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  1. Article: Editorial: Advanced echocardiographic techniques in structural heart intervention.

    Wong, Randolph H L / Fan, Yiting / Izumo, Masaki / Lee, Alex P W

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 970515

    Language English
    Publishing date 2022-07-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.970515
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  2. Article ; Online: Management of left subclavian artery in total arch replacement and frozen elephant trunk procedure.

    Ho, Jacky Y K / Bashir, Mohamad / Jakob, Heinz / Wong, Randolph H L

    JTCVS techniques

    2021  Volume 7, Page(s) 36–40

    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2021.03.020
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  3. Article ; Online: Pre-emptive BioGlue priming of the branched Evita Open NEO hybrid prosthesis: tackling excessive oozing.

    Ho, Jacky Y K / Lim, Kevin / Fujikawa, Takuya / Wong, Randolph H L

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Volume 61, Issue 3, Page(s) 728–729

    Abstract: Excessive oozing after total arch replacement with the frozen elephant trunk technique through the fabric of the E-vita Open NEO raised concern about its early adaptation. The mechanism is speculated to be multifactorial. Our goal was to report our ... ...

    Abstract Excessive oozing after total arch replacement with the frozen elephant trunk technique through the fabric of the E-vita Open NEO raised concern about its early adaptation. The mechanism is speculated to be multifactorial. Our goal was to report our approach using pre-emptive BioGlue priming on the fabric against the oozing phenomenon.
    MeSH term(s) Aneurysm, Dissecting/surgery ; Aorta, Thoracic/surgery ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/methods ; Humans ; Proteins ; Stents ; Treatment Outcome
    Chemical Substances Bio-glue ; Proteins
    Language English
    Publishing date 2021-09-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab398
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  4. Article ; Online: Open conversion with Crawford extent 3 thoracoabdominal aortic replacement after candy-plug implantation.

    Fujikawa, Takuya / Chow, Simon C Y / Ho, Jacky Y K / Wong, Randolph H L

    Journal of cardiac surgery

    2022  Volume 37, Issue 7, Page(s) 2152–2154

    Abstract: A patient who underwent candy-plug insertion in the year 2016 developed type 1B endoleak with rapid enlargement of distal descending thoracic aortic aneurysm in the year 2021 despite the initial successful false lumen occlusion and thrombosis. Open ... ...

    Abstract A patient who underwent candy-plug insertion in the year 2016 developed type 1B endoleak with rapid enlargement of distal descending thoracic aortic aneurysm in the year 2021 despite the initial successful false lumen occlusion and thrombosis. Open conversion with Crawford extent 3 thoracoabdominal aortic replacement was performed successfully and the patient was discharged home without any major complications.
    MeSH term(s) Aneurysm, Dissecting/surgery ; Aortic Aneurysm, Thoracic/complications ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation ; Endovascular Procedures ; Humans ; Prosthesis Design ; Stents ; Treatment Outcome
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16540
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  5. Article: Three-dimensional printing in structural heart disease and intervention.

    Fan, Yiting / Wong, Randolph H L / Lee, Alex Pui-Wai

    Annals of translational medicine

    2019  Volume 7, Issue 20, Page(s) 579

    Abstract: Three-dimensional (3D) printing refers to the process by which physical objects are built by depositing materials in layers based on a specific digital design. It was initially used in manufacture industry. Inspired by the technology, clinicians have ... ...

    Abstract Three-dimensional (3D) printing refers to the process by which physical objects are built by depositing materials in layers based on a specific digital design. It was initially used in manufacture industry. Inspired by the technology, clinicians have recently attempted to integrate 3D printing into medical applications. One of the medical specialties that has recently made such attempt is cardiology, especially in the field of structural heart disease (SHD). SHD refers to a group of non-coronary cardiovascular disorders and related interventions. Obvious examples are aortic stenosis, mitral regurgitation, atrial septal defect, and known or potential left atrial appendage (LAA) clots. In the last decade, cardiologists have witnessed a dramatic increase in the types and complexity of catheter-based interventions for SHD. Current imaging modalities have important limitations in accurate delineation of cardiac anatomies necessary for SHD interventions. Application of 3D printing in SHD interventional planning enables tangible appreciation of cardiac anatomy and allows
    Language English
    Publishing date 2019-11-22
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.09.73
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  6. Article ; Online: Launching the E-vita Open Neo amid COVID-Challenges and strategies.

