Materials and methods An electronic survey was distributed nationally through professional networks to ... ...

    Abstract Introduction Denture loss prevalence in community settings is unknown and results in deteriorating residents' systemic and psychosocial wellbeing.Materials and methods An electronic survey was distributed nationally through professional networks to community residential settings.Results Of the 156 responses from community residential settings, 69% of settings experienced at least one denture lost in the last two years. Sixty percent of responders reported no dentures were labelled, only 64% had received training about how to care for dentures and 86% felt they would benefit from further training on mouth care. In addition, 68% of staff found arranging dental care for their residents challenging.Discussion Extrapolated data suggest that at least 10,205 dentures are lost annually in community residential settings and are never found, costing the NHS Business Service Authority more than £3 million. A high prevalence of denture loss in community residential settings is likely due to residents with multiple comorbidities and frailty. Remaking dentures poses financial, logistical, and patient challenges, which may result in patients being unable to wear a remade denture.Conclusion The prevalence of denture loss within community residential settings needs to be understood to encourage targeted interventions, inform stakeholders, and encourage workflows that will improve service delivery and patients' oral health-related quality of life.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-023-6714-8
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.143: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 447: Show issues

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  5. Article ; Online: Applying Machine Learning and Point-Set Registration to Automatically Measure the Severity of Spinal Curvature on Radiographs.

    Wong, Jason / Reformat, Marek / Lou, Edmond

    IEEE journal of translational engineering in health and medicine

    2023  Volume 12, Page(s) 151–161

    Abstract: Objective: Measuring the severity of the lateral spinal curvature, or Cobb angle, is critical for monitoring and making treatment decisions for children with adolescent idiopathic scoliosis (AIS). However, manual measurement is time-consuming and ... ...

    Abstract Objective: Measuring the severity of the lateral spinal curvature, or Cobb angle, is critical for monitoring and making treatment decisions for children with adolescent idiopathic scoliosis (AIS). However, manual measurement is time-consuming and subject to human error. Therefore, clinicians seek an automated measurement method to streamline workflow and improve accuracy. This paper reports on a novel machine learning algorithm of cascaded convolutional neural networks (CNN) to measure the Cobb angle on spinal radiographs automatically.
    Methods: The developed method consisted of spinal column segmentation using a CNN, vertebra localization and segmentation using iterative vertebra body location coupled with another CNN, point-set registration to correct vertebra segmentations, and Cobb angle measurement using the final segmentations. Measurement performance was evaluated with the circular mean absolute error (CMAE) and percentage within clinical acceptance ([Formula: see text]) between automatic and manual measurements. Analysis was separated by curve severity to identify any potential systematic biases using independent samples Student's t-tests.
    Results: The method detected 346 of the 352 manually measured Cobb angles (98%), with a CMAE of 2.8° and 91% of measurements within the 5° clinical acceptance. No statistically significant differences were found between the CMAEs of mild ([Formula: see text]), moderate (25°-45°), and severe ([Formula: see text]) groups. The average measurement time per radiograph was 17.7±10.2s, improving upon the estimated average of 30s it takes an experienced rater to measure. Additionally, the algorithm outputs segmentations with the measurement, allowing clinicians to interpret measurement results.
    Discussion/conclusion: The developed method measured Cobb angles on radiographs automatically with high accuracy, quick measurement time, and interpretability, suggesting clinical feasibility.
    MeSH term(s) Adolescent ; Child ; Humans ; Spine/diagnostic imaging ; Scoliosis/diagnosis ; Radiography ; Kyphosis ; Algorithms
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2696555-0
    ISSN 2168-2372 ; 2168-2372
    ISSN (online) 2168-2372
    ISSN 2168-2372
    DOI 10.1109/JTEHM.2023.3332618
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  6. Article ; Online: How controlled motion alters the biophysical properties of musculoskeletal tissue architecture.

    Hardy, Maureen / Feehan, Lynne / Savvides, Georgia / Wong, Jason

    Journal of hand therapy : official journal of the American Society of Hand Therapists

    2023  Volume 36, Issue 2, Page(s) 269–279

    Abstract: Introduction: Movement is fundamental to the normal behaviour of the hand, not only for day-to-day activity, but also for fundamental processes like development, tissue homeostasis and repair. Controlled motion is a concept that hand therapists apply to ...

