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  1. Article ; Online: Discovery of Artemisinins as Microsomal Prostaglandins Synthase-2 Inhibitors for the Treatment of Colorectal Cancer via Chemoproteomics.

    Geng, Yiyun / Li, Weichao / Wong, Nai-Kei / Xue, Fuchong / Li, Qing / Zhang, Yang / Xu, Jingyuan / Deng, Zhangshuang / Zhou, Yiqing

    Journal of medicinal chemistry

    2024  Volume 67, Issue 3, Page(s) 2083–2094

    Abstract: Colorectal cancer remains the second leading cause of cancer-related mortalities worldwide. While artemisinin (ART), a key active compound from the traditional Chinese medicinal ... ...

    Abstract Colorectal cancer remains the second leading cause of cancer-related mortalities worldwide. While artemisinin (ART), a key active compound from the traditional Chinese medicinal herb
    MeSH term(s) Humans ; Artemisinins/metabolism ; Cyclooxygenase 2 ; Colorectal Neoplasms/drug therapy ; Colonic Neoplasms ; Prostaglandins
    Chemical Substances artemisinin (9RMU91N5K2) ; Artemisinins ; Cyclooxygenase 2 (EC 1.14.99.1) ; Prostaglandins
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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  2. Article ; Online: ROS/RNS as molecular signatures of chronic liver diseases.

    Che, Zhaodi / Zhou, Ziyuan / Li, Si-Qi / Gao, Lei / Xiao, Jia / Wong, Nai-Kei

    Trends in molecular medicine

    2023  Volume 29, Issue 11, Page(s) 951–967

    Abstract: The liver can succumb to oxidant damage during the development of chronic liver diseases. Despite their physiological relevance to hepatic homeostasis, excessive reactive oxygen/nitrogen species (ROS/RNS) production under pathological conditions is ... ...

    Abstract The liver can succumb to oxidant damage during the development of chronic liver diseases. Despite their physiological relevance to hepatic homeostasis, excessive reactive oxygen/nitrogen species (ROS/RNS) production under pathological conditions is detrimental to all liver constituents. Chronic oxidative stress coupled to unresolved inflammation sets in motion the activation of profibrogenic hepatic stellate cells (HSCs) and later pathogenesis of liver fibrosis, cirrhosis, and liver cancer. The liver antioxidant and repair systems, along with autophagic and ferroptotic machineries, are implicated in the onset and trajectory of disease development. In this review, we discuss the ROS/RNS-related mechanisms underlying liver fibrosis of distinct etiologies and highlight preclinical and clinical trials of antifibrotic therapies premised on remediating oxidative/nitrosative stress in hepatocytes or targeting HSC activation.
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2023.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sulfoxanthicillin from the deep-sea derived Penicillium sp. SCSIO sof101: an antimicrobial compound against Gram-positive and -negative pathogens.

    Yang, Jiafan / Song, Yongxiang / Zhou, Zhenbin / Huang, Yun / Wang, Songtao / Yuan, Jie / Wong, Nai-Kei / Yan, Yan / Ju, Jianhua

    The Journal of antibiotics

    2023  Volume 76, Issue 3, Page(s) 113–120

    Abstract: Natural products along with their analogs have been intensively explored for their antimicrobial potential against 'ESKAPE' pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin (1), along with its ... ...

    Abstract Natural products along with their analogs have been intensively explored for their antimicrobial potential against 'ESKAPE' pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin (1), along with its decomposed product peniformamide (2), and the known compound xanthocillin X (3) from the deep-sea derived Penicillium sp. SCSIO sof101. The structures of compounds 1 and 2 were determined by extensive spectroscopic analysis. Compound 1 showed significant activity against series pathogens with MIC values ranging 0.06-8.0 μg mL
    MeSH term(s) Humans ; Penicillium/chemistry ; Anti-Infective Agents/chemistry ; Anti-Bacterial Agents/chemistry ; Cell Line, Tumor ; Molecular Structure
    Chemical Substances xantocillin (06Z55VZ40D) ; Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-022-00593-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 207: Show issues Location:
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  4. Article ; Online: Alternaphenol B2, a new IDH1 inhibitor from the coral-derived fungus

    Li, Xiaoyue / Shen, Wenbin / Li, Guochao / Song, Yongxiang / Lu, Xinhua / Wong, Nai-Kei / Yan, Yan

    Natural product research

    2023  , Page(s) 1–7

    Abstract: A new aromatic polyketide, alternaphenol B2 ( ...

    Abstract A new aromatic polyketide, alternaphenol B2 (
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2269462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mn

    Ling, Kai / Zheng, Jintao / Jiang, Xiaohong / Huang, Weijie / Mai, Youqing / Liao, Chuanghong / Fan, Shuting / Bu, Jianlan / Li, Rui / Zeng, Bingchun / Zheng, Qiunuan / Huang, Ruibin / Li, Zhiyang / Wong, Nai-Kei / Jiang, Hongyan

    ACS nano

    2024  Volume 18, Issue 4, Page(s) 2841–2860

    Abstract: Manganese ions ( ... ...

    Abstract Manganese ions (Mn
    MeSH term(s) Humans ; Oligodeoxyribonucleotides/pharmacology ; Combined Modality Therapy ; Nanoparticles ; Immunotherapy ; Neoplasms/drug therapy ; Tumor Microenvironment
    Chemical Substances Oligodeoxyribonucleotides
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c07123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: IS

    Wei, Da-Wei / Wong, Nai-Kei / Song, Yuqin / Zhang, Gang / Wang, Chao / Li, Juan / Feng, Jie

    mBio

    2022  Volume 13, Issue 1, Page(s) e0334021

    Abstract: Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection. Although unstable gene amplification has been recognized to crucially ... ...