    Ho, Jacky Y K / Bashir, Mohamad / Teh, Gloria / Jakob, Heinz / Wong, Randolph H L

    Journal of cardiac surgery

    2021  Volume 36, Issue 3, Page(s) 793–795

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.15197
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  7. Article ; Online: Midterm clinical outcome of a case of aortic arch aneurysm treated with a novel arch stentgraft system.

    Singh, Sukhdeep / Chow, Simon C Y / Ho, Jacky Y K / Fujikawa, Takuya / Chu, Cheuk Man / Yu, Simon C H / Wong, Randolph H L

    Journal of cardiac surgery

    2022  Volume 37, Issue 11, Page(s) 3908–3911

    Abstract: Introduction: Open surgery is the gold standard treatment for aortic arch disease. However, due to its complexity, open arch replacement is associated with considerable risk of mortality and morbidity.: Method: We report a case of a 71-year-old ... ...

    Abstract Introduction: Open surgery is the gold standard treatment for aortic arch disease. However, due to its complexity, open arch replacement is associated with considerable risk of mortality and morbidity.
    Method: We report a case of a 71-year-old gentleman with multiple comorbidities and symptomatic 7 cm aortic arch aneurysm who was treated with a single-stage carotid-carotid and left carotid-axillary bypass followed by zone 0 aortic arch stenting with bimodular Nexus™ stent graft.
    Results: Post-operatively, the patient suffered from a minor stroke with full neurological recovery. Follow-up computed tomography of the aorta 3 years post-stenting showed excellent stent position with no endoleak and complete resolution of the saccular aneurysm.
    Discussion: The midterm result of our patient who was successfully treated with an off-the-shelf single branch, bimodular stent graft system is excellent with complete resolution of the arch saccular aneurysm at 3-year after the operation.
    MeSH term(s) Aged ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Aortic Aneurysm/surgery ; Aortic Aneurysm, Thoracic/surgery ; Aortic Diseases/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/methods ; Endovascular Procedures ; Humans ; Male ; Stents ; Treatment Outcome
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16940
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  8. Article: Initial Asian experience of the branched E-vita open NEO in complex aortic pathologies.

    Ho, Jacky Y K / Kim, Chong Hoon / Chow, Simon C Y / Kwok, Micky W T / Lee, Ha / Kim, Tae-Hoon / Fujikawa, Takuya / Wong, Randolph H L / Song, Suk-Won

    Journal of thoracic disease

    2023  Volume 15, Issue 2, Page(s) 484–493

    Abstract: Background: Aortic arch pathology often requires staged segmental repairs. Total aortic arch replacement with frozen elephant trunk (FET) offers surgical options for these pathologies. The Jotec E-vita Open NEO™ branched prosthesis was introduced in ... ...

    Abstract Background: Aortic arch pathology often requires staged segmental repairs. Total aortic arch replacement with frozen elephant trunk (FET) offers surgical options for these pathologies. The Jotec E-vita Open NEO™ branched prosthesis was introduced in 2020; we sought to share our initial experience focusing on the prosthesis selection strategies, surgical techniques, anastomosis-bleeding and graft-oozing control methods, and early clinical outcomes from two Asian centers.
    Methods: We performed a retrospective cohort study in patients with aortic arch pathologies who underwent total arch replacement using the FET procedure with Jotec E-vita Open NEO™ branched prosthesis from two Asian centers between October 2020 and August 2021. The primary outcome was overall 30-day mortality, and the secondary outcomes were operative complications.
    Results: Twenty-five consecutive patients underwent total arch replacement with FET with the novel hybrid prosthesis. Overall 30-day mortality from both centers was 0%. Overall mean operative, cardiopulmonary bypass, hypothermic circulatory arrest, and selective antegrade cerebral perfusion times were 353.4±80.5, 183.2±39.6, 57.2±14.7, and 138.2±28.6 minutes, respectively. No patient developed stroke. Permanent spinal cord injury (SCI) was recorded in one patient (4%) and one (4%) had transient lower limb weakness that resolved after spinal drainage. There was no requirement of re-sternotomy for hemostasis.
    Conclusions: We reported a multicenter Asian case series with the novel FET hybrid prosthesis demonstrating the feasibility and safety of promising initial clinical outcomes. The technique of circumferential reinforcement of vascular anastomosis for hemostasis may be one of the methods for lowering the rates of re-sternotomy for hemostasis, and proper surgical or transfusion strategies would overcome the excessive oozing of the prosthesis. Long-term follow-up is required for further evaluation of aortic pathology progression and device-related outcomes.
    Language English
    Publishing date 2023-02-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-22-1055
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  9. Article ; Online: Deep Parasternal Intercostal Plane Block for Intraoperative Pain Control in Cardiac Surgical Patients for Sternotomy: A Prospective Randomized Controlled Trial.

    Wong, Henry M K / Chen, P Y / Tang, Geoffrey C C / Chiu, Sandra L C / Mok, Louis Y H / Au, Sylvia S W / Wong, Randolph H L

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 38, Issue 3, Page(s) 683–690

    Abstract: Objectives: Sternotomy pain is common after cardiac surgery. The deep parasternal intercostal plane (DPIP) block is a novel technique that provides analgesia to the anterior chest wall. The aim of this study was to investigate the analgesic effect of ... ...

    Abstract Objectives: Sternotomy pain is common after cardiac surgery. The deep parasternal intercostal plane (DPIP) block is a novel technique that provides analgesia to the anterior chest wall. The aim of this study was to investigate the analgesic effect of bilateral DPIP blocks on intraoperative pain control in cardiac surgery.
    Design: This is a double-blinded, prospective randomized controlled trial (Oct 2020-Dec 2022).
    Settings: This study was conducted in a single institution, which is an academic university hospital.
    Participants: Eighty-six elective cardiac surgical patients with median sternotomy were recruited.
    Interventions: Patients were randomly divided into DPIP or control group. Either 20ml 0.25% levobupivacaine or 0.9% normal saline was injected for the DPIP under ultrasound guidance after induction of general anaesthesia.
    Measurements and main results: The primary outcome was intraoperative opioids consumption and hemodynamic changes at sternotomy. Secondary outcomes included postoperative morphine consumption, postoperative pain and time to tracheal extubation. Intraoperative opioids requirement was reduced from a median (IQR) intravenous morphine equivalence of 21.4mg (13.8-24.3mg) in control group to 9.5mg (7.3-11.2mg) in the DPIP group (P<0.001). Hemodynamic parameters were more stable in DPIP group at sternotomy, as evidenced by lower percentage increase in systolic, diastolic and mean arterial blood pressure from baseline. No difference was observed in time to tracheal extubation, postoperative morphine consumption, postoperative pain score and spirometry.
    Conclusions: Bilateral DPIP block provides effective intraoperative analgesia and opioid-sparing. It may be included as part of the multimodal analgesia for enhanced recovery in cardiac surgery.
    MeSH term(s) Humans ; Sternotomy/adverse effects ; Prospective Studies ; Nerve Block/methods ; Cardiac Surgical Procedures/methods ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Analgesics, Opioid ; Morphine ; Iopanoic Acid/analogs & derivatives
    Chemical Substances 1,3-dihydroxypropan-2-one 1,3-diiopanoate ; Analgesics, Opioid ; Morphine (76I7G6D29C) ; Iopanoic Acid (FE9794P71J)
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.11.038
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  10. Article ; Online: Surgical ventricular restoration with double-patch postinfarction ventricular septal rupture repair.

    Ho, Jacky Y K / Chow, Simon C Y / Fujikawa, Takuya / Wong, Randolph H L

    Interactive cardiovascular and thoracic surgery

    2020  Volume 31, Issue 5, Page(s) 751

    Language English
    Publishing date 2020-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivaa181
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