    Abstract Introduction: Movement is fundamental to the normal behaviour of the hand, not only for day-to-day activity, but also for fundamental processes like development, tissue homeostasis and repair. Controlled motion is a concept that hand therapists apply to their patients daily for functional gains, yet the scientific understanding of how this works is poorly understood.
    Purpose of the article: To review the biology of the tissues in the hand that respond to movement and provide a basic science understanding of how it can be manipulated to facilitate better functionThe review outlines the concept of controlled motion and actions across the scales of tissue architecture, highlighting the the role of movement forces in tissue development, homeostasis and repair. The biophysical behaviour of mechanosensitve tissues of the hand such as skin, tendon, bone and cartilage are discussed.
    Conclusion: Controlled motion during early healing is a form of controlled stress and can be harnessed to generate appropriate reparative tissues. Understanding the temporal and spatial biology of tissue repair allows therapists to tailor therapies that allow optimal recovery based around progressive biophysical stimuli by movement.
    MeSH term(s) Humans ; Musculoskeletal System ; Musculoskeletal Physiological Phenomena ; Movement
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639284-2
    ISSN 1545-004X ; 0894-1130
    ISSN (online) 1545-004X
    ISSN 0894-1130
    DOI 10.1016/j.jht.2022.12.003
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  7. Article ; Online: The effect of weather on plastic surgery trauma referrals.

    Chotai, Nikhil / Wong, Jason K / Reid, Adam J

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2023  Volume 79, Page(s) 98–100

    MeSH term(s) Humans ; Surgery, Plastic ; Weather ; Referral and Consultation ; Plastic Surgery Procedures ; Temperature ; Trauma Centers
    Language English
    Publishing date 2023-02-28
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2023.02.028
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  8. Article ; Online: Proteogenomic interrogation of cancer cell lines: an overview of the field.

    Tsang, Olson / Wong, Jason W H

    Expert review of proteomics

    2021  Volume 18, Issue 3, Page(s) 221–232

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Cell Line ; Genomics ; Humans ; Neoplasms/genetics ; Proteogenomics ; Proteomics
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2299100-1
    ISSN 1744-8387 ; 1478-9450
    ISSN (online) 1744-8387
    ISSN 1478-9450
    DOI 10.1080/14789450.2021.1914594
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  9. Article ; Online: SARS-CoV-2 dependence on host pathways.

    Wong, Jason P / Damania, Blossom

    Science (New York, N.Y.)

    2021  Volume 371, Issue 6532, Page(s) 884–885

    MeSH term(s) COVID-19/drug therapy ; Depsipeptides ; Host-Pathogen Interactions ; Humans ; Peptides, Cyclic ; SARS-CoV-2
    Chemical Substances Depsipeptides ; Peptides, Cyclic ; plitidepsin (Y76ID234HW)
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abg6837
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  10. Article ; Online: Assessing the Evolutionary Conservation of Protein Disulphide Bonds.

    Wong, Jason W H

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1967, Page(s) 9–19

    Abstract: Studying the evolutionary conservation of proteins can be a valuable tool for understanding its function. At the sequence level, the conservation of each residue can be used to infer the importance of the particular regions of proteins. In the case of ... ...

    Abstract Studying the evolutionary conservation of proteins can be a valuable tool for understanding its function. At the sequence level, the conservation of each residue can be used to infer the importance of the particular regions of proteins. In the case of protein disulphide bonds, the conservation of the cysteines involved can be used to infer the conservation of the disulphide bond itself. In this chapter, bioinformatics methods are described that can be used to assess the conservation of a protein disulphide bond with a focus on the study of human proteins. Conservation will be assessed at the species and at the human population level. The methods described make use of publicly available databases and can be applied by any researcher using a standard desktop computer with Internet access.
    MeSH term(s) Amino Acid Sequence/genetics ; Computational Biology/methods ; Cysteine/chemistry ; Databases, Protein ; Disulfides/chemistry ; Humans ; Protein Conformation ; Protein Folding ; Proteins/chemistry ; Proteins/genetics ; Sequence Alignment
    Chemical Substances Disulfides ; Proteins ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2019-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9187-7_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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