    Abstract Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection. Although unstable gene amplification has been recognized to crucially contribute to underestimation or misestimation of antimicrobial resistance in clinical isolates, the precise mechanisms underlying carbapenem resistance driven by amplification of
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Plasmids ; Klebsiella Infections ; beta-Lactamases/genetics ; Bacterial Proteins/genetics ; DNA Transposable Elements ; Klebsiella pneumoniae/genetics ; Genomics ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Carbapenems ; beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins ; DNA Transposable Elements
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03340-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Erratum for Wei et al., "IS

    Wei, Da-Wei / Wong, Nai-Kei / Song, Yuqin / Zhang, Gang / Wang, Chao / Li, Juan / Feng, Jie

    mBio

    2022  Volume 13, Issue 2, Page(s) e0041422

    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00414-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Blue or Near-Infrared Light-Triggered Release of Halogens via Blebbistatin Photocage.

    Situ, Zicong / Chen, Wenbin / Yang, Sirui / Fan, Xiaolin / Liu, Fan / Wong, Nai-Kei / Dang, Li / Phillips, David Lee / Li, Ming-De

    The journal of physical chemistry. B

    2022  Volume 126, Issue 17, Page(s) 3338–3346

    Abstract: Photocages can provide spatial and temporal control to accurately release the various chemicals and bioactive groups when excited by light. Although the absorption spectra of most photocages are in the ultraviolet absorption region, only a few absorb in ... ...

    Abstract Photocages can provide spatial and temporal control to accurately release the various chemicals and bioactive groups when excited by light. Although the absorption spectra of most photocages are in the ultraviolet absorption region, only a few absorb in the visible or near-infrared region. Blebbistatin (
    MeSH term(s) Humans ; Halogens/chemistry ; Heterocyclic Compounds, 4 or More Rings ; Infrared Rays ; Photolysis
    Chemical Substances blebbistatin (20WC4J7CQ6) ; Halogens ; Heterocyclic Compounds, 4 or More Rings
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c01440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Resistance traits and molecular characterization of multidrug-resistant Acinetobacter baumannii isolates from an intensive care unit of a tertiary hospital in Guangdong, southern China.

    Chen, Zhuo-Ran / Guo, Hui-Wu / Liu, Jun / Pan, Qing / Fu, Mao-Zhang / Qiu, Ying-Kun / Wong, Nai-Kei / Huang, Yuan-Chun

    International microbiology : the official journal of the Spanish Society for Microbiology

    2022  Volume 25, Issue 3, Page(s) 471–479

    Abstract: Purpose: This study aims to characterize antimicrobial resistance (AMR) of all the non-duplicated Acinetobacter baumannii strains isolated from an intensive care unit in a tertiary hospital during the period of January 1 to December 31, 2015.: Methods! ...

    Abstract Purpose: This study aims to characterize antimicrobial resistance (AMR) of all the non-duplicated Acinetobacter baumannii strains isolated from an intensive care unit in a tertiary hospital during the period of January 1 to December 31, 2015.
    Methods: A. baumannii (n = 95 strains) isolated from patients was subjected to antimicrobial susceptibility test (AST) by Vitek 2 Compact system to determine minimum inhibitory concentrations, followed by genotyping by enterobacterial repetitive intergenic consensus-PCR (ERIC-PCR). Resistance genes of interest were PCR amplified and sequenced.
    Results: All isolates were qualified as MDR, with a resistance rate of > 80% to 8 antimicrobials tested. In terms of beta-lactamase detection, the bla
    Conclusions: All of the A. baumannii strains detected in the ICU were MDR clones exhibiting extremely high resistance to carbapenems and aminoglycosides as monitored throughout the study period. They principally belonged to a single cluster of isolates carrying bla
    MeSH term(s) Acinetobacter baumannii/genetics ; Aminoglycosides/genetics ; Aminoglycosides/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins/genetics ; Bacterial Proteins/pharmacology ; Drug Resistance, Multiple, Bacterial/genetics ; Enterobacteriaceae ; Humans ; Intensive Care Units ; Microbial Sensitivity Tests ; Tertiary Care Centers ; beta-Lactamases/genetics
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1454951-7
    ISSN 1618-1905 ; 1139-6709
    ISSN (online) 1618-1905
    ISSN 1139-6709
    DOI 10.1007/s10123-022-00233-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4964: Show issues Location:
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  10. Article: Selective profiling of steviol-catalyzing UDP-glycosyltransferases with a metabolically synthesized probe

    Wong, Nai-Kei / Zhong, Suyun / Li, Weichao / Zhou, Fugui / Deng, Zhangshuang / Zhou, Yiqing

    Chemical communications. 2020 Oct. 15, v. 56, no. 82

    2020  

    Abstract: Selective profiling of steviol-catalyzing UDP-glycosyltransferases in plants was accomplished with a probe metabolically synthesized from two substrate-derived components comprising an alkynylated sugar receptor (steviol) module and a diazirine-modified ... ...

    Abstract Selective profiling of steviol-catalyzing UDP-glycosyltransferases in plants was accomplished with a probe metabolically synthesized from two substrate-derived components comprising an alkynylated sugar receptor (steviol) module and a diazirine-modified sugar donor (UDP-glucose) module, thereby illustrating a facile approach for harnessing biosynthetic enzymes of natural glycosides in plants for synthetic biology.
    Keywords biosynthesis ; glycosides ; steviol ; sugars ; synthetic biology
    Language English
    Dates of publication 2020-1015
    Size p. 12387-12390.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc04948d
    Database NAL-Catalogue (AGRICOLA)